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The map label for this gene is hemA [H]

Identifier: 62389317

GI number: 62389317

Start: 438515

End: 439906

Strand: Direct

Name: hemA [H]

Synonym: cg0497

Alternate gene names: 62389317

Gene position: 438515-439906 (Clockwise)

Preceding gene: 62389316

Following gene: 62389318

Centisome position: 13.36

GC content: 55.68

Gene sequence:

>1392_bases
GTGAGTGTACTCATCGTAGGGATGTCGCACAGGTCTGCGCCTGTGTCGCTTCTTGAACGTCTGAGCATGGATGATTCAGT
ACGTGGTGAAACAACTCAAGCACTCCTGGGTAGGGCGTCTTTAAGCGAGGCCCTCATTGTCTCTACGTGTAACCGCCTGG
AGGTCTACACCGTCACTAGCAGTTTCCATACTGGTGTTAATGATGTGGTGGAGGTTCTCCATGAGGCAAGTGGCGTAGAT
ATTGAAACTTTGCGCGGATATCTTTATGTCCGTTACGCCGATGCTGCTGCTGAACACATGTTGGTGGTGACTTCCGGGTT
GGATTCCATGGTGTTGGGTGAGCAGCAGATCATTGGTCAGGTGCGCACTGCGTACCAAGCAGCTAATGAATATGGTTCTG
TCGGTCCTGCTTTGCATTCACTTACCCAGACCGCGCTGCATACCGGCAAGCGCGTGCATTCGGAGACTGCTATTGATGAT
GCTGGTGCATCGATGGTGTCTTTCGCTGTGGATCGCGCGTTGGTGCAGATGGGTCTTGATTCGGAGGCAGAAGCCCCACT
ATCTGGCAAGACAGCCTTGGTGTTGGGCGCTGGCGCGATGAGTTCTCTTGCAGCCACTCACCTTGGTCGCGCTGGAATTT
CCAACTTGATCATGGCCAACCGCACTCTGGAACGTGCCGAAAGGCTTGCGGAGCATTCCCTAGAAGCCGGAGTTCCTGCA
GAGGTTGTGGAATACGATCAGCGAGCTTCCGCCTACAATCGCGTTGACCTGGTAGTTTCCGCCACGGGAGCGGATGATTT
CACCGTGAAGCCTGAGGATATTCCAGAAGGTGCTTCGTTGATGTTGGTGGATTTGTCCATGCCACGAGACATCGATGATG
CTTGTGCGGATCTGCCGGGCGTTGATTTGGTGAACATCGAACGCCTGCACAAGGCCTCCCGTGAGGGTGGATCGGGCATG
GCGCCAAGCGAGGAAGAAGCTTTGGCGATTGTTCGGGAAGAGTTGGATTCTTTCACCTCTGAGCAGCGCATTCGCGATAT
CGTTCCAGCTGTGTCCGCGTTGCGCAGGCAGGCCGCGTCGGTGGGAAGCGATGAATTGGATCGACTCCGCCAACGTGCCC
CCGGGATTTCCGAGGTGGAATGGGGGGAAGTGGAGAAAACAGTGAGACGGGTCGTCGATAAGCTTCTTCATGAACCCACT
GTGCGCGTCAAGGAACTGGCGGCCCGGTCCGGCAGCATCTCTTATGATTCAGCTCTGCAAGAGCTGTTCGGTTTGGAGTC
GCTGGCGAGCACCGCAGCACCGGCAACCACGTCCGTCAACGCGTCAGAACTGCCGGATGCGGGTATCGTCGCATTCGTGA
ACGCACCTTCTGCCACACAAACGAGGGAGTAA

Upstream 100 bases:

>100_bases
GCTTTGTTGTGATGTCCGCGAATGAAAGCTACCGTATTTTAATCAACTAGGATTCATTCTTTTGGTGGATCAAAGGCTCC
GTTGAAAGTCGGGTGGAATG

Downstream 100 bases:

>100_bases
CATGACCTTAAAAATTGGTACCCGAGGATCCAAACTTGCCACCACCCAAGCTGGCACCATCCGCGACCAGCTGAAACACT
ACGGACGCGACGCTGAACTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEASGVD
IETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAIDD
AGASMVSFAVDRALVQMGLDSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISNLIMANRTLERAERLAEHSLEAGVPA
EVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPGVDLVNIERLHKASREGGSGM
APSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAASVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHEPT
VRVKELAARSGSISYDSALQELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE

Sequences:

>Translated_463_residues
MSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEASGVD
IETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAIDD
AGASMVSFAVDRALVQMGLDSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISNLIMANRTLERAERLAEHSLEAGVPA
EVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPGVDLVNIERLHKASREGGSGM
APSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAASVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHEPT
VRVKELAARSGSISYDSALQELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE
>Mature_462_residues
SVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTSSFHTGVNDVVEVLHEASGVDI
ETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQVRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAIDDA
GASMVSFAVDRALVQMGLDSEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISNLIMANRTLERAERLAEHSLEAGVPAE
VVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPGVDLVNIERLHKASREGGSGMA
PSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAASVGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHEPTV
RVKELAARSGSISYDSALQELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=438, Percent_Identity=28.7671232876712, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 49217; Mature: 49086

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTS
CEEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SFHTGVNDVVEVLHEASGVDIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQ
CHHCCHHHHHHHHHHHCCCCHHHHCCEEEEEEECHHHCEEEEEECCCCHHHHHHHHHHHH
VRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAIDDAGASMVSFAVDRALVQMGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
SEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISNLIMANRTLERAERLAEHSLEAGVPA
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPG
HHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCCEEEEEECCCCCHHHHHHCCCC
VDLVNIERLHKASREGGSGMAPSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAAS
CCEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHEPTVRVKELAARSGSISYDSALQ
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
ELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE
HHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
SVLIVGMSHRSAPVSLLERLSMDDSVRGETTQALLGRASLSEALIVSTCNRLEVYTVTS
EEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SFHTGVNDVVEVLHEASGVDIETLRGYLYVRYADAAAEHMLVVTSGLDSMVLGEQQIIGQ
CHHCCHHHHHHHHHHHCCCCHHHHCCEEEEEEECHHHCEEEEEECCCCHHHHHHHHHHHH
VRTAYQAANEYGSVGPALHSLTQTALHTGKRVHSETAIDDAGASMVSFAVDRALVQMGLD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
SEAEAPLSGKTALVLGAGAMSSLAATHLGRAGISNLIMANRTLERAERLAEHSLEAGVPA
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EVVEYDQRASAYNRVDLVVSATGADDFTVKPEDIPEGASLMLVDLSMPRDIDDACADLPG
HHHHHHHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCCEEEEEECCCCCHHHHHHCCCC
VDLVNIERLHKASREGGSGMAPSEEEALAIVREELDSFTSEQRIRDIVPAVSALRRQAAS
CCEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGSDELDRLRQRAPGISEVEWGEVEKTVRRVVDKLLHEPTVRVKELAARSGSISYDSALQ
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHH
ELFGLESLASTAAPATTSVNASELPDAGIVAFVNAPSATQTRE
HHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA