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The map label for this gene is fumC [H]

Identifier: 62389896

GI number: 62389896

Start: 1063677

End: 1065086

Strand: Reverse

Name: fumC [H]

Synonym: cg1145

Alternate gene names: 62389896

Gene position: 1065086-1063677 (Counterclockwise)

Preceding gene: 62389898

Following gene: 62389893

Centisome position: 32.45

GC content: 56.67

Gene sequence:

>1410_bases
ATGACCGAGCAGGAATTCCGTATTGAGCACGACACCATGGGTGAAGTGAAGGTTCCAGCAAAGGCTCTGTGGCAGGCACA
GACCCAGCGCGCTGTTGAGAACTTCCCTATCTCTGGTCGTGGTCTGGAATCCGCACAGATCCGCGCAATGGGTCTGCTGA
AGGCAGCTTGTGCGCAGGTAAACAAGGACTCCGGTGCGCTGGATGCAGAGAAGGCAGATGCCATCATTGCAGCTGGTAAG
GAGATCGCGTCCGGTAAGCATGACGCTGAGTTCCCAATTGATGTGTTCCAGACTGGTTCCGGTACTTCCTCCAACATGAA
CACCAATGAGGTTATCGCTTCCATCGCGAAGGCTAACGGCGTTGAGGTTCACCCAAATGACCACGTCAACATGGGTCAGT
CCTCCAATGACACCTTCCCTACTGCAACTCACGTTGCTGCAACCGAAGCTGCTGTCAATGACCTCATCCCAGGCCTGAAG
GTTCTGCACGAGTCTTTGGCGAAGAAGGCTAACGAGTGGTCTGAGGTTGTTAAGTCCGGCCGCACCCACCTGATGGACGC
TGTTCCAGTAACCCTGGGCCAGGAGTTCGGTGGCTACGCTCGCCAGATCCAGCTCGGCATCGAGCGCGTTGAGGCTACTC
TTCCTCGCCTTGGTGAGCTGGCTATTGGTGGCACCGCTGCTGGTACCGGTATCAACACCTCCGCTGATTTCGGCGGCAAG
GTTGTTGCTGAACTGATCAACTTGACCGACGTCAAGGAGCTCAAGGAAGCTGAGAACCACTTCGAGGCTCAGGCTGCACG
CGACGCTCTTGTTGAGTTCTCCGGCGCAATGCGCGTTATCGCTGTCTCCTTGTACAAGATCGCTAACGATATCCGCCTCA
TGGGCTCCGGCCCACTGACCGGTCTTGGCGAGATCCGTCTCCCAGACCTGCAGCCAGGTTCCTCCATCATGCCAGGCAAG
GTCAACCCAGTTCTCTGTGAGACCGCTACCCAGGTTTCCGCTCAGGTTATCGGCAATGACGCAGCTGTTGCGTTCTCCGG
CACCCAGGGCCAGTTCGAGCTCAACGTGTTCATCCCAGTGATGGCTCGCAACGTGCTTGAGTCCGCTCGCCTGCTGGCTA
ACACTTCCCGCGTGTTCGCAACCCGTCTCGTTGATGGCATTGAGCCAAACGAGGCACACATGAAGGAGCTCGCTGAGTCT
TCACCTTCCATCGTTACCCCACTGAACTCTGCAATCGGCTACGAAGCTGCTGCAAAGGTGGCTAAGACTGCTTTGGCTGA
GGGCAAGACCATCCGCCAGACTGTCATCGATTTGGGCTTGGTTGATGGCGAGAAGCTCACCGAGGAAGAGCTGGACAAGC
GCCTCGACGTTCTTGCTATGGCTCACACCGAGCGCGAGAACAAGTTCTAA

Upstream 100 bases:

>100_bases
ACCCACCTCACTCTAGGGGTGGACTCCAGTGTTTCGCGACAACACAATGAGTAAGCTTGTGACAGCCGTATTTAATTCTC
AGTAAGAAATGAGTGATTTC

Downstream 100 bases:

>100_bases
AACTAGAACCCGATAAATAAGGACCTTCACTTCTTAAGAAGTGAAGGTCCCTTTTTCGCTACATATCTAGATCGCGGGGC
TTGCCGAAATCTCCGAAATC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTEQEFRIEHDTMGEVKVPAKALWQAQTQRAVENFPISGRGLESAQIRAMGLLKAACAQVNKDSGALDAEKADAIIAAGK
EIASGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKANGVEVHPNDHVNMGQSSNDTFPTATHVAATEAAVNDLIPGLK
VLHESLAKKANEWSEVVKSGRTHLMDAVPVTLGQEFGGYARQIQLGIERVEATLPRLGELAIGGTAAGTGINTSADFGGK
VVAELINLTDVKELKEAENHFEAQAARDALVEFSGAMRVIAVSLYKIANDIRLMGSGPLTGLGEIRLPDLQPGSSIMPGK
VNPVLCETATQVSAQVIGNDAAVAFSGTQGQFELNVFIPVMARNVLESARLLANTSRVFATRLVDGIEPNEAHMKELAES
SPSIVTPLNSAIGYEAAAKVAKTALAEGKTIRQTVIDLGLVDGEKLTEEELDKRLDVLAMAHTERENKF

Sequences:

>Translated_469_residues
MTEQEFRIEHDTMGEVKVPAKALWQAQTQRAVENFPISGRGLESAQIRAMGLLKAACAQVNKDSGALDAEKADAIIAAGK
EIASGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKANGVEVHPNDHVNMGQSSNDTFPTATHVAATEAAVNDLIPGLK
VLHESLAKKANEWSEVVKSGRTHLMDAVPVTLGQEFGGYARQIQLGIERVEATLPRLGELAIGGTAAGTGINTSADFGGK
VVAELINLTDVKELKEAENHFEAQAARDALVEFSGAMRVIAVSLYKIANDIRLMGSGPLTGLGEIRLPDLQPGSSIMPGK
VNPVLCETATQVSAQVIGNDAAVAFSGTQGQFELNVFIPVMARNVLESARLLANTSRVFATRLVDGIEPNEAHMKELAES
SPSIVTPLNSAIGYEAAAKVAKTALAEGKTIRQTVIDLGLVDGEKLTEEELDKRLDVLAMAHTERENKF
>Mature_468_residues
TEQEFRIEHDTMGEVKVPAKALWQAQTQRAVENFPISGRGLESAQIRAMGLLKAACAQVNKDSGALDAEKADAIIAAGKE
IASGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKANGVEVHPNDHVNMGQSSNDTFPTATHVAATEAAVNDLIPGLKV
LHESLAKKANEWSEVVKSGRTHLMDAVPVTLGQEFGGYARQIQLGIERVEATLPRLGELAIGGTAAGTGINTSADFGGKV
VAELINLTDVKELKEAENHFEAQAARDALVEFSGAMRVIAVSLYKIANDIRLMGSGPLTGLGEIRLPDLQPGSSIMPGKV
NPVLCETATQVSAQVIGNDAAVAFSGTQGQFELNVFIPVMARNVLESARLLANTSRVFATRLVDGIEPNEAHMKELAESS
PSIVTPLNSAIGYEAAAKVAKTALAEGKTIRQTVIDLGLVDGEKLTEEELDKRLDVLAMAHTERENKF

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=456, Percent_Identity=51.3157894736842, Blast_Score=439, Evalue=1e-123,
Organism=Escherichia coli, GI1787896, Length=453, Percent_Identity=48.3443708609272, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI87082375, Length=467, Percent_Identity=39.6145610278373, Blast_Score=301, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17553882, Length=456, Percent_Identity=50.8771929824561, Blast_Score=420, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=52.6479750778816, Blast_Score=321, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6324993, Length=456, Percent_Identity=50.219298245614, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=50.8658008658009, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=50.6493506493506, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI78710009, Length=448, Percent_Identity=50.6696428571429, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24662684, Length=447, Percent_Identity=47.8747203579418, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24583245, Length=441, Percent_Identity=42.8571428571429, Blast_Score=365, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49764; Mature: 49633

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQEFRIEHDTMGEVKVPAKALWQAQTQRAVENFPISGRGLESAQIRAMGLLKAACAQV
CCCCCCEECCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
NKDSGALDAEKADAIIAAGKEIASGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKANG
CCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHCCC
VEVHPNDHVNMGQSSNDTFPTATHVAATEAAVNDLIPGLKVLHESLAKKANEWSEVVKSG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAVPVTLGQEFGGYARQIQLGIERVEATLPRLGELAIGGTAAGTGINTSADFGGK
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCHH
VVAELINLTDVKELKEAENHFEAQAARDALVEFSGAMRVIAVSLYKIANDIRLMGSGPLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
GLGEIRLPDLQPGSSIMPGKVNPVLCETATQVSAQVIGNDAAVAFSGTQGQFELNVFIPV
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEHHH
MARNVLESARLLANTSRVFATRLVDGIEPNEAHMKELAESSPSIVTPLNSAIGYEAAAKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AKTALAEGKTIRQTVIDLGLVDGEKLTEEELDKRLDVLAMAHTERENKF
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEQEFRIEHDTMGEVKVPAKALWQAQTQRAVENFPISGRGLESAQIRAMGLLKAACAQV
CCCCCEECCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
NKDSGALDAEKADAIIAAGKEIASGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKANG
CCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHCCC
VEVHPNDHVNMGQSSNDTFPTATHVAATEAAVNDLIPGLKVLHESLAKKANEWSEVVKSG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTHLMDAVPVTLGQEFGGYARQIQLGIERVEATLPRLGELAIGGTAAGTGINTSADFGGK
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCHH
VVAELINLTDVKELKEAENHFEAQAARDALVEFSGAMRVIAVSLYKIANDIRLMGSGPLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
GLGEIRLPDLQPGSSIMPGKVNPVLCETATQVSAQVIGNDAAVAFSGTQGQFELNVFIPV
CCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEHHH
MARNVLESARLLANTSRVFATRLVDGIEPNEAHMKELAESSPSIVTPLNSAIGYEAAAKV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
AKTALAEGKTIRQTVIDLGLVDGEKLTEEELDKRLDVLAMAHTERENKF
HHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]