Click here to switch to the map view.

The map label for this gene is hemY [H]

Identifier: 62389336

GI number: 62389336

Start: 461111

End: 462457

Strand: Direct

Name: hemY [H]

Synonym: cg0517

Alternate gene names: 62389336

Gene position: 461111-462457 (Clockwise)

Preceding gene: 62389335

Following gene: 62389337

Centisome position: 14.05

GC content: 59.39

Gene sequence:

>1347_bases
ATGCGTTTTGCCATCATCGGTGCAGGCCTTGCGGGTCTGACTGCTGCATATGAGATCCATAAAGCTGATCCCACTGCCCA
AATCGATGTGTTGGAAGCAGGCGAACGCATTGGCGGCAAGCTTTTTACGGTGCCGTTTGCTTCCGGACCTACCGATATTG
GAGCGGAGGCGTTTTTAGCTGCGCGTTCCGATGCGGTGGAGTTTTTTACTGAGCTTGGGTTGGCTGATTCTTTGGTCAGC
CCGTCTGCTGCGAAGTCTCAGTATTTCGCGGGCGGTGCGCTGCATGCGTTCCCCGCAGGTGGAGTGATGGGTATTCCAAG
CAATCCACCAGCAGGCGCGCAAGACACCGCTTTTGATTGGACTCCTGGCCAAGACATTTCTGTTGGCGCCTTAGTGCGCC
GTCAGTATGGCGATGAGATCGTCGATACTGTGGTGTCTTCGCTGCTTGGTGGCGTTTATTCCTCCACCGCTGATGATCTG
GGTGTGCGCGCTTCCGTGCCGGCACTTGCTGCAGCCCTTGATCAGCTGGCTGAGGCCGGCGAGCCGGTGACTCTGTCAGC
TGCGGTCAAGGCCGTGGAAGCTCAGCGGGAAGCCGCAAAAACAACTTCAGAAACCCGCCCCGTTTTCCAGACCTTCAAGG
GCGGATACGCGGAGCTGTACGAAGCGTTGGCAGAGCAATACGGTGCAGATATTCACTTGGATAGTTTCGTTTCCGCCATC
ACCAAAGATGGTGAAGGTTTTGCCATCAAGGGCGGTGGCGAAGGCACCTACGACAAGGTGATTTTGGCGGTTCCCGCTCC
AACCGCCGCTGTGCTGCTCCGCGACTTGGCACCGGCCGCAGCGCCACATTTGCGCGCAATTAAGTTGGCTTCTTCAGCAG
TCGTCGGCATGCGTTTCGATTCCAGCGAGGGCCTGCCCGACAACTCCGGCGTCCTGGTCGCTGTTAATGAGCCGGGCATC
ACGGCGAAGGCCTTCACGTTCTCCTCAAAGAAGTGGCCTCACCTGGAGGCTCGCGGGGGCGCGCTCGTGCGCGCGTCGTT
CGGCAGGCTAGGCGATGAGGCGTCGGCACGCATGGACGAGGATTTGCTTGTCGACGCCGCCCTCGACGATCTCCTCACCA
TAACCGGGTTCGACGGCCGGGCTGCCGGACTGGGTGAAATTTTCGTGCAGCGCTGGTTCGGTGGGCTCCCAGCCTATGGA
GTTGATCACATTGCTACCGTTTCGGCTGCGCGTGCAGAGATCGCAGCCGTGCCTGGCGTGGAAGCAATTGGCGCGTGGGC
TGGGGGAGTGGGAGTTCCCGCAGTTATCGCAGATGCCCAGGCAGCAGTACACAGGTTGCTGGGATAA

Upstream 100 bases:

>100_bases
CCATATCTTTAACCTTGGTCATGGTGTGCTTCCTAATACGGTGGCGGAAGATATTACTGAAGCCGTCTCCATCATTCATT
CTTAAACTAAGAGGAGTTTC

Downstream 100 bases:

>100_bases
GCACCCAAAAACACTATTGACCACCCCAATCGCTGTTGAGAGTTTGTAAAGTTCGACTGTCAACGAGCTGGATTGGCTTC
ACAGATTGAATTAATACAAT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRFAIIGAGLAGLTAAYEIHKADPTAQIDVLEAGERIGGKLFTVPFASGPTDIGAEAFLAARSDAVEFFTELGLADSLVS
PSAAKSQYFAGGALHAFPAGGVMGIPSNPPAGAQDTAFDWTPGQDISVGALVRRQYGDEIVDTVVSSLLGGVYSSTADDL
GVRASVPALAAALDQLAEAGEPVTLSAAVKAVEAQREAAKTTSETRPVFQTFKGGYAELYEALAEQYGADIHLDSFVSAI
TKDGEGFAIKGGGEGTYDKVILAVPAPTAAVLLRDLAPAAAPHLRAIKLASSAVVGMRFDSSEGLPDNSGVLVAVNEPGI
TAKAFTFSSKKWPHLEARGGALVRASFGRLGDEASARMDEDLLVDAALDDLLTITGFDGRAAGLGEIFVQRWFGGLPAYG
VDHIATVSAARAEIAAVPGVEAIGAWAGGVGVPAVIADAQAAVHRLLG

Sequences:

>Translated_448_residues
MRFAIIGAGLAGLTAAYEIHKADPTAQIDVLEAGERIGGKLFTVPFASGPTDIGAEAFLAARSDAVEFFTELGLADSLVS
PSAAKSQYFAGGALHAFPAGGVMGIPSNPPAGAQDTAFDWTPGQDISVGALVRRQYGDEIVDTVVSSLLGGVYSSTADDL
GVRASVPALAAALDQLAEAGEPVTLSAAVKAVEAQREAAKTTSETRPVFQTFKGGYAELYEALAEQYGADIHLDSFVSAI
TKDGEGFAIKGGGEGTYDKVILAVPAPTAAVLLRDLAPAAAPHLRAIKLASSAVVGMRFDSSEGLPDNSGVLVAVNEPGI
TAKAFTFSSKKWPHLEARGGALVRASFGRLGDEASARMDEDLLVDAALDDLLTITGFDGRAAGLGEIFVQRWFGGLPAYG
VDHIATVSAARAEIAAVPGVEAIGAWAGGVGVPAVIADAQAAVHRLLG
>Mature_448_residues
MRFAIIGAGLAGLTAAYEIHKADPTAQIDVLEAGERIGGKLFTVPFASGPTDIGAEAFLAARSDAVEFFTELGLADSLVS
PSAAKSQYFAGGALHAFPAGGVMGIPSNPPAGAQDTAFDWTPGQDISVGALVRRQYGDEIVDTVVSSLLGGVYSSTADDL
GVRASVPALAAALDQLAEAGEPVTLSAAVKAVEAQREAAKTTSETRPVFQTFKGGYAELYEALAEQYGADIHLDSFVSAI
TKDGEGFAIKGGGEGTYDKVILAVPAPTAAVLLRDLAPAAAPHLRAIKLASSAVVGMRFDSSEGLPDNSGVLVAVNEPGI
TAKAFTFSSKKWPHLEARGGALVRASFGRLGDEASARMDEDLLVDAALDDLLTITGFDGRAAGLGEIFVQRWFGGLPAYG
VDHIATVSAARAEIAAVPGVEAIGAWAGGVGVPAVIADAQAAVHRLLG

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=448, Percent_Identity=24.1071428571429, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4506001, Length=448, Percent_Identity=24.1071428571429, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 45760; Mature: 45760

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFAIIGAGLAGLTAAYEIHKADPTAQIDVLEAGERIGGKLFTVPFASGPTDIGAEAFLA
CEEEEEECCHHHHHHHHEEECCCCCCEEEHHHHHHHHCCEEEEEECCCCCCCCCHHHHHH
ARSDAVEFFTELGLADSLVSPSAAKSQYFAGGALHAFPAGGVMGIPSNPPAGAQDTAFDW
HHHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCCEEECCCCCEECCCCCCCCCCCCCCCCC
TPGQDISVGALVRRQYGDEIVDTVVSSLLGGVYSSTADDLGVRASVPALAAALDQLAEAG
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHCC
EPVTLSAAVKAVEAQREAAKTTSETRPVFQTFKGGYAELYEALAEQYGADIHLDSFVSAI
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEHHHHHHHH
TKDGEGFAIKGGGEGTYDKVILAVPAPTAAVLLRDLAPAAAPHLRAIKLASSAVVGMRFD
HCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEEEC
SSEGLPDNSGVLVAVNEPGITAKAFTFSSKKWPHLEARGGALVRASFGRLGDEASARMDE
CCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEECCCCEEEEEHHHCCCCHHHHCCCH
DLLVDAALDDLLTITGFDGRAAGLGEIFVQRWFGGLPAYGVDHIATVSAARAEIAAVPGV
HHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCH
EAIGAWAGGVGVPAVIADAQAAVHRLLG
HHHHHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRFAIIGAGLAGLTAAYEIHKADPTAQIDVLEAGERIGGKLFTVPFASGPTDIGAEAFLA
CEEEEEECCHHHHHHHHEEECCCCCCEEEHHHHHHHHCCEEEEEECCCCCCCCCHHHHHH
ARSDAVEFFTELGLADSLVSPSAAKSQYFAGGALHAFPAGGVMGIPSNPPAGAQDTAFDW
HHHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCCEEECCCCCEECCCCCCCCCCCCCCCCC
TPGQDISVGALVRRQYGDEIVDTVVSSLLGGVYSSTADDLGVRASVPALAAALDQLAEAG
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHCC
EPVTLSAAVKAVEAQREAAKTTSETRPVFQTFKGGYAELYEALAEQYGADIHLDSFVSAI
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEHHHHHHHH
TKDGEGFAIKGGGEGTYDKVILAVPAPTAAVLLRDLAPAAAPHLRAIKLASSAVVGMRFD
HCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEEEC
SSEGLPDNSGVLVAVNEPGITAKAFTFSSKKWPHLEARGGALVRASFGRLGDEASARMDE
CCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEECCCCEEEEEHHHCCCCHHHHCCCH
DLLVDAALDDLLTITGFDGRAAGLGEIFVQRWFGGLPAYGVDHIATVSAARAEIAAVPGV
HHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCH
EAIGAWAGGVGVPAVIADAQAAVHRLLG
HHHHHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]