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The map label for this gene is proC

Identifier: 62389310

GI number: 62389310

Start: 434885

End: 435697

Strand: Direct

Name: proC

Synonym: cg0490

Alternate gene names: 62389310

Gene position: 434885-435697 (Clockwise)

Preceding gene: 62389309

Following gene: 62389311

Centisome position: 13.25

GC content: 57.2

Gene sequence:

>813_bases
ATGACAACAATTGCTGTAATCGGCGGCGGACAAATCGGCGAGGCTTTAGTCTCAGGTTTGATCGCGGCCAACATGAATCC
ACAAAATATTCGCGTCACCAACCGTTCGGAAGAGCGCGGCCAAGAGCTGCGTGACCGCTACGGCATCCTCAACATGACGG
ATAATTCCCAAGCCGCAGACGAAGCCGACGTGGTGTTCCTGTGCGTGAAGCCGAAATTTATCGTCGAAGTGCTCTCCGAA
ATCACCGGCACTTTGGATAACAACTCCGCACAAAGTGTTGTGGTCAGCATGGCCGCAGGCATCAGCATCGCTGCCATGGA
AGAAAGCGCCTCTGCGGGGCTCCCCGTCGTGCGCGTCATGCCGAACACTCCAATGCTCGTGGGCAAGGGCATGTCGACTG
TCACCAAAGGCCGCTACGTTGACGCGGAACAGTTGGAACAAGTCAAGGACTTGTTGAGCACCGTTGGAGACGTCCTCGAA
GTCGCGGAATCAGACATCGACGCAGTCACCGCGATGTCCGGATCCTCCCCTGCATACCTGTTCCTTGTGACCGAAGCGCT
CATTGAGGCAGGAGTTAATCTAGGCCTGCCCCGCGCGACCGCTAAAAAGCTCGCTGTGGCCTCATTCGAAGGTGCTGCAA
CCATGATGAAGGAAACCGGCAAAGAACCCTCAGAATTGCGCGCAGGCGTTTCCTCACCCGCAGGCACCACCGTCGCAGCC
ATCCGAGAACTCGAAGAAAGCGGAATCCGAGGCGCTTTCTACCGCGCAGCCCAAGCTTGCGCCGACCGATCTGAAGAACT
CGGAAAGCGCTAG

Upstream 100 bases:

>100_bases
CCTGGTCATGACGTTCGGGCCGCTGGCAATCGTCATGTAATTTGTCGTTTTGGGCCCCCGCTGCTGCAAAACAGGGGTGG
TTAGTGGCAGTGTGGGAACC

Downstream 100 bases:

>100_bases
AAACCGTTATTTCCCCGTTATCAGCTCGTTGTTTAGGAAGAAATTCACGAAAACGTTTTTCTTCCACCAACTCCAATGAC
CTGCAGATTCACATTCGAAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEVLSE
ITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLE
VAESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAA
IRELEESGIRGAFYRAAQACADRSEELGKR

Sequences:

>Translated_270_residues
MTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEVLSE
ITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLE
VAESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAA
IRELEESGIRGAFYRAAQACADRSEELGKR
>Mature_269_residues
TTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAADEADVVFLCVKPKFIVEVLSEI
TGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVMPNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEV
AESDIDAVTAMSGSSPAYLFLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAAI
RELEESGIRGAFYRAAQACADRSEELGKR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family

Homologues:

Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=36.1623616236162, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=36.1623616236162, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=36.2637362637363, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI198041662, Length=271, Percent_Identity=30.6273062730627, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=39.7003745318352, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=40.590405904059, Blast_Score=173, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=28.5211267605634, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=31.5972222222222, Blast_Score=144, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=36.0902255639098, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=35.4014598540146, Blast_Score=164, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=40.4761904761905, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): P5CR_CORGL (P0C1E4)

Other databases:

- EMBL:   BA000036
- EMBL:   BX927149
- RefSeq:   NP_599658.1
- RefSeq:   YP_224712.1
- ProteinModelPortal:   P0C1E4
- SMR:   P0C1E4
- GeneID:   1021078
- GeneID:   3343255
- GenomeReviews:   BA000036_GR
- GenomeReviews:   BX927147_GR
- KEGG:   cgb:cg0490
- KEGG:   cgl:NCgl0398
- HOGENOM:   HBG726602
- OMA:   RTFNEHQ
- PhylomeDB:   P0C1E4
- ProtClustDB:   PRK11880
- BioCyc:   CGLU196627:CG0490-MONOMER
- BRENDA:   1.5.1.2
- GO:   GO:0005737
- GO:   GO:0005488
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11645
- PIRSF:   PIRSF000193
- TIGRFAMs:   TIGR00112

Pfam domain/function: PF03807 F420_oxidored; SSF48179 6DGDH_C_like

EC number: =1.5.1.2

Molecular weight: Translated: 28242; Mature: 28111

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAAD
CCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCCCCC
EADVVFLCVKPKFIVEVLSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVM
CCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEC
PNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEVAESDIDAVTAMSGSSPAYL
CCCCEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEE
FLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCCCCCHHHHH
IRELEESGIRGAFYRAAQACADRSEELGKR
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTIAVIGGGQIGEALVSGLIAANMNPQNIRVTNRSEERGQELRDRYGILNMTDNSQAAD
CEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCEEEECCCCCCCC
EADVVFLCVKPKFIVEVLSEITGTLDNNSAQSVVVSMAAGISIAAMEESASAGLPVVRVM
CCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEC
PNTPMLVGKGMSTVTKGRYVDAEQLEQVKDLLSTVGDVLEVAESDIDAVTAMSGSSPAYL
CCCCEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEE
FLVTEALIEAGVNLGLPRATAKKLAVASFEGAATMMKETGKEPSELRAGVSSPAGTTVAA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHCCCCCCCCHHHHH
IRELEESGIRGAFYRAAQACADRSEELGKR
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626