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The map label for this gene is arsC2 [H]

Identifier: 62390393

GI number: 62390393

Start: 1594870

End: 1595982

Strand: Direct

Name: arsC2 [H]

Synonym: cg1705

Alternate gene names: 62390393

Gene position: 1594870-1595982 (Clockwise)

Preceding gene: 62390390

Following gene: 62390394

Centisome position: 48.58

GC content: 47.26

Gene sequence:

>1113_bases
ATGACAAACTCAACTCAGACGCGGGCCAAGCCAGCCCGAATCTCATTTCTTGATAAATACATTCCACTTTGGATTATTTT
GGCGATGGCGTTTGGGCTATTTTTAGGCCGGAGCGTTTCGGGACTCTCAGGCTTTCTAGGCGCAATGGAAGTCGGAGGGA
TCTCCTTGCCAATCGCTTTAGGCCTCCTTGTAATGATGTACCCACCGTTGGCCAAAGTTCGGTATGACAAAACTAAACAA
ATTGCCACTGATAAGCATTTGATGGGCGTGTCACTCATTCTCAATTGGGTGGTGGGTCCTGCCTTAATGTTCGCGCTAGC
TTGGTTGTTCCTCCCAGACCAACCGGAATTACGAACCGGCCTGATTATTGTAGGACTCGCACGATGTATTGCGATGGTCT
TGGTTTGGTCTGATATGTCCTGTGGAGACCGCGAGGCTACAGCAGTTCTCGTAGCCATTAATTCAGTTTTTCAAGTCGCA
ATGTTTGGTGCACTTGGCTGGTTCTATCTGCAAGTTTTACCATCCTGGCTAGGATTACCAACTACCACCGCTCAATTCTC
TTTCTGGTCAATTGTGACTTCGGTTTTGGTGTTCCTCGGAATACCTCTACTTGCTGGAGTTTTCTCGCGAATTATTGGCG
AAAAGATCAAGGGACGTGAGTGGTATGAACAAAAGTTCCTTCCGGCAATCTCTCCATTTGCACTAATCGGTCTGCTTTAT
ACGATCGTCTTGTTGTTTTCATTGCAAGGTGATCAGATCGTCTCTCAACCATGGGCTGTAGTTCGTCTCGCGATACCATT
GGTTATCTATTTCGTTGGAATGTTTTTCATTTCACTCATTGCGTCAAAACTATCTGGCATGAACTATGCAAAGTCTGCAT
CCGTCTCTTTCACTGCAGCTGGCAACAATTTTGAACTTGCGATTGCGGTGTCGATCGGAACGTTTGGCGCAACTTCTGCA
CAGGCTATGGCAGGAACGATTGGTCCCTTGATTGAAATTCCAGTACTTGTCGGCTTGGTCTACGCCATGCTGTGGCTAGG
CCCCAAGTTGTTCCCAAATGACCCCACGCTGCCATCATCAGCTCGTTCTACCAGCCAAATCATCAACTCATAG

Upstream 100 bases:

>100_bases
ATTGTGTGGAGAGTGGTCATAAATCCACTATATATTGACGAATGTCGATATTGAAAGTATTTTGAATATCGACAGGTATC
AATATACCGAAAGGTGTCGC

Downstream 100 bases:

>100_bases
CGAAGGAATCAACTTCATGAATAATCAACCATCAGTACTTTTCGTTTGCGTCGGCAATGGTGGAAAATCTCAAATGGCCG
CAGCGCTAGCCAAAAAACAT

Product: arsenite efflux pump ACR3 or related permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTNSTQTRAKPARISFLDKYIPLWIILAMAFGLFLGRSVSGLSGFLGAMEVGGISLPIALGLLVMMYPPLAKVRYDKTKQ
IATDKHLMGVSLILNWVVGPALMFALAWLFLPDQPELRTGLIIVGLARCIAMVLVWSDMSCGDREATAVLVAINSVFQVA
MFGALGWFYLQVLPSWLGLPTTTAQFSFWSIVTSVLVFLGIPLLAGVFSRIIGEKIKGREWYEQKFLPAISPFALIGLLY
TIVLLFSLQGDQIVSQPWAVVRLAIPLVIYFVGMFFISLIASKLSGMNYAKSASVSFTAAGNNFELAIAVSIGTFGATSA
QAMAGTIGPLIEIPVLVGLVYAMLWLGPKLFPNDPTLPSSARSTSQIINS

Sequences:

>Translated_370_residues
MTNSTQTRAKPARISFLDKYIPLWIILAMAFGLFLGRSVSGLSGFLGAMEVGGISLPIALGLLVMMYPPLAKVRYDKTKQ
IATDKHLMGVSLILNWVVGPALMFALAWLFLPDQPELRTGLIIVGLARCIAMVLVWSDMSCGDREATAVLVAINSVFQVA
MFGALGWFYLQVLPSWLGLPTTTAQFSFWSIVTSVLVFLGIPLLAGVFSRIIGEKIKGREWYEQKFLPAISPFALIGLLY
TIVLLFSLQGDQIVSQPWAVVRLAIPLVIYFVGMFFISLIASKLSGMNYAKSASVSFTAAGNNFELAIAVSIGTFGATSA
QAMAGTIGPLIEIPVLVGLVYAMLWLGPKLFPNDPTLPSSARSTSQIINS
>Mature_369_residues
TNSTQTRAKPARISFLDKYIPLWIILAMAFGLFLGRSVSGLSGFLGAMEVGGISLPIALGLLVMMYPPLAKVRYDKTKQI
ATDKHLMGVSLILNWVVGPALMFALAWLFLPDQPELRTGLIIVGLARCIAMVLVWSDMSCGDREATAVLVAINSVFQVAM
FGALGWFYLQVLPSWLGLPTTTAQFSFWSIVTSVLVFLGIPLLAGVFSRIIGEKIKGREWYEQKFLPAISPFALIGLLYT
IVLLFSLQGDQIVSQPWAVVRLAIPLVIYFVGMFFISLIASKLSGMNYAKSASVSFTAAGNNFELAIAVSIGTFGATSAQ
AMAGTIGPLIEIPVLVGLVYAMLWLGPKLFPNDPTLPSSARSTSQIINS

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=339, Percent_Identity=34.5132743362832, Blast_Score=183, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 40011; Mature: 39880

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCC
>Mature Secondary Structure 
TNSTQTRAKPARISFLDKYIPLWIILAMAFGLFLGRSVSGLSGFLGAMEVGGISLPIAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHH
GLLVMMYPPLAKVRYDKTKQIATDKHLMGVSLILNWVVGPALMFALAWLFLPDQPELRTG
HHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LIIVGLARCIAMVLVWSDMSCGDREATAVLVAINSVFQVAMFGALGWFYLQVLPSWLGLP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TTTAQFSFWSIVTSVLVFLGIPLLAGVFSRIIGEKIKGREWYEQKFLPAISPFALIGLLY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHH
TIVLLFSLQGDQIVSQPWAVVRLAIPLVIYFVGMFFISLIASKLSGMNYAKSASVSFTAA
HHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
GNNFELAIAVSIGTFGATSAQAMAGTIGPLIEIPVLVGLVYAMLWLGPKLFPNDPTLPSS
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
ARSTSQIINS
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]