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The map label for this gene is pyrD [H]

Identifier: 62390401

GI number: 62390401

Start: 1602159

End: 1603274

Strand: Direct

Name: pyrD [H]

Synonym: cg1713

Alternate gene names: 62390401

Gene position: 1602159-1603274 (Clockwise)

Preceding gene: 62390400

Following gene: 62390403

Centisome position: 48.81

GC content: 56.81

Gene sequence:

>1116_bases
ATGAGCAAGCAATCCCCCACCCGCAAGCTGCGTCAAACCGTCTACGATGCCAGCCTCAAAGTGATGTTCACCCTGCGCCC
CGAACGCATCCACGGGATAATGAACAAAGCACTCGGAGTCGTCGACGGCGTCGCACCTCTAAACCGCACCATGGAAAAAA
TCATCGCAGTGCACGATGATTCCCTCTCCCAGGAAGTCTTCGGCGTCACCTTCCCACGACCACTAGGCCTCGCCGCAGGT
TTCGACAAAAACGCATCAATGGCTGATGCCTGGGGTGCCGTTGGATTCGGATACGCCGAACTTGGCACCGTCACCGCCTC
CCCACAGCCAGGAAACCCCACCCCGCGCCTTTTCCGCCTGCCTGCCGACAAAGCTATCTTGAACCGCATGGGATTCAACA
ACCTGGGTGCAGCAGAAGTCGCAAAAAACCTGCGCAACCGGAAATCCACCGATGTCATCGGCATCAACATCGGTAAAACC
AAAGTGGTTCCCGCTGAACACGCAGTAGATGACTACCGCCGTTCTGCATCTTTGTTAGGTGATCTTGCTGATTACCTGGT
TGTCAACGTTTCCTCCCCCAACACTCCGGGTCTCCGCGATCTGCAGGCTGTGGAATCTTTGCGACCAATCCTCGCCGCAG
TGCAGGAATCCACCACCGTCCCAGTCTTGGTGAAAATCGCACCAGACCTCTCCGACGAAGACATCGACGCCGTAGCTGAC
CTGGCAGTTGAGCTCAAACTCGCCGGAATCGTAGCCACCAATACCACCATTTCCCGCGAAGGCCTCAACACTCCTTCAGG
TGAAGTCGAAGCCATGGGTGCTGGCGGAATCTCCGGTGCTCCAGTAGCAGCCCGATCTTTGGAGGTACTCAAGCGCCTCT
ACGCACGGGTAGGCAAAGAGATGGTGTTGATCTCTGTCGGTGGCATCAGCACCCCTGAGCAAGCCTGGGAACGCATCACC
TCCGGCGCAACCCTTCTGCAGGGATACACCCCATTCATCTACGGTGGCCCCGATTGGATCAGAGATATCCACCTTGGTAT
CGCCAAGCAGCTGAAAGCTCACGGTCTGCGCAACATCGCTGACGCTGTGGGCAGCGAATTGGAGTGGAAGAACTAA

Upstream 100 bases:

>100_bases
AAAACCTCGTGGTATTAAGCGATTCCACCCTCGTCGTAGCATCCGCAACCGGCGACGGCATCCAAATCATCGACAACCCA
GCATCTTAAAAAGGACACCC

Downstream 100 bases:

>100_bases
ACAGACCAAACACACGTGCCAGGATCTTGCTGAAACAGCGGATCTTGGCACGTGTGTCTGTCTTTTGTCTGTTCTGGTGC
CTCACATGCCGCTTTGGACT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSKQSPTRKLRQTVYDASLKVMFTLRPERIHGIMNKALGVVDGVAPLNRTMEKIIAVHDDSLSQEVFGVTFPRPLGLAAG
FDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVAKNLRNRKSTDVIGINIGKT
KVVPAEHAVDDYRRSASLLGDLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
LAVELKLAGIVATNTTISREGLNTPSGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKEMVLISVGGISTPEQAWERIT
SGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIADAVGSELEWKN

Sequences:

>Translated_371_residues
MSKQSPTRKLRQTVYDASLKVMFTLRPERIHGIMNKALGVVDGVAPLNRTMEKIIAVHDDSLSQEVFGVTFPRPLGLAAG
FDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVAKNLRNRKSTDVIGINIGKT
KVVPAEHAVDDYRRSASLLGDLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
LAVELKLAGIVATNTTISREGLNTPSGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKEMVLISVGGISTPEQAWERIT
SGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIADAVGSELEWKN
>Mature_370_residues
SKQSPTRKLRQTVYDASLKVMFTLRPERIHGIMNKALGVVDGVAPLNRTMEKIIAVHDDSLSQEVFGVTFPRPLGLAAGF
DKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVAKNLRNRKSTDVIGINIGKTK
VVPAEHAVDDYRRSASLLGDLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVADL
AVELKLAGIVATNTTISREGLNTPSGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKEMVLISVGGISTPEQAWERITS
GATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIADAVGSELEWKN

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=324, Percent_Identity=40.7407407407407, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=41.1411411411411, Blast_Score=244, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17509475, Length=321, Percent_Identity=36.7601246105919, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI281361352, Length=326, Percent_Identity=39.2638036809816, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17137316, Length=326, Percent_Identity=39.2638036809816, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39562; Mature: 39431

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQSPTRKLRQTVYDASLKVMFTLRPERIHGIMNKALGVVDGVAPLNRTMEKIIAVHDD
CCCCCHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
SLSQEVFGVTFPRPLGLAAGFDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRL
CCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHCEEECCCCCCCCCCCEEEC
PADKAILNRMGFNNLGAAEVAKNLRNRKSTDVIGINIGKTKVVPAEHAVDDYRRSASLLG
CCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHH
DLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
HHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
LAVELKLAGIVATNTTISREGLNTPSGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKE
HHHHEEEEEEEEECCEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCE
MVLISVGGISTPEQAWERITSGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIA
EEEEEECCCCCHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
DAVGSELEWKN
HHHCCCCCCCC
>Mature Secondary Structure 
SKQSPTRKLRQTVYDASLKVMFTLRPERIHGIMNKALGVVDGVAPLNRTMEKIIAVHDD
CCCCHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
SLSQEVFGVTFPRPLGLAAGFDKNASMADAWGAVGFGYAELGTVTASPQPGNPTPRLFRL
CCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHCEEECCCCCCCCCCCEEEC
PADKAILNRMGFNNLGAAEVAKNLRNRKSTDVIGINIGKTKVVPAEHAVDDYRRSASLLG
CCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHHHHHHHH
DLADYLVVNVSSPNTPGLRDLQAVESLRPILAAVQESTTVPVLVKIAPDLSDEDIDAVAD
HHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHH
LAVELKLAGIVATNTTISREGLNTPSGEVEAMGAGGISGAPVAARSLEVLKRLYARVGKE
HHHHEEEEEEEEECCEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCE
MVLISVGGISTPEQAWERITSGATLLQGYTPFIYGGPDWIRDIHLGIAKQLKAHGLRNIA
EEEEEECCCCCHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
DAVGSELEWKN
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA