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The map label for this gene is rmlA2 [H]

Identifier: 62389630

GI number: 62389630

Start: 781559

End: 782647

Strand: Direct

Name: rmlA2 [H]

Synonym: cg0849

Alternate gene names: 62389630

Gene position: 781559-782647 (Clockwise)

Preceding gene: 62389629

Following gene: 62389631

Centisome position: 23.81

GC content: 57.39

Gene sequence:

>1089_bases
ATGACTTTAACTGACAACAGCAAAAACGTTGATGCTGTCATCTTGGTCGGTGGCAAAGGTACCCGACTGCGCCCCCTGAC
CGTCAATACTCCAAAGCCAATGCTGCCAACTGCTGGCCACCCATTCTTGACCCACCTTTTGGCCCGCATCAAGGCCGCAG
GCATCACACACGTCGTGCTGGGAACGTCATTCAAAGCTGAAGTCTTCGAGGAATACTTCGGAGATGGCTCCGAAATGGGC
TTGGAAATTGAATATGTCGTCGAGGATCAGCCTTTGGGCACTGGTGGTGGCATCCGAAACGTCTACGACAAGCTGCGTCA
CGATACTGCGATTGTGTTCAACGGCGATGTGCTCTCCGGTGCGGATCTCAACAGCATTCTGGACACCCACCGCGAAAAGG
ACGCAGATCTGACCATGCATCTCGTGCGCGTAGCTAACCCTCGTGCGTTTGGTTGCGTCCCCACCGATGAGGATGGTCGC
GTCAGCGAATTCCTTGAAAAGACCGAAGATCCACCAACCGATCAGATCAACGCCGGCTGCTACGTGTTCAAGAAGGAACT
CATCGAGCAGATCCCGGCAGGCCGAGCAGTTTCCGTCGAGCGCGAAACCTTCCCTCAGCTGTTGGAAGAAGGCAAGCGAG
TCTTCGGCCACGTCGACGCTTCCTACTGGCGCGACATGGGCACCCCAAGCGACTTCGTCCGCGGCTCGGCTGACCTGGTC
CGCGGCATTGCGTACTCCCCATTGCTCGAAGGCAAAACAGGAGAGTCGCTTGTCGACGCCTCCGCCGGCGTTCGCGACGG
CGTCCTGCTGCTCGGCGGAACCGTAGTCGGCCGCGGCACTGAGATCGGTGCCGGCTGCCGCGTTGACAACACTGTTATTT
TCGACGGCGTCACCATTGAACCAGGTGCGGTCATTGAAAATTCCATCATTTCCTCGGGAGCACGCATCGGTGCTAATGCG
CACATCTCCGGTTGCATCATTGGCGAGGGCGCACAGGTTGGTGCTCGGTGTGAACTCAACGCAGGGATGCGCGTCTTCCC
AGGCGTTGTGATCCCAGACAGCGGAATTCGTTTTTCGTCTGATCAGTAG

Upstream 100 bases:

>100_bases
TGAAATGGATTTGCTGCGGCCCCGGAATTACCCTTTTCGCGGCCGTCATCAAATTTGTACCCCCTTAAAGACACCCTAAA
CACGAGTGAAATAGGAACAC

Downstream 100 bases:

>100_bases
GCATTTTTAGCCCTTTTGGACGGGCGTTTTCACAGCGACCGTTCGGGGGCGAAAATGTTTTTGGTTGAGCGGTTTTTGGA
GATTATGCAGCACTGCTTAT

Product: GDP-mannose pyrophosphorylase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTLTDNSKNVDAVILVGGKGTRLRPLTVNTPKPMLPTAGHPFLTHLLARIKAAGITHVVLGTSFKAEVFEEYFGDGSEMG
LEIEYVVEDQPLGTGGGIRNVYDKLRHDTAIVFNGDVLSGADLNSILDTHREKDADLTMHLVRVANPRAFGCVPTDEDGR
VSEFLEKTEDPPTDQINAGCYVFKKELIEQIPAGRAVSVERETFPQLLEEGKRVFGHVDASYWRDMGTPSDFVRGSADLV
RGIAYSPLLEGKTGESLVDASAGVRDGVLLLGGTVVGRGTEIGAGCRVDNTVIFDGVTIEPGAVIENSIISSGARIGANA
HISGCIIGEGAQVGARCELNAGMRVFPGVVIPDSGIRFSSDQ

Sequences:

>Translated_362_residues
MTLTDNSKNVDAVILVGGKGTRLRPLTVNTPKPMLPTAGHPFLTHLLARIKAAGITHVVLGTSFKAEVFEEYFGDGSEMG
LEIEYVVEDQPLGTGGGIRNVYDKLRHDTAIVFNGDVLSGADLNSILDTHREKDADLTMHLVRVANPRAFGCVPTDEDGR
VSEFLEKTEDPPTDQINAGCYVFKKELIEQIPAGRAVSVERETFPQLLEEGKRVFGHVDASYWRDMGTPSDFVRGSADLV
RGIAYSPLLEGKTGESLVDASAGVRDGVLLLGGTVVGRGTEIGAGCRVDNTVIFDGVTIEPGAVIENSIISSGARIGANA
HISGCIIGEGAQVGARCELNAGMRVFPGVVIPDSGIRFSSDQ
>Mature_361_residues
TLTDNSKNVDAVILVGGKGTRLRPLTVNTPKPMLPTAGHPFLTHLLARIKAAGITHVVLGTSFKAEVFEEYFGDGSEMGL
EIEYVVEDQPLGTGGGIRNVYDKLRHDTAIVFNGDVLSGADLNSILDTHREKDADLTMHLVRVANPRAFGCVPTDEDGRV
SEFLEKTEDPPTDQINAGCYVFKKELIEQIPAGRAVSVERETFPQLLEEGKRVFGHVDASYWRDMGTPSDFVRGSADLVR
GIAYSPLLEGKTGESLVDASAGVRDGVLLLGGTVVGRGTEIGAGCRVDNTVIFDGVTIEPGAVIENSIISSGARIGANAH
ISGCIIGEGAQVGARCELNAGMRVFPGVVIPDSGIRFSSDQ

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=339, Percent_Identity=30.6784660766962, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI11761621, Length=330, Percent_Identity=30.6060606060606, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI31881779, Length=358, Percent_Identity=25.4189944134078, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI45447090, Length=358, Percent_Identity=25.4189944134078, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1788351, Length=231, Percent_Identity=25.974025974026, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790224, Length=234, Percent_Identity=25.6410256410256, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789837, Length=391, Percent_Identity=24.0409207161125, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=347, Percent_Identity=30.2593659942363, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17509979, Length=332, Percent_Identity=27.710843373494, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17509981, Length=323, Percent_Identity=26.3157894736842, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320148, Length=353, Percent_Identity=29.4617563739377, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21355443, Length=332, Percent_Identity=31.6265060240964, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24644084, Length=332, Percent_Identity=31.6265060240964, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24653912, Length=371, Percent_Identity=25.0673854447439, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 38519; Mature: 38388

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTDNSKNVDAVILVGGKGTRLRPLTVNTPKPMLPTAGHPFLTHLLARIKAAGITHVVL
CCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
GTSFKAEVFEEYFGDGSEMGLEIEYVVEDQPLGTGGGIRNVYDKLRHDTAIVFNGDVLSG
CCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCEECC
ADLNSILDTHREKDADLTMHLVRVANPRAFGCVPTDEDGRVSEFLEKTEDPPTDQINAGC
CCHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCH
YVFKKELIEQIPAGRAVSVERETFPQLLEEGKRVFGHVDASYWRDMGTPSDFVRGSADLV
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHEECCCHHHHHCCCCCHHHHCCCHHHH
RGIAYSPLLEGKTGESLVDASAGVRDGVLLLGGTVVGRGTEIGAGCRVDNTVIFDGVTIE
HHHHHCCCCCCCCCCHHHHCCCCCCCCEEEECCEEEECCCCCCCCCEECCEEEECCEEEC
PGAVIENSIISSGARIGANAHISGCIIGEGAQVGARCELNAGMRVFPGVVIPDSGIRFSS
CCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCEECCCEEECCCCCCCCC
DQ
CC
>Mature Secondary Structure 
TLTDNSKNVDAVILVGGKGTRLRPLTVNTPKPMLPTAGHPFLTHLLARIKAAGITHVVL
CCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEE
GTSFKAEVFEEYFGDGSEMGLEIEYVVEDQPLGTGGGIRNVYDKLRHDTAIVFNGDVLSG
CCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCEECC
ADLNSILDTHREKDADLTMHLVRVANPRAFGCVPTDEDGRVSEFLEKTEDPPTDQINAGC
CCHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCH
YVFKKELIEQIPAGRAVSVERETFPQLLEEGKRVFGHVDASYWRDMGTPSDFVRGSADLV
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHEECCCHHHHHCCCCCHHHHCCCHHHH
RGIAYSPLLEGKTGESLVDASAGVRDGVLLLGGTVVGRGTEIGAGCRVDNTVIFDGVTIE
HHHHHCCCCCCCCCCHHHHCCCCCCCCEEEECCEEEECCCCCCCCCEECCEEEECCEEEC
PGAVIENSIISSGARIGANAHISGCIIGEGAQVGARCELNAGMRVFPGVVIPDSGIRFSS
CCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCEECCCEEECCCCCCCCC
DQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]