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The map label for this gene is leuD [H]

Identifier: 62390199

GI number: 62390199

Start: 1383369

End: 1383962

Strand: Direct

Name: leuD [H]

Synonym: cg1488

Alternate gene names: 62390199

Gene position: 1383369-1383962 (Clockwise)

Preceding gene: 62390198

Following gene: 62390201

Centisome position: 42.14

GC content: 57.91

Gene sequence:

>594_bases
ATGGAAAAATTTACCACCTACACCGGCGTTGGCGTTCCACTGCAGCGATCCAACGTGGACACCGACCAGATCATCCCAGC
CGTCTACCTCAAGCGCGTCACCCGGACCGGCTTCGAAGACGGACTGTTTTCCAACTGGCGCCAAAACGACCCCAACTTTG
TCCTCAACACCGACACCTACAAGAACGGCTCCGTTCTCGTAGCAGGCCCTGACTTTGGCACCGGCTCCTCCCGCGAGCAC
GCCGTCTGGGCACTCATGGACTACGGCTTCCGCGCTGTCTTCTCCTCACGATTCGCCGACATCTTCCGCGGCAACTCCGG
AAAAGCGGGCATGCTCACCGGCATCATGGAACAGTCCGACATCGAACTTCTGTGGAAGCTCATGGAACAAACCCCAGGCC
TCGAACTGACCGTGAACCTGGAAAAGCAGATCGTCACCGCAGGCGACGTAGTGATCAGCTTCGAAGTTGACCCCTACATC
CGCTGGCGTTTGATGGAAGGCCTCGACGACGCTGGCCTGACCCTGCGCAAGCTCGATGAAATTGAAGACTACGAGGCTAA
GCGCCCTGCGTTTAAGCCACGCACTAACGCTTAA

Upstream 100 bases:

>100_bases
GGAGGCCGCACCCACCTGGTATCCCCAGCAGTCGCAGCCGCCACCGCAATCCGCGGCACCCTGTCCTCACCTGCAGATAT
CTAAGGAAGGCTAGAAAACA

Downstream 100 bases:

>100_bases
GTTTCAGTCTGATAGCGAAAGCACCCCGTGATCTTCCGTCGCGGGGTGCTTTTGTGCGTCTTGGTGGGCGAGTGGAGTGG
GCATGTCTGGAATAGACCAA

Product: isopropylmalate isomerase small subunit

Products: NA

Alternate protein names: Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MEKFTTYTGVGVPLQRSNVDTDQIIPAVYLKRVTRTGFEDGLFSNWRQNDPNFVLNTDTYKNGSVLVAGPDFGTGSSREH
AVWALMDYGFRAVFSSRFADIFRGNSGKAGMLTGIMEQSDIELLWKLMEQTPGLELTVNLEKQIVTAGDVVISFEVDPYI
RWRLMEGLDDAGLTLRKLDEIEDYEAKRPAFKPRTNA

Sequences:

>Translated_197_residues
MEKFTTYTGVGVPLQRSNVDTDQIIPAVYLKRVTRTGFEDGLFSNWRQNDPNFVLNTDTYKNGSVLVAGPDFGTGSSREH
AVWALMDYGFRAVFSSRFADIFRGNSGKAGMLTGIMEQSDIELLWKLMEQTPGLELTVNLEKQIVTAGDVVISFEVDPYI
RWRLMEGLDDAGLTLRKLDEIEDYEAKRPAFKPRTNA
>Mature_197_residues
MEKFTTYTGVGVPLQRSNVDTDQIIPAVYLKRVTRTGFEDGLFSNWRQNDPNFVLNTDTYKNGSVLVAGPDFGTGSSREH
AVWALMDYGFRAVFSSRFADIFRGNSGKAGMLTGIMEQSDIELLWKLMEQTPGLELTVNLEKQIVTAGDVVISFEVDPYI
RWRLMEGLDDAGLTLRKLDEIEDYEAKRPAFKPRTNA

Specific function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate [H]

COG id: COG0066

COG function: function code E; 3-isopropylmalate dehydratase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leuD family. LeuD type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786258, Length=197, Percent_Identity=47.7157360406091, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321429, Length=201, Percent_Identity=40.2985074626866, Blast_Score=141, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004431
- InterPro:   IPR012305
- InterPro:   IPR015937
- InterPro:   IPR015928
- InterPro:   IPR000573 [H]

Pfam domain/function: PF00694 Aconitase_C [H]

EC number: =4.2.1.33 [H]

Molecular weight: Translated: 22199; Mature: 22199

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFTTYTGVGVPLQRSNVDTDQIIPAVYLKRVTRTGFEDGLFSNWRQNDPNFVLNTDTY
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEEECCCC
KNGSVLVAGPDFGTGSSREHAVWALMDYGFRAVFSSRFADIFRGNSGKAGMLTGIMEQSD
CCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCH
IELLWKLMEQTPGLELTVNLEKQIVTAGDVVISFEVDPYIRWRLMEGLDDAGLTLRKLDE
HHHHHHHHHHCCCCEEEEECCCEEEEECCEEEEEECCHHHHHHHHCCCCCCCCHHHHHHH
IEDYEAKRPAFKPRTNA
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MEKFTTYTGVGVPLQRSNVDTDQIIPAVYLKRVTRTGFEDGLFSNWRQNDPNFVLNTDTY
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCEEEECCCC
KNGSVLVAGPDFGTGSSREHAVWALMDYGFRAVFSSRFADIFRGNSGKAGMLTGIMEQSD
CCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCH
IELLWKLMEQTPGLELTVNLEKQIVTAGDVVISFEVDPYIRWRLMEGLDDAGLTLRKLDE
HHHHHHHHHHCCCCEEEEECCCEEEEECCEEEEEECCHHHHHHHHCCCCCCCCHHHHHHH
IEDYEAKRPAFKPRTNA
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA