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The map label for this gene is moeA2 [H]

Identifier: 62389772

GI number: 62389772

Start: 936820

End: 938079

Strand: Direct

Name: moeA2 [H]

Synonym: cg1005

Alternate gene names: 62389772

Gene position: 936820-938079 (Clockwise)

Preceding gene: 62389771

Following gene: 62389773

Centisome position: 28.54

GC content: 58.41

Gene sequence:

>1260_bases
GTGCGATCAGTCGAGCAACAGCTATCCATTGTCACCGAGGCAGCGGTAGCTCCAGAGCCAGTGCGTATTGCTATTGCAGA
GGCACTGGGTTTGATGTGCGCGGAAGAGGTTCAAGCTAGTCGTGCTTTGCCGGGTTTCGCGCAAGCAGCGATTGATGGTT
ATGCGGTTCGAGCAGTCGATGTCGGCGGCGAGAAGTCGCTTAGCCAGCAACTGCCGGTTGCTCCTCCGGAAAAATCCCTG
CCCGTGGTGGGTGAAGTAGCTGCGGGTTCTCAGCAGCCGTTGCGCCTGCAGCCTAAACAAGCAGTCATGGTCCACACCGG
TGCGCCACTGCCGATGCTTGCGGATGCGGTGCTGCCCATGGCGTGGTCAGATCGTGGCCGCAAACGAGTAACCGCGCAGC
GACCTGTGCGCTCTGGCGAGTTTGTGCGCAAAGAAGGCGATGACATCCAACCGGGAGACATCGCAGTCAGCGCCGGCGCG
GTCTTAGGCCCTGCCCAAATTGGTTTGCTCGCAGCTGTTGGTCGCTCCAAAGTGTTGGTGTACCCACGCCCACGCATGTC
GGTTATCTCCGTAGGCGCTGAACTTGTTGATATTGATCGCCAGCCAGGCCTCGGCCAGGTTTATGATGTCAATTCCTATT
CTCTGGCTGCCGCCGGTAGGGAAGCGGGCGCAGATGTGTACCGCTACGGCATTGCTGCCGGTGAACCTCGTCGCATCAAA
GAGATCATTGAATCCCAGATGCTGCGCTCGGAAATCATCGTCATCACCGGAGCTGTTGGCGGTGCTGGTTCAGCTGGCGT
GCGCCAGGTTCTCAACGAGCTAGGCGATATCGACACCGAACGCGTCGCAATGCACCCCGGTTCTGTCCAAGGATTCGGTC
TGCTCGGCGAGAACAAGATTCCATGCTTCCTTCTGCCTTCCAATCCGGTGGCGTCGTTAGTTATTTTTGAAACCTTCGTC
CGCCCGGTCGTGCGCATGAGCCTGGGCAAGAGCAATGCGGCGCGCCGGGTTGTTCGAGCTCGAGCGCTCAACCACGTTGT
GTCTGTGGCGGGTCGAAAAGGTTTCATCAGGTCCAGGCTCATGCGCGATGCAGAAACCCAGGACTACCTCGTGGAGGCTT
TGGGTGGTGCAACGGGCGCACCATCGCACCTATTGGCAGGATTGTCCGAAGCAAACGGTATGATCCGCATTCCAGAAGAT
GTCACAGAAATCCGACCGGGAGATGTCGTGGACGTGATCTTCCTTGCCCAAGGTCGATAG

Upstream 100 bases:

>100_bases
GATGCAATCAAACAGATTTTGGCTGAACATGAAGCTGCGGAACGTATTGCAGACGATTCTCAAGTAAAATAGCTGCCTGG
TTCCGATTAGGAGGTCCGTA

Downstream 100 bases:

>100_bases
TTCGATGCGTAATGCACCGTCAGGTCCGACGCATTTTCGACACCCCGGCTGGCCAGAGTCAACGCAAACGGTCATTTTGC
CGGATGGCGGCAGGCTACGT

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRSVEQQLSIVTEAAVAPEPVRIAIAEALGLMCAEEVQASRALPGFAQAAIDGYAVRAVDVGGEKSLSQQLPVAPPEKSL
PVVGEVAAGSQQPLRLQPKQAVMVHTGAPLPMLADAVLPMAWSDRGRKRVTAQRPVRSGEFVRKEGDDIQPGDIAVSAGA
VLGPAQIGLLAAVGRSKVLVYPRPRMSVISVGAELVDIDRQPGLGQVYDVNSYSLAAAGREAGADVYRYGIAAGEPRRIK
EIIESQMLRSEIIVITGAVGGAGSAGVRQVLNELGDIDTERVAMHPGSVQGFGLLGENKIPCFLLPSNPVASLVIFETFV
RPVVRMSLGKSNAARRVVRARALNHVVSVAGRKGFIRSRLMRDAETQDYLVEALGGATGAPSHLLAGLSEANGMIRIPED
VTEIRPGDVVDVIFLAQGR

Sequences:

>Translated_419_residues
MRSVEQQLSIVTEAAVAPEPVRIAIAEALGLMCAEEVQASRALPGFAQAAIDGYAVRAVDVGGEKSLSQQLPVAPPEKSL
PVVGEVAAGSQQPLRLQPKQAVMVHTGAPLPMLADAVLPMAWSDRGRKRVTAQRPVRSGEFVRKEGDDIQPGDIAVSAGA
VLGPAQIGLLAAVGRSKVLVYPRPRMSVISVGAELVDIDRQPGLGQVYDVNSYSLAAAGREAGADVYRYGIAAGEPRRIK
EIIESQMLRSEIIVITGAVGGAGSAGVRQVLNELGDIDTERVAMHPGSVQGFGLLGENKIPCFLLPSNPVASLVIFETFV
RPVVRMSLGKSNAARRVVRARALNHVVSVAGRKGFIRSRLMRDAETQDYLVEALGGATGAPSHLLAGLSEANGMIRIPED
VTEIRPGDVVDVIFLAQGR
>Mature_419_residues
MRSVEQQLSIVTEAAVAPEPVRIAIAEALGLMCAEEVQASRALPGFAQAAIDGYAVRAVDVGGEKSLSQQLPVAPPEKSL
PVVGEVAAGSQQPLRLQPKQAVMVHTGAPLPMLADAVLPMAWSDRGRKRVTAQRPVRSGEFVRKEGDDIQPGDIAVSAGA
VLGPAQIGLLAAVGRSKVLVYPRPRMSVISVGAELVDIDRQPGLGQVYDVNSYSLAAAGREAGADVYRYGIAAGEPRRIK
EIIESQMLRSEIIVITGAVGGAGSAGVRQVLNELGDIDTERVAMHPGSVQGFGLLGENKIPCFLLPSNPVASLVIFETFV
RPVVRMSLGKSNAARRVVRARALNHVVSVAGRKGFIRSRLMRDAETQDYLVEALGGATGAPSHLLAGLSEANGMIRIPED
VTEIRPGDVVDVIFLAQGR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=415, Percent_Identity=30.8433734939759, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI10880983, Length=415, Percent_Identity=30.8433734939759, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=28.9817232375979, Blast_Score=133, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25147659, Length=355, Percent_Identity=28.7323943661972, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562606, Length=390, Percent_Identity=21.7948717948718, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136978, Length=340, Percent_Identity=25.8823529411765, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24638841, Length=340, Percent_Identity=25.8823529411765, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44182; Mature: 44182

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEQQLSIVTEAAVAPEPVRIAIAEALGLMCAEEVQASRALPGFAQAAIDGYAVRAVD
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEEE
VGGEKSLSQQLPVAPPEKSLPVVGEVAAGSQQPLRLQPKQAVMVHTGAPLPMLADAVLPM
CCCCHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHCC
AWSDRGRKRVTAQRPVRSGEFVRKEGDDIQPGDIAVSAGAVLGPAQIGLLAAVGRSKVLV
HHCCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEEECCCEECHHHHHHHHHCCCCEEEE
YPRPRMSVISVGAELVDIDRQPGLGQVYDVNSYSLAAAGREAGADVYRYGIAAGEPRRIK
ECCCCCHHHHHCCHHEECCCCCCCCEEEECCCCEEECCCCCCCCHHHHHCCCCCCHHHHH
EIIESQMLRSEIIVITGAVGGAGSAGVRQVLNELGDIDTERVAMHPGSVQGFGLLGENKI
HHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHEEECCCCCCEEEEECCCCC
PCFLLPSNPVASLVIFETFVRPVVRMSLGKSNAARRVVRARALNHVVSVAGRKGFIRSRL
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MRDAETQDYLVEALGGATGAPSHLLAGLSEANGMIRIPEDVTEIRPGDVVDVIFLAQGR
HHCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECCCHHHHCCCCCEEEEEEEECCC
>Mature Secondary Structure
MRSVEQQLSIVTEAAVAPEPVRIAIAEALGLMCAEEVQASRALPGFAQAAIDGYAVRAVD
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEEE
VGGEKSLSQQLPVAPPEKSLPVVGEVAAGSQQPLRLQPKQAVMVHTGAPLPMLADAVLPM
CCCCHHHHHCCCCCCCCCCCCEEEECCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHCC
AWSDRGRKRVTAQRPVRSGEFVRKEGDDIQPGDIAVSAGAVLGPAQIGLLAAVGRSKVLV
HHCCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCEEEECCCEECHHHHHHHHHCCCCEEEE
YPRPRMSVISVGAELVDIDRQPGLGQVYDVNSYSLAAAGREAGADVYRYGIAAGEPRRIK
ECCCCCHHHHHCCHHEECCCCCCCCEEEECCCCEEECCCCCCCCHHHHHCCCCCCHHHHH
EIIESQMLRSEIIVITGAVGGAGSAGVRQVLNELGDIDTERVAMHPGSVQGFGLLGENKI
HHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHEEECCCCCCEEEEECCCCC
PCFLLPSNPVASLVIFETFVRPVVRMSLGKSNAARRVVRARALNHVVSVAGRKGFIRSRL
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MRDAETQDYLVEALGGATGAPSHLLAGLSEANGMIRIPEDVTEIRPGDVVDVIFLAQGR
HHCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECCCHHHHCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]