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The map label for this gene is lysA

Identifier: 62390068

GI number: 62390068

Start: 1241397

End: 1242734

Strand: Direct

Name: lysA

Synonym: cg1334

Alternate gene names: 62390068

Gene position: 1241397-1242734 (Clockwise)

Preceding gene: 62390067

Following gene: 62390071

Centisome position: 37.82

GC content: 58.89

Gene sequence:

>1338_bases
ATGGCTACAGTTGAAAATTTCAATGAACTTCCCGCACACGTATGGCCACGCAATGCCGTGCGCCAAGAAGACGGCGTTGT
CACCGTCGCTGGTGTGCCTCTGCCTGACCTCGCTGAAGAATACGGAACCCCACTGTTCGTAGTCGACGAGGACGATTTCC
GTTCCCGCTGTCGCGACATGGCTACCGCATTCGGTGGACCAGGCAATGTGCACTACGCATCTAAAGCGTTCCTGACCAAG
ACCATTGCACGTTGGGTTGATGAAGAGGGGCTGGCACTGGACATTGCATCCATCAACGAACTGGGCATTGCCCTGGCCGC
TGGTTTCCCCGCCAGCCGTATCACCGCGCACGGCAACAACAAAGGCGTAGAGTTCCTGCGCGCGTTGGTTCAAAACGGTG
TGGGACACGTGGTGCTGGACTCCGCACAGGAACTAGAACTGTTGGATTACGTTGCCGCTGGTGAAGGCAAGATTCAGGAC
GTGTTGATCCGCGTAAAGCCAGGCATCGAAGCACACACCCACGAGTTCATCGCCACTAGCCACGAAGACCAGAAGTTCGG
ATTCTCCCTGGCATCCGGTTCCGCATTCGAAGCAGCAAAAGCCGCCAACAACGCAGAAAACCTGAACCTGGTTGGCCTGC
ACTGCCACGTTGGTTCCCAGGTGTTCGACGCCGAAGGCTTCAAGCTGGCAGCAGAACGCGTGTTGGGCCTGTACTCACAG
ATCCACAGCGAACTGGGCGTTGCCCTTCCTGAACTGGATCTCGGTGGCGGATACGGCATTGCCTATACCGCAGCTGAAGA
ACCACTCAACGTCGCAGAAGTTGCCTCCGACCTGCTCACCGCAGTCGGAAAAATGGCAGCGGAACTAGGCATCGACGCAC
CAACCGTGCTTGTTGAGCCCGGCCGCGCTATCGCAGGCCCCTCCACCGTGACCATCTACGAAGTCGGCACCACCAAAGAC
GTCCACGTAGACGACGACAAAACCCGCCGTTACATCGCCGTGGACGGAGGCATGTCCGACAACATCCGCCCAGCACTCTA
CGGCTCCGAATACGACGCCCGCGTAGTATCCCGCTTCGCCGAAGGAGACCCAGTAAGCACCCGCATCGTGGGCTCCCACT
GCGAATCCGGCGATATCCTGATCAACGATGAAATCTACCCATCTGACATCACCAGCGGCGACTTCCTTGCACTCGCAGCC
ACCGGCGCATACTGCTACGCCATGAGCTCCCGCTACAACGCCTTCACACGGCCCGCCGTCGTGTCCGTCCGCGCTGGCAG
CTCCCGCCTCATGCTGCGCCGCGAAACGCTCGACGACATCCTCTCACTAGAGGCATAA

Upstream 100 bases:

>100_bases
CAATCCACACAGCACGTCTGGCACTTGCAGCAGCAACCCGCCAGACCCTCGCTAACGCCCTGCACCTGGTTGGCGTTTCC
GCACCGGAGAAGATGTAACA

Downstream 100 bases:

>100_bases
CGCTTTTCGACGCCTGACCCCGCCCTTCACCTTCGCCGTGGAGGGCGGTTTTGGGTTTCTGGGTTTCTTTGCGAACTTAA
GGTGTCTAGGGGTCTGCAGT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTK
TIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNNKGVEFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQD
VLIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
IHSELGVALPELDLGGGYGIAYTAAEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKD
VHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFAEGDPVSTRIVGSHCESGDILINDEIYPSDITSGDFLALAA
TGAYCYAMSSRYNAFTRPAVVSVRAGSSRLMLRRETLDDILSLEA

Sequences:

>Translated_445_residues
MATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTK
TIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNNKGVEFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQD
VLIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
IHSELGVALPELDLGGGYGIAYTAAEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKD
VHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFAEGDPVSTRIVGSHCESGDILINDEIYPSDITSGDFLALAA
TGAYCYAMSSRYNAFTRPAVVSVRAGSSRLMLRRETLDDILSLEA
>Mature_444_residues
ATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTKT
IARWVDEEGLALDIASINELGIALAAGFPASRITAHGNNKGVEFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQDV
LIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQI
HSELGVALPELDLGGGYGIAYTAAEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEPGRAIAGPSTVTIYEVGTTKDV
HVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFAEGDPVSTRIVGSHCESGDILINDEIYPSDITSGDFLALAAT
GAYCYAMSSRYNAFTRPAVVSVRAGSSRLMLRRETLDDILSLEA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family

Homologues:

Organism=Homo sapiens, GI4505489, Length=377, Percent_Identity=25.1989389920424, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=30.5882352941176, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1789307, Length=244, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=377, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCDA_CORGL (P09890)

Other databases:

- EMBL:   X07563
- EMBL:   BA000036
- EMBL:   BX927151
- EMBL:   X54740
- EMBL:   Z21501
- PIR:   S03827
- RefSeq:   NP_600406.1
- RefSeq:   YP_225470.1
- ProteinModelPortal:   P09890
- SMR:   P09890
- GeneID:   1019163
- GeneID:   3344931
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1334
- KEGG:   cgl:NCgl1133
- HOGENOM:   HBG672375
- OMA:   HYASKAF
- ProtClustDB:   CLSK633261
- BioCyc:   CGLU196627:CG1334-MONOMER
- BRENDA:   4.1.1.20
- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR01181
- PRINTS:   PR01179
- TIGRFAMs:   TIGR01048

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC; SSF50621 Racem_decarbox_C

EC number: =4.1.1.20

Molecular weight: Translated: 47412; Mature: 47280

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00878 ODR_DC_2_1; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDM
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ATAFGGPGNVHYASKAFLTKTIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNN
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHEEECCCC
KGVEFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQDVLIRVKPGIEAHTHEFIATS
CHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCC
HEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
CCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHH
IHSELGVALPELDLGGGYGIAYTAAEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEP
HHHHHCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
GRAIAGPSTVTIYEVGTTKDVHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFA
CCEECCCCEEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCCEEECCCHHHHHHHHHH
EGDPVSTRIVGSHCESGDILINDEIYPSDITSGDFLALAATGAYCYAMSSRYNAFTRPAV
CCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEE
VSVRAGSSRLMLRRETLDDILSLEA
EEEECCCCEEEEEHHHHHHHHHCCC
>Mature Secondary Structure 
ATVENFNELPAHVWPRNAVRQEDGVVTVAGVPLPDLAEEYGTPLFVVDEDDFRSRCRDM
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ATAFGGPGNVHYASKAFLTKTIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNN
HHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHEEECCCC
KGVEFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKIQDVLIRVKPGIEAHTHEFIATS
CHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHCCC
HEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQ
CCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHH
IHSELGVALPELDLGGGYGIAYTAAEEPLNVAEVASDLLTAVGKMAAELGIDAPTVLVEP
HHHHHCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
GRAIAGPSTVTIYEVGTTKDVHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFA
CCEECCCCEEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCCEEECCCHHHHHHHHHH
EGDPVSTRIVGSHCESGDILINDEIYPSDITSGDFLALAATGAYCYAMSSRYNAFTRPAV
CCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEE
VSVRAGSSRLMLRRETLDDILSLEA
EEEECCCCEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2836698; 12948626; 2082143; 8226683