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The map label for this gene is lysI

Identifier: 62389859

GI number: 62389859

Start: 1031836

End: 1033341

Strand: Reverse

Name: lysI

Synonym: cg1105

Alternate gene names: 62389859

Gene position: 1033341-1031836 (Counterclockwise)

Preceding gene: 62389862

Following gene: 62389858

Centisome position: 31.48

GC content: 52.92

Gene sequence:

>1506_bases
GTGAATACTCAATCAGATTCTGCGGGGTCTCAAGGTGCAGCGGCCACAAGTCGTACTGTATCTATTAGAACCCTCATCGC
GCTGATCATCGGATCGACCGTCGGCGCGGGAATTTTCTCCATCCCTCAAAACATCGGCTCAGTCGCAGGTCCCGGCGCGA
TGCTCATCGGCTGGCTGATCGCCGGTGTGGGCATGTTGTCCGTAGCGTTCGTGTTCCATGTTCTTGCCCGCCGTAAACCT
CACCTCGATTCTGGCGTCTACGCATATGCGCGTGTTGGATTGGGCGATTATGTAGGTTTCTCCTCCGCTTGGGGTTATTG
GCTGGGTTCAGTCATCGCCCAAGTTGGCTACGCAACGTTATTTTTCTCCACGTTGGGCCACTACGTACCGCTGTTTTCCC
AAGATCATCCATTTGTGTCAGCGTTGGCAGTTAGCGCTTTGACCTGGCTGGTGTTTGGAGTTGTTTCCCGAGGAATTAGC
CAAGCTGCTTTCTTGACAACGGTCACCACCGTGGCCAAAATTCTGCCTCTGTTGTGCTTCATCATCCTTGTTGCATTCTT
GGGCTTTAGCTGGGAGAAGTTCACTGTTGATTTATGGGCGCGTGATGGTGGCGTGGGCAGCATTTTTGATCAGGTGCGCG
GCATCATGGTGTACACCGTGTGGGTGTTCATCGGTATCGAAGGTGCATCGGTATATTCCCGCCAGGCACGCTCACGCAGT
GATGTCAGCCGAGCTACCGTGATTGGTTTTGTGGCTGTTCTCCTTTTGCTGGTGTCGATTTCTTCGCTGAGCTTCGGTGT
ACTGACCCAACAAGAGCTCGCTGCGTTACCAGATAATTCCATGGCGTCGGTGCTCGAAGCTGTTGTTGGTCCATGGGGTG
CCGCATTGATTTCGTTGGGTCTGTGTCTTTCGGTTCTTGGGGCCTATGTGTCCTGGCAGATGCTCTGCGCAGAACCACTG
GCGTTGATGGCAATGGATGGCCTCATTCCAAGCAAAATCGGGGCCATCAACAGCCGCGGTGCTGCCTGGATGGCTCAGCT
GATCTCCACCATCGTGATTCAGATTTTCATCATCATTTTCTTCCTCAACGAGACCACCTACGTCTCCATGGTGCAATTGG
CTACCAACCTATACTTGGTGCCTTACCTGTTCTCTGCCTTTTATCTGGTCATGCTGGCAACACGTGGAAAAGGAATCACC
CACCCACATGCCGGCACACGTTTTGATGATTCCGGTCCAGAGATATCCCGCCGAGAAAACCGCAAACACCTCATCGTCGG
TTTAGTAGCAACGGTGTATTCAGTGTGGCTGTTTTACGCTGCAGAACCGCAGTTTGTCCTCTTCGGAGCCATGGCGATGC
TTCCCGGCTTAATCCCCTATGTGTGGACAAGGATTTATCGTGGCGAACAGGTGTTTAACCGCTTTGAAATCGGCGTGGTT
GTTGTCCTGGTCGTTGCTGCCAGCGCGGGCGTTATTGGTTTGGTCAACGGATCACTATCGCTTTAA

Upstream 100 bases:

>100_bases
GGTCTCCAGCCTTTCTAAACAATTCATCTGCACTTGATTAATTGGCCCCAAGATTACGCGAAGTTTAGCGACTTCGCCGT
ACGTCAACTACGTTAAATGA

Downstream 100 bases:

>100_bases
ACACCGAAACCTTCCTGCTAGTTCACCAAGATTTTTAAGTTTTACCGCAATTTCTTGAGAGCTTTGGGAGGATAATGGCG
GTGTGAATGAATGGCGAACA

Product: L-lysine permease

Products: NA

Alternate protein names: L-lysine permease

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNTQSDSAGSQGAAATSRTVSIRTLIALIIGSTVGAGIFSIPQNIGSVAGPGAMLIGWLIAGVGMLSVAFVFHVLARRKP
HLDSGVYAYARVGLGDYVGFSSAWGYWLGSVIAQVGYATLFFSTLGHYVPLFSQDHPFVSALAVSALTWLVFGVVSRGIS
QAAFLTTVTTVAKILPLLCFIILVAFLGFSWEKFTVDLWARDGGVGSIFDQVRGIMVYTVWVFIGIEGASVYSRQARSRS
DVSRATVIGFVAVLLLLVSISSLSFGVLTQQELAALPDNSMASVLEAVVGPWGAALISLGLCLSVLGAYVSWQMLCAEPL
ALMAMDGLIPSKIGAINSRGAAWMAQLISTIVIQIFIIIFFLNETTYVSMVQLATNLYLVPYLFSAFYLVMLATRGKGIT
HPHAGTRFDDSGPEISRRENRKHLIVGLVATVYSVWLFYAAEPQFVLFGAMAMLPGLIPYVWTRIYRGEQVFNRFEIGVV
VVLVVAASAGVIGLVNGSLSL

Sequences:

>Translated_501_residues
MNTQSDSAGSQGAAATSRTVSIRTLIALIIGSTVGAGIFSIPQNIGSVAGPGAMLIGWLIAGVGMLSVAFVFHVLARRKP
HLDSGVYAYARVGLGDYVGFSSAWGYWLGSVIAQVGYATLFFSTLGHYVPLFSQDHPFVSALAVSALTWLVFGVVSRGIS
QAAFLTTVTTVAKILPLLCFIILVAFLGFSWEKFTVDLWARDGGVGSIFDQVRGIMVYTVWVFIGIEGASVYSRQARSRS
DVSRATVIGFVAVLLLLVSISSLSFGVLTQQELAALPDNSMASVLEAVVGPWGAALISLGLCLSVLGAYVSWQMLCAEPL
ALMAMDGLIPSKIGAINSRGAAWMAQLISTIVIQIFIIIFFLNETTYVSMVQLATNLYLVPYLFSAFYLVMLATRGKGIT
HPHAGTRFDDSGPEISRRENRKHLIVGLVATVYSVWLFYAAEPQFVLFGAMAMLPGLIPYVWTRIYRGEQVFNRFEIGVV
VVLVVAASAGVIGLVNGSLSL
>Mature_501_residues
MNTQSDSAGSQGAAATSRTVSIRTLIALIIGSTVGAGIFSIPQNIGSVAGPGAMLIGWLIAGVGMLSVAFVFHVLARRKP
HLDSGVYAYARVGLGDYVGFSSAWGYWLGSVIAQVGYATLFFSTLGHYVPLFSQDHPFVSALAVSALTWLVFGVVSRGIS
QAAFLTTVTTVAKILPLLCFIILVAFLGFSWEKFTVDLWARDGGVGSIFDQVRGIMVYTVWVFIGIEGASVYSRQARSRS
DVSRATVIGFVAVLLLLVSISSLSFGVLTQQELAALPDNSMASVLEAVVGPWGAALISLGLCLSVLGAYVSWQMLCAEPL
ALMAMDGLIPSKIGAINSRGAAWMAQLISTIVIQIFIIIFFLNETTYVSMVQLATNLYLVPYLFSAFYLVMLATRGKGIT
HPHAGTRFDDSGPEISRRENRKHLIVGLVATVYSVWLFYAAEPQFVLFGAMAMLPGLIPYVWTRIYRGEQVFNRFEIGVV
VVLVVAASAGVIGLVNGSLSL

Specific function: Permease that is involved in the transport across the membrane of lysine

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Escherichia coli, GI1787890, Length=477, Percent_Identity=35.2201257861635, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI2367353, Length=432, Percent_Identity=24.537037037037, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790575, Length=394, Percent_Identity=22.8426395939086, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYSI_CORGL (P35865)

Other databases:

- EMBL:   X60312
- EMBL:   BA000036
- EMBL:   BX927150
- PIR:   S18573
- RefSeq:   NP_600195.1
- RefSeq:   YP_225261.1
- GeneID:   1018958
- GeneID:   3343706
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg1105
- KEGG:   cgl:NCgl0929
- HOGENOM:   HBG586921
- OMA:   AFRLDIF
- PhylomeDB:   P35865
- ProtClustDB:   CLSK633141
- BioCyc:   CGLU196627:CG1105-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060
- TIGRFAMs:   TIGR00905

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 53631; Mature: 53631

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10822c70)-; HASH(0x11c38454)-; HASH(0x12d7ec44)-; HASH(0x12f6f334)-; HASH(0x12711294)-; HASH(0x12ea19a0)-; HASH(0x12db6020)-; HASH(0x122b65a4)-; HASH(0x12f2a2f4)-; HASH(0x12f00fb0)-; HASH(0x12f15f04)-; HASH(0x12f27f00)-; HASH(0x12f01004)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCEEEEECCCCCH
>Mature Secondary Structure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HHHHHHHCCCEEEEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1667221; 12948626