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The map label for this gene is hemH [H]

Identifier: 62390419

GI number: 62390419

Start: 1623305

End: 1624417

Strand: Reverse

Name: hemH [H]

Synonym: cg1734

Alternate gene names: 62390419

Gene position: 1624417-1623305 (Counterclockwise)

Preceding gene: 62390420

Following gene: 62390417

Centisome position: 49.48

GC content: 55.88

Gene sequence:

>1113_bases
ATGAATGAACGCACATCGGATGCATTTGACGCCCTCCTTGTGCTCTCCTTCGGTGGTCCCGAAGGGCACGAGGAGGTTCG
TCCGTTTTTGGAGAATGTCACTCACGGAAGGGGGATTCCGCCGGAACGTCTAGATGAAGTGGCGGTTCATTACCACCACT
TCGGTGGTATCAGCCCCATCAATGCGCTGAACAGGGAAATTATCGCCAATGTGGAAAAAGAATTGGCGTCTCGCGATCAC
AAGCTGCCTGTTTATTTTGGTAACCGCAACTGGAAGCCGTTTGATAATGAGGCCGCTGAACAAATGGCTGATGACGGCGT
GAAAAACGCGCTGGTGTTGGCAACTTCCGCTTGGGGTGGCTACTCCGGTTGTCGGCAGTACCAGGAAGATATTCAGGGCA
TGATCAAGCACCTGGAGTCTCAGGGGCAGTCGATCACGTTCACCAAGCTGCGTCAGTTCTACGATCACCCTCGTTTTGTC
TCCACCATGGCTCAATTGGTTCAGGATTCCTACGCGAAGCTTCCCGATGAGCTGCGAGATGAGGCGCGTCTGGTCTTCAC
CGCGCACTCCATTCCACTGACTGCGGACAATGCTGCGGGAACCCCTGAGGATGGCTCCTTGTATTCCACACAGGTCAAGG
AAGCGTCAGCACTGATTGCTGAGGCTGTTGGTGTGTCAGATTTTGATGTGGTGTGGCAGTCCCGCTCGGGTAGCCCGCAC
ACTCCGTGGCTGGAGCCTGACATCGTGGATCACGCAGTGGAGCTCAACGAGAAGGGTCAAAAAGCGCTCGTTGTCTGCCC
TGTAGGCTTTATTTCTGATCATATGGAAGTCATTTGGGATCTTGATTCCGAGCTGATGGAAGAAGCCGAGAAGCGCAACA
TGGTGGTCGAGCGTGTCGCTACCGTTGGCCCCACCGATGAATTCGCAGCCCTTGTGGTTGATCTCATCGAGGAGGCAGAG
CTCAAGCGCGTTATCGAGCGCCTTGGAAAGCTGCCAGCACGCGGAAGTTCCGTCAACGGCGCACCGTGTGGCGACGGCTG
CTGTGGTACCGCCAAGCATAAAACCGCGCGGGTGAACCCCAACGCTCGCTCAGCGGCGCCAGCTGCCAACTAG

Upstream 100 bases:

>100_bases
ACCGAGAGCGTGGTACGCCTCATTTAGTTTCCTCCTATGAATCTTGATGTGGTTCATGCGTTTTTATGCAATATCAACCA
AAAGTTGGTACGATCCTCAT

Downstream 100 bases:

>100_bases
GAGTGATAGTCCCTCGCAAACTCTGCGAGGGCATAACTCACCCCAGCCATGCGCGCGGTCCGAATATGGCTCCACAGGAA
AATCAACTGTGGATCCAGGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTHGRGIPPERLDEVAVHYHHFGGISPINALNREIIANVEKELASRDH
KLPVYFGNRNWKPFDNEAAEQMADDGVKNALVLATSAWGGYSGCRQYQEDIQGMIKHLESQGQSITFTKLRQFYDHPRFV
STMAQLVQDSYAKLPDELRDEARLVFTAHSIPLTADNAAGTPEDGSLYSTQVKEASALIAEAVGVSDFDVVWQSRSGSPH
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVATVGPTDEFAALVVDLIEEAE
LKRVIERLGKLPARGSSVNGAPCGDGCCGTAKHKTARVNPNARSAAPAAN

Sequences:

>Translated_370_residues
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTHGRGIPPERLDEVAVHYHHFGGISPINALNREIIANVEKELASRDH
KLPVYFGNRNWKPFDNEAAEQMADDGVKNALVLATSAWGGYSGCRQYQEDIQGMIKHLESQGQSITFTKLRQFYDHPRFV
STMAQLVQDSYAKLPDELRDEARLVFTAHSIPLTADNAAGTPEDGSLYSTQVKEASALIAEAVGVSDFDVVWQSRSGSPH
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVATVGPTDEFAALVVDLIEEAE
LKRVIERLGKLPARGSSVNGAPCGDGCCGTAKHKTARVNPNARSAAPAAN
>Mature_370_residues
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTHGRGIPPERLDEVAVHYHHFGGISPINALNREIIANVEKELASRDH
KLPVYFGNRNWKPFDNEAAEQMADDGVKNALVLATSAWGGYSGCRQYQEDIQGMIKHLESQGQSITFTKLRQFYDHPRFV
STMAQLVQDSYAKLPDELRDEARLVFTAHSIPLTADNAAGTPEDGSLYSTQVKEASALIAEAVGVSDFDVVWQSRSGSPH
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVATVGPTDEFAALVVDLIEEAE
LKRVIERLGKLPARGSSVNGAPCGDGCCGTAKHKTARVNPNARSAAPAAN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=286, Percent_Identity=24.8251748251748, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI60499025, Length=286, Percent_Identity=24.8251748251748, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324750, Length=327, Percent_Identity=24.7706422018349, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864156, Length=319, Percent_Identity=26.0188087774295, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45552018, Length=163, Percent_Identity=28.2208588957055, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24651774, Length=259, Percent_Identity=25.8687258687259, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 40580; Mature: 40580

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTHGRGIPPERLDEVAVHYHHFGGISPI
CCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHH
NALNREIIANVEKELASRDHKLPVYFGNRNWKPFDNEAAEQMADDGVKNALVLATSAWGG
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
YSGCRQYQEDIQGMIKHLESQGQSITFTKLRQFYDHPRFVSTMAQLVQDSYAKLPDELRD
HHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHC
EARLVFTAHSIPLTADNAAGTPEDGSLYSTQVKEASALIAEAVGVSDFDVVWQSRSGSPH
CCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCC
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVA
CCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TVGPTDEFAALVVDLIEEAELKRVIERLGKLPARGSSVNGAPCGDGCCGTAKHKTARVNP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
NARSAAPAAN
CCCCCCCCCC
>Mature Secondary Structure
MNERTSDAFDALLVLSFGGPEGHEEVRPFLENVTHGRGIPPERLDEVAVHYHHFGGISPI
CCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHH
NALNREIIANVEKELASRDHKLPVYFGNRNWKPFDNEAAEQMADDGVKNALVLATSAWGG
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
YSGCRQYQEDIQGMIKHLESQGQSITFTKLRQFYDHPRFVSTMAQLVQDSYAKLPDELRD
HHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHC
EARLVFTAHSIPLTADNAAGTPEDGSLYSTQVKEASALIAEAVGVSDFDVVWQSRSGSPH
CCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCC
TPWLEPDIVDHAVELNEKGQKALVVCPVGFISDHMEVIWDLDSELMEEAEKRNMVVERVA
CCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TVGPTDEFAALVVDLIEEAELKRVIERLGKLPARGSSVNGAPCGDGCCGTAKHKTARVNP
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCC
NARSAAPAAN
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA