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The map label for this gene is prpD2

Identifier: 62389547

GI number: 62389547

Start: 672615

End: 674129

Strand: Direct

Name: prpD2

Synonym: cg0759

Alternate gene names: 62389547

Gene position: 672615-674129 (Clockwise)

Preceding gene: 62389546

Following gene: 62389548

Centisome position: 20.49

GC content: 55.84

Gene sequence:

>1515_bases
ATGATTAACCACGAAGTGCGCACCCACCGTTCTGCGGAAGAGTTCCCGTACGAGGAGCACCTGGCTCACAAGATCGCTCG
CGTTGCAGCCGACCCAGTTGAGGTTGCTGCGGACACTCAGGAAATGATCATCAACCGCATCATCGACAATGCATCGGTGC
AGGCAGCTTCCGTGTTGCGTCGACCAGTTAGCTCTGCCCGTGCGATGGCACAGGTCAGGCCAGTTACCGATGGTCGGGGT
GCATCTGTTTTCGGTCTGCCAGGACGTTATGCCGCGGAATGGGCTGCGCTTGCTAACGGCACTGCGGTGCGTGAGCTTGA
TTTCCATGACACGTTCCTCGCTGCGGAATACTCCCACCCAGGAGATAACATTCCTCCGATTTTGGCTGCAGCACAGCAGG
CTGGAAAAGGTGGCAAGGATCTGATCCGTGGCATCGCTACTGGGTATGAGATTCAGGTTAACTTGGTGCGTGGAATGTGC
CTGCATGAGCACAAGATTGATCACGTTGCTCATCTTGGACCATCAGCGGCTGCTGGTATCGGAACCTTGCTAGACCTAGA
TGTGGACACCATCTACCAGGCAATTGGTCAGGCATTGCACACCACCACGGCGACGAGGCAGTCCCGTAAAGGTGCGATTT
CTTCATGGAAGGCATTTGCTCCTGCGTTTGCGGGCAAGATGTCCATCGAGGCAGTAGATCGCGCAATGCGTGGCGAGGGC
GCACCGTCACCAATCTGGGAAGGCGAAGACGGCGTAATCGCGTGGCTGCTGTCCGGTCTTGATCACATCTACACCATTCC
TTTGCCTGCAGAAGGTGAAGCCAAACGAGCAATCTTGGATACCTACACCAAGGAACACTCGGCGGAATACCAGTCACAGG
CACCGATCGACTTGGCGCGCAGCATGGGGGAGAAGCTGGCAGCACAGGGCTTGGACCTGCGTGATGTGGACTCCATCGTT
TTGCACACCTCCCACCACACTCACTACGTGATCGGCACCGGATCTAATGATCCACAGAAGTTCGATCCAGATGCATCGCG
AGAAACCCTTGATCACTCCATCATGTACATTTTCGCTGTCGCGCTGGAGGATCGCGCGTGGCACCACGAGCGTTCCTATG
CTCCTGAGCGAGCCCACCGCCGAGAGACCATCGAGCTGTGGAACAAGATTTCCACGGTGGAGGATCCTGAATGGACCAGG
CGTTACCACTCCGTTGATCCTGCAGAAAAGGCCTTCGGCGCACGCGCAGTGATCACCTTCAAGGATGGAACCGTCGTGGA
AGATGAACTGGCTGTGGCGGATGCGCATCCTCTGGGAGCACGGCCTTTCGCTAGGGAGCAGTACATTCAGAAATTCCGCA
CCTTGGCTGAAGGTGTTGTGTCCGAAAAGGAACAGGATCGCTTCTTGGATGCGGCACAGCGTACGCACGAGCTTGAGGAT
CTTTCAGAACTCAACATTGAATTGGATGCCGATATTTTGGCCAAGGCTCCTGTGATTCCGGAAGGACTGTTCTGA

Upstream 100 bases:

>100_bases
GTCACAAAATTACACAACTTTTACAGTGACCTACATTGCTTTTTAAAGAATTAGTGTGGTGTGCAACATTAGTTCGTTGA
GAAGGAGTCACATTCCAGCC

Downstream 100 bases:

>100_bases
TGGCGGGTTTGTTTTCCTCTGCTGTTGCACCAACGGAGCGTCGAAAAGCATTACGCGCGGCACTGGCTGCGCCTGAAATT
GCCCGCATGCCTGGTGCATT

Product: propionate catabolism protein prpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLRRPVSSARAMAQVRPVTDGRG
ASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHPGDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMC
LHEHKIDHVAHLGPSAAAGIGTLLDLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
APSPIWEGEDGVIAWLLSGLDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLARSMGEKLAAQGLDLRDVDSIV
LHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAVALEDRAWHHERSYAPERAHRRETIELWNKISTVEDPEWTR
RYHSVDPAEKAFGARAVITFKDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
LSELNIELDADILAKAPVIPEGLF

Sequences:

>Translated_504_residues
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLRRPVSSARAMAQVRPVTDGRG
ASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHPGDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMC
LHEHKIDHVAHLGPSAAAGIGTLLDLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
APSPIWEGEDGVIAWLLSGLDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLARSMGEKLAAQGLDLRDVDSIV
LHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAVALEDRAWHHERSYAPERAHRRETIELWNKISTVEDPEWTR
RYHSVDPAEKAFGARAVITFKDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
LSELNIELDADILAKAPVIPEGLF
>Mature_504_residues
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLRRPVSSARAMAQVRPVTDGRG
ASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHPGDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMC
LHEHKIDHVAHLGPSAAAGIGTLLDLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
APSPIWEGEDGVIAWLLSGLDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLARSMGEKLAAQGLDLRDVDSIV
LHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAVALEDRAWHHERSYAPERAHRRETIELWNKISTVEDPEWTR
RYHSVDPAEKAFGARAVITFKDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
LSELNIELDADILAKAPVIPEGLF

Specific function: Catalyzes the dehydration of 2-methylcitrate to 2- methyl-cis-aconitate

COG id: COG2079

COG function: function code R; Uncharacterized protein involved in propionate catabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prpD family

Homologues:

Organism=Escherichia coli, GI1786528, Length=411, Percent_Identity=24.5742092457421, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325258, Length=452, Percent_Identity=26.1061946902655, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): PRPD2_CORGL (Q8NSL3)

Other databases:

- EMBL:   AF434799
- EMBL:   BA000036
- EMBL:   BX927149
- RefSeq:   NP_599889.1
- RefSeq:   YP_224949.1
- ProteinModelPortal:   Q8NSL3
- SMR:   Q8NSL3
- GeneID:   1018657
- GeneID:   3343400
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0759
- KEGG:   cgl:NCgl0628
- HOGENOM:   HBG292381
- OMA:   WKAYAPA
- PhylomeDB:   Q8NSL3
- ProtClustDB:   CLSK871899
- BioCyc:   CGLU196627:CG0759-MONOMER
- BRENDA:   4.2.1.79
- InterPro:   IPR005656

Pfam domain/function: PF03972 MmgE_PrpD; SSF103378 MmgE_PrpD

EC number: =4.2.1.79

Molecular weight: Translated: 55397; Mature: 55397

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLR
CCCCCHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
RPVSSARAMAQVRPVTDGRGASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHP
HHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEEEECCCCCEEEEECCCC
GDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMCLHEHKIDHVAHLGPSAAAGI
CCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHH
GTLLDLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
APSPIWEGEDGVIAWLLSGLDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLAR
CCCCCCCCCCHHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
SMGEKLAAQGLDLRDVDSIVLHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAV
HHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ALEDRAWHHERSYAPERAHRRETIELWNKISTVEDPEWTRRYHSVDPAEKAFGARAVITF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCEEEEEE
KDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
CCCCEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LSELNIELDADILAKAPVIPEGLF
HHHCCEEECCHHHHCCCCCCCCCC
>Mature Secondary Structure
MINHEVRTHRSAEEFPYEEHLAHKIARVAADPVEVAADTQEMIINRIIDNASVQAASVLR
CCCCCHHHCCCHHHCCHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHH
RPVSSARAMAQVRPVTDGRGASVFGLPGRYAAEWAALANGTAVRELDFHDTFLAAEYSHP
HHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHCCCCEEEEECCCCCEEEEECCCC
GDNIPPILAAAQQAGKGGKDLIRGIATGYEIQVNLVRGMCLHEHKIDHVAHLGPSAAAGI
CCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHH
GTLLDLDVDTIYQAIGQALHTTTATRQSRKGAISSWKAFAPAFAGKMSIEAVDRAMRGEG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCC
APSPIWEGEDGVIAWLLSGLDHIYTIPLPAEGEAKRAILDTYTKEHSAEYQSQAPIDLAR
CCCCCCCCCCHHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
SMGEKLAAQGLDLRDVDSIVLHTSHHTHYVIGTGSNDPQKFDPDASRETLDHSIMYIFAV
HHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
ALEDRAWHHERSYAPERAHRRETIELWNKISTVEDPEWTRRYHSVDPAEKAFGARAVITF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCEEEEEE
KDGTVVEDELAVADAHPLGARPFAREQYIQKFRTLAEGVVSEKEQDRFLDAAQRTHELED
CCCCEECHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LSELNIELDADILAKAPVIPEGLF
HHHCCEEECCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11976302; 12948626