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The map label for this gene is manB [H]

Identifier: 62389635

GI number: 62389635

Start: 784657

End: 786033

Strand: Direct

Name: manB [H]

Synonym: cg0854

Alternate gene names: 62389635

Gene position: 784657-786033 (Clockwise)

Preceding gene: 62389634

Following gene: 62389636

Centisome position: 23.9

GC content: 54.83

Gene sequence:

>1377_bases
ATGCGTACCCGTGAATCTGTCACAGCTGTAATTAAGGCGTATGACGTCCGTGGTGTTGTTGGTGTCGATATTGATGCTGA
TTTCATTTCTGAGACTGGCGCTGCCTTTGGTCGGCTCATGCGTAGTGAGGGTGAAACCACCGTTGCTATTGGCCATGACA
TGCGTGATTCCTCCCCTGAATTGGCCAAGGCGTTTGCCGATGGCGTGACTGCACAGGGTTTGGATGTTGTTCATTTGGGA
CTGACTTCTACTGATGAGCTGTACTTTGCGTCCGGAACCTTGAAGTGTGCTGGTGCGATGTTTACTGCGTCGCATAACCC
CGCTGAGTACAACGGCATCAAGTTGTGTCGTGCGGGTGCTCGTCCGGTCGGTCAGGATTCTGGTTTGGCCAACATCATTG
ATGATCTGGTTGAGGGTGTTCCAGCGTTTGATGGTGAGTCAGGTTCGGTTTCTGAGCAGGATTTGCTGAGCGCATATGCC
GAGTACCTCAATGAGCTTGTTGATCTGAAGAACATCCGCCCGTTGAAGGTTGCTGTGGATGCGGCAAACGGCATGGGTGG
GTTCACTGTCCCTGAGGTATTCAAGGGTCTGCCACTTGATGTTGCGCCACTGTATTTTGAGCTTGACGGCAATTTCCCCA
ACCATGAGGCCAATCCTCTGGAGCCTGCCAACCTGGTTGATTTGCAGAAGTTTACCGTAGAGACCGGATCTGATATCGGT
TTGGCGTTCGACGGCGATGCGGATCGTTGCTTCGTGGTCGATGAGAAGGGCCAGCCAGTCAGCCCTTCGGCGATCTGTGC
GATCGTAGCGGAGCGTTACTTGGAGAAGCTTCCGGGTTCCACCATCATCCACAACCTGATTACCTCTAAGGCTGTGCCTG
AGGTGATTGCTGAAAACGGTGGCACTGCGGTGCGTACTCGCGTGGGTCACTCCTTCATCAAGGCGAAGATGGCAGAGACC
GGTGCGGCCTTTGGTGGCGAGCACTCTGCGCACTACTACTTCACTGAGTTCTTCAATGCGGACTCCGGCATTTTGGCTGC
GATGCACGTGCTGGCTGCGCTGGGAAGCCAGGACCAGCCACTCAGTGAGATGATGGCTAGGTATAACCGGTACGTTGCTT
CAGGCGAGTTGAACTCCCGTTTGGCTAATGCAGAGGCGCAGCAAGAGCGCACCCAGGCTGTGCTCGATGCGTTCGCTGAT
CGCACCGAGTCCGTGGACACCCTTGACGGCGTGACTGTGGAACTCAAGGACACCTCCGCGTGGTTCAACGTGCGTGCGTC
CAACACCGAGCCGCTGCTTCGCCTCAATGTTGAAGCTGCATCGAAGGAAGAAGTCGATGCGTTGGTAGCGGAGATTCTAG
GGATTATCCGCGCATAA

Upstream 100 bases:

>100_bases
CCTGATCAGGACGAATCATAAGGTTTGCTATTCGGATTGGATCCTTTGGCAGGGGTAGGATTGCAAGCGTTATTTTGTTC
CCTAACCCCTTCGAGGATTT

Downstream 100 bases:

>100_bases
TCCCATTTTCCGGCGGGCATCACGGGAATTCCTTATCCTTGGTAGTCAAAGTCAAGGAAAGGACTTCAATCCCCGTGGTG
CAAGTGGACAATACCTTTTA

Product: phosphomannomutase/phosphoglucomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MRTRESVTAVIKAYDVRGVVGVDIDADFISETGAAFGRLMRSEGETTVAIGHDMRDSSPELAKAFADGVTAQGLDVVHLG
LTSTDELYFASGTLKCAGAMFTASHNPAEYNGIKLCRAGARPVGQDSGLANIIDDLVEGVPAFDGESGSVSEQDLLSAYA
EYLNELVDLKNIRPLKVAVDAANGMGGFTVPEVFKGLPLDVAPLYFELDGNFPNHEANPLEPANLVDLQKFTVETGSDIG
LAFDGDADRCFVVDEKGQPVSPSAICAIVAERYLEKLPGSTIIHNLITSKAVPEVIAENGGTAVRTRVGHSFIKAKMAET
GAAFGGEHSAHYYFTEFFNADSGILAAMHVLAALGSQDQPLSEMMARYNRYVASGELNSRLANAEAQQERTQAVLDAFAD
RTESVDTLDGVTVELKDTSAWFNVRASNTEPLLRLNVEAASKEEVDALVAEILGIIRA

Sequences:

>Translated_458_residues
MRTRESVTAVIKAYDVRGVVGVDIDADFISETGAAFGRLMRSEGETTVAIGHDMRDSSPELAKAFADGVTAQGLDVVHLG
LTSTDELYFASGTLKCAGAMFTASHNPAEYNGIKLCRAGARPVGQDSGLANIIDDLVEGVPAFDGESGSVSEQDLLSAYA
EYLNELVDLKNIRPLKVAVDAANGMGGFTVPEVFKGLPLDVAPLYFELDGNFPNHEANPLEPANLVDLQKFTVETGSDIG
LAFDGDADRCFVVDEKGQPVSPSAICAIVAERYLEKLPGSTIIHNLITSKAVPEVIAENGGTAVRTRVGHSFIKAKMAET
GAAFGGEHSAHYYFTEFFNADSGILAAMHVLAALGSQDQPLSEMMARYNRYVASGELNSRLANAEAQQERTQAVLDAFAD
RTESVDTLDGVTVELKDTSAWFNVRASNTEPLLRLNVEAASKEEVDALVAEILGIIRA
>Mature_458_residues
MRTRESVTAVIKAYDVRGVVGVDIDADFISETGAAFGRLMRSEGETTVAIGHDMRDSSPELAKAFADGVTAQGLDVVHLG
LTSTDELYFASGTLKCAGAMFTASHNPAEYNGIKLCRAGARPVGQDSGLANIIDDLVEGVPAFDGESGSVSEQDLLSAYA
EYLNELVDLKNIRPLKVAVDAANGMGGFTVPEVFKGLPLDVAPLYFELDGNFPNHEANPLEPANLVDLQKFTVETGSDIG
LAFDGDADRCFVVDEKGQPVSPSAICAIVAERYLEKLPGSTIIHNLITSKAVPEVIAENGGTAVRTRVGHSFIKAKMAET
GAAFGGEHSAHYYFTEFFNADSGILAAMHVLAALGSQDQPLSEMMARYNRYVASGELNSRLANAEAQQERTQAVLDAFAD
RTESVDTLDGVTVELKDTSAWFNVRASNTEPLLRLNVEAASKEEVDALVAEILGIIRA

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=440, Percent_Identity=38.1818181818182, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1789566, Length=462, Percent_Identity=27.0562770562771, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 48815; Mature: 48815

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRESVTAVIKAYDVRGVVGVDIDADFISETGAAFGRLMRSEGETTVAIGHDMRDSSPE
CCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
LAKAFADGVTAQGLDVVHLGLTSTDELYFASGTLKCAGAMFTASHNPAEYNGIKLCRAGA
HHHHHHCCCCCCCCEEEEECCCCCCCEEEECCCEEECCEEEECCCCCCCCCCEEEEECCC
RPVGQDSGLANIIDDLVEGVPAFDGESGSVSEQDLLSAYAEYLNELVDLKNIRPLKVAVD
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
AANGMGGFTVPEVFKGLPLDVAPLYFELDGNFPNHEANPLEPANLVDLQKFTVETGSDIG
CCCCCCCCCHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHEECCCCCEE
LAFDGDADRCFVVDEKGQPVSPSAICAIVAERYLEKLPGSTIIHNLITSKAVPEVIAENG
EEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
GTAVRTRVGHSFIKAKMAETGAAFGGEHSAHYYFTEFFNADSGILAAMHVLAALGSQDQP
CCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCC
LSEMMARYNRYVASGELNSRLANAEAQQERTQAVLDAFADRTESVDTLDGVTVELKDTSA
HHHHHHHHHHEEECCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCE
WFNVRASNTEPLLRLNVEAASKEEVDALVAEILGIIRA
EEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTRESVTAVIKAYDVRGVVGVDIDADFISETGAAFGRLMRSEGETTVAIGHDMRDSSPE
CCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHH
LAKAFADGVTAQGLDVVHLGLTSTDELYFASGTLKCAGAMFTASHNPAEYNGIKLCRAGA
HHHHHHCCCCCCCCEEEEECCCCCCCEEEECCCEEECCEEEECCCCCCCCCCEEEEECCC
RPVGQDSGLANIIDDLVEGVPAFDGESGSVSEQDLLSAYAEYLNELVDLKNIRPLKVAVD
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
AANGMGGFTVPEVFKGLPLDVAPLYFELDGNFPNHEANPLEPANLVDLQKFTVETGSDIG
CCCCCCCCCHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHEECCCCCEE
LAFDGDADRCFVVDEKGQPVSPSAICAIVAERYLEKLPGSTIIHNLITSKAVPEVIAENG
EEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
GTAVRTRVGHSFIKAKMAETGAAFGGEHSAHYYFTEFFNADSGILAAMHVLAALGSQDQP
CCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCC
LSEMMARYNRYVASGELNSRLANAEAQQERTQAVLDAFADRTESVDTLDGVTVELKDTSA
HHHHHHHHHHEEECCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCE
WFNVRASNTEPLLRLNVEAASKEEVDALVAEILGIIRA
EEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]