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The map label for this gene is thrB [H]

Identifier: 62390072

GI number: 62390072

Start: 1245323

End: 1246252

Strand: Direct

Name: thrB [H]

Synonym: cg1338

Alternate gene names: 62390072

Gene position: 1245323-1246252 (Clockwise)

Preceding gene: 62390071

Following gene: 62390079

Centisome position: 37.94

GC content: 54.3

Gene sequence:

>930_bases
ATGGCAATTGAACTGAACGTCGGTCGTAAGGTTACCGTCACGGTACCTGGATCTTCTGCAAACCTCGGACCTGGCTTTGA
CACTTTAGGTTTGGCACTGTCGGTATACGACACTGTCGAAGTGGAAATTATTCCATCTGGCTTGGAAGTGGAAGTTTTTG
GCGAAGGCCAAGGCGAAGTCCCTCTTGATGGCTCCCACCTGGTGGTTAAAGCTATTCGTGCTGGCCTGAAGGCAGCTGAC
GCTGAAGTTCCTGGATTGCGAGTGGTGTGCCACAACAACATTCCGCAGTCTCGTGGTCTTGGCTCCTCTGCTGCAGCGGC
GGTTGCTGGTGTTGCTGCAGCTAATGGTTTGGCGGATTTCCCGCTGACTCAAGAGCAGATTGTTCAGTTGTCCTCTGCCT
TTGAAGGCCACCCAGATAATGCTGCGGCTTCTGTGCTGGGTGGAGCAGTGGTGTCGTGGACAAATCTGTCTATCGACGGC
AAGAGCCAGCCACAGTATGCTGCTGTACCACTTGAGGTGCAGGACAATATTCGTGCGACTGCGCTGGTTCCTAATTTCCA
CGCATCCACCGAAGCTGTGCGCCGAGTCCTTCCCACTGAAGTCACTCACATCGATGCGCGATTTAACGTGTCCCGCGTTG
CAGTGATGATCGTTGCGTTGCAGCAGCGTCCTGATTTGCTGTGGGAGGGTACTCGTGACCGTCTGCACCAGCCTTATCGT
GCAGAAGTGTTGCCTATTACCTCTGAGTGGGTAAACCGCCTGCGCAACCGTGGCTACGCGGCATACCTTTCCGGTGCCGG
CCCAACCGCCATGGTGCTGTCCACTGAGCCAATTCCAGACAAGGTTTTGGAAGATGCTCGTGAGTCTGGCATTAAGGTGC
TTGAGCTTGAGGTTGCGGGACCAGTCAAGGTTGAAGTTAACCAACCTTAG

Upstream 100 bases:

>100_bases
GAATCTGATCTTTCCCGCACCGTTGAACTGCTGAAGGCTAAGCCTGTTGTTAAGGCAATCAACAGTGTGATCCGCCTCGA
AAGGGACTAATTTTACTGAC

Downstream 100 bases:

>100_bases
GCCCAACAAGGAAGGCCCCCTTCGAATCAAGAAGGGGGCCTTATTAGTGCAGCAATTATTCGCTGAACACGTGAACCTTA
CAGGTGCCCGGCGCGTTGAG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MAIELNVGRKVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEVPLDGSHLVVKAIRAGLKAAD
AEVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADFPLTQEQIVQLSSAFEGHPDNAAASVLGGAVVSWTNLSIDG
KSQPQYAAVPLEVQDNIRATALVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRPDLLWEGTRDRLHQPYR
AEVLPITSEWVNRLRNRGYAAYLSGAGPTAMVLSTEPIPDKVLEDARESGIKVLELEVAGPVKVEVNQP

Sequences:

>Translated_309_residues
MAIELNVGRKVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEVPLDGSHLVVKAIRAGLKAAD
AEVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADFPLTQEQIVQLSSAFEGHPDNAAASVLGGAVVSWTNLSIDG
KSQPQYAAVPLEVQDNIRATALVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRPDLLWEGTRDRLHQPYR
AEVLPITSEWVNRLRNRGYAAYLSGAGPTAMVLSTEPIPDKVLEDARESGIKVLELEVAGPVKVEVNQP
>Mature_308_residues
AIELNVGRKVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEVPLDGSHLVVKAIRAGLKAADA
EVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADFPLTQEQIVQLSSAFEGHPDNAAASVLGGAVVSWTNLSIDGK
SQPQYAAVPLEVQDNIRATALVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRPDLLWEGTRDRLHQPYRA
EVLPITSEWVNRLRNRGYAAYLSGAGPTAMVLSTEPIPDKVLEDARESGIKVLELEVAGPVKVEVNQP

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=313, Percent_Identity=25.8785942492013, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321814, Length=338, Percent_Identity=31.0650887573964, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32620; Mature: 32489

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIELNVGRKVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEV
CEEEEECCCEEEEEECCCCCCCCCCCHHHHEEEEEEEEEEEEEECCCCEEEEEECCCCCC
PLDGSHLVVKAIRAGLKAADAEVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADF
CCCCCHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC
PLTQEQIVQLSSAFEGHPDNAAASVLGGAVVSWTNLSIDGKSQPQYAAVPLEVQDNIRAT
CCCHHHHHHHHHHCCCCCCHHHHHHHCCEEEEEEEEEECCCCCCCEEEEEEEECCCCEEE
ALVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRPDLLWEGTRDRLHQPYR
EEECCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHEEHHHHCCCCCEECCCHHHCCCCCC
AEVLPITSEWVNRLRNRGYAAYLSGAGPTAMVLSTEPIPDKVLEDARESGIKVLELEVAG
EEEEEEHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECC
PVKVEVNQP
CEEEEECCC
>Mature Secondary Structure 
AIELNVGRKVTVTVPGSSANLGPGFDTLGLALSVYDTVEVEIIPSGLEVEVFGEGQGEV
EEEEECCCEEEEEECCCCCCCCCCCHHHHEEEEEEEEEEEEEECCCCEEEEEECCCCCC
PLDGSHLVVKAIRAGLKAADAEVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLADF
CCCCCHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC
PLTQEQIVQLSSAFEGHPDNAAASVLGGAVVSWTNLSIDGKSQPQYAAVPLEVQDNIRAT
CCCHHHHHHHHHHCCCCCCHHHHHHHCCEEEEEEEEEECCCCCCCEEEEEEEECCCCEEE
ALVPNFHASTEAVRRVLPTEVTHIDARFNVSRVAVMIVALQQRPDLLWEGTRDRLHQPYR
EEECCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHEEHHHHCCCCCEECCCHHHCCCCCC
AEVLPITSEWVNRLRNRGYAAYLSGAGPTAMVLSTEPIPDKVLEDARESGIKVLELEVAG
EEEEEEHHHHHHHHHHCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECC
PVKVEVNQP
CEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA