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The map label for this gene is ksgA [H]

Identifier: 62389800

GI number: 62389800

Start: 966444

End: 967325

Strand: Direct

Name: ksgA [H]

Synonym: cg1038

Alternate gene names: 62389800

Gene position: 966444-967325 (Clockwise)

Preceding gene: 62389799

Following gene: 62389801

Centisome position: 29.44

GC content: 55.33

Gene sequence:

>882_bases
ATGGAAGAACCCTCAGGTGCACAGCTGCTCGGCCCGGTAGAAATCCGTGCGCTGGCAGAAAAGCTCGACGTCACACCAAC
TAAGAAGTTGGGGCAGAACTTTGTTCACGATCCCAACACGGTGCGTCGCATTGTTGCTGCGGCAGAGCTCACCCCAGACG
ACCACGTGGTGGAAGTTGGCCCTGGTCTGGGCTCTCTGACCCTTGCCCTGGTGGAATCTGCTGCTTCAGTAACTGCGGTG
GAAATTGATCCCCGTTTGGCTGCGGAATTGCCGGAGACTTTTCAGTGGCGCGCGCCGGCCCTTGCTCACAAGTTGAGCAT
CGTGCTGAAAGACGCCCTGAAGGTTCAACAATCCGATATGGCTGTTCAACCCACCGCCTTGGTGGCTAACTTGCCGTACA
ACGTCTCTGTCCCTGTCTTGTTGCACATGATGGAGGAGTTTCCCACCATCAACAAGGTGCTTGTCATGGTGCAGGCAGAG
GTTGCTGATCGTTTGGCTGCGGATCCAGGATCGAAGATTTATGGTGTGCCTAGCGTGAAGGCGTCCTTCTACGGTCCAGT
TACTCGCGCCGGGTCGATTGGTAAGAATGTCTTTTGGCCAGCTCCAAAGATCGAATCCGGTTTGGTGAAGATCGTGCGCG
AAGACACCGCGTGGAAGCAGGACGATGAGACGCGTAAGAAGGTGTGGCCGATCATTGATGCTGCTTTCTTGCAGCGCCGT
AAAACCCTAAGAGCTGCGCTTTCTGGACACTACGGTTCTGGCCAGGCAGCTGAGGAAGCTTTGCGGGCCGCTGATATTGA
TCCAACGCTTCGTGGCGAAAAGCTTGATGTCACTGACTATGTGCGCCTAGCTGGGGTGTTGCAGCAAAAGGATGAGAAGT
GA

Upstream 100 bases:

>100_bases
GGTTCAGGCTGCACAAGGTTGGGGAGCATGGCCTGCTTGCACCGCAAGCTTGGGCATCCGATAGTAGAAATCTGGCATCC
AATAGGTAGATTGGGATGCT

Downstream 100 bases:

>100_bases
AAATTACCGCTAAGGCGTGGGCGAAAACCAACCTGCATTTAGGTGTGGGACCGGCTCACGACGATGGATTTCACGAGCTC
ATGACGGTGTTTCAAACCAT

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MEEPSGAQLLGPVEIRALAEKLDVTPTKKLGQNFVHDPNTVRRIVAAAELTPDDHVVEVGPGLGSLTLALVESAASVTAV
EIDPRLAAELPETFQWRAPALAHKLSIVLKDALKVQQSDMAVQPTALVANLPYNVSVPVLLHMMEEFPTINKVLVMVQAE
VADRLAADPGSKIYGVPSVKASFYGPVTRAGSIGKNVFWPAPKIESGLVKIVREDTAWKQDDETRKKVWPIIDAAFLQRR
KTLRAALSGHYGSGQAAEEALRAADIDPTLRGEKLDVTDYVRLAGVLQQKDEK

Sequences:

>Translated_293_residues
MEEPSGAQLLGPVEIRALAEKLDVTPTKKLGQNFVHDPNTVRRIVAAAELTPDDHVVEVGPGLGSLTLALVESAASVTAV
EIDPRLAAELPETFQWRAPALAHKLSIVLKDALKVQQSDMAVQPTALVANLPYNVSVPVLLHMMEEFPTINKVLVMVQAE
VADRLAADPGSKIYGVPSVKASFYGPVTRAGSIGKNVFWPAPKIESGLVKIVREDTAWKQDDETRKKVWPIIDAAFLQRR
KTLRAALSGHYGSGQAAEEALRAADIDPTLRGEKLDVTDYVRLAGVLQQKDEK
>Mature_293_residues
MEEPSGAQLLGPVEIRALAEKLDVTPTKKLGQNFVHDPNTVRRIVAAAELTPDDHVVEVGPGLGSLTLALVESAASVTAV
EIDPRLAAELPETFQWRAPALAHKLSIVLKDALKVQQSDMAVQPTALVANLPYNVSVPVLLHMMEEFPTINKVLVMVQAE
VADRLAADPGSKIYGVPSVKASFYGPVTRAGSIGKNVFWPAPKIESGLVKIVREDTAWKQDDETRKKVWPIIDAAFLQRR
KTLRAALSGHYGSGQAAEEALRAADIDPTLRGEKLDVTDYVRLAGVLQQKDEK

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=219, Percent_Identity=35.6164383561644, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI156415992, Length=298, Percent_Identity=29.1946308724832, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786236, Length=266, Percent_Identity=34.2105263157895, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25146882, Length=181, Percent_Identity=35.9116022099448, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25141369, Length=290, Percent_Identity=26.8965517241379, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324989, Length=182, Percent_Identity=36.2637362637363, Blast_Score=115, Evalue=9e-27,
Organism=Drosophila melanogaster, GI21358017, Length=235, Percent_Identity=33.1914893617021, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357273, Length=305, Percent_Identity=27.2131147540984, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 31774; Mature: 31774

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEPSGAQLLGPVEIRALAEKLDVTPTKKLGQNFVHDPNTVRRIVAAAELTPDDHVVEVG
CCCCCCCCEECHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEC
PGLGSLTLALVESAASVTAVEIDPRLAAELPETFQWRAPALAHKLSIVLKDALKVQQSDM
CCCHHHHHHHHHHHHCEEEEEECCHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
AVQPTALVANLPYNVSVPVLLHMMEEFPTINKVLVMVQAEVADRLAADPGSKIYGVPSVK
CCCCHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
ASFYGPVTRAGSIGKNVFWPAPKIESGLVKIVREDTAWKQDDETRKKVWPIIDAAFLQRR
HHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KTLRAALSGHYGSGQAAEEALRAADIDPTLRGEKLDVTDYVRLAGVLQQKDEK
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEEPSGAQLLGPVEIRALAEKLDVTPTKKLGQNFVHDPNTVRRIVAAAELTPDDHVVEVG
CCCCCCCCEECHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEC
PGLGSLTLALVESAASVTAVEIDPRLAAELPETFQWRAPALAHKLSIVLKDALKVQQSDM
CCCHHHHHHHHHHHHCEEEEEECCHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
AVQPTALVANLPYNVSVPVLLHMMEEFPTINKVLVMVQAEVADRLAADPGSKIYGVPSVK
CCCCHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
ASFYGPVTRAGSIGKNVFWPAPKIESGLVKIVREDTAWKQDDETRKKVWPIIDAAFLQRR
HHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
KTLRAALSGHYGSGQAAEEALRAADIDPTLRGEKLDVTDYVRLAGVLQQKDEK
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA