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The map label for this gene is mcmB [H]

Identifier: 62390411

GI number: 62390411

Start: 1613698

End: 1615911

Strand: Reverse

Name: mcmB [H]

Synonym: cg1725

Alternate gene names: 62390411

Gene position: 1615911-1613698 (Counterclockwise)

Preceding gene: 62390412

Following gene: 62390410

Centisome position: 49.22

GC content: 56.82

Gene sequence:

>2214_bases
ATGACGTCGATCCCTAATTTTTCAGACATCCCATTGACTGCTGAGACACGTGCATCGGAGTCACACAACGTTGACGCCGG
CAAGGTGTGGAACACTCCCGAAGGCATTGATGTCAAGCGCGTATTCACGCAGGCTGACCGCGACGAGGCGCAAGCGGCGG
GACATCCGGTGGATTCTTTGCCAGGTCAAAAGCCATTTATGCGCGGGCCGTACCCAACTATGTACACCAATCAGCCGTGG
ACGATTCGCCAGTACGCAGGCTTTTCAACCGCCGCGGAATCCAATGCGTTTTATCGGAGGAACCTTGCTGCGGGTCAAAA
AGGTTTGTCGGTTGCGTTCGATCTAGCGACCCACCGCGGTTATGACTCGGATAATGAGCGCGTGGTCGGCGATGTGGGTA
TGGCCGGCGTGGCGATTGATTCGATTTTGGATATGCGTCAGCTGTTTGATGGCATTGATTTGTCCAGCGTGTCGGTGTCG
ATGACCATGAATGGCGCTGTGCTGCCGATTCTTGCGTTCTATATCGTGGCGGCTGAGGAACAAGGTGTGGGTCCGGAGCA
GCTTGCGGGCACGATCCAGAATGACATCTTGAAAGAATTTATGGTGCGCAACACCTATATTTATCCGCCGAAGCCGTCGA
TGCGCATCATTTCCAACATCTTTGAGTACACCTCCTTGAAGATGCCACGTTTTAACTCCATTTCGATTTCTGGCTATCAC
ATCCAGGAAGCGGGAGCGACTGCCGATTTGGAGCTGGCCTACACTCTGGCGGATGGTATTGAATACATCCGTGCAGGTAA
AGAGGTAGGCCTTGACGTGGATAAGTTCGCGCCTCGTCTGTCCTTCTTCTGGGGTATTTCTATGTACACCTTCATGGAGA
TCGCAAAGCTGCGTGCGGGACGACTGCTGTGGAGCGAGTTGGTGGCAAAATTCGATCCGAAAAACGCCAAGTCCCAGTCG
CTGCGCACGCACTCGCAGACCTCTGGTTGGTCGTTGACCGCGCAGGATGTGTACAACAACGTCGCCCGCACCGCGATTGA
GGCGATGGCTGCAACCCAGGGCCACACCCAGTCGCTGCACACCAATGCACTTGATGAGGCGTTGGCGCTGCCCACCGATT
TCTCTGCTCGTATCGCCCGAAACACCCAGCTGTTGCTGCAGCAGGAATCTGGCACGGTGCGTCCAGTTGATCCATGGGCG
GGCTCCTATTACGTGGAGTGGTTGACCAATGAGCTGGCTAACCGCGCGCGCAAGCACATCGATGAGGTGGAGGAAGCCGG
CGGAATGGCGCAGGCCACCGCGCAGGGAATTCCTAAGCTGCGCATTGAGGAATCAGCGGCACGCACCCAGGCTCGCATTG
ATTCCGGCCGCCAGGCGCTGATCGGCGTGAATCGCTACGTGGCGGAAGAAGATGAGGAAATTGAAGTCCTCAAGGTTGAC
AACACCAAGGTTCGCGCAGAACAGTTGGCTAAACTCGCGCAACTGAAAGCAGAGCGCAACGATGCGGAAGTCAAGGCTGC
GCTGGATGCGTTGACAGCTGCTGCCCGCAACGAGCATAAAGAGCCAGGGGATTTGGATCAGAACCTGCTCAAACTTGCCG
TCGATGCTGCGCGCGCAAAAGCTACCATTGGAGAGATCTCCGATGCTTTGGAAGTTGTCTTTGGCCGCCACGAAGCAGAA
ATCAGGACGCTGTCTGGCGTGTACAAGGATGAGGTTGGAAAGGAAGGCACAGTGAGCAACGTCGAACGCGCGATCGCCCT
GGCTGACGCCTTTGAGGCTGAGGAAGGCCGCCGCCCACGTATCTTTATTGCCAAGATGGGCCAGGATGGACATGACCGTG
GACAGAAGGTTGTCGCGTCTGCCTATGCTGACCTGGGCATGGACGTGGATGTTGGACCGCTGTTTCAAACTCCAGCCGAA
GCTGCCCGCGCCGCCGTGGACGCCGATGTTCACGTGGTGGGTATGTCTTCGCTGGCAGCAGGCCACCTCACCTTGCTGCC
CGAGCTGAAGAAAGAACTTGCAGCTCTTGGCCGCGATGACATTCTGGTCACCGTGGGCGGCGTCATTCCGCCGGGCGATT
TCCAGGATCTCTACGATATGGGTGCCGCCGCGATTTACCCTCCAGGAACCGTCATCGCGGAGTCGGCGATCGATCTGATC
ACCCGACTCGCCGCACACCTGGGCTTTGACCTGGATGTGGATGTGAATGAGTGA

Upstream 100 bases:

>100_bases
CTTTGAGGGCAGCGCGCATGCGCCCGATGGTTATTTGAACATGACAATTGATGCCGCGGCGACGCTGGCTGACCTGCTAG
ATGCTTTGGGAGCTTAAATC

Downstream 100 bases:

>100_bases
TCACGGTTTCCTAGAAGACAACCTAGGTACCCTCACCACCACCGGAGGCACTGATTTAGGGCGCAGCACCGCAGTGGCTC
CGGAGGCGCTCAAGCGCGCC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 737; Mature: 736

Protein sequence:

>737_residues
MTSIPNFSDIPLTAETRASESHNVDAGKVWNTPEGIDVKRVFTQADRDEAQAAGHPVDSLPGQKPFMRGPYPTMYTNQPW
TIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNERVVGDVGMAGVAIDSILDMRQLFDGIDLSSVSVS
MTMNGAVLPILAFYIVAAEEQGVGPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYH
IQEAGATADLELAYTLADGIEYIRAGKEVGLDVDKFAPRLSFFWGISMYTFMEIAKLRAGRLLWSELVAKFDPKNAKSQS
LRTHSQTSGWSLTAQDVYNNVARTAIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTVRPVDPWA
GSYYVEWLTNELANRARKHIDEVEEAGGMAQATAQGIPKLRIEESAARTQARIDSGRQALIGVNRYVAEEDEEIEVLKVD
NTKVRAEQLAKLAQLKAERNDAEVKAALDALTAAARNEHKEPGDLDQNLLKLAVDAARAKATIGEISDALEVVFGRHEAE
IRTLSGVYKDEVGKEGTVSNVERAIALADAFEAEEGRRPRIFIAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAE
AARAAVDADVHVVGMSSLAAGHLTLLPELKKELAALGRDDILVTVGGVIPPGDFQDLYDMGAAAIYPPGTVIAESAIDLI
TRLAAHLGFDLDVDVNE

Sequences:

>Translated_737_residues
MTSIPNFSDIPLTAETRASESHNVDAGKVWNTPEGIDVKRVFTQADRDEAQAAGHPVDSLPGQKPFMRGPYPTMYTNQPW
TIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNERVVGDVGMAGVAIDSILDMRQLFDGIDLSSVSVS
MTMNGAVLPILAFYIVAAEEQGVGPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYH
IQEAGATADLELAYTLADGIEYIRAGKEVGLDVDKFAPRLSFFWGISMYTFMEIAKLRAGRLLWSELVAKFDPKNAKSQS
LRTHSQTSGWSLTAQDVYNNVARTAIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTVRPVDPWA
GSYYVEWLTNELANRARKHIDEVEEAGGMAQATAQGIPKLRIEESAARTQARIDSGRQALIGVNRYVAEEDEEIEVLKVD
NTKVRAEQLAKLAQLKAERNDAEVKAALDALTAAARNEHKEPGDLDQNLLKLAVDAARAKATIGEISDALEVVFGRHEAE
IRTLSGVYKDEVGKEGTVSNVERAIALADAFEAEEGRRPRIFIAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAE
AARAAVDADVHVVGMSSLAAGHLTLLPELKKELAALGRDDILVTVGGVIPPGDFQDLYDMGAAAIYPPGTVIAESAIDLI
TRLAAHLGFDLDVDVNE
>Mature_736_residues
TSIPNFSDIPLTAETRASESHNVDAGKVWNTPEGIDVKRVFTQADRDEAQAAGHPVDSLPGQKPFMRGPYPTMYTNQPWT
IRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNERVVGDVGMAGVAIDSILDMRQLFDGIDLSSVSVSM
TMNGAVLPILAFYIVAAEEQGVGPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYHI
QEAGATADLELAYTLADGIEYIRAGKEVGLDVDKFAPRLSFFWGISMYTFMEIAKLRAGRLLWSELVAKFDPKNAKSQSL
RTHSQTSGWSLTAQDVYNNVARTAIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTVRPVDPWAG
SYYVEWLTNELANRARKHIDEVEEAGGMAQATAQGIPKLRIEESAARTQARIDSGRQALIGVNRYVAEEDEEIEVLKVDN
TKVRAEQLAKLAQLKAERNDAEVKAALDALTAAARNEHKEPGDLDQNLLKLAVDAARAKATIGEISDALEVVFGRHEAEI
RTLSGVYKDEVGKEGTVSNVERAIALADAFEAEEGRRPRIFIAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEA
ARAAVDADVHVVGMSSLAAGHLTLLPELKKELAALGRDDILVTVGGVIPPGDFQDLYDMGAAAIYPPGTVIAESAIDLIT
RLAAHLGFDLDVDVNE

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=693, Percent_Identity=61.9047619047619, Blast_Score=888, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=699, Percent_Identity=60.9442060085837, Blast_Score=836, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=701, Percent_Identity=62.7674750356633, Blast_Score=904, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 80111; Mature: 79980

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIPNFSDIPLTAETRASESHNVDAGKVWNTPEGIDVKRVFTQADRDEAQAAGHPVDSL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCC
PGQKPFMRGPYPTMYTNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRG
CCCCCCCCCCCCCCCCCCCEEEHHHCCCCCHHCCCCHHHHHHHCCCCCCEEEEEHHHHCC
YDSDNERVVGDVGMAGVAIDSILDMRQLFDGIDLSSVSVSMTMNGAVLPILAFYIVAAEE
CCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHCCC
QGVGPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYH
CCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCEE
IQEAGATADLELAYTLADGIEYIRAGKEVGLDVDKFAPRLSFFWGISMYTFMEIAKLRAG
ECCCCCCCCEEEEHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLWSELVAKFDPKNAKSQSLRTHSQTSGWSLTAQDVYNNVARTAIEAMAATQGHTQSLH
HHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHH
TNALDEALALPTDFSARIARNTQLLLQQESGTVRPVDPWAGSYYVEWLTNELANRARKHI
HHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEVEEAGGMAQATAQGIPKLRIEESAARTQARIDSGRQALIGVNRYVAEEDEEIEVLKVD
HHHHHHCCHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCEEEEEEC
NTKVRAEQLAKLAQLKAERNDAEVKAALDALTAAARNEHKEPGDLDQNLLKLAVDAARAK
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ATIGEISDALEVVFGRHEAEIRTLSGVYKDEVGKEGTVSNVERAIALADAFEAEEGRRPR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
IFIAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEAARAAVDADVHVVGMSSLAA
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHCC
GHLTLLPELKKELAALGRDDILVTVGGVIPPGDFQDLYDMGAAAIYPPGTVIAESAIDLI
CHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCEECCCCHHHHHHHHHHH
TRLAAHLGFDLDVDVNE
HHHHHHHCCCCEEECCC
>Mature Secondary Structure 
TSIPNFSDIPLTAETRASESHNVDAGKVWNTPEGIDVKRVFTQADRDEAQAAGHPVDSL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCC
PGQKPFMRGPYPTMYTNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRG
CCCCCCCCCCCCCCCCCCCEEEHHHCCCCCHHCCCCHHHHHHHCCCCCCEEEEEHHHHCC
YDSDNERVVGDVGMAGVAIDSILDMRQLFDGIDLSSVSVSMTMNGAVLPILAFYIVAAEE
CCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHCCC
QGVGPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISNIFEYTSLKMPRFNSISISGYH
CCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCEE
IQEAGATADLELAYTLADGIEYIRAGKEVGLDVDKFAPRLSFFWGISMYTFMEIAKLRAG
ECCCCCCCCEEEEHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLWSELVAKFDPKNAKSQSLRTHSQTSGWSLTAQDVYNNVARTAIEAMAATQGHTQSLH
HHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHH
TNALDEALALPTDFSARIARNTQLLLQQESGTVRPVDPWAGSYYVEWLTNELANRARKHI
HHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEVEEAGGMAQATAQGIPKLRIEESAARTQARIDSGRQALIGVNRYVAEEDEEIEVLKVD
HHHHHHCCHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCEEEEEEC
NTKVRAEQLAKLAQLKAERNDAEVKAALDALTAAARNEHKEPGDLDQNLLKLAVDAARAK
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ATIGEISDALEVVFGRHEAEIRTLSGVYKDEVGKEGTVSNVERAIALADAFEAEEGRRPR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
IFIAKMGQDGHDRGQKVVASAYADLGMDVDVGPLFQTPAEAARAAVDADVHVVGMSSLAA
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHCC
GHLTLLPELKKELAALGRDDILVTVGGVIPPGDFQDLYDMGAAAIYPPGTVIAESAIDLI
CHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCCEECCCCHHHHHHHHHHH
TRLAAHLGFDLDVDVNE
HHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]