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The map label for this gene is prpD1

Identifier: 62389583

GI number: 62389583

Start: 714211

End: 715707

Strand: Direct

Name: prpD1

Synonym: cg0796

Alternate gene names: 62389583

Gene position: 714211-715707 (Clockwise)

Preceding gene: 62389582

Following gene: 62389584

Centisome position: 21.76

GC content: 55.98

Gene sequence:

>1497_bases
ATGCGCATCCACGATGTTTATACCCACCTTTCGGCCGATAACTTTCCCAAAGCAGAGCACCTTGCGTGGAAATTCTCCGA
GCTTGCCACCGACCCCGTGGAGGTGACACCGGATGTTTCGGAGATGATCATCAACCGGATCATCGACAACGCGGCGGTGT
CTGCCGCGTCGGTGTTGCGCCGGCCTGTGACTGTGGCCAGGCAACAAGCGCAGTCCCATCCGCGGGAAAAGGGCGGAAAA
GTTTTTGGAATTTCAGGCAGCTACTCACCAGAGTGGGCTGCCTTTGCTAATGGTGTGGCCGTACGTGAATTGGACTTCCA
CGATACATTTTTAGCAGCTGAATACTCCCATCCCGGCGACAATATTCCACCACTTCTTGCAGTAGCGCAGGCTCAGAGAA
GCAGCGGCAGGGATCTCATTCGGGGTATCGCCACTGCCTATGAGGTGCAGGTGGAATTGGTGAGGGGGATCTGCTTGCAT
GAGCACAAAATTGATCACGTAGCCCACCTTGGTCCCAGCGCTGCAGCGGGTTTGGGCACGTTGTTGCATGTAGATGAGGA
AACCATCTACCAGGCGATCGGCCAGGCATTGCACACCACGACGGCTACGAGGCAGTCGCGAAAAGGTGAGATTTCCAGCT
GGAAGGCGTTCGCGCCAGCGTTTGCGGGAAAGATGGCCATTGAGGCGATGGATCGTGCGATGCGTGGGGAGGGTTCGCCC
GCACCGATTTGGGAGGGCGAAGACGGGGTCATCGCGTGGCTGTTATCGGGCAAAGATCATGTTTATCATGTGCCATTGCC
GGAACACGGCGAGCCCAAGCTGGGGATTCTAGAGACTTACACAAAGGAACATTCAGCGGAATATCAATCGCAGGCACCGA
TTGATCTGGCGCGCAGGATGAAGCCACTGGTTGACGCGGCTGGCGGAACGGAACACATTGCAGAGATTGTGCTGCGCACC
AGTCACCACACGCATTATGTGATTGGCACTGGGGCGAACGATCCGCAGAAGATGGATCCGCAGGCCTCGCGTGAAACCCT
GGATCATTCCATCATGTACATTTTCGCCGTCGCGCTTCAAGATGGCGTGTGGCACCACGAGTTTTCCTACACCCGCAAGC
GTTCCACCCGCCCGGAAACTGTGGAGCTGTGGCACAAGATTCGCACCGTGGAGGATCCTGAATGGACGCGCCGATACCAT
TCTGATGATCCTGCAAAAAAGGCCTTTGGTGCGAAAGCAGTGATCACAATGGCTGATGGCACCGTGATTGAGGATGAATT
GGCTGTCGCGGATGCCCACCCGCTGGGTGCTCGGCCGTTTGCGCGGGAGAATTACATTGAAAAATTCCGCACACTCGCGC
AGGGGATTGTCATTGATTCAGAACAGGAACGCTTCTTGCATGCCGTGCAAAGCCTGCCTGACCTGGATGATCTTGATCAG
CTCAACATCGAAGTCGACATAAGCAACCAGGCCGCGACGAAAGCGGGGCTGTTATGA

Upstream 100 bases:

>100_bases
CGCGCAGAGCTAAACTGCGTGAGGTTGTGGCCTGTCACACATAATCGGCCTAGGGTGGGACTTTAAGGAAACAGTGCACA
AATAAATCTCAAGGAGCCCC

Downstream 100 bases:

>100_bases
ATCTCTTTTCGAATGGTGTTGATGTGGGGAGGCGTCGACAAGCATTTAAAGCGGCACTCGCCGCACCCCACATCGCCCGG
CTGCCCGGCGCATTCTCCCC

Product: propionate catabolic protein PRPD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MRIHDVYTHLSADNFPKAEHLAWKFSELATDPVEVTPDVSEMIINRIIDNAAVSAASVLRRPVTVARQQAQSHPREKGGK
VFGISGSYSPEWAAFANGVAVRELDFHDTFLAAEYSHPGDNIPPLLAVAQAQRSSGRDLIRGIATAYEVQVELVRGICLH
EHKIDHVAHLGPSAAAGLGTLLHVDEETIYQAIGQALHTTTATRQSRKGEISSWKAFAPAFAGKMAIEAMDRAMRGEGSP
APIWEGEDGVIAWLLSGKDHVYHVPLPEHGEPKLGILETYTKEHSAEYQSQAPIDLARRMKPLVDAAGGTEHIAEIVLRT
SHHTHYVIGTGANDPQKMDPQASRETLDHSIMYIFAVALQDGVWHHEFSYTRKRSTRPETVELWHKIRTVEDPEWTRRYH
SDDPAKKAFGAKAVITMADGTVIEDELAVADAHPLGARPFARENYIEKFRTLAQGIVIDSEQERFLHAVQSLPDLDDLDQ
LNIEVDISNQAATKAGLL

Sequences:

>Translated_498_residues
MRIHDVYTHLSADNFPKAEHLAWKFSELATDPVEVTPDVSEMIINRIIDNAAVSAASVLRRPVTVARQQAQSHPREKGGK
VFGISGSYSPEWAAFANGVAVRELDFHDTFLAAEYSHPGDNIPPLLAVAQAQRSSGRDLIRGIATAYEVQVELVRGICLH
EHKIDHVAHLGPSAAAGLGTLLHVDEETIYQAIGQALHTTTATRQSRKGEISSWKAFAPAFAGKMAIEAMDRAMRGEGSP
APIWEGEDGVIAWLLSGKDHVYHVPLPEHGEPKLGILETYTKEHSAEYQSQAPIDLARRMKPLVDAAGGTEHIAEIVLRT
SHHTHYVIGTGANDPQKMDPQASRETLDHSIMYIFAVALQDGVWHHEFSYTRKRSTRPETVELWHKIRTVEDPEWTRRYH
SDDPAKKAFGAKAVITMADGTVIEDELAVADAHPLGARPFARENYIEKFRTLAQGIVIDSEQERFLHAVQSLPDLDDLDQ
LNIEVDISNQAATKAGLL
>Mature_498_residues
MRIHDVYTHLSADNFPKAEHLAWKFSELATDPVEVTPDVSEMIINRIIDNAAVSAASVLRRPVTVARQQAQSHPREKGGK
VFGISGSYSPEWAAFANGVAVRELDFHDTFLAAEYSHPGDNIPPLLAVAQAQRSSGRDLIRGIATAYEVQVELVRGICLH
EHKIDHVAHLGPSAAAGLGTLLHVDEETIYQAIGQALHTTTATRQSRKGEISSWKAFAPAFAGKMAIEAMDRAMRGEGSP
APIWEGEDGVIAWLLSGKDHVYHVPLPEHGEPKLGILETYTKEHSAEYQSQAPIDLARRMKPLVDAAGGTEHIAEIVLRT
SHHTHYVIGTGANDPQKMDPQASRETLDHSIMYIFAVALQDGVWHHEFSYTRKRSTRPETVELWHKIRTVEDPEWTRRYH
SDDPAKKAFGAKAVITMADGTVIEDELAVADAHPLGARPFARENYIEKFRTLAQGIVIDSEQERFLHAVQSLPDLDDLDQ
LNIEVDISNQAATKAGLL

Specific function: Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate

COG id: COG2079

COG function: function code R; Uncharacterized protein involved in propionate catabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpD family

Homologues:

Organism=Escherichia coli, GI1786528, Length=377, Percent_Identity=26.790450928382, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325258, Length=439, Percent_Identity=25.2847380410023, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): PRPD1_CORGL (Q8NSH9)

Other databases:

- EMBL:   AF434798
- EMBL:   BA000036
- EMBL:   BX927150
- RefSeq:   NP_599926.1
- RefSeq:   YP_224985.1
- ProteinModelPortal:   Q8NSH9
- SMR:   Q8NSH9
- GeneID:   1018693
- GeneID:   3343519
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0796
- KEGG:   cgl:NCgl0664
- HOGENOM:   HBG292381
- OMA:   YNTLLIR
- PhylomeDB:   Q8NSH9
- ProtClustDB:   CLSK871899
- BioCyc:   CGLU196627:CG0796-MONOMER
- BRENDA:   4.2.1.79
- InterPro:   IPR005656
- PANTHER:   PTHR16943

Pfam domain/function: PF03972 MmgE_PrpD; SSF103378 MmgE_PrpD

EC number: =4.2.1.79

Molecular weight: Translated: 55013; Mature: 55013

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIHDVYTHLSADNFPKAEHLAWKFSELATDPVEVTPDVSEMIINRIIDNAAVSAASVLR
CCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RPVTVARQQAQSHPREKGGKVFGISGSYSPEWAAFANGVAVRELDFHDTFLAAEYSHPGD
HHHHHHHHHHHCCHHHHCCEEEEECCCCCCCHHHHHCCEEEEEECCCCCEEEEECCCCCC
NIPPLLAVAQAQRSSGRDLIRGIATAYEVQVELVRGICLHEHKIDHVAHLGPSAAAGLGT
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHH
LLHVDEETIYQAIGQALHTTTATRQSRKGEISSWKAFAPAFAGKMAIEAMDRAMRGEGSP
EEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APIWEGEDGVIAWLLSGKDHVYHVPLPEHGEPKLGILETYTKEHSAEYQSQAPIDLARRM
CCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
KPLVDAAGGTEHIAEIVLRTSHHTHYVIGTGANDPQKMDPQASRETLDHSIMYIFAVALQ
HHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DGVWHHEFSYTRKRSTRPETVELWHKIRTVEDPEWTRRYHSDDPAKKAFGAKAVITMADG
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCCEEEEEECCC
TVIEDELAVADAHPLGARPFARENYIEKFRTLAQGIVIDSEQERFLHAVQSLPDLDDLDQ
CEECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCHHHHHHHHHHCCCCCCCCCC
LNIEVDISNQAATKAGLL
EEEEEEECCCHHHHHCCC
>Mature Secondary Structure
MRIHDVYTHLSADNFPKAEHLAWKFSELATDPVEVTPDVSEMIINRIIDNAAVSAASVLR
CCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RPVTVARQQAQSHPREKGGKVFGISGSYSPEWAAFANGVAVRELDFHDTFLAAEYSHPGD
HHHHHHHHHHHCCHHHHCCEEEEECCCCCCCHHHHHCCEEEEEECCCCCEEEEECCCCCC
NIPPLLAVAQAQRSSGRDLIRGIATAYEVQVELVRGICLHEHKIDHVAHLGPSAAAGLGT
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHH
LLHVDEETIYQAIGQALHTTTATRQSRKGEISSWKAFAPAFAGKMAIEAMDRAMRGEGSP
EEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APIWEGEDGVIAWLLSGKDHVYHVPLPEHGEPKLGILETYTKEHSAEYQSQAPIDLARRM
CCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
KPLVDAAGGTEHIAEIVLRTSHHTHYVIGTGANDPQKMDPQASRETLDHSIMYIFAVALQ
HHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
DGVWHHEFSYTRKRSTRPETVELWHKIRTVEDPEWTRRYHSDDPAKKAFGAKAVITMADG
CCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHCCCEEEEEECCC
TVIEDELAVADAHPLGARPFARENYIEKFRTLAQGIVIDSEQERFLHAVQSLPDLDDLDQ
CEECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCHHHHHHHHHHCCCCCCCCCC
LNIEVDISNQAATKAGLL
EEEEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626