Click here to switch to the map view.

The map label for this gene is hemE [H]

Identifier: 62389335

GI number: 62389335

Start: 460019

End: 461095

Strand: Direct

Name: hemE [H]

Synonym: cg0516

Alternate gene names: 62389335

Gene position: 460019-461095 (Clockwise)

Preceding gene: 62389334

Following gene: 62389336

Centisome position: 14.01

GC content: 52.92

Gene sequence:

>1077_bases
ATGTCTGCTCTTACTATTCCAGCTGCGCGTCGCACGCTAAATAACGCGCCCATTATTGATGCCGCTAATGGCAAGACCCC
GACTCGCACTCCGGTGTGGTTTATGCGCCAGGCGGGTAGGTCGTTGCCTGAGTACAAGAAGGTCCGTGAGGGAATCAGCA
TGTTGGATTCCTGTTTCATGCCGGAGTTGTTGGCGGAGATTACTTTGCAGCCGGTTCGTCGTCATGATGTGGATGCTGCG
ATTTTGTTCTCTGACATTGTGGTGCCGTTGCGTGCTGCGGGTGTTGGTGTGGAAATCGTGGCGGGTCGTGGACCTGTGTT
GGATGCGCCGGTGCGGAGCCGTGGGGATGTGTTGAATCTTCCTATTTTGGAGGGCAACGTTCCGGAGGTGGAGCAGGGTA
TTGGCATCATTTTGGATGAGTTGTCTGATTCTCAGGCGTTGATTGGTTTTGCTGGTGCGCCGTTTACGTTGGCGAGTTAC
TTGGTTGAGGGTGGTCCTTCCAAGAATCATGAGAAGACCAAAGCAATGATGCATGGTGATCCTGAGACGTGGCATGCGTT
GATGGCTCGTTTGGTGCCGACGATTGTGAATTCTTTGAAGTCGCAGATCGATGCGGGTATCGATGCGGTGCAGTTGTTTG
ATTCGTGGGCTGGGTTCCTCACTGAGCGTGATTACACCGAGTTCGTGTTGCCGTATTCCACTGAGATTTTGGAGGAAGTG
GGCAAGTACCAGCTGCCTCGTATTCACTTTGGTGTGGGTACTGGTGAGTTGCTTGGTGCGATGAGCAAGGCTGGCTCAGA
GGTCATGGGTGTGGATTGGCGGGTGCCGTTGGATAAGGCTGCGGAGCGTATTGCTGCGGTATCAGGTCCTAAGGTGTTGC
AGGGTAACCTCGATCCTGCGTTGTTGTTTGCGGGTCGCGCACCTTTGACTAAGGAAATTGAGCGCATCAAGGCAGAGGCT
CAGACTGCTGTTGATGCAGGTCATGCAACGGGCCATATCTTTAACCTTGGTCATGGTGTGCTTCCTAATACGGTGGCGGA
AGATATTACTGAAGCCGTCTCCATCATTCATTCTTAA

Upstream 100 bases:

>100_bases
CCAAAAACCCCTCCCATATAGTTCTTTTTACTGATGCATTGTCCTCAATTAGGTGTGGCTTCTTTTCCTAAATTGGGATA
AATGGGGCAAGATTGAGCGC

Downstream 100 bases:

>100_bases
ACTAAGAGGAGTTTCATGCGTTTTGCCATCATCGGTGCAGGCCTTGCGGGTCTGACTGCTGCATATGAGATCCATAAAGC
TGATCCCACTGCCCAAATCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAA
ILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSRGDVLNLPILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASY
LVEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAVQLFDSWAGFLTERDYTEFVLPYSTEILEEV
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEA
QTAVDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS

Sequences:

>Translated_358_residues
MSALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAA
ILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSRGDVLNLPILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASY
LVEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAVQLFDSWAGFLTERDYTEFVLPYSTEILEEV
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEA
QTAVDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS
>Mature_357_residues
SALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFMPELLAEITLQPVRRHDVDAAI
LFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSRGDVLNLPILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASYL
VEGGPSKNHEKTKAMMHGDPETWHALMARLVPTIVNSLKSQIDAGIDAVQLFDSWAGFLTERDYTEFVLPYSTEILEEVG
KYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPALLFAGRAPLTKEIERIKAEAQ
TAVDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=356, Percent_Identity=37.0786516853933, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI2367337, Length=341, Percent_Identity=41.6422287390029, Blast_Score=244, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6320252, Length=345, Percent_Identity=33.9130434782609, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI221330099, Length=357, Percent_Identity=35.8543417366947, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19921920, Length=358, Percent_Identity=36.0335195530726, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38414; Mature: 38282

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFM
CCCCCCCHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
PELLAEITLQPVRRHDVDAAILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSRGDVLNL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCCCEEEC
PILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASYLVEGGPSKNHEKTKAMMHGD
CEECCCCCHHHHCCHHEECCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCC
PETWHALMARLVPTIVNSLKSQIDAGIDAVQLFDSWAGFLTERDYTEFVLPYSTEILEEV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEECCCCHHHHHHH
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPA
HHCCCCEEEECCCHHHHHHHHHHCCCCEECCEECCCHHHHHHHHHHCCCCCEEECCCCCE
LLFAGRAPLTKEIERIKAEAQTAVDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SALTIPAARRTLNNAPIIDAANGKTPTRTPVWFMRQAGRSLPEYKKVREGISMLDSCFM
CCCCCCHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
PELLAEITLQPVRRHDVDAAILFSDIVVPLRAAGVGVEIVAGRGPVLDAPVRSRGDVLNL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCCCEEEC
PILEGNVPEVEQGIGIILDELSDSQALIGFAGAPFTLASYLVEGGPSKNHEKTKAMMHGD
CEECCCCCHHHHCCHHEECCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCC
PETWHALMARLVPTIVNSLKSQIDAGIDAVQLFDSWAGFLTERDYTEFVLPYSTEILEEV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEECCCCHHHHHHH
GKYQLPRIHFGVGTGELLGAMSKAGSEVMGVDWRVPLDKAAERIAAVSGPKVLQGNLDPA
HHCCCCEEEECCCHHHHHHHHHHCCCCEECCEECCCHHHHHHHHHHCCCCCEEECCCCCE
LLFAGRAPLTKEIERIKAEAQTAVDAGHATGHIFNLGHGVLPNTVAEDITEAVSIIHS
EEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA