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The map label for this gene is uvrD [H]

Identifier: 62389668

GI number: 62389668

Start: 820727

End: 822763

Strand: Direct

Name: uvrD [H]

Synonym: cg0889

Alternate gene names: 62389668

Gene position: 820727-822763 (Clockwise)

Preceding gene: 62389667

Following gene: 62389670

Centisome position: 25.0

GC content: 57.54

Gene sequence:

>2037_bases
GTGATCAATTTGCAGGACCTCGACGAGGATCAACGCATCGCTGCTTCTGCGCCTCGCGGACCAGTGTGCATTCTCGCCGG
AGCCGGCACGGGTAAAACTCGAACGATTACTTATCGCATCGCGCATCTGATTGATCAGGGTTTTGTGAGCCCGAATCGTG
TTCTTGCTGTGACGTTTACATCCCGCGCGGCAGGGGAGATGCGTCATCGCTTGAATCTCATGGGGATCGGTGGCGTGCAG
GCAAGGACATTCCACGCAGCAGCGAGGAAGCAGTTGTTGTATTTCTGGCCTCAGGTGGCGGGTAATCTGCCGTGGCGCCT
GTTGGATAATAAGTTTCAACTTGTGGGTCGTGCGGTTCGTGGTGCGCGGTTGGAATCGCAGACTGAAAAAGTTCGCGATA
TTTTGGGTGAAATTGAGTGGGCGAAGGCGTCGTTGATTACACCTGAGCAGTATCCGGATCGTTTGGGTACGAGGACCCCT
CCGGCGCCCGCGGAGAAAATCGCTGAGGTGTATCAGCGATACGAAAACATGAAGGCAACCCCTGAGGGGATGTTGCTTGA
TTTCGACGATCTGTTGCTTCACACCGCCGGCGCGTTGGAGAATTCCCCGGCGGTGGCGGAGGAGTTCCGCCAGCAGTATC
GCAGCTTTGTGGTCGATGAGTATCAGGATGTGACGCCTCTGCAGCAGCGGGTGCTCGATGCGTGGCTCGGCGATCGCGAT
GACCTGACGGTTGTCGGCGATGCGAACCAGACGATTTATTCGTTCACGGGGGCAACACCTGAATTTTTGCTTAATTTCTC
GAGGAAATATCCGGAGGCAACCGTCGTCAAGCTGCAGCGCGACTACCGCTCAACGCCGCAGGTCACCGCGCTGGCCAATA
CCGTCATCGGCCAGGCGCGGGGGCGCGTTGCTGGCACGCGCCTGGAGCTTCAGGGAATGCGGATCGCCGGGCCGGAGCCC
GAATTTTCGGCTTTCGACGACGAACCCACCGAAGCCCGCGAAGTTGCGGGCCGCATTTTGACGCTGCTTAAAAACGGCGT
TCAGGCCTCAGAAATCGCCGTTTTGTACCGCATCAACGCGCAGTCGGCGGTTTTCGAGCAAGCGCTTGCCGACGCCGGCA
TCGTATATCAGGTGCGCGGCGGCGAAGGCTTTTTCACCCGCCCAGAAATTCGCCAAGCCCTGAGTCAACTGATCCGCACT
TCCCAACGCGACGTCGATGAAAGCGATCTGGTGCGTCTGACGCAACGCACACTCGTGCCACTTGGGTTGAGTTCGGAAGA
GCCCAGCGGTGCCCAAGAGCGGGAACGCTGGCAATCGCTCAACGCTTTAGTCGATCTGGTGAAAGACCTTGTTAAAGCCA
CACCAGATTTGGATCTCACAGGCTTGCTGCTGAAACTTCGGGAACGCCAAGAGGCGAAGCATCCGCCGACCGTCGAAGGT
GTCACCTTGGCATCGCTACACGCGGCGAAAGGCCTCGAATGGGATGCGGTGTTTCTTGTCGGACTTGTCGATTCCACGTT
ACCGATCAGCCACGCCATTAAATCTGGCGATGAAGCAATCGAAGAGGAACGTCGCCTGTTCTATGTCGGTGTGACCCGTG
CCCGCGAACACCTCCACTGCAGTTGGGCACTCGCGAGGCAAGAAGGCGGACGGAAATCGAGAAAGCGGAGTCGATTCCTC
GATGGCATAGTCGTGGAGATGGCCTCCGAATCGGGCACACCTCGCAGCAATCGTCCGAAAAACTGCCGAGTGTGCGGATC
GGTTCTTTCAAGCCCTGCCGAAAAAGCTGTCGGTCGGTGTGCGAGTTGCCCGATCCAAGCGGATGAACGAGTCTTCGAAC
AGCTGCGAACGTGGCGCAATGACACCGCGAAGCGCGAAAACAAAGCGGCGTACATGGTGTTCAGCAATGCAACGTTGATG
GCGATCGCTGAAATGAACCCCACCAACGAAAACGAATTGCTCAGCGTGCCGGGTGTGGGGCCGATGAAGATCGAGAACTA
TGGCGATGACGTGCTCGCGATTTTGGGAGCACTTTAG

Upstream 100 bases:

>100_bases
TTATCGATCGTAAGATTCCGATCGCCCCACCCGGATCGATTGCCTACGACATGATCAACGCCTGGGCGCGAGATAAACAA
AACTAAGGGAGCTTTTTACA

Downstream 100 bases:

>100_bases
GAACCTAAACTCCAACACATCGGACATTTTGGATGCACAGGGAGGGTGCGTACCGAGTTTGTTCGATCGTGGGGGTTTAC
TTCCTCCACAACGCCGGGCA

Product: DNA helicase RECQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MINLQDLDEDQRIAASAPRGPVCILAGAGTGKTRTITYRIAHLIDQGFVSPNRVLAVTFTSRAAGEMRHRLNLMGIGGVQ
ARTFHAAARKQLLYFWPQVAGNLPWRLLDNKFQLVGRAVRGARLESQTEKVRDILGEIEWAKASLITPEQYPDRLGTRTP
PAPAEKIAEVYQRYENMKATPEGMLLDFDDLLLHTAGALENSPAVAEEFRQQYRSFVVDEYQDVTPLQQRVLDAWLGDRD
DLTVVGDANQTIYSFTGATPEFLLNFSRKYPEATVVKLQRDYRSTPQVTALANTVIGQARGRVAGTRLELQGMRIAGPEP
EFSAFDDEPTEAREVAGRILTLLKNGVQASEIAVLYRINAQSAVFEQALADAGIVYQVRGGEGFFTRPEIRQALSQLIRT
SQRDVDESDLVRLTQRTLVPLGLSSEEPSGAQERERWQSLNALVDLVKDLVKATPDLDLTGLLLKLRERQEAKHPPTVEG
VTLASLHAAKGLEWDAVFLVGLVDSTLPISHAIKSGDEAIEEERRLFYVGVTRAREHLHCSWALARQEGGRKSRKRSRFL
DGIVVEMASESGTPRSNRPKNCRVCGSVLSSPAEKAVGRCASCPIQADERVFEQLRTWRNDTAKRENKAAYMVFSNATLM
AIAEMNPTNENELLSVPGVGPMKIENYGDDVLAILGAL

Sequences:

>Translated_678_residues
MINLQDLDEDQRIAASAPRGPVCILAGAGTGKTRTITYRIAHLIDQGFVSPNRVLAVTFTSRAAGEMRHRLNLMGIGGVQ
ARTFHAAARKQLLYFWPQVAGNLPWRLLDNKFQLVGRAVRGARLESQTEKVRDILGEIEWAKASLITPEQYPDRLGTRTP
PAPAEKIAEVYQRYENMKATPEGMLLDFDDLLLHTAGALENSPAVAEEFRQQYRSFVVDEYQDVTPLQQRVLDAWLGDRD
DLTVVGDANQTIYSFTGATPEFLLNFSRKYPEATVVKLQRDYRSTPQVTALANTVIGQARGRVAGTRLELQGMRIAGPEP
EFSAFDDEPTEAREVAGRILTLLKNGVQASEIAVLYRINAQSAVFEQALADAGIVYQVRGGEGFFTRPEIRQALSQLIRT
SQRDVDESDLVRLTQRTLVPLGLSSEEPSGAQERERWQSLNALVDLVKDLVKATPDLDLTGLLLKLRERQEAKHPPTVEG
VTLASLHAAKGLEWDAVFLVGLVDSTLPISHAIKSGDEAIEEERRLFYVGVTRAREHLHCSWALARQEGGRKSRKRSRFL
DGIVVEMASESGTPRSNRPKNCRVCGSVLSSPAEKAVGRCASCPIQADERVFEQLRTWRNDTAKRENKAAYMVFSNATLM
AIAEMNPTNENELLSVPGVGPMKIENYGDDVLAILGAL
>Mature_678_residues
MINLQDLDEDQRIAASAPRGPVCILAGAGTGKTRTITYRIAHLIDQGFVSPNRVLAVTFTSRAAGEMRHRLNLMGIGGVQ
ARTFHAAARKQLLYFWPQVAGNLPWRLLDNKFQLVGRAVRGARLESQTEKVRDILGEIEWAKASLITPEQYPDRLGTRTP
PAPAEKIAEVYQRYENMKATPEGMLLDFDDLLLHTAGALENSPAVAEEFRQQYRSFVVDEYQDVTPLQQRVLDAWLGDRD
DLTVVGDANQTIYSFTGATPEFLLNFSRKYPEATVVKLQRDYRSTPQVTALANTVIGQARGRVAGTRLELQGMRIAGPEP
EFSAFDDEPTEAREVAGRILTLLKNGVQASEIAVLYRINAQSAVFEQALADAGIVYQVRGGEGFFTRPEIRQALSQLIRT
SQRDVDESDLVRLTQRTLVPLGLSSEEPSGAQERERWQSLNALVDLVKDLVKATPDLDLTGLLLKLRERQEAKHPPTVEG
VTLASLHAAKGLEWDAVFLVGLVDSTLPISHAIKSGDEAIEEERRLFYVGVTRAREHLHCSWALARQEGGRKSRKRSRFL
DGIVVEMASESGTPRSNRPKNCRVCGSVLSSPAEKAVGRCASCPIQADERVFEQLRTWRNDTAKRENKAAYMVFSNATLM
AIAEMNPTNENELLSVPGVGPMKIENYGDDVLAILGAL

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=654, Percent_Identity=30.5810397553517, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI48994965, Length=418, Percent_Identity=33.2535885167464, Blast_Score=172, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322369, Length=434, Percent_Identity=28.110599078341, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324477, Length=391, Percent_Identity=24.5524296675192, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR002121
- InterPro:   IPR014016
- InterPro:   IPR010997 [H]

Pfam domain/function: PF00570 HRDC; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 75111; Mature: 75111

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINLQDLDEDQRIAASAPRGPVCILAGAGTGKTRTITYRIAHLIDQGFVSPNRVLAVTFT
CCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEC
SRAAGEMRHRLNLMGIGGVQARTFHAAARKQLLYFWPQVAGNLPWRLLDNKFQLVGRAVR
CHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GARLESQTEKVRDILGEIEWAKASLITPEQYPDRLGTRTPPAPAEKIAEVYQRYENMKAT
CCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
PEGMLLDFDDLLLHTAGALENSPAVAEEFRQQYRSFVVDEYQDVTPLQQRVLDAWLGDRD
CCCCEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
DLTVVGDANQTIYSFTGATPEFLLNFSRKYPEATVVKLQRDYRSTPQVTALANTVIGQAR
CEEEEECCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GRVAGTRLELQGMRIAGPEPEFSAFDDEPTEAREVAGRILTLLKNGVQASEIAVLYRINA
CCEECCEEEEECCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECC
QSAVFEQALADAGIVYQVRGGEGFFTRPEIRQALSQLIRTSQRDVDESDLVRLTQRTLVP
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEE
LGLSSEEPSGAQERERWQSLNALVDLVKDLVKATPDLDLTGLLLKLRERQEAKHPPTVEG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VTLASLHAAKGLEWDAVFLVGLVDSTLPISHAIKSGDEAIEEERRLFYVGVTRAREHLHC
EEHHHHHHHCCCCCHHHHEEEHHCCCCCHHHHHHCCHHHHHHCCEEEEEEEHHHHHHHHH
SWALARQEGGRKSRKRSRFLDGIVVEMASESGTPRSNRPKNCRVCGSVLSSPAEKAVGRC
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
ASCPIQADERVFEQLRTWRNDTAKRENKAAYMVFSNATLMAIAEMNPTNENELLSVPGVG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEEECCCCCCCCEEECCCCC
PMKIENYGDDVLAILGAL
CEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MINLQDLDEDQRIAASAPRGPVCILAGAGTGKTRTITYRIAHLIDQGFVSPNRVLAVTFT
CCCCCCCCCCHHHHCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEC
SRAAGEMRHRLNLMGIGGVQARTFHAAARKQLLYFWPQVAGNLPWRLLDNKFQLVGRAVR
CHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GARLESQTEKVRDILGEIEWAKASLITPEQYPDRLGTRTPPAPAEKIAEVYQRYENMKAT
CCHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
PEGMLLDFDDLLLHTAGALENSPAVAEEFRQQYRSFVVDEYQDVTPLQQRVLDAWLGDRD
CCCCEECHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
DLTVVGDANQTIYSFTGATPEFLLNFSRKYPEATVVKLQRDYRSTPQVTALANTVIGQAR
CEEEEECCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GRVAGTRLELQGMRIAGPEPEFSAFDDEPTEAREVAGRILTLLKNGVQASEIAVLYRINA
CCEECCEEEEECCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECC
QSAVFEQALADAGIVYQVRGGEGFFTRPEIRQALSQLIRTSQRDVDESDLVRLTQRTLVP
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEE
LGLSSEEPSGAQERERWQSLNALVDLVKDLVKATPDLDLTGLLLKLRERQEAKHPPTVEG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VTLASLHAAKGLEWDAVFLVGLVDSTLPISHAIKSGDEAIEEERRLFYVGVTRAREHLHC
EEHHHHHHHCCCCCHHHHEEEHHCCCCCHHHHHHCCHHHHHHCCEEEEEEEHHHHHHHHH
SWALARQEGGRKSRKRSRFLDGIVVEMASESGTPRSNRPKNCRVCGSVLSSPAEKAVGRC
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
ASCPIQADERVFEQLRTWRNDTAKRENKAAYMVFSNATLMAIAEMNPTNENELLSVPGVG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEEEEEECCCCCCCCEEECCCCC
PMKIENYGDDVLAILGAL
CEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]