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The map label for this gene is tyrS

Identifier: 62390291

GI number: 62390291

Start: 1478017

End: 1479279

Strand: Direct

Name: tyrS

Synonym: cg1594

Alternate gene names: 62390291

Gene position: 1478017-1479279 (Clockwise)

Preceding gene: 62390290

Following gene: 62390293

Centisome position: 45.02

GC content: 57.64

Gene sequence:

>1263_bases
ATGAACATCATTGACGAACTCTCCTGGCGCGGACTCATCAACCAGTCCACCGACCTTGAGGCCCTTCGCGAGGAAGCTTC
AACCCCCATCACCTTGTACTGCGGATTCGACCCAACCGGTCCATCCCTCCACGCAGGACACCTCGTTCCACTGCTCATGC
TGCGCCGTTTCCAGCAAGCAGGACACAACCCAATCGTGCTCGCAGGTGGCGCAACCGGCATGATCGGCGACCCCCGCGAT
GTCGGCGAGCGCACCATGAACTCCGCAGACACCGTCTCTGATTGGGCAGAACGCATCTCCGGTCAGCTCAGCCGCTTCGT
TGATTTCGACGGCGAGCACGCAGCCCGTCTGGTCAACAACGCCGAGTGGACCAACGAAATGTCCGTAGTGACCTTCCTCC
GTGATGTAGGAAAGCACTTCTCCCTCAACACCATGCTCGCCCGCGACACCGTCAAGCGTCGCCTCGAGTCCGACGGCATT
TCCTACACCGAGTTCTCCTACATGCTGCTACAGGCCAACGACTACGTTGAACTGAACAAGCGCTTCGGCTGCACCCTGCA
GGTAGGTGGCGGTGACCAGTGGGGCAACATCGTTTCTGGCGTTGACCTCAACCGTCGCGTCAACGGCACCTCTGTCCACG
CAGTGACCGTACCTTTGGTTACCGATTCCGACGGCAAGAAGTTCGGCAAGTCCACCGGCGGCGGAAGCCTCTGGTTGGAT
CCGGAAATGACCAGCCCATACGCTTGGTACCAGTACTTCATCAACGCATCCGACGCTGACGTGATCCGTTACCTCCGCTG
GTTCACCTTCCTCACCCAGGAAGAACTTGCTGAGTTGGAAGTTGAAGTTGCAGAGCGCCCATTCAAGCGCGAAGCACAGC
GTCGTCTTGCACGCGAAATGACCAACTTGGTTCACGGAACCGAAGCAACCGAAGCAGTCGAGCTTGCTGCTCAAGCACTG
TTCGGCCGCGCAGAACTCCGCGACCTAGACGAAAAAACTCTCGCTGCATCCGTTTCTGAAACTGCAGTTGCAGAAATCAA
GGCAGGGGAGCCACGCACCATCATAGATCTGCTCGTGGCCAGCGGACTTGCTGATTCCAAGGGCGCAGCAAAGCGTGCAG
TCAAGGAAGGCGGTGCGTACGTAAACAACGAACGCATCGAATCGGATGATTGGGAGCCTTTCGCTGAAGATCTTCTTCAC
GGTTCATGGCTAGTACTGCGCCGTGGCAAGAAGAACTTCGCAGGAGTTCAGATCCTCGGCTAA

Upstream 100 bases:

>100_bases
GGCCTATCGCATTGACGACGGAATTCCGGTGCTTCTCATCGACGAAGCCACCGAGTGGACCCCCAACAACTAGAAGTACA
TCAAGGACATTTTTAACACC

Downstream 100 bases:

>100_bases
TAATCGCTGAAATGATTGCGGTTTTTCATTTGTCTGACTTCTGGAAAACCAAAAGGAGGGGTGAGCACCAAATTCTGGTG
CTCACCCCTCCTTTTAGCAA

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQAGHNPIVLAGGATGMIGDPRD
VGERTMNSADTVSDWAERISGQLSRFVDFDGEHAARLVNNAEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGI
SYTEFSYMLLQANDYVELNKRFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD
PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREMTNLVHGTEATEAVELAAQAL
FGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVASGLADSKGAAKRAVKEGGAYVNNERIESDDWEPFAEDLLH
GSWLVLRRGKKNFAGVQILG

Sequences:

>Translated_420_residues
MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQAGHNPIVLAGGATGMIGDPRD
VGERTMNSADTVSDWAERISGQLSRFVDFDGEHAARLVNNAEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGI
SYTEFSYMLLQANDYVELNKRFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD
PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREMTNLVHGTEATEAVELAAQAL
FGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVASGLADSKGAAKRAVKEGGAYVNNERIESDDWEPFAEDLLH
GSWLVLRRGKKNFAGVQILG
>Mature_420_residues
MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQAGHNPIVLAGGATGMIGDPRD
VGERTMNSADTVSDWAERISGQLSRFVDFDGEHAARLVNNAEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGI
SYTEFSYMLLQANDYVELNKRFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD
PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREMTNLVHGTEATEAVELAAQAL
FGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVASGLADSKGAAKRAVKEGGAYVNNERIESDDWEPFAEDLLH
GSWLVLRRGKKNFAGVQILG

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=410, Percent_Identity=35.3658536585366, Blast_Score=231, Evalue=1e-60,
Organism=Escherichia coli, GI1787925, Length=418, Percent_Identity=47.8468899521531, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI25145802, Length=401, Percent_Identity=34.4139650872818, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25145805, Length=275, Percent_Identity=35.2727272727273, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6325160, Length=448, Percent_Identity=34.1517857142857, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI20130383, Length=410, Percent_Identity=35.8536585365854, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_CORGL (Q8NQM8)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927152
- RefSeq:   NP_600625.1
- RefSeq:   YP_225693.1
- ProteinModelPortal:   Q8NQM8
- SMR:   Q8NQM8
- GeneID:   1019382
- GeneID:   3345673
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1594
- KEGG:   cgl:NCgl1352
- HOGENOM:   HBG288125
- OMA:   TFYIGFD
- PhylomeDB:   Q8NQM8
- ProtClustDB:   PRK05912
- BioCyc:   CGLU196627:CG1594-MONOMER
- BRENDA:   6.1.1.1
- GO:   GO:0005737
- HAMAP:   MF_02006
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 46446; Mature: 46446

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 33-33 BINDING 167-167 BINDING 171-171 BINDING 230-230

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQA
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
GHNPIVLAGGATGMIGDPRDVGERTMNSADTVSDWAERISGQLSRFVDFDGEHAARLVNN
CCCCEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGISYTEFSYMLLQANDYVELNK
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHEEEEEEECCCCEEECC
RFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD
CCCCEEEECCCCCCCCHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCCCCEEEC
PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREM
CCCCCCCEEHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TNLVHGTEATEAVELAAQALFGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVA
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SGLADSKGAAKRAVKEGGAYVNNERIESDDWEPFAEDLLHGSWLVLRRGKKNFAGVQILG
CCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCEEEEC
>Mature Secondary Structure
MNIIDELSWRGLINQSTDLEALREEASTPITLYCGFDPTGPSLHAGHLVPLLMLRRFQQA
CCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
GHNPIVLAGGATGMIGDPRDVGERTMNSADTVSDWAERISGQLSRFVDFDGEHAARLVNN
CCCCEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
AEWTNEMSVVTFLRDVGKHFSLNTMLARDTVKRRLESDGISYTEFSYMLLQANDYVELNK
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEHEEEEEEECCCCEEECC
RFGCTLQVGGGDQWGNIVSGVDLNRRVNGTSVHAVTVPLVTDSDGKKFGKSTGGGSLWLD
CCCCEEEECCCCCCCCHHCCCCCCCCCCCCEEEEEEEEEEECCCCHHHCCCCCCCCEEEC
PEMTSPYAWYQYFINASDADVIRYLRWFTFLTQEELAELEVEVAERPFKREAQRRLAREM
CCCCCCCEEHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TNLVHGTEATEAVELAAQALFGRAELRDLDEKTLAASVSETAVAEIKAGEPRTIIDLLVA
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SGLADSKGAAKRAVKEGGAYVNNERIESDDWEPFAEDLLHGSWLVLRRGKKNFAGVQILG
CCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626