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The map label for this gene is ppx2 [H]

Identifier: 62389868

GI number: 62389868

Start: 1038918

End: 1039883

Strand: Direct

Name: ppx2 [H]

Synonym: cg1115

Alternate gene names: 62389868

Gene position: 1038918-1039883 (Clockwise)

Preceding gene: 62389867

Following gene: 62389870

Centisome position: 31.65

GC content: 54.66

Gene sequence:

>966_bases
ATGACCCGTTACGCGGCCATCGATTGCGGAACAAACTCCATCCGCCTCCTGATCACTGAAGTCACTCCTGAGGGATTCAA
AGAGATCACCCGTGAAAACACCATCGTTCGCCTGGGCAAAGGCGTCGACGCCACCGGTCAGCTAGACCCCGAGGCAATCG
AGCGCACTCGTGTCGCTTTGGAAAACTACGTTGAACTCATGGAAACCCATGGGGTAGAGGCCGTACGAATGGTTGCCACC
TCCGCAACCCGCGATGCGTCCAACCGCGATGAATTCTTTTCGATGACCCGCCAGCTTCTGTCCAAGATCCGTCCTGGATA
CCAAGCTGAAGTAATTTCCGGCGAAGAGGAAGCTCTGCTGTCCTTCCGAGGTGCAATCGTTGACCTGCCTGAAGACCAAG
GTCCTTTCTGTGTTATCGACCTTGGCGGTGGATCCACTGAGTTCATCGTTGGCACCTACGACGGTGAAATCCTAGGCTCC
CACTCAACCCAAATGGGATGCGTGCGCCTGACCGAACGAATCATGCGCAGCGACCCACCGACTGAAACCGAAGTGGAAAT
CGCCCGCGACTACGTTGCAGAACGCATCCAGGAAGTAAAAGCCATCGTCCCAATTTCAAAGGCAAAAACCTTTGTGGGAT
GCGCAGGCACCTTCACCACAATCTCCGCCTGGGTGCAAGGCCTAGAAAGCTACGACCGCGACGCGATCCACCTCTCTGCA
CTCAACTTCGATGCACTGCGAGTTGTCACCGATGAGATCATTTCAGAATCATCATCACAGCGCGCCAGCAACCCAGTTGT
TGATCCAGGTCGCGCCGACGTCATCGGTGGCGGATCCGTTGTTGTCCAAGCAGCGATCGACTTAGCCTCCAAAGAAGCCG
GTGTAGACTACATCATTATTTCCGAAAAAGACATCCTCGACGGCCTCATCCTTGGCCTGGTAGAAGCCGACTCTTTGAAG
AAATAG

Upstream 100 bases:

>100_bases
GCGACCTCCGCGGTACCGCCATCCCAGAGGACTGGCCAACAGTACAAGACCTGGGCATCAACATGGAGGACTTTGATTTC
TCCCGAGCAGGTGGGGCTTA

Downstream 100 bases:

>100_bases
GACCCTAGTTTTAAACCACTGGGTCATCATGTTCTATGATGTGTAAGCACCAAGTAAATGGCATTGGAAGCATACATATG
TATCCTGACAATGCTGCTTG

Product: exopolyphosphatase

Products: NA

Alternate protein names: 3-dehydroquinate synthase; Unknown phosphatase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTRYAAIDCGTNSIRLLITEVTPEGFKEITRENTIVRLGKGVDATGQLDPEAIERTRVALENYVELMETHGVEAVRMVAT
SATRDASNRDEFFSMTRQLLSKIRPGYQAEVISGEEEALLSFRGAIVDLPEDQGPFCVIDLGGGSTEFIVGTYDGEILGS
HSTQMGCVRLTERIMRSDPPTETEVEIARDYVAERIQEVKAIVPISKAKTFVGCAGTFTTISAWVQGLESYDRDAIHLSA
LNFDALRVVTDEIISESSSQRASNPVVDPGRADVIGGGSVVVQAAIDLASKEAGVDYIIISEKDILDGLILGLVEADSLK
K

Sequences:

>Translated_321_residues
MTRYAAIDCGTNSIRLLITEVTPEGFKEITRENTIVRLGKGVDATGQLDPEAIERTRVALENYVELMETHGVEAVRMVAT
SATRDASNRDEFFSMTRQLLSKIRPGYQAEVISGEEEALLSFRGAIVDLPEDQGPFCVIDLGGGSTEFIVGTYDGEILGS
HSTQMGCVRLTERIMRSDPPTETEVEIARDYVAERIQEVKAIVPISKAKTFVGCAGTFTTISAWVQGLESYDRDAIHLSA
LNFDALRVVTDEIISESSSQRASNPVVDPGRADVIGGGSVVVQAAIDLASKEAGVDYIIISEKDILDGLILGLVEADSLK
K
>Mature_320_residues
TRYAAIDCGTNSIRLLITEVTPEGFKEITRENTIVRLGKGVDATGQLDPEAIERTRVALENYVELMETHGVEAVRMVATS
ATRDASNRDEFFSMTRQLLSKIRPGYQAEVISGEEEALLSFRGAIVDLPEDQGPFCVIDLGGGSTEFIVGTYDGEILGSH
STQMGCVRLTERIMRSDPPTETEVEIARDYVAERIQEVKAIVPISKAKTFVGCAGTFTTISAWVQGLESYDRDAIHLSAL
NFDALRVVTDEIISESSSQRASNPVVDPGRADVIGGGSVVVQAAIDLASKEAGVDYIIISEKDILDGLILGLVEADSLKK

Specific function: Conversion Of Pppgpp To Ppgpp. Guanosine Pentaphosphate (Pppgpp) Is A Cytoplasmic Signaling Molecule Which Together With Ppgpp Controls The "Stringent Response", An Adaptive Process That Allows Bacteria To Respond To Amino Acid Starvation, Resulting In T

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=220, Percent_Identity=31.3636363636364, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788848, Length=214, Percent_Identity=29.9065420560748, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002658
- InterPro:   IPR016037
- InterPro:   IPR003695 [H]

Pfam domain/function: PF01761 DHQ_synthase; PF02541 Ppx-GppA [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 34764; Mature: 34632

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYAAIDCGTNSIRLLITEVTPEGFKEITRENTIVRLGKGVDATGQLDPEAIERTRVAL
CCEEEEEECCCCCEEEEEEECCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ENYVELMETHGVEAVRMVATSATRDASNRDEFFSMTRQLLSKIRPGYQAEVISGEEEALL
HHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
SFRGAIVDLPEDQGPFCVIDLGGGSTEFIVGTYDGEILGSHSTQMGCVRLTERIMRSDPP
HHCCCEEECCCCCCCEEEEECCCCCEEEEEEECCCCEECCCCCHHHHHHHHHHHHHCCCC
TETEVEIARDYVAERIQEVKAIVPISKAKTFVGCAGTFTTISAWVQGLESYDRDAIHLSA
CCHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEE
LNFDALRVVTDEIISESSSQRASNPVVDPGRADVIGGGSVVVQAAIDLASKEAGVDYIII
ECCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEE
SEKDILDGLILGLVEADSLKK
CCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRYAAIDCGTNSIRLLITEVTPEGFKEITRENTIVRLGKGVDATGQLDPEAIERTRVAL
CEEEEEECCCCCEEEEEEECCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHH
ENYVELMETHGVEAVRMVATSATRDASNRDEFFSMTRQLLSKIRPGYQAEVISGEEEALL
HHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHH
SFRGAIVDLPEDQGPFCVIDLGGGSTEFIVGTYDGEILGSHSTQMGCVRLTERIMRSDPP
HHCCCEEECCCCCCCEEEEECCCCCEEEEEEECCCCEECCCCCHHHHHHHHHHHHHCCCC
TETEVEIARDYVAERIQEVKAIVPISKAKTFVGCAGTFTTISAWVQGLESYDRDAIHLSA
CCHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEEE
LNFDALRVVTDEIISESSSQRASNPVVDPGRADVIGGGSVVVQAAIDLASKEAGVDYIII
ECCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEE
SEKDILDGLILGLVEADSLKK
CCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]