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The map label for this gene is lpd [H]

Identifier: 62389264

GI number: 62389264

Start: 387693

End: 389102

Strand: Direct

Name: lpd [H]

Synonym: cg0441

Alternate gene names: 62389264

Gene position: 387693-389102 (Clockwise)

Preceding gene: 62389262

Following gene: 62389265

Centisome position: 11.81

GC content: 49.93

Gene sequence:

>1410_bases
GTGACTGAACATTATGACGTAGTAGTACTCGGAGCCGGCCCCGGTGGCTATGTCTCCGCCATCCGTGCAGCGCAGCTTGG
CAAGAAGGTTGCTGTAATTGAGAAGCAGTACTGGGGTGGTGTTTGCCTAAACGTGGGCTGCATTCCTTCCAAGTCTCTGA
TCAAAAACGCTGAAGTTGCCCATACCTTTACCCATGAGAAGAAGACCTTCGGCATCAATGGCGAAGTGACCTTCAACTAT
GAGGATGCTCACAAGCGTTCCCGTGGCGTTTCCGACAAGATCGTTGGAGGCGTTCATTACTTGATGAAGAAGAACAAGAT
CATCGAAATTCATGGTCTTGGAAACTTCAAGGATGCTAAGACTCTTGAGGTCACCGACGGTAAGGATGCTGGCAAGACCA
TCACCTTTGATGACTGCATCATCGCAACCGGTTCGGTAGTCAACACCCTCCGTGGCGTTGACTTCTCAGAGAACGTTGTG
TCTTTTGAAGAGCAGATTCTTAACCCTGTTGCGCCAAAGAAGATGGTCATTGTTGGTGCAGGCGCAATTGGAATGGAATT
CGCCTACGTTCTTGGTAACTACGGTGTAGATGTAACCGTCATCGAGTTCATGGATCGTGTGCTTCCAAATGAAGATGCTG
AAGTCTCCAAGGTTATTGCAAAGGCCTACAAGAAGATGGGCGTTAAGCTTCTTCCTGGCCATGCAACCACTGCTGTTCGG
GACAACGGTGACTTTGTCGAGGTTGATTACCAGAAGAAGGGCTCTGACAAGACAGAGACTCTTACTGTTGATCGAGTCAT
GGTTTCCGTTGGTTTCCGTCCACGCGTTGAGGGATTTGGTCTTGAAAACACTGGCGTTAAGCTCACCGAGCGTGGCGCAA
TCGAGATCGATGATTACATGCGTACCAACGTCGATGGCATTTACGCCATCGGTGACGTGACCGCCAAGCTTCAGCTTGCT
CACGTCGCAGAAGCACAGGGCATTGTTGCCGCAGAGACTATTGCTGGTGCAGAAACTCAGACTCTTGGTGATTACATGAT
GATGCCACGTGCAACCTTCTGCAACCCACAGGTTTCTTCCTTTGGTTACACCGAAGAGCAGGCCAAGGAGAAGTGGCCAG
ATCGTGAGATCAAGGTTGCTTCCTTCCCATTCTCTGCAAACGGTAAAGCAGTTGGCCTGGCAGAAACTGATGGTTTCGCA
AAGATCGTTGCTGATGCAGAATTCGGTGAGCTGCTCGGTGCACACCTGGTTGGAGCAAATGCATCAGAGCTCATCAATGA
ATTGGTGCTTGCTCAGAACTGGGATCTCACCACTGAAGAGATCTCTCGTAGCGTCCATATTCACCCAACGCTATCTGAGG
CAGTTAAGGAAGCTGCACACGGTATCTCTGGACACATGATCAACTTCTAG

Upstream 100 bases:

>100_bases
GTGGGTGTTTTTCATTTTCTTCCACTCTAAAATTAAGTATGGAAAACCAACCGCACCCGGATGCACGACAATGACCCACT
AAACACGTATCCTTGAATGC

Downstream 100 bases:

>100_bases
AATCCACCTCGTTGGCCCTGTTTCTGTATGGAAACAGGGCCAAAACCGATTTTCAATCCAAACCGAGTGCTGGTTAGTGC
TCATACTCACACAAACTTTT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGVCLNVGCIPSKSLIKNAEVAHTFTHEKKTFGINGEVTFNY
EDAHKRSRGVSDKIVGGVHYLMKKNKIIEIHGLGNFKDAKTLEVTDGKDAGKTITFDDCIIATGSVVNTLRGVDFSENVV
SFEEQILNPVAPKKMVIVGAGAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
DNGDFVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIEIDDYMRTNVDGIYAIGDVTAKLQLA
HVAEAQGIVAAETIAGAETQTLGDYMMMPRATFCNPQVSSFGYTEEQAKEKWPDREIKVASFPFSANGKAVGLAETDGFA
KIVADAEFGELLGAHLVGANASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF

Sequences:

>Translated_469_residues
MTEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGVCLNVGCIPSKSLIKNAEVAHTFTHEKKTFGINGEVTFNY
EDAHKRSRGVSDKIVGGVHYLMKKNKIIEIHGLGNFKDAKTLEVTDGKDAGKTITFDDCIIATGSVVNTLRGVDFSENVV
SFEEQILNPVAPKKMVIVGAGAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
DNGDFVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIEIDDYMRTNVDGIYAIGDVTAKLQLA
HVAEAQGIVAAETIAGAETQTLGDYMMMPRATFCNPQVSSFGYTEEQAKEKWPDREIKVASFPFSANGKAVGLAETDGFA
KIVADAEFGELLGAHLVGANASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF
>Mature_468_residues
TEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGVCLNVGCIPSKSLIKNAEVAHTFTHEKKTFGINGEVTFNYE
DAHKRSRGVSDKIVGGVHYLMKKNKIIEIHGLGNFKDAKTLEVTDGKDAGKTITFDDCIIATGSVVNTLRGVDFSENVVS
FEEQILNPVAPKKMVIVGAGAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVRD
NGDFVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIEIDDYMRTNVDGIYAIGDVTAKLQLAH
VAEAQGIVAAETIAGAETQTLGDYMMMPRATFCNPQVSSFGYTEEQAKEKWPDREIKVASFPFSANGKAVGLAETDGFAK
IVADAEFGELLGAHLVGANASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=472, Percent_Identity=38.5593220338983, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=29.5258620689655, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI291045266, Length=454, Percent_Identity=27.0925110132159, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI33519430, Length=452, Percent_Identity=27.4336283185841, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI33519428, Length=452, Percent_Identity=27.4336283185841, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI33519426, Length=452, Percent_Identity=27.4336283185841, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI148277065, Length=452, Percent_Identity=27.4336283185841, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI148277071, Length=452, Percent_Identity=27.4336283185841, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI291045268, Length=453, Percent_Identity=26.0485651214128, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI22035672, Length=462, Percent_Identity=27.0562770562771, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1786307, Length=466, Percent_Identity=34.7639484978541, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789915, Length=456, Percent_Identity=30.9210526315789, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=27.4509803921569, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=27.3706896551724, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=37.1739130434783, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=27.027027027027, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=28.4444444444444, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=28.4444444444444, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71982272, Length=476, Percent_Identity=24.7899159663866, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559934, Length=197, Percent_Identity=34.010152284264, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=37.4468085106383, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=28.997867803838, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=27.906976744186, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21358499, Length=476, Percent_Identity=39.2857142857143, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=28.781512605042, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=28.781512605042, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=28.781512605042, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=28, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50652; Mature: 50521

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGVCLNVGCIPSKSLIKNAEVA
CCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEHHCCCCEEEEECCCCCHHHHCCCHHH
HTFTHEKKTFGINGEVTFNYEDAHKRSRGVSDKIVGGVHYLMKKNKIIEIHGLGNFKDAK
EEECCCCEEECCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC
TLEVTDGKDAGKTITFDDCIIATGSVVNTLRGVDFSENVVSFEEQILNPVAPKKMVIVGA
EEEEECCCCCCCEEEECCEEEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
CHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEE
DNGDFVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIEIDDYM
CCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEECHHH
RTNVDGIYAIGDVTAKLQLAHVAEAQGIVAAETIAGAETQTLGDYMMMPRATFCNPQVSS
HCCCCCEEEECCCEEEEEEEHHHHHCCCEEEHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
FGYTEEQAKEKWPDREIKVASFPFSANGKAVGLAETDGFAKIVADAEFGELLGAHLVGAN
CCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCC
ASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF
HHHHHHHHHHHCCCCCCHHHHCCEEEECCCHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure 
TEHYDVVVLGAGPGGYVSAIRAAQLGKKVAVIEKQYWGGVCLNVGCIPSKSLIKNAEVA
CCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEEHHCCCCEEEEECCCCCHHHHCCCHHH
HTFTHEKKTFGINGEVTFNYEDAHKRSRGVSDKIVGGVHYLMKKNKIIEIHGLGNFKDAK
EEECCCCEEECCCCEEEEEEHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC
TLEVTDGKDAGKTITFDDCIIATGSVVNTLRGVDFSENVVSFEEQILNPVAPKKMVIVGA
EEEEECCCCCCCEEEECCEEEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GAIGMEFAYVLGNYGVDVTVIEFMDRVLPNEDAEVSKVIAKAYKKMGVKLLPGHATTAVR
CHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEE
DNGDFVEVDYQKKGSDKTETLTVDRVMVSVGFRPRVEGFGLENTGVKLTERGAIEIDDYM
CCCCEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEECHHH
RTNVDGIYAIGDVTAKLQLAHVAEAQGIVAAETIAGAETQTLGDYMMMPRATFCNPQVSS
HCCCCCEEEECCCEEEEEEEHHHHHCCCEEEHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
FGYTEEQAKEKWPDREIKVASFPFSANGKAVGLAETDGFAKIVADAEFGELLGAHLVGAN
CCCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHCCCC
ASELINELVLAQNWDLTTEEISRSVHIHPTLSEAVKEAAHGISGHMINF
HHHHHHHHHHHCCCCCCHHHHCCEEEECCCHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]