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The map label for this gene is dld [H]

Identifier: 62389792

GI number: 62389792

Start: 957152

End: 958867

Strand: Reverse

Name: dld [H]

Synonym: cg1027

Alternate gene names: 62389792

Gene position: 958867-957152 (Counterclockwise)

Preceding gene: 62389793

Following gene: 62389787

Centisome position: 29.21

GC content: 62.12

Gene sequence:

>1716_bases
ATGACGCAACCAGGACAGACCACCACGACTTCGCACGAAGCGATCGATGCGTTCAAGAGAATCGTCGGCGACGAACATGT
ACTGACCTCTGAGCGTGCCACGATGCCATTCAGCAAAGGCTATCGATTCGGCGGAGGACCAGTCTTCGCCGTGGTGCGCC
CCGGCACGCTGGTCGAGATGTGGCGGGCGCTGCAGGTATCCGTCGACAACAACCTCATCGTCATCCCGCAGGCATCGAAC
ACGGGCCTGACTGGTGGATCCGGCCCCGGCTTCCAAGACTACGATCGCCCCATTGTGATCATCTCGACTCACCGCATCGA
TGAGGTGCACCTCATCAACGACGCGCGCGAGGCGATCTCGCTCGCGGGCACCCCGCTGACACACCTGACCGACGCGCTCG
CCAAGCACCAGCGCGAGCCGCACTCGGTGATCGGGTCGACATCAATCGGCGCCTCGGTCATCGGCGGCATCGCGAACAAC
TCGGGCGGCAGCCAGATTCGCAAGGGTCCGGCATTCACGCGCGAAGCGATCTTCGCCCGCGTCAACGACGACGGCAAGGT
CGAGCTGGTCAATCACCTGGGCATCTCGCTCGGAGACGACCCTGAGGTCGCACTCGACCGTCTACAGCGCGGCGAGTGGT
CTCCCGAGGATGTCACCCCAGCTCCCGAAGACTCGAACGAGACCGAGTACGCCGAGCACTTGCGCAAGATCGTGCCTTCG
CCTGCTCGCTACAATGCGAACCCCGAGTACCTGTTCGAGGCTTCCGGCTCGGCCGGCAAGCTGATGGTGTTCGCGGTGCG
CACCCGCACCTTCCCTCGCGAAGTGCACCCGACCGTGTTTTACATCGGCACGAACAACACGCACGAGCTCGAAGAGATCC
GTCGGTTGTTCCTCGAAGCCGACATGCCGCTGCCTATCTCTGGTGAGTACATGGGCCGCAGTGCCTTCGACTTGGCCGAG
AAGTACGGCAAAGACACCTTCGTCTTCCTGAAGTTCATGAGTCCAGCGCTGCAGACGCGCATGTTCTCGTTCAAGACGTG
GGCCAACGGCTTGTTCTCGAAGATTCCCGGCATTGGTCCGACCTTCGCCGACACGGTATCGCAAGCCATGTTCAGCGTGC
TGCCCAACCAGCTGCCCAAGCGCATGATGGAGTACCGCAACCGTTTCGAGCATCACCTGCTGCTCACCGTCAGCGAGTCG
CAGAAGGCCGCGAGCGAGAAGATGCTCAAGGAGTTCTTCGCAGAGCCCGAGCACACTGGTGAGTTCTTCATCTGCACGTC
TGATGAAGAAAAGAGCGCGTCGCTCAACCGGTTCGGCGCGGCCAGTGCCGCCACTCGCTACGCCGCGTTGAAGCGCCGGC
ACATCGCAGGGCTCATCCCCATCGATGTGGCCCTGCGTCGCGACGATTGGAACTGGCTCGAGGTGCTGCCGGAGGAGATC
GACGACCAGCTTGAGGTCAAGGCGTATTACGGGCACTTCTTCTGCCATGTGATGCACCAGGACTATGTCGCCAAGCAGGG
CGTGGATCTCGAGGCGCTGCACGACCGCATCCAGCACCTGCTGGAGGAGCGCGGCGCGAAGCTGCCCGCCGAGCACAACT
ACGGTCGCATCTACAAGCTGCCGGAGTCCATGGAAGAGCACTTCAAGGAGCTCGATCCGACGAATACGTTCAACGCCGGT
ATCGGCGGCACGTCGCCGCACAAGGACTGGGCCTAA

Upstream 100 bases:

>100_bases
CCATCAAAAAATGAACGACCGCGGACTAGCTCGGATCAAGGCGACATCCCCTCAGCATCATGACGCGCTTGTGATGCAAC
TGAATATAGGAAGCTTAGAG

Downstream 100 bases:

>100_bases
GTCCCCAAGGTAGCGCGACGCCGTGAGAGCCTGAGCGATGTCTTATCCATCTCGGGTGGACCTAGGGCTCGACTCCCTAG
GTCCACCGGGACGGATGAGT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: Respiratory D-lactate dehydrogenase [H]

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MTQPGQTTTTSHEAIDAFKRIVGDEHVLTSERATMPFSKGYRFGGGPVFAVVRPGTLVEMWRALQVSVDNNLIVIPQASN
TGLTGGSGPGFQDYDRPIVIISTHRIDEVHLINDAREAISLAGTPLTHLTDALAKHQREPHSVIGSTSIGASVIGGIANN
SGGSQIRKGPAFTREAIFARVNDDGKVELVNHLGISLGDDPEVALDRLQRGEWSPEDVTPAPEDSNETEYAEHLRKIVPS
PARYNANPEYLFEASGSAGKLMVFAVRTRTFPREVHPTVFYIGTNNTHELEEIRRLFLEADMPLPISGEYMGRSAFDLAE
KYGKDTFVFLKFMSPALQTRMFSFKTWANGLFSKIPGIGPTFADTVSQAMFSVLPNQLPKRMMEYRNRFEHHLLLTVSES
QKAASEKMLKEFFAEPEHTGEFFICTSDEEKSASLNRFGAASAATRYAALKRRHIAGLIPIDVALRRDDWNWLEVLPEEI
DDQLEVKAYYGHFFCHVMHQDYVAKQGVDLEALHDRIQHLLEERGAKLPAEHNYGRIYKLPESMEEHFKELDPTNTFNAG
IGGTSPHKDWA

Sequences:

>Translated_571_residues
MTQPGQTTTTSHEAIDAFKRIVGDEHVLTSERATMPFSKGYRFGGGPVFAVVRPGTLVEMWRALQVSVDNNLIVIPQASN
TGLTGGSGPGFQDYDRPIVIISTHRIDEVHLINDAREAISLAGTPLTHLTDALAKHQREPHSVIGSTSIGASVIGGIANN
SGGSQIRKGPAFTREAIFARVNDDGKVELVNHLGISLGDDPEVALDRLQRGEWSPEDVTPAPEDSNETEYAEHLRKIVPS
PARYNANPEYLFEASGSAGKLMVFAVRTRTFPREVHPTVFYIGTNNTHELEEIRRLFLEADMPLPISGEYMGRSAFDLAE
KYGKDTFVFLKFMSPALQTRMFSFKTWANGLFSKIPGIGPTFADTVSQAMFSVLPNQLPKRMMEYRNRFEHHLLLTVSES
QKAASEKMLKEFFAEPEHTGEFFICTSDEEKSASLNRFGAASAATRYAALKRRHIAGLIPIDVALRRDDWNWLEVLPEEI
DDQLEVKAYYGHFFCHVMHQDYVAKQGVDLEALHDRIQHLLEERGAKLPAEHNYGRIYKLPESMEEHFKELDPTNTFNAG
IGGTSPHKDWA
>Mature_570_residues
TQPGQTTTTSHEAIDAFKRIVGDEHVLTSERATMPFSKGYRFGGGPVFAVVRPGTLVEMWRALQVSVDNNLIVIPQASNT
GLTGGSGPGFQDYDRPIVIISTHRIDEVHLINDAREAISLAGTPLTHLTDALAKHQREPHSVIGSTSIGASVIGGIANNS
GGSQIRKGPAFTREAIFARVNDDGKVELVNHLGISLGDDPEVALDRLQRGEWSPEDVTPAPEDSNETEYAEHLRKIVPSP
ARYNANPEYLFEASGSAGKLMVFAVRTRTFPREVHPTVFYIGTNNTHELEEIRRLFLEADMPLPISGEYMGRSAFDLAEK
YGKDTFVFLKFMSPALQTRMFSFKTWANGLFSKIPGIGPTFADTVSQAMFSVLPNQLPKRMMEYRNRFEHHLLLTVSESQ
KAASEKMLKEFFAEPEHTGEFFICTSDEEKSASLNRFGAASAATRYAALKRRHIAGLIPIDVALRRDDWNWLEVLPEEID
DQLEVKAYYGHFFCHVMHQDYVAKQGVDLEALHDRIQHLLEERGAKLPAEHNYGRIYKLPESMEEHFKELDPTNTFNAGI
GGTSPHKDWA

Specific function: First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids [H]

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788454, Length=565, Percent_Identity=46.3716814159292, Blast_Score=524, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016172
- InterPro:   IPR016173
- InterPro:   IPR012256
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR015409
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF09330 Lact-deh-memb [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 63724; Mature: 63592

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPGQTTTTSHEAIDAFKRIVGDEHVLTSERATMPFSKGYRFGGGPVFAVVRPGTLVEM
CCCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHCCCCCCCCCEEEEECCCHHHHH
WRALQVSVDNNLIVIPQASNTGLTGGSGPGFQDYDRPIVIISTHRIDEVHLINDAREAIS
HHHHEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHH
LAGTPLTHLTDALAKHQREPHSVIGSTSIGASVIGGIANNSGGSQIRKGPAFTREAIFAR
HCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHCCCCCCCCCCHHHCCCCHHHHHHEEE
VNDDGKVELVNHLGISLGDDPEVALDRLQRGEWSPEDVTPAPEDSNETEYAEHLRKIVPS
ECCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PARYNANPEYLFEASGSAGKLMVFAVRTRTFPREVHPTVFYIGTNNTHELEEIRRLFLEA
CCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHC
DMPLPISGEYMGRSAFDLAEKYGKDTFVFLKFMSPALQTRMFSFKTWANGLFSKIPGIGP
CCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TFADTVSQAMFSVLPNQLPKRMMEYRNRFEHHLLLTVSESQKAASEKMLKEFFAEPEHTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCC
EFFICTSDEEKSASLNRFGAASAATRYAALKRRHIAGLIPIDVALRRDDWNWLEVLPEEI
CEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHCCHHC
DDQLEVKAYYGHFFCHVMHQDYVAKQGVDLEALHDRIQHLLEERGAKLPAEHNYGRIYKL
CCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
PESMEEHFKELDPTNTFNAGIGGTSPHKDWA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQPGQTTTTSHEAIDAFKRIVGDEHVLTSERATMPFSKGYRFGGGPVFAVVRPGTLVEM
CCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHCCCCCCCCCEEEEECCCHHHHH
WRALQVSVDNNLIVIPQASNTGLTGGSGPGFQDYDRPIVIISTHRIDEVHLINDAREAIS
HHHHEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHH
LAGTPLTHLTDALAKHQREPHSVIGSTSIGASVIGGIANNSGGSQIRKGPAFTREAIFAR
HCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHCCCCCCCCCCHHHCCCCHHHHHHEEE
VNDDGKVELVNHLGISLGDDPEVALDRLQRGEWSPEDVTPAPEDSNETEYAEHLRKIVPS
ECCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PARYNANPEYLFEASGSAGKLMVFAVRTRTFPREVHPTVFYIGTNNTHELEEIRRLFLEA
CCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHC
DMPLPISGEYMGRSAFDLAEKYGKDTFVFLKFMSPALQTRMFSFKTWANGLFSKIPGIGP
CCCCCCCCCCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TFADTVSQAMFSVLPNQLPKRMMEYRNRFEHHLLLTVSESQKAASEKMLKEFFAEPEHTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCC
EFFICTSDEEKSASLNRFGAASAATRYAALKRRHIAGLIPIDVALRRDDWNWLEVLPEEI
CEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHCCHHC
DDQLEVKAYYGHFFCHVMHQDYVAKQGVDLEALHDRIQHLLEERGAKLPAEHNYGRIYKL
CCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEC
PESMEEHFKELDPTNTFNAGIGGTSPHKDWA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6386470; 3882663; 9278503; 10944213 [H]