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The map label for this gene is prpC1

Identifier: 62389585

GI number: 62389585

Start: 716614

End: 717759

Strand: Direct

Name: prpC1

Synonym: cg0798

Alternate gene names: 62389585

Gene position: 716614-717759 (Clockwise)

Preceding gene: 62389584

Following gene: 62389588

Centisome position: 21.83

GC content: 54.62

Gene sequence:

>1146_bases
ATGAGTGACAGCCAAGTCCGCAAAGGACTCAACGGCGTCATCTCTGACTACACAAGCATTTCCAAAGTGATGCCAGAGAG
CAACTCGCTGACTTACCGTGGCTACGCCGTGGAGGATTTGGTGGAAAACTGCAGCTTTGAAGAAGTGATCTACCTCCTGT
GGTTTGGGGAGCTGCCCACCACTGAACAACTCCGGACCTTCAACACGACAGGTCGAAGCTACCGCTCACTCGACGCCGGA
CTGATTTCCCTCATCCACTCCTTACCCAACACCTGCCACCCCATGGACGTGCTGCGCACCGCAGTGTCCTACATGGGTAC
CTTTGATCCCGATCCGTTTACCCGCGATGCCGATCATATCCGAAGCATTGGACACAACCTGCTTGCGCAGCTTCCCATGG
TGGTTGCCATGGATATCCGCAGGCGAAGTGGGGAAGAGATCATCGCACCTGACCACAACAAAGGTATCGCTTCGAATTTC
TTATCCATGGTGTTTGGCAATGATGATGGTTCTGTAGCCAACTCCGCAGATGACATCCGCGATTTTGAACGCTCCCTCAT
CCTCTACGCCGAGCACTCCTTCAACGCCTCCACATTCTCAGCCCGCGTGATCTCATCAACGCGATCCGATACGTATTCGG
CGATCACAGGTGCGATCGGTGCTCTCAAAGGCCCACTGCACGGAGGTGCCAATGAGTTTGTCATGCACACCATGCTGGAT
ATCGACGATCCCAACAATGCTGCCGACTGGATGGGCAAGGCGTTGGATCGTAAAGAACGCATCATGGGATTCGGGCACCG
CGTGTACAAAAACGGCGACTCCAGGGTCCCCTCCATGGAGAAATCCATGCGCTCCCTTGCTGCTCGTCACCGTGGTCAAA
AATGGGTGCACATGTATGAGTCGATGCAAGAAGTCATGGAGGCTCGCACTGGCATTAAACCCAACCTCGACTTCCCGGCC
GGCCCTGCCTATTACATGCTGGGATTCCCCGTCGACTTCTTCACACCACTGTTTGTGCTGGCCCGAGTGTCAGGGTGGAC
GGCACACATCGTGGAGCAATTTGAAAACAATGCGCTGATCCGACCATTGTCTGCCTACAACGGAGTGGAAGAAAGGGAGG
TGGTGCCCATTTCGGAGAGAACCTAA

Upstream 100 bases:

>100_bases
GACCGCATGCAACACCGCAGCAGATTATATGAGCTCCTGCGATACGAAGACTACAACGTCTTTGACCAGCACATTTTCAC
CTACAGAAAAGGAGAAAACA

Downstream 100 bases:

>100_bases
TCAGTGAGGCTGATTTCTAAATAGCCTTGTGCCCATCTGGTGATGGTGTCGCGGCCCTCCGCCACAGCATCGCCGATGGT
TTTCGGAGCGAGCACTGGAT

Product: citrate synthase

Products: NA

Alternate protein names: Methylcitrate synthase 1; Citrate synthase 1

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPTTEQLRTFNTTGRSYRSLDAG
LISLIHSLPNTCHPMDVLRTAVSYMGTFDPDPFTRDADHIRSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNF
LSMVFGNDDGSVANSADDIRDFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYESMQEVMEARTGIKPNLDFPA
GPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALIRPLSAYNGVEEREVVPISERT

Sequences:

>Translated_381_residues
MSDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPTTEQLRTFNTTGRSYRSLDAG
LISLIHSLPNTCHPMDVLRTAVSYMGTFDPDPFTRDADHIRSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNF
LSMVFGNDDGSVANSADDIRDFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYESMQEVMEARTGIKPNLDFPA
GPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALIRPLSAYNGVEEREVVPISERT
>Mature_380_residues
SDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPTTEQLRTFNTTGRSYRSLDAGL
ISLIHSLPNTCHPMDVLRTAVSYMGTFDPDPFTRDADHIRSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNFL
SMVFGNDDGSVANSADDIRDFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLDI
DDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYESMQEVMEARTGIKPNLDFPAG
PAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALIRPLSAYNGVEEREVVPISERT

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also has a citrate synthase activity

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family

Homologues:

Organism=Homo sapiens, GI38327625, Length=378, Percent_Identity=23.2804232804233, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1786527, Length=373, Percent_Identity=38.8739946380697, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1786939, Length=381, Percent_Identity=29.9212598425197, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17555174, Length=382, Percent_Identity=21.9895287958115, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6325257, Length=404, Percent_Identity=22.7722772277228, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640126, Length=328, Percent_Identity=23.780487804878, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640124, Length=328, Percent_Identity=23.780487804878, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRPC1_CORGL (Q8NSH7)

Other databases:

- EMBL:   AF434798
- EMBL:   BA000036
- EMBL:   BX927150
- RefSeq:   NP_599928.1
- RefSeq:   YP_224987.1
- ProteinModelPortal:   Q8NSH7
- SMR:   Q8NSH7
- GeneID:   1018695
- GeneID:   3345454
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0798
- KEGG:   cgl:NCgl0666
- HOGENOM:   HBG649489
- OMA:   DIRRRSG
- PhylomeDB:   Q8NSH7
- ProtClustDB:   PRK14033
- BioCyc:   CGLU196627:CG0798-MONOMER
- BRENDA:   2.3.3.5
- GO:   GO:0005737
- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- Gene3D:   G3DSA:1.10.580.10
- Gene3D:   G3DSA:1.10.230.10
- PANTHER:   PTHR11739
- PRINTS:   PR00143
- TIGRFAMs:   TIGR01800

Pfam domain/function: PF00285 Citrate_synt; SSF48256 Citrate_synthase_core

EC number: =2.3.3.5

Molecular weight: Translated: 42568; Mature: 42436

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: ACT_SITE 266-266 ACT_SITE 317-317

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPT
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCCCHHHHHHHHEECCCCC
TEQLRTFNTTGRSYRSLDAGLISLIHSLPNTCHPMDVLRTAVSYMGTFDPDPFTRDADHI
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
RSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNFLSMVFGNDDGSVANSADDIR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
DFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
HHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SMQEVMEARTGIKPNLDFPAGPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALI
HHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEE
RPLSAYNGVEEREVVPISERT
EEHHHHCCCCCCEECCCCCCC
>Mature Secondary Structure 
SDSQVRKGLNGVISDYTSISKVMPESNSLTYRGYAVEDLVENCSFEEVIYLLWFGELPT
CHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHCCCHHHHHHHHEECCCCC
TEQLRTFNTTGRSYRSLDAGLISLIHSLPNTCHPMDVLRTAVSYMGTFDPDPFTRDADHI
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
RSIGHNLLAQLPMVVAMDIRRRSGEEIIAPDHNKGIASNFLSMVFGNDDGSVANSADDIR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
DFERSLILYAEHSFNASTFSARVISSTRSDTYSAITGAIGALKGPLHGGANEFVMHTMLD
HHHHHEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHC
IDDPNNAADWMGKALDRKERIMGFGHRVYKNGDSRVPSMEKSMRSLAARHRGQKWVHMYE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
SMQEVMEARTGIKPNLDFPAGPAYYMLGFPVDFFTPLFVLARVSGWTAHIVEQFENNALI
HHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEE
RPLSAYNGVEEREVVPISERT
EEHHHHCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626