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The map label for this gene is ctpB [H]

Identifier: 62389334

GI number: 62389334

Start: 457266

End: 459902

Strand: Direct

Name: ctpB [H]

Synonym: cg0515

Alternate gene names: 62389334

Gene position: 457266-459902 (Clockwise)

Preceding gene: 62389333

Following gene: 62389335

Centisome position: 13.93

GC content: 54.15

Gene sequence:

>2637_bases
GTGAGCACACCGGATTCTTCCTCGGTGGACAAGGCCGTAAACACTGCTATCTCTGACGCCAAAACAGCGGCGCTCAAGGC
AGGTGTTGGATTGAACCGAGCCACCGCCTCAGAAGAAGAGGAAGATTTAAGCTCAAGCATTAAGGTTTCTTTGGCCTTTG
AGCTCGAGGGGTTAAGCAATGCACCATCGTTGATGGTGGTGGAAAAAGCCCTAGAGAAGATCCCCGGTGTATCCGCGGAT
CTGATTTACCCTTCACAAACTGCATGGATTACAGCAACTGATCGGGTACATCCCGAAACCCTCATTGAGGTGTTTGAGCA
GTTCGGCATCAAAGCACACCTTTCTAATTCATCGCTGCTGCGCAGGCATCAACAGCTCAGCGCGGAAGTAAATAGGGAAG
CACGCCTTGATCGTTACCGCTCCCGAATGGATGCCAAGCGAATCTCGCCTCGTGTGCGAAGGCATAACCGACAAGAAATG
GTACATGCGGTACGCGCTCGTGAAAGTGGTTGGATTAAACGCAGGAATCACACCACCTCGCAGCATGAAGACCCAATGTC
GGGCGATGTGCTGTTCACCGCCCGCGCACTGATTACACCTAAGCGTTTGTGGGTGTCGTTGCCGTTTGCGCTCATCGTAT
TGGCGTTATCGTTGAATCCTTCGTGGCAGTTTGATTATTGGCAGTGGTTGTCCGCTGTGTTGGCTATTCCTGTGGTGGTG
TGGGGTGCCTGGCCGTTTCACCGCGCTGCAGCAGGCGGTATTCGTCGAGGAATTTCCGCTCTTGATGCGACCAGCTCAAT
CGCTATTGCTGCTGCATACGCGTGGTCTATCGCCATGCTGTTGTTTGAAACCCCAGGAGGTAAATCCTGGCGGTCATATC
CGTCCTGGTTCGCTTTTGACCACGGCACGTTGACCCAAAACGAGATTTATTTTGATGTGGCCTGCGGAATCACCGTGTTG
CTTCTTGCCGGACGGCTGCTGACAAGGCGTCGAAGCCAATCCAGTTTGTTAGCGGAACTTGGTCGCCTCCAAATCGATCC
ACAGCGCATTGTCACTGTGGTGCGTAAACACCGATTGAAGCGCGTAGTCCAGGAACTGAACATTCCAGTGCAGGAAGTCC
GTGTCAATGACGATGTGAAAGTTCCACCTAATACCACGATCCCTGTGGATGGCACTGTCATCGGTGGCGGTTCGCGGATC
GCAGCTAGCATCATCATGGGACAAGACCAGCGTGATGTAAAAGTAAATGACAAAGTTTTCGCCGGCAGCCTCAACCTCGA
ATCCGAAATCAAGGTTCGTGTTATTCGCACTGGTCACCGCACCCGCATCGCCGCGGTACATAGGTGGGTTAAAGAAGCGA
CGTTGAAGGAAAACCGCCACAATAGGGCAGCGATCCGTTCGGCCGGTAACCTTGTGCCCATCACGTTCACCCTTGCTGTG
GTGGACTTCTGTCTGTGGGCACTGATCTCTGGAAACATCAACGCTGCATTTACCACTACCTTGGCTGTCCTTGCGTGCGT
GGCTCCGGTGGCCTTAGCGTTGTCTGCTCCACTTGCCACGAGGAATTCCATCGAAGCTGCAGCACGACACGGTATTTTGG
TCCGCTCTGGTGAAATTTTCCGAGTTCTCGATGATGTGGATACTGCCGTATTTAATCGTGTGGGCACACTAACCGATGGC
GAAATGACAGTGGAAACCGTCACAGCAGACAAAGGCGAGGACCCAGAACTAGTGCTGCGTGTCGCCGGGGCGTTGGCCAT
GGAATCCCACCACGCGATTTCCAAAGCACTGGTGAAAGCATCCCGTGAAGCTCGTGATACCGGCGCCGGTGGTGAAGATG
TCCCACACTGGATTGAAGTAGGCAACGTGGAAATCACCGAAGCCGGCTCATTCCAAGCAACCATCGAGCTGCCACTGATC
AAACCATCTGGCGAAAAAATCATGCGCACCACAGAAGCACTCCTGTGGCGACCACGATCCATGACAGAAGTCCGTGAGCA
CTTAAGCCCCCGACTAGTGGCAGCAGCAACCTCAGGTGGCGCACCACTGATCGTGCGATGGAAAGGCAAAGACCGCGGAG
TTATCACTCTAAGTGACCACGTGAGATCAGATTCCTCCGATGCGATTATTGCGATTGAAGAACAAGGCATCGAGACCATG
ATGCTTTCACGTGATACTTACCCGGTGGCACGTCGATACGCAGACAGCTTAGGCATCACCCACGTCTTGGCCGGCATCGC
GCCGGGCAAGAAAGCCCAGGTCGTCCGTGCAGTCCACACCCGCGGATCCACTGTCGCGATGATCGGCGATGAATCAGTAA
TGGACTGTTTGAAAGTCGCTGACGTGGGTGTACTGATGGGCGTCGATCGTCCCTCAGATCTGCGTGATGATTCCGATGAC
CCGGCAGCTGACGTTGTGGTCATGCGCGAAGAGGTCATGAGCGTGCCGACGCTGTTTAAACTGGCTCGACGCTACGCCAA
GTTGGTCAATGGCAATATTGCTCTGGCCTGGATCTATAACGGTGTTGCCATGGTGCTTGCAGTGTCTGGCTTGCTGCATC
CAATGGCTGCGACCGTGGCTATGCTGGCGTCTTCGCTGCTTATTGAATGGCGCTCGGGCAGGGCGCGCAAGTACTAA

Upstream 100 bases:

>100_bases
TACTTTTTCGCTACCGTGAGTCTTACCGTGAGCCTTATACTGTGAGGACATTAAAAGTGACACCTCTTTTTCTATCTTTT
ACAACCCAAGAAGGTTTATC

Downstream 100 bases:

>100_bases
CCAGCAATTCCCAAGCCCAAAAACCCCTCCCATATAGTTCTTTTTACTGATGCATTGTCCTCAATTAGGTGTGGCTTCTT
TTCCTAAATTGGGATAAATG

Product: cation-transporting P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 878; Mature: 877

Protein sequence:

>878_residues
MSTPDSSSVDKAVNTAISDAKTAALKAGVGLNRATASEEEEDLSSSIKVSLAFELEGLSNAPSLMVVEKALEKIPGVSAD
LIYPSQTAWITATDRVHPETLIEVFEQFGIKAHLSNSSLLRRHQQLSAEVNREARLDRYRSRMDAKRISPRVRRHNRQEM
VHAVRARESGWIKRRNHTTSQHEDPMSGDVLFTARALITPKRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGGKSWRSYPSWFAFDHGTLTQNEIYFDVACGITVL
LLAGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRI
AASIIMGQDQRDVKVNDKVFAGSLNLESEIKVRVIRTGHRTRIAAVHRWVKEATLKENRHNRAAIRSAGNLVPITFTLAV
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRVGTLTDG
EMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLI
KPSGEKIMRTTEALLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVADVGVLMGVDRPSDLRDDSDD
PAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGVAMVLAVSGLLHPMAATVAMLASSLLIEWRSGRARKY

Sequences:

>Translated_878_residues
MSTPDSSSVDKAVNTAISDAKTAALKAGVGLNRATASEEEEDLSSSIKVSLAFELEGLSNAPSLMVVEKALEKIPGVSAD
LIYPSQTAWITATDRVHPETLIEVFEQFGIKAHLSNSSLLRRHQQLSAEVNREARLDRYRSRMDAKRISPRVRRHNRQEM
VHAVRARESGWIKRRNHTTSQHEDPMSGDVLFTARALITPKRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGGKSWRSYPSWFAFDHGTLTQNEIYFDVACGITVL
LLAGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRI
AASIIMGQDQRDVKVNDKVFAGSLNLESEIKVRVIRTGHRTRIAAVHRWVKEATLKENRHNRAAIRSAGNLVPITFTLAV
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRVGTLTDG
EMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLI
KPSGEKIMRTTEALLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVADVGVLMGVDRPSDLRDDSDD
PAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGVAMVLAVSGLLHPMAATVAMLASSLLIEWRSGRARKY
>Mature_877_residues
STPDSSSVDKAVNTAISDAKTAALKAGVGLNRATASEEEEDLSSSIKVSLAFELEGLSNAPSLMVVEKALEKIPGVSADL
IYPSQTAWITATDRVHPETLIEVFEQFGIKAHLSNSSLLRRHQQLSAEVNREARLDRYRSRMDAKRISPRVRRHNRQEMV
HAVRARESGWIKRRNHTTSQHEDPMSGDVLFTARALITPKRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVVW
GAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGGKSWRSYPSWFAFDHGTLTQNEIYFDVACGITVLL
LAGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRIA
ASIIMGQDQRDVKVNDKVFAGSLNLESEIKVRVIRTGHRTRIAAVHRWVKEATLKENRHNRAAIRSAGNLVPITFTLAVV
DFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDTAVFNRVGTLTDGE
MTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLIK
PSGEKIMRTTEALLWRPRSMTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETMM
LSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVADVGVLMGVDRPSDLRDDSDDP
AADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGVAMVLAVSGLLHPMAATVAMLASSLLIEWRSGRARKY

Specific function: Involved In Copper Efflux. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=678, Percent_Identity=26.2536873156342, Blast_Score=177, Evalue=5e-44,
Organism=Homo sapiens, GI115529486, Length=696, Percent_Identity=24.4252873563218, Blast_Score=163, Evalue=8e-40,
Organism=Homo sapiens, GI55743073, Length=553, Percent_Identity=26.9439421338156, Blast_Score=154, Evalue=5e-37,
Organism=Escherichia coli, GI1786691, Length=666, Percent_Identity=24.4744744744745, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1789879, Length=532, Percent_Identity=23.8721804511278, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1786914, Length=440, Percent_Identity=23.1818181818182, Blast_Score=63, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17556548, Length=696, Percent_Identity=25.1436781609195, Blast_Score=148, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320475, Length=679, Percent_Identity=24.8895434462445, Blast_Score=148, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319772, Length=651, Percent_Identity=22.5806451612903, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221329854, Length=407, Percent_Identity=25.0614250614251, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000579
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 95908; Mature: 95777

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPDSSSVDKAVNTAISDAKTAALKAGVGLNRATASEEEEDLSSSIKVSLAFELEGLSN
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCEEEEEEEEECCCCC
APSLMVVEKALEKIPGVSADLIYPSQTAWITATDRVHPETLIEVFEQFGIKAHLSNSSLL
CCHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHH
RRHQQLSAEVNREARLDRYRSRMDAKRISPRVRRHNRQEMVHAVRARESGWIKRRNHTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCEECCCCCCC
QHEDPMSGDVLFTARALITPKRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
CCCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGGKSWRSYPSWFAFD
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEC
HGTLTQNEIYFDVACGITVLLLAGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLK
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRIAASIIMGQDQRDVKVNDKVF
HHHHHHCCCHHHEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCEECCEEE
AGSLNLESEIKVRVIRTGHRTRIAAVHRWVKEATLKENRHNRAAIRSAGNLVPITFTLAV
EECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEHHHHHHH
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEECCCEE
RVLDDVDTAVFNRVGTLTDGEMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKA
EHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLIKPSGEKIMRTTEALLWRPRS
HHHHHCCCCCCCCCCCCEEECCEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCC
MTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
HHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCEEE
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVA
EECCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
DVGVLMGVDRPSDLRDDSDDPAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYN
HHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEHHH
GVAMVLAVSGLLHPMAATVAMLASSLLIEWRSGRARKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STPDSSSVDKAVNTAISDAKTAALKAGVGLNRATASEEEEDLSSSIKVSLAFELEGLSN
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCEEEEEEEEECCCCC
APSLMVVEKALEKIPGVSADLIYPSQTAWITATDRVHPETLIEVFEQFGIKAHLSNSSLL
CCHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCEEECCCHHHH
RRHQQLSAEVNREARLDRYRSRMDAKRISPRVRRHNRQEMVHAVRARESGWIKRRNHTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHCCCEECCCCCCC
QHEDPMSGDVLFTARALITPKRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVV
CCCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
WGAWPFHRAAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGGKSWRSYPSWFAFD
HCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEC
HGTLTQNEIYFDVACGITVLLLAGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLK
CCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RVVQELNIPVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRIAASIIMGQDQRDVKVNDKVF
HHHHHHCCCHHHEECCCCCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCCCCCEECCEEE
AGSLNLESEIKVRVIRTGHRTRIAAVHRWVKEATLKENRHNRAAIRSAGNLVPITFTLAV
EECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEHHHHHHH
VDFCLWALISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIF
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEEECCCEE
RVLDDVDTAVFNRVGTLTDGEMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKA
EHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SREARDTGAGGEDVPHWIEVGNVEITEAGSFQATIELPLIKPSGEKIMRTTEALLWRPRS
HHHHHCCCCCCCCCCCCEEECCEEEEECCCEEEEEEEEEECCCCHHHHHHHHHHHCCCCC
MTEVREHLSPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETM
HHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCEEE
MLSRDTYPVARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVA
EECCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
DVGVLMGVDRPSDLRDDSDDPAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYN
HHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEHHH
GVAMVLAVSGLLHPMAATVAMLASSLLIEWRSGRARKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]