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The map label for this gene is hisN

Identifier: 62389689

GI number: 62389689

Start: 842987

End: 843769

Strand: Reverse

Name: hisN

Synonym: cg0910

Alternate gene names: 62389689

Gene position: 843769-842987 (Counterclockwise)

Preceding gene: 62389690

Following gene: 62389688

Centisome position: 25.7

GC content: 60.79

Gene sequence:

>783_bases
ATGAGCAAATATGCAGACGATTTAGCCTTAGCCCTCGAACTTGCCGAACTTGCCGATTCCATCACCCTCGACCGCTTCGA
AGCCTCTGACCTGGAAGTATCCTCCAAGCCAGACATGACTCCCGTCAGCGATGCCGACCTGGCGACCGAAGAAGCACTCC
GTGAGAAAATCGCCACCGCCCGCCCCGCCGACTCCATCCTCGGTGAAGAATTCGGTGGCGACGTAGAATTCAGCGGCCGC
CAGTGGATCATCGACCCCATCGACGGCACCAAAAACTACGTCCGCGGCGTCCCCGTATGGGCAACCCTGATCGCGCTGCT
CGACAACGGCAAACCCGTCGCAGGTGTCATCTCCGCACCCGCACTGGCTAGGCGTTGGTGGGCATCCGAAGGGGCCGGCG
CATGGCGCACCTTCAACGGCAGCTCCCCACGCAAACTGTCCGTGTCCCAGGTGTCCAAGCTTGACGACGCCTCCCTCTCC
TTCTCCTCCCTCTCCGGCTGGGCCGAACGAGATTTGCGCGATCAGTTCGTCTCCCTAACTGATACCACCTGGCGACTCCG
CGGCTACGGCGACTTCTTCTCCTACTGCCTCGTCGCCGAAGGTGCCGTCGATATCGCCGCTGAACCAGAAGTCAGCCTCT
GGGATCTTGCTCCCCTGTCCATCCTGGTCACCGAAGCCGGAGGAAAGTTCACCTCACTGGCTGGCGTCGATGGACCACAC
GGTGGCGATGCAGTAGCCACCAACGGCATCCTGCACGATGAGACGCTGGATCGTTTAAAATAG

Upstream 100 bases:

>100_bases
CATCAAAGTGACCGCCGGCGGCGTCGAATGGTCCGTTGCAGGAAACGCGGAAGCAGTTAGTGAGATCTCCGAAACTTTAA
GCGCACTAGACTAACAACAC

Downstream 100 bases:

>100_bases
ACTCCCGGGTTTTGCTTGGTTTTCCGGATACCGTCCTATTTGACCGACGTCTGGGGTGGGGTGGATCTTTCGGCCACCTG
GTCGAATTTTCCTCAACCCC

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSKYADDLALALELAELADSITLDRFEASDLEVSSKPDMTPVSDADLATEEALREKIATARPADSILGEEFGGDVEFSGR
QWIIDPIDGTKNYVRGVPVWATLIALLDNGKPVAGVISAPALARRWWASEGAGAWRTFNGSSPRKLSVSQVSKLDDASLS
FSSLSGWAERDLRDQFVSLTDTTWRLRGYGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVTEAGGKFTSLAGVDGPH
GGDAVATNGILHDETLDRLK

Sequences:

>Translated_260_residues
MSKYADDLALALELAELADSITLDRFEASDLEVSSKPDMTPVSDADLATEEALREKIATARPADSILGEEFGGDVEFSGR
QWIIDPIDGTKNYVRGVPVWATLIALLDNGKPVAGVISAPALARRWWASEGAGAWRTFNGSSPRKLSVSQVSKLDDASLS
FSSLSGWAERDLRDQFVSLTDTTWRLRGYGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVTEAGGKFTSLAGVDGPH
GGDAVATNGILHDETLDRLK
>Mature_259_residues
SKYADDLALALELAELADSITLDRFEASDLEVSSKPDMTPVSDADLATEEALREKIATARPADSILGEEFGGDVEFSGRQ
WIIDPIDGTKNYVRGVPVWATLIALLDNGKPVAGVISAPALARRWWASEGAGAWRTFNGSSPRKLSVSQVSKLDDASLSF
SSLSGWAERDLRDQFVSLTDTTWRLRGYGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVTEAGGKFTSLAGVDGPHG
GDAVATNGILHDETLDRLK

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable)

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Localized On The Inner Face Of The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family

Homologues:

Organism=Homo sapiens, GI5031789, Length=241, Percent_Identity=30.7053941908714, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI221625487, Length=240, Percent_Identity=30.8333333333333, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1790659, Length=203, Percent_Identity=29.064039408867, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788882, Length=245, Percent_Identity=28.1632653061224, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193202570, Length=242, Percent_Identity=29.3388429752066, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI193202572, Length=234, Percent_Identity=29.9145299145299, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320493, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357957, Length=238, Percent_Identity=31.0924369747899, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664922, Length=248, Percent_Identity=27.0161290322581, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664918, Length=212, Percent_Identity=30.188679245283, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664926, Length=239, Percent_Identity=27.6150627615063, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357329, Length=212, Percent_Identity=28.7735849056604, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357303, Length=207, Percent_Identity=28.9855072463768, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISN_CORGL (Q8NS80)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927150
- RefSeq:   NP_600028.1
- RefSeq:   YP_225091.1
- HSSP:   P29218
- ProteinModelPortal:   Q8NS80
- SMR:   Q8NS80
- GeneID:   1018794
- GeneID:   3342571
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0910
- KEGG:   cgl:NCgl0765
- HOGENOM:   HBG730251
- OMA:   KRDDTPV
- PhylomeDB:   Q8NS80
- ProtClustDB:   CLSK2754324
- BioCyc:   CGLU196627:CG0910-MONOMER
- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- PANTHER:   PTHR20854
- PRINTS:   PR00377
- TIGRFAMs:   TIGR02067

Pfam domain/function: PF00459 Inositol_P

EC number: =3.1.3.15

Molecular weight: Translated: 27893; Mature: 27762

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00629 IMP_1; PS00630 IMP_2

Important sites: BINDING 69-69 BINDING 187-187 BINDING 215-215

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYADDLALALELAELADSITLDRFEASDLEVSSKPDMTPVSDADLATEEALREKIATA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
RPADSILGEEFGGDVEFSGRQWIIDPIDGTKNYVRGVPVWATLIALLDNGKPVAGVISAP
CCHHHHHHHHCCCCEEECCCEEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCEEHHHHCH
ALARRWWASEGAGAWRTFNGSSPRKLSVSQVSKLDDASLSFSSLSGWAERDLRDQFVSLT
HHHHHHHCCCCCCCEEECCCCCCCEECHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHC
DTTWRLRGYGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVTEAGGKFTSLAGVDGPH
CCEEEEECCHHHHHHHHHHCCCEEECCCCCCCEECCCCEEEEEECCCCCEEEECCCCCCC
GGDAVATNGILHDETLDRLK
CCCCEEECCEECHHHHHHCC
>Mature Secondary Structure 
SKYADDLALALELAELADSITLDRFEASDLEVSSKPDMTPVSDADLATEEALREKIATA
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
RPADSILGEEFGGDVEFSGRQWIIDPIDGTKNYVRGVPVWATLIALLDNGKPVAGVISAP
CCHHHHHHHHCCCCEEECCCEEEEECCCCCHHHHCCCHHHHHHHHHHCCCCCEEHHHHCH
ALARRWWASEGAGAWRTFNGSSPRKLSVSQVSKLDDASLSFSSLSGWAERDLRDQFVSLT
HHHHHHHCCCCCCCEEECCCCCCCEECHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHC
DTTWRLRGYGDFFSYCLVAEGAVDIAAEPEVSLWDLAPLSILVTEAGGKFTSLAGVDGPH
CCEEEEECCHHHHHHHHHHCCCEEECCCCCCCEECCCCEEEEEECCCCCEEEECCCCCCC
GGDAVATNGILHDETLDRLK
CCCCEEECCEECHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12948626