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The map label for this gene is sdhA [H]

Identifier: 62389269

GI number: 62389269

Start: 393495

End: 395516

Strand: Direct

Name: sdhA [H]

Synonym: cg0446

Alternate gene names: 62389269

Gene position: 393495-395516 (Clockwise)

Preceding gene: 62389268

Following gene: 62389270

Centisome position: 11.99

GC content: 59.74

Gene sequence:

>2022_bases
ATGAGCACTCACTCTGAAACCACCCGCCCAGAGTTCATCCACCCAGTCTCAGTCCTCCCAGAGGTCTCAGCTGGTACGGT
CCTTGACGCTGCAGAGCCAGCAGGCGTTCCCACCAAAGATATGTGGGAATACCAAAAAGACCACATGAACCTGGTCTCCC
CACTGAACCGACGCAAGTTCCGTGTCCTCGTCGTTGGCACCGGCCTGTCCGGTGGTGCTGCAGCAGCAGCCCTCGGCGAA
CTCGGATACGACGTCAAGGCGTTCACCTACCACGACGCACCTCGCCGTGCGCACTCCATTGCTGCACAGGGTGGCGTTAA
CTCCGCCCGCGGCAAGAAGGTAGACAACGACGGCGCATACCGCCACGTCAAGGACACCGTCAAGGGCGGCGACTACCGTG
GTCGCGAGTCCGACTGCTGGCGTCTCGCCGTCGAGTCCGTCCGCGTCATCGACCACATGAACGCCATCGGTGCACCATTC
GCCCGCGAATACGGTGGCGCCTTGGCAACCCGTTCCTTCGGTGGTGTGCAGGTCTCCCGTACCTACTACACCCGTGGACA
AACCGGACAGCAGCTGCAGCTCTCCACCGCATCCGCACTACAGCGCCAGATCCACCTCGGCTCCGTAGAAATCTTCACCC
ATAACGAAATGGTTGACGTCATTGTCACCGAACGTAACGGTGAAAAGCGCTGCGAAGGCCTGATCATGCGCAACCTGATC
ACCGGCGAGCTCACCGCACACACCGGCCATGCCGTTATCCTGGCAACCGGTGGCTACGGCAACGTGTACCACATGTCCAC
CCTGGCCAAGAACTCCAACGCCTCGGCCATCATGCGTGCATACGAAGCCGGCGCATACTTCGCGTCCCCATCGTTCATCC
AGTTCCACCCAACCGGCCTGCCTGTGAACTCCACCTGGCAGTCCAAGACCATTCTGATGTCCGAGTCGCTGCGTAACGAC
GGCCGCATCTGGTCCCCTAAGGAACCGAACGATAACCGCGATCCAAACACCATCCCTGAGGATGAGCGCGACTACTTCCT
GGAGCGCCGCTACCCAGCATTCGGTAACCTCGTCCCACGTGACGTTGCTTCCCGTGCGATCTCCCAGCAGATCAATGCTG
GTCTCGGTGTTGGACCTCTGAACAACGCTGCATACCTGGACTTCCGCGACGCCACCGAGCGCCTCGGACAGGACACCATC
CGCGAGCGTTACTCCAACCTCTTCACCATGTACGAAGAGGCAATTGGCGAGGACCCATACTCCAGCCCAATGCGTATTGC
ACCGACCTGCCACTTCACCATGGGTGGCCTCTGGACTGACTTCAACGAAATGACGTCACTCCCAGGTCTGTTCTGCGCAG
GCGAAGCATCCTGGACCTACCACGGTGCAAACCGTCTGGGCGCAAACTCCCTGCTCTCCGCTTCCGTCGATGGCTGGTTC
ACCCTGCCATTCACCATCCCTAACTACCTCGGCCCATTGCTTGGCTCCGAGCGTCTGTCAGAGGATGCACCAGAAGCACA
GGCAGCGATTGCGCGTGCACAGGCTCGCATTGACCGCCTCATGGGCAACCGCCCAGAGTGGGTCGGTGACAACGTTCACG
GACCTGAGTACTACCACCGCCAGCTTGGCGATATCCTGTACTTCTCCTGTGGCGTTTCCCGAAACGTAGAAGACCTCCAG
GATGGCATCAACAAGATCCGTGCCCTCCGCGATGACTTCTGGAAGAACATGCGCATCACCGGCAGCACCGATGAGATGAA
CCAGGTTCTCGAATACGCAGCACGCGTAGCCGACTACATCGACCTCGGCGAACTCATGTGTGTCGACGCCCTCGACCGCG
ACGAGTCCTGTGGCGCTCACTTCCGCGACGACCACCTCTCCGAAGATGGCGAAGCAGAACGTGACGACGAAAACTGGTGC
TTCGTCTCCGCATGGGAACCAGGCGAGAACGGAACCTTCGTCCGCCACGCAGAACCACTGTTCTTCGAATCCGTCCCACT
GCAGACAAGGAACTACAAGTAA

Upstream 100 bases:

>100_bases
GCAGTTGCGTACATCGTTCCTGCACTGGTCCTGATCGGCAACATCACCATTCCGTTCGCCATCGCTGTTGGCTGGATTGC
GTAAAGGTTAGGAAGAATTT

Downstream 100 bases:

>100_bases
TGAAACTTACACTTGAGATCTGGCGTCAAGCAGGCCCAACTGCGGAAGGCAAGTTCGAAACCGTCCAGGTTGACGACGCC
GTCGCGCAGATGTCCATCCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSTHSETTRPEFIHPVSVLPEVSAGTVLDAAEPAGVPTKDMWEYQKDHMNLVSPLNRRKFRVLVVGTGLSGGAAAAALGE
LGYDVKAFTYHDAPRRAHSIAAQGGVNSARGKKVDNDGAYRHVKDTVKGGDYRGRESDCWRLAVESVRVIDHMNAIGAPF
AREYGGALATRSFGGVQVSRTYYTRGQTGQQLQLSTASALQRQIHLGSVEIFTHNEMVDVIVTERNGEKRCEGLIMRNLI
TGELTAHTGHAVILATGGYGNVYHMSTLAKNSNASAIMRAYEAGAYFASPSFIQFHPTGLPVNSTWQSKTILMSESLRND
GRIWSPKEPNDNRDPNTIPEDERDYFLERRYPAFGNLVPRDVASRAISQQINAGLGVGPLNNAAYLDFRDATERLGQDTI
RERYSNLFTMYEEAIGEDPYSSPMRIAPTCHFTMGGLWTDFNEMTSLPGLFCAGEASWTYHGANRLGANSLLSASVDGWF
TLPFTIPNYLGPLLGSERLSEDAPEAQAAIARAQARIDRLMGNRPEWVGDNVHGPEYYHRQLGDILYFSCGVSRNVEDLQ
DGINKIRALRDDFWKNMRITGSTDEMNQVLEYAARVADYIDLGELMCVDALDRDESCGAHFRDDHLSEDGEAERDDENWC
FVSAWEPGENGTFVRHAEPLFFESVPLQTRNYK

Sequences:

>Translated_673_residues
MSTHSETTRPEFIHPVSVLPEVSAGTVLDAAEPAGVPTKDMWEYQKDHMNLVSPLNRRKFRVLVVGTGLSGGAAAAALGE
LGYDVKAFTYHDAPRRAHSIAAQGGVNSARGKKVDNDGAYRHVKDTVKGGDYRGRESDCWRLAVESVRVIDHMNAIGAPF
AREYGGALATRSFGGVQVSRTYYTRGQTGQQLQLSTASALQRQIHLGSVEIFTHNEMVDVIVTERNGEKRCEGLIMRNLI
TGELTAHTGHAVILATGGYGNVYHMSTLAKNSNASAIMRAYEAGAYFASPSFIQFHPTGLPVNSTWQSKTILMSESLRND
GRIWSPKEPNDNRDPNTIPEDERDYFLERRYPAFGNLVPRDVASRAISQQINAGLGVGPLNNAAYLDFRDATERLGQDTI
RERYSNLFTMYEEAIGEDPYSSPMRIAPTCHFTMGGLWTDFNEMTSLPGLFCAGEASWTYHGANRLGANSLLSASVDGWF
TLPFTIPNYLGPLLGSERLSEDAPEAQAAIARAQARIDRLMGNRPEWVGDNVHGPEYYHRQLGDILYFSCGVSRNVEDLQ
DGINKIRALRDDFWKNMRITGSTDEMNQVLEYAARVADYIDLGELMCVDALDRDESCGAHFRDDHLSEDGEAERDDENWC
FVSAWEPGENGTFVRHAEPLFFESVPLQTRNYK
>Mature_672_residues
STHSETTRPEFIHPVSVLPEVSAGTVLDAAEPAGVPTKDMWEYQKDHMNLVSPLNRRKFRVLVVGTGLSGGAAAAALGEL
GYDVKAFTYHDAPRRAHSIAAQGGVNSARGKKVDNDGAYRHVKDTVKGGDYRGRESDCWRLAVESVRVIDHMNAIGAPFA
REYGGALATRSFGGVQVSRTYYTRGQTGQQLQLSTASALQRQIHLGSVEIFTHNEMVDVIVTERNGEKRCEGLIMRNLIT
GELTAHTGHAVILATGGYGNVYHMSTLAKNSNASAIMRAYEAGAYFASPSFIQFHPTGLPVNSTWQSKTILMSESLRNDG
RIWSPKEPNDNRDPNTIPEDERDYFLERRYPAFGNLVPRDVASRAISQQINAGLGVGPLNNAAYLDFRDATERLGQDTIR
ERYSNLFTMYEEAIGEDPYSSPMRIAPTCHFTMGGLWTDFNEMTSLPGLFCAGEASWTYHGANRLGANSLLSASVDGWFT
LPFTIPNYLGPLLGSERLSEDAPEAQAAIARAQARIDRLMGNRPEWVGDNVHGPEYYHRQLGDILYFSCGVSRNVEDLQD
GINKIRALRDDFWKNMRITGSTDEMNQVLEYAARVADYIDLGELMCVDALDRDESCGAHFRDDHLSEDGEAERDDENWCF
VSAWEPGENGTFVRHAEPLFFESVPLQTRNYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=419, Percent_Identity=29.1169451073986, Blast_Score=149, Evalue=7e-36,
Organism=Escherichia coli, GI1790597, Length=560, Percent_Identity=29.4642857142857, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1786942, Length=603, Percent_Identity=27.6948590381426, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI1788928, Length=590, Percent_Identity=25.2542372881356, Blast_Score=129, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17505833, Length=561, Percent_Identity=27.807486631016, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17550100, Length=557, Percent_Identity=28.1867145421903, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322701, Length=602, Percent_Identity=28.7375415282392, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=612, Percent_Identity=27.9411764705882, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI17137288, Length=550, Percent_Identity=28, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24655642, Length=550, Percent_Identity=28, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24655647, Length=550, Percent_Identity=28, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24663005, Length=603, Percent_Identity=25.5389718076285, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 74680; Mature: 74549

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTHSETTRPEFIHPVSVLPEVSAGTVLDAAEPAGVPTKDMWEYQKDHMNLVSPLNRRKF
CCCCCCCCCCCCCCCHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
RVLVVGTGLSGGAAAAALGELGYDVKAFTYHDAPRRAHSIAAQGGVNSARGKKVDNDGAY
EEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCH
RHVKDTVKGGDYRGRESDCWRLAVESVRVIDHMNAIGAPFAREYGGALATRSFGGVQVSR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCCCCCEEEEE
TYYTRGQTGQQLQLSTASALQRQIHLGSVEIFTHNEMVDVIVTERNGEKRCEGLIMRNLI
EEEECCCCCCEEEHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHH
TGELTAHTGHAVILATGGYGNVYHMSTLAKNSNASAIMRAYEAGAYFASPSFIQFHPTGL
CCCEEECCCCEEEEEECCCCCEEEEHHHHCCCCHHHHHHHHHCCCEECCCCEEEECCCCC
PVNSTWQSKTILMSESLRNDGRIWSPKEPNDNRDPNTIPEDERDYFLERRYPAFGNLVPR
CCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHCCCCCH
DVASRAISQQINAGLGVGPLNNAAYLDFRDATERLGQDTIRERYSNLFTMYEEAIGEDPY
HHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
SSPMRIAPTCHFTMGGLWTDFNEMTSLPGLFCAGEASWTYHGANRLGANSLLSASVDGWF
CCCCEECCEEEEECCCCCCCHHHHHCCCCEEEECCCCEEECCCCCCCCHHHHHCCCCCEE
TLPFTIPNYLGPLLGSERLSEDAPEAQAAIARAQARIDRLMGNRPEWVGDNVHGPEYYHR
EECEECHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QLGDILYFSCGVSRNVEDLQDGINKIRALRDDFWKNMRITGSTDEMNQVLEYAARVADYI
HHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHH
DLGELMCVDALDRDESCGAHFRDDHLSEDGEAERDDENWCFVSAWEPGENGTFVRHAEPL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCC
FFESVPLQTRNYK
EEECCCCCCCCCC
>Mature Secondary Structure 
STHSETTRPEFIHPVSVLPEVSAGTVLDAAEPAGVPTKDMWEYQKDHMNLVSPLNRRKF
CCCCCCCCCCCCCCHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
RVLVVGTGLSGGAAAAALGELGYDVKAFTYHDAPRRAHSIAAQGGVNSARGKKVDNDGAY
EEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCH
RHVKDTVKGGDYRGRESDCWRLAVESVRVIDHMNAIGAPFAREYGGALATRSFGGVQVSR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHCCCCCCEEEEE
TYYTRGQTGQQLQLSTASALQRQIHLGSVEIFTHNEMVDVIVTERNGEKRCEGLIMRNLI
EEEECCCCCCEEEHHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHH
TGELTAHTGHAVILATGGYGNVYHMSTLAKNSNASAIMRAYEAGAYFASPSFIQFHPTGL
CCCEEECCCCEEEEEECCCCCEEEEHHHHCCCCHHHHHHHHHCCCEECCCCEEEECCCCC
PVNSTWQSKTILMSESLRNDGRIWSPKEPNDNRDPNTIPEDERDYFLERRYPAFGNLVPR
CCCCCCCCCEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHCCCCCH
DVASRAISQQINAGLGVGPLNNAAYLDFRDATERLGQDTIRERYSNLFTMYEEAIGEDPY
HHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
SSPMRIAPTCHFTMGGLWTDFNEMTSLPGLFCAGEASWTYHGANRLGANSLLSASVDGWF
CCCCEECCEEEEECCCCCCCHHHHHCCCCEEEECCCCEEECCCCCCCCHHHHHCCCCCEE
TLPFTIPNYLGPLLGSERLSEDAPEAQAAIARAQARIDRLMGNRPEWVGDNVHGPEYYHR
EECEECHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
QLGDILYFSCGVSRNVEDLQDGINKIRALRDDFWKNMRITGSTDEMNQVLEYAARVADYI
HHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHH
DLGELMCVDALDRDESCGAHFRDDHLSEDGEAERDDENWCFVSAWEPGENGTFVRHAEPL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEECCCC
FFESVPLQTRNYK
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]