Click here to switch to the map view.

The map label for this gene is emrY [C]

Identifier: 62389279

GI number: 62389279

Start: 401149

End: 402798

Strand: Direct

Name: emrY [C]

Synonym: cg0455

Alternate gene names: 62389279

Gene position: 401149-402798 (Clockwise)

Preceding gene: 62389278

Following gene: 62389280

Centisome position: 12.22

GC content: 53.52

Gene sequence:

>1650_bases
ATGACATCACAGGTCAAGCCGGACGACGAACGTCCGGTAACAACAATTTCAAAAAGTGGTGCACCTTCGGCCCACACCTC
AGCACCATATGGTGCAGCAGCAACTGAAGAAGCTGTCGAGGAAAAAACCAAAGGTCGCGTTGGATTTATCATCGCAGCCC
TCATGTTGGCGATGCTTCTTAGCTCCTTGGGTCAGACCATTTTCGGTTCTGCCCTGCCAACGATTGTTGGTGAGCTTGGC
GGCGTTAACCACATGACCTGGGTGATTACCGCCTTCCTCTTGGGCCAGACCATTTCATTGCCTATTTTCGGCAAGTTGGG
TGACCAGTTTGGTCGCAAATACCTCTTCATGTTTGCCATCGCACTGTTCGTGGTGGGTTCCATCATCGGTGCTTTGGCTC
AGAACATGACCACCTTGATTGTGGCTCGTGCACTGCAGGGTATCGCCGGTGGTGGCTTGATGATTCTTTCTCAGGCAATT
ACCGCTGATGTCACCACCGCCCGTGAGCGTGCAAAGTACATGGGCATCATGGGTTCCGTTTTCGGACTGTCCTCCATCCT
TGGCCCATTGCTTGGTGGCTGGTTCACTGACGGTCCAGGCTGGCGTTGGGGTCTGTGGTTGAACGTTCCAATCGGCATCA
TCGCACTGGTTGCTATCGCTGTGCTGCTGAAACTTCCAGCTCGTGAACGTGGCAAGGTCTCCGTTGACTGGTTGGGAAGC
ATCTTCATGGCTATCGCCACCACCGCATTTGTCCTCGCAGTGACCTGGGGTGGCAATGAATATGAGTGGGCATCACCAAT
GATCATCGGTTTGTTCATCACGACATTGGTCGCTGCGATAGTGTTCGTTTTCGTCGAAAAGCGTGCTGTTGACCCACTGG
TCCCCATGGGCCTTTTCTCGAACCGCAACTTCGTGCTCACCGCCGTCGCCGGTATCGGCGTAGGCCTGTTTATGATGGGC
ACCATCGCGTACATGCCTACCTACCTGCAGATGGTTCATGGTCTGAACCCAACGCAAGCTGGTCTGATGCTGATCCCAAT
GATGATCGGCCTGATTGGTACATCCACTGTGGTGGGCAACATCGTGTCCAAGACTGGCAAGTACAAGTGGTACCCATTCA
TCGGCATGCTCATCATGGTCCTTGCCCTAGTACTGCTATCGACGCTGACACCTTCGGCAAGCTTGGCTCTCATTGGACTG
TACTTCTTCGTCTTCGGATTCGGCCTGGGCTGTGCAATGCAGATTTTGGTTCTCATCGTGCAGAACTCCTTCCCAATCAC
CATGGTTGGCACCGCGACCGGTTCCAACAACTTCTTCCGCCAAATCGGTGGAGCAGTAGGTTCCGCACTGATCGGTGGCC
TGTTTATCTCCAACCTGTCCGACCGATTCACCGAAAACGTCCCCGCAGCAGTGGCTTCCATGGGTGAAGAAGGCGCACAA
TACGCCTCAGCAATGTCCGATTTCTCCGGTGCATCCAACCTCACTCCACACCTTGTTGAATCACTTCCACAAGCACTCCG
TGAAGCAATTCAACTTTCTTACAACGACGCCCTGACACCAATCTTCTTGGCGCTCACCCCGATCGCAGTAGTCGCCGCGA
TCCTCCTCTTTTTCATCCGTGAAGATCACCTCAAGGAAACGCACGAATAA

Upstream 100 bases:

>100_bases
GTGAATGGCACGACATGCCACAAGGCACGCAAGCTGATTTCCAAGCCTGCTGTCGCAAAGCAATTAAAAATACTTTTCTT
CTTAGAGGTGGATTTTCAGA

Downstream 100 bases:

>100_bases
TGACACACGAAACTTCCGTCCCCGGACCTGCCGACGCGCAGGTCGCAGGAGATACGAAGCTGCGCAAAGGCCGCGCGAAG
AAGGAAAAAACTCCTTCATC

Product: major facilitator superfamily permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MTSQVKPDDERPVTTISKSGAPSAHTSAPYGAAATEEAVEEKTKGRVGFIIAALMLAMLLSSLGQTIFGSALPTIVGELG
GVNHMTWVITAFLLGQTISLPIFGKLGDQFGRKYLFMFAIALFVVGSIIGALAQNMTTLIVARALQGIAGGGLMILSQAI
TADVTTARERAKYMGIMGSVFGLSSILGPLLGGWFTDGPGWRWGLWLNVPIGIIALVAIAVLLKLPARERGKVSVDWLGS
IFMAIATTAFVLAVTWGGNEYEWASPMIIGLFITTLVAAIVFVFVEKRAVDPLVPMGLFSNRNFVLTAVAGIGVGLFMMG
TIAYMPTYLQMVHGLNPTQAGLMLIPMMIGLIGTSTVVGNIVSKTGKYKWYPFIGMLIMVLALVLLSTLTPSASLALIGL
YFFVFGFGLGCAMQILVLIVQNSFPITMVGTATGSNNFFRQIGGAVGSALIGGLFISNLSDRFTENVPAAVASMGEEGAQ
YASAMSDFSGASNLTPHLVESLPQALREAIQLSYNDALTPIFLALTPIAVVAAILLFFIREDHLKETHE

Sequences:

>Translated_549_residues
MTSQVKPDDERPVTTISKSGAPSAHTSAPYGAAATEEAVEEKTKGRVGFIIAALMLAMLLSSLGQTIFGSALPTIVGELG
GVNHMTWVITAFLLGQTISLPIFGKLGDQFGRKYLFMFAIALFVVGSIIGALAQNMTTLIVARALQGIAGGGLMILSQAI
TADVTTARERAKYMGIMGSVFGLSSILGPLLGGWFTDGPGWRWGLWLNVPIGIIALVAIAVLLKLPARERGKVSVDWLGS
IFMAIATTAFVLAVTWGGNEYEWASPMIIGLFITTLVAAIVFVFVEKRAVDPLVPMGLFSNRNFVLTAVAGIGVGLFMMG
TIAYMPTYLQMVHGLNPTQAGLMLIPMMIGLIGTSTVVGNIVSKTGKYKWYPFIGMLIMVLALVLLSTLTPSASLALIGL
YFFVFGFGLGCAMQILVLIVQNSFPITMVGTATGSNNFFRQIGGAVGSALIGGLFISNLSDRFTENVPAAVASMGEEGAQ
YASAMSDFSGASNLTPHLVESLPQALREAIQLSYNDALTPIFLALTPIAVVAAILLFFIREDHLKETHE
>Mature_548_residues
TSQVKPDDERPVTTISKSGAPSAHTSAPYGAAATEEAVEEKTKGRVGFIIAALMLAMLLSSLGQTIFGSALPTIVGELGG
VNHMTWVITAFLLGQTISLPIFGKLGDQFGRKYLFMFAIALFVVGSIIGALAQNMTTLIVARALQGIAGGGLMILSQAIT
ADVTTARERAKYMGIMGSVFGLSSILGPLLGGWFTDGPGWRWGLWLNVPIGIIALVAIAVLLKLPARERGKVSVDWLGSI
FMAIATTAFVLAVTWGGNEYEWASPMIIGLFITTLVAAIVFVFVEKRAVDPLVPMGLFSNRNFVLTAVAGIGVGLFMMGT
IAYMPTYLQMVHGLNPTQAGLMLIPMMIGLIGTSTVVGNIVSKTGKYKWYPFIGMLIMVLALVLLSTLTPSASLALIGLY
FFVFGFGLGCAMQILVLIVQNSFPITMVGTATGSNNFFRQIGGAVGSALIGGLFISNLSDRFTENVPAAVASMGEEGAQY
ASAMSDFSGASNLTPHLVESLPQALREAIQLSYNDALTPIFLALTPIAVVAAILLFFIREDHLKETHE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=420, Percent_Identity=29.5238095238095, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789042, Length=420, Percent_Identity=27.3809523809524, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788392, Length=316, Percent_Identity=33.5443037974684, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790195, Length=372, Percent_Identity=25.2688172043011, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI87081983, Length=396, Percent_Identity=25.5050505050505, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790146, Length=177, Percent_Identity=26.5536723163842, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323735, Length=327, Percent_Identity=32.4159021406728, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322958, Length=468, Percent_Identity=24.7863247863248, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6319770, Length=407, Percent_Identity=27.027027027027, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321663, Length=358, Percent_Identity=24.8603351955307, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325455, Length=314, Percent_Identity=25.1592356687898, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319783, Length=383, Percent_Identity=24.5430809399478, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324954, Length=340, Percent_Identity=25, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=230, Percent_Identity=27.3913043478261, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 58167; Mature: 58035

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQVKPDDERPVTTISKSGAPSAHTSAPYGAAATEEAVEEKTKGRVGFIIAALMLAMLL
CCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SSLGQTIFGSALPTIVGELGGVNHMTWVITAFLLGQTISLPIFGKLGDQFGRKYLFMFAI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ALFVVGSIIGALAQNMTTLIVARALQGIAGGGLMILSQAITADVTTARERAKYMGIMGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLSSILGPLLGGWFTDGPGWRWGLWLNVPIGIIALVAIAVLLKLPARERGKVSVDWLGS
HHHHHHHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHH
IFMAIATTAFVLAVTWGGNEYEWASPMIIGLFITTLVAAIVFVFVEKRAVDPLVPMGLFS
HHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NRNFVLTAVAGIGVGLFMMGTIAYMPTYLQMVHGLNPTQAGLMLIPMMIGLIGTSTVVGN
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IVSKTGKYKWYPFIGMLIMVLALVLLSTLTPSASLALIGLYFFVFGFGLGCAMQILVLIV
HHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNSFPITMVGTATGSNNFFRQIGGAVGSALIGGLFISNLSDRFTENVPAAVASMGEEGAQ
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHH
YASAMSDFSGASNLTPHLVESLPQALREAIQLSYNDALTPIFLALTPIAVVAAILLFFIR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EDHLKETHE
HHHHHHCCC
>Mature Secondary Structure 
TSQVKPDDERPVTTISKSGAPSAHTSAPYGAAATEEAVEEKTKGRVGFIIAALMLAMLL
CCCCCCCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SSLGQTIFGSALPTIVGELGGVNHMTWVITAFLLGQTISLPIFGKLGDQFGRKYLFMFAI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ALFVVGSIIGALAQNMTTLIVARALQGIAGGGLMILSQAITADVTTARERAKYMGIMGSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGLSSILGPLLGGWFTDGPGWRWGLWLNVPIGIIALVAIAVLLKLPARERGKVSVDWLGS
HHHHHHHHHHHCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHH
IFMAIATTAFVLAVTWGGNEYEWASPMIIGLFITTLVAAIVFVFVEKRAVDPLVPMGLFS
HHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NRNFVLTAVAGIGVGLFMMGTIAYMPTYLQMVHGLNPTQAGLMLIPMMIGLIGTSTVVGN
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
IVSKTGKYKWYPFIGMLIMVLALVLLSTLTPSASLALIGLYFFVFGFGLGCAMQILVLIV
HHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QNSFPITMVGTATGSNNFFRQIGGAVGSALIGGLFISNLSDRFTENVPAAVASMGEEGAQ
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHH
YASAMSDFSGASNLTPHLVESLPQALREAIQLSYNDALTPIFLALTPIAVVAAILLFFIR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EDHLKETHE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]