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The map label for this gene is yheI [H]

Identifier: 62390316

GI number: 62390316

Start: 1510280

End: 1511836

Strand: Direct

Name: yheI [H]

Synonym: cg1621

Alternate gene names: 62390316

Gene position: 1510280-1511836 (Clockwise)

Preceding gene: 62390312

Following gene: 62390317

Centisome position: 46.01

GC content: 54.98

Gene sequence:

>1557_bases
GTGCAACAAACGAAATCCACACCTTTAGATAGGTATAAAAACCTCCCCGGGCCCGGCGCGCGACCGTCCAAGATGCCGGC
GTTGGATGCCAAATTATGGACTCTCAAAGTGGCGTTGTCGCAGCGGCCGTGGAGCTTTGTGGCGTCTGCTGGCATGGCGG
CGTCTTTTATCTGCAATGGGTTAACGCCTGTGATTGTGGGTAAGGCGGTGGATGAGGCTATTGGCACGAGCGATCTGCAG
CGATTGTGGTTCTGGATTGCCATGTTGGCGGTTCTTTTCTTAACGGCGATGACGGTGAACTGGATTGCTCGGTACATGTT
GGTGCGGAGCCAGCAGTTGGTCAGCCATGATTTGCGCATGTTGGTGACTGATCGGATTCAAGATCCGCGTGGTTTTGCTG
GAAAAGAGCGCACTGCGGGTGGATTGTTGTCGATTGCGTCATCGGATACGCAGCGGGTGGGCGATATCGTCATGATGACG
GTGTTCCCGGTGGCGGAATTGGCGTCGATTATTTATGGCGCCGTGGTGATGTACAGCATTAATCCGTGGTTGAGTGTGGC
TGTGCTGATTGGTGGACCGCTGCTGGTTGTGGTGGCTATTCAGGTCTCAAAGCCGTTGCAGAAGCGTTCGGGTGCTCGTC
AGCAGGCGGTGGCACAGGCTGCGGCTACTGCAACTGATGTGGTGCAGGGCTTGAGAATTTTGAAGGGTTTGGGCGCGATT
GTCACGGTGCGCCGTCGGTACGAGGCGATTTCTGGTGAGGCTTATCGGAAGACGGTTCATGCGGATGCTGCGGAAGCTCG
CTTGAATGGTGTCACCGATGCGGCGGGCGCCATCTTTGTGTCCGCGTTGGGTATTGGAGCAGGATTTTTGGCGCTGCAAG
GTCAGATGAGTATTGGTGATTTGATCACGGTTGTGGGACTCACACAGTTTTTGATCATGCCGATGACCATGCTTGGTCGA
AATGTGGCATCGCGCTGGGCATCGGCGGAGGCGTCGGCAAAGCGTATTAGGGGAGTGCTCGGTGCTGATTTTGAGAGAGT
GTCTGCGCATGATGCGGACAAGGCTGAGGAGATTATCCAACAACTTGCCAAAGGTTTGACGGTTATTCGAGGCACTGATG
AGCAGCTCGTTGAGGTATTAGAGCAGTTGCCACGTACTCGGGTGATTGTGGCTCCTCATGCGGCGGATCTTTTTGATCAA
AGTGTCAGGGACAATGTGCATCCCGTGGCAGAGGTCGCGGAGAAAGCCATTGAAGTTGCCTCCTGTGACGATATTCCAGG
TGGTAGTTCCAAGATTGTGGGCGAGGGTGGACGGTTGCTCTCGGGTGGTCAGCGTCAGCGCGTTGCACTGGCTCGGGCGA
TTGCTTTTGATCCAGAGGTGTTGGTGCTTCAAGATCCCACAACGGCAGTGGATTCTGTGACGGAGCAAAACATTGCTCAG
CAAGTGGCAGCACACCGTGCAGGAAAAGTGACCATTGTGTTTAGTGAGGCACCCGCGTGGAGTGCGGTGGCTGATCAACA
CGTTGAGGCAGCTGCTTTGCGGGAGGTTATGAAATGA

Upstream 100 bases:

>100_bases
TGAGCTGGATCATTCATATCAGATGTTAATCCTAGCGGGCTACCACCACCTTCACTAGCGATATATCGCTTAACGTGCTC
ATGAGATACAGTATCTCCTT

Downstream 100 bases:

>100_bases
GTGGGGAGACGTCGAAAAGCATGCGCTTTCCGTTGGCCAGCCTGCCGCAAGTGCGGCGCGAGGTGGCCCGGCAGGTGGGT
CGTATTCCGCGGGCGAAGTG

Product: ABC-type multidrug/protein/lipid transport system, ATPase component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MQQTKSTPLDRYKNLPGPGARPSKMPALDAKLWTLKVALSQRPWSFVASAGMAASFICNGLTPVIVGKAVDEAIGTSDLQ
RLWFWIAMLAVLFLTAMTVNWIARYMLVRSQQLVSHDLRMLVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDIVMMT
VFPVAELASIIYGAVVMYSINPWLSVAVLIGGPLLVVVAIQVSKPLQKRSGARQQAVAQAAATATDVVQGLRILKGLGAI
VTVRRRYEAISGEAYRKTVHADAAEARLNGVTDAAGAIFVSALGIGAGFLALQGQMSIGDLITVVGLTQFLIMPMTMLGR
NVASRWASAEASAKRIRGVLGADFERVSAHDADKAEEIIQQLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAADLFDQ
SVRDNVHPVAEVAEKAIEVASCDDIPGGSSKIVGEGGRLLSGGQRQRVALARAIAFDPEVLVLQDPTTAVDSVTEQNIAQ
QVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALREVMK

Sequences:

>Translated_518_residues
MQQTKSTPLDRYKNLPGPGARPSKMPALDAKLWTLKVALSQRPWSFVASAGMAASFICNGLTPVIVGKAVDEAIGTSDLQ
RLWFWIAMLAVLFLTAMTVNWIARYMLVRSQQLVSHDLRMLVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDIVMMT
VFPVAELASIIYGAVVMYSINPWLSVAVLIGGPLLVVVAIQVSKPLQKRSGARQQAVAQAAATATDVVQGLRILKGLGAI
VTVRRRYEAISGEAYRKTVHADAAEARLNGVTDAAGAIFVSALGIGAGFLALQGQMSIGDLITVVGLTQFLIMPMTMLGR
NVASRWASAEASAKRIRGVLGADFERVSAHDADKAEEIIQQLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAADLFDQ
SVRDNVHPVAEVAEKAIEVASCDDIPGGSSKIVGEGGRLLSGGQRQRVALARAIAFDPEVLVLQDPTTAVDSVTEQNIAQ
QVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALREVMK
>Mature_518_residues
MQQTKSTPLDRYKNLPGPGARPSKMPALDAKLWTLKVALSQRPWSFVASAGMAASFICNGLTPVIVGKAVDEAIGTSDLQ
RLWFWIAMLAVLFLTAMTVNWIARYMLVRSQQLVSHDLRMLVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDIVMMT
VFPVAELASIIYGAVVMYSINPWLSVAVLIGGPLLVVVAIQVSKPLQKRSGARQQAVAQAAATATDVVQGLRILKGLGAI
VTVRRRYEAISGEAYRKTVHADAAEARLNGVTDAAGAIFVSALGIGAGFLALQGQMSIGDLITVVGLTQFLIMPMTMLGR
NVASRWASAEASAKRIRGVLGADFERVSAHDADKAEEIIQQLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAADLFDQ
SVRDNVHPVAEVAEKAIEVASCDDIPGGSSKIVGEGGRLLSGGQRQRVALARAIAFDPEVLVLQDPTTAVDSVTEQNIAQ
QVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALREVMK

Specific function: Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1786653, Length=504, Percent_Identity=22.0238095238095, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1787143, Length=525, Percent_Identity=20.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202349, Length=139, Percent_Identity=32.3741007194245, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=122, Percent_Identity=32.7868852459016, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17541710, Length=139, Percent_Identity=30.2158273381295, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=117, Percent_Identity=35.8974358974359, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=118, Percent_Identity=33.8983050847458, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569145, Length=133, Percent_Identity=27.0676691729323, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=117, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=121, Percent_Identity=31.404958677686, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322640, Length=98, Percent_Identity=34.6938775510204, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357851, Length=151, Percent_Identity=35.0993377483444, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45551501, Length=151, Percent_Identity=35.0993377483444, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45551502, Length=151, Percent_Identity=35.0993377483444, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI23397593, Length=97, Percent_Identity=39.1752577319588, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI85726357, Length=118, Percent_Identity=35.5932203389831, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 55288; Mature: 55288

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQTKSTPLDRYKNLPGPGARPSKMPALDAKLWTLKVALSQRPWSFVASAGMAASFICNG
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCHHEEEEEHHCCCCHHHHHHHHHHHHHHHCC
LTPVIVGKAVDEAIGTSDLQRLWFWIAMLAVLFLTAMTVNWIARYMLVRSQQLVSHDLRM
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTDRIQDPRGFAGKERTAGGLLSIASSDTQRVGDIVMMTVFPVAELASIIYGAVVMYSI
HHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NPWLSVAVLIGGPLLVVVAIQVSKPLQKRSGARQQAVAQAAATATDVVQGLRILKGLGAI
CHHHHHHHHHCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTVRRRYEAISGEAYRKTVHADAAEARLNGVTDAAGAIFVSALGIGAGFLALQGQMSIGD
HHHHHHHHHHCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCHHHHHEECCCCHHH
LITVVGLTQFLIMPMTMLGRNVASRWASAEASAKRIRGVLGADFERVSAHDADKAEEIIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
QLAKGLTVIRGTDEQLVEVLEQLPRTRVIVAPHAADLFDQSVRDNVHPVAEVAEKAIEVA
HHHCCCEEEECCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SCDDIPGGSSKIVGEGGRLLSGGQRQRVALARAIAFDPEVLVLQDPTTAVDSVTEQNIAQ
CCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
QVAAHRAGKVTIVFSEAPAWSAVADQHVEAAALREVMK
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure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HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]