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The map label for this gene is capD [H]

Identifier: 62389245

GI number: 62389245

Start: 366833

End: 368647

Strand: Direct

Name: capD [H]

Synonym: cg0417

Alternate gene names: 62389245

Gene position: 366833-368647 (Clockwise)

Preceding gene: 62389244

Following gene: 62389246

Centisome position: 11.17

GC content: 47.82

Gene sequence:

>1815_bases
ATGGCAATAAGCATTGGTAAAGCAGGACAGAACTTAAAAGGGTCAGTGCCTATCGGAAAAGTCCTTTTTCTCATTGATGC
CCTTGCCTGGATTTCTGCACTATTTATCGGTGTGGTTTTGCGGTATGAATTCAATCTGAGTTCTATCAACTGGAGTGCGT
TTGCATGGTTCGGGCTTGCTGCAGTTATTTTGCAGTTTGTTCTCGGACTTTCTCTCCATCTTTACCGCAAGGGATTACGT
CACCTTTTCGGTAGCTTCGAAGATACACTAAACGTTTCTATCTCGGTCATTGTTGTCGGTGTTGTCCTTTGGATCGCCTC
ACTATTTGTTGGTCAGCGTTGGGAAATCTCACGCGGTGTCATGCTGCTAGTTATCCCGCTTGCTCTCGTATTCGTATTGG
CAGTGCGTTATCTCGCGCGTATGCGAGTTGAGCGTCTTCGTCGTCCGGCTGCGGATTCCACACCAGCATTGATTCTTGGT
GGTGGATACATCGGTACCAACCTGATCCAGTGGATGATGTCCGATCCTAAGTCGCCTTTCCGCCCAGTCGGCGTTATTGA
TGATAACCCTGAATTAGCATGGCAACGCGTACGTGGTGTGCCGGTTCTTGGCAAGTTTGATGATATCGCCCAAGTTGCAT
CAGACACTGGCGCAGAACTTCTTATCGTTGCTATTGGTGATGCCGACTCTGCACTTTTAAGGCGTGTCCAAGATACCGCT
AATAAAAATGGTCTTTCAGTAAAGGTAATGCCGGCTATTGACCGCGTCGTTTCTAAGGGCGTTCGTGGAAACGATTTGCG
TGATCTCTCTATTGAAGATTTGCTTGGACGTCAACCTGTTGAAACCAATGTTTCAGAAATTACTGGCTATCTAACAGGTA
AGCGTGTTCTTGTTACCGGTGCAGGTGGGTCAATTGGTTCCCAGCTATGTACGGAAATTGCCAAATACGGACCTGCTGAG
CTTATGATGCTTGATCGCGATGAGACTGGTTTGCAGCAGGTTCTGATTAACGTTGCTGGTAACGGTTTGTTGGATACGGA
TGCTGTGGTTCTTGCGGATATCCGCGAAGCAGACGCGATGAAAGAGATTTTTCTCAAGCGTAAACCAGAAGTTGTCTTCC
ATGCAGCAGCATTAAAGCACTTGCCAATGCTGGAGCAGTATCCAGATGAGGGCTGGAAAACAAACGTTCTAGGAACTCTT
AACGTTCTTGCTGCCGCAGAAGCTGTTGGTGTTGAGACTTTCGTCAATATTTCCACCGATAAGGCAGCTAATCCAACCAG
CGTCTTAGGGCACTCAAAGCGAGTCGCTGAAAAGCTGACTGCCTGGTATGGACAGAATTCCACCAGCAAGTACCTATCGG
TTCGATTTGGAAACGTCATTGGTAGCCGTGGATCGATGCTCCCGACTTTCACCAGGCTAATCATGGAAGATAAACCGCTA
ACAGTGACGCACCCGGATGTCACTAGGTTCTTCATGACAATTCCTGAAGCTTGCCAATTGGTCCTGCAAGCCGGTGGTAT
TGGACGTTCCGGCGAGGTTCTCATCCTTGACATGGGTGAGCCTGTAAGCATCCTTGAAATTGCACAGCGCATGATCGCAA
TGTCCGGTAAAGATATTGACATCGTGTTCACCGGCCTTCGCGAGGGCGAAAAGATGCACGAAGAGCTGGTTGGTGATGGT
GAAACCGAAGATCGTCCATTCCACTCAAAGATTTCGCATGCACATGCAGAAAGCCTCGCTCCTAATAATCTCGATAGAGA
TCGATTTATGCAACGTGCTGGAAAACTAGCTTCAACAGATTCGGAGATCATCTAA

Upstream 100 bases:

>100_bases
GTGAATCCGATGCCGGACAGATCGCAGCAACTCAATTTGGAGATTCAGTTTTAGCCTGGGTTGGCGAAACCCAATTTATT
TCAAAAGATGGTGGACAAAC

Downstream 100 bases:

>100_bases
ATGACTAATGAACGAATTTTTCTATCATCGCCAGATGTAACACAGTTAGAGGAAGACGCATTGGTACGCGCAATCCGATC
AGGATGGATTGCACCGCTTG

Product: dTDP-glucose 4,6-dehydratase transmembrane protein

Products: UDPglucoseal [C]

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MAISIGKAGQNLKGSVPIGKVLFLIDALAWISALFIGVVLRYEFNLSSINWSAFAWFGLAAVILQFVLGLSLHLYRKGLR
HLFGSFEDTLNVSISVIVVGVVLWIASLFVGQRWEISRGVMLLVIPLALVFVLAVRYLARMRVERLRRPAADSTPALILG
GGYIGTNLIQWMMSDPKSPFRPVGVIDDNPELAWQRVRGVPVLGKFDDIAQVASDTGAELLIVAIGDADSALLRRVQDTA
NKNGLSVKVMPAIDRVVSKGVRGNDLRDLSIEDLLGRQPVETNVSEITGYLTGKRVLVTGAGGSIGSQLCTEIAKYGPAE
LMMLDRDETGLQQVLINVAGNGLLDTDAVVLADIREADAMKEIFLKRKPEVVFHAAALKHLPMLEQYPDEGWKTNVLGTL
NVLAAAEAVGVETFVNISTDKAANPTSVLGHSKRVAEKLTAWYGQNSTSKYLSVRFGNVIGSRGSMLPTFTRLIMEDKPL
TVTHPDVTRFFMTIPEACQLVLQAGGIGRSGEVLILDMGEPVSILEIAQRMIAMSGKDIDIVFTGLREGEKMHEELVGDG
ETEDRPFHSKISHAHAESLAPNNLDRDRFMQRAGKLASTDSEII

Sequences:

>Translated_604_residues
MAISIGKAGQNLKGSVPIGKVLFLIDALAWISALFIGVVLRYEFNLSSINWSAFAWFGLAAVILQFVLGLSLHLYRKGLR
HLFGSFEDTLNVSISVIVVGVVLWIASLFVGQRWEISRGVMLLVIPLALVFVLAVRYLARMRVERLRRPAADSTPALILG
GGYIGTNLIQWMMSDPKSPFRPVGVIDDNPELAWQRVRGVPVLGKFDDIAQVASDTGAELLIVAIGDADSALLRRVQDTA
NKNGLSVKVMPAIDRVVSKGVRGNDLRDLSIEDLLGRQPVETNVSEITGYLTGKRVLVTGAGGSIGSQLCTEIAKYGPAE
LMMLDRDETGLQQVLINVAGNGLLDTDAVVLADIREADAMKEIFLKRKPEVVFHAAALKHLPMLEQYPDEGWKTNVLGTL
NVLAAAEAVGVETFVNISTDKAANPTSVLGHSKRVAEKLTAWYGQNSTSKYLSVRFGNVIGSRGSMLPTFTRLIMEDKPL
TVTHPDVTRFFMTIPEACQLVLQAGGIGRSGEVLILDMGEPVSILEIAQRMIAMSGKDIDIVFTGLREGEKMHEELVGDG
ETEDRPFHSKISHAHAESLAPNNLDRDRFMQRAGKLASTDSEII
>Mature_603_residues
AISIGKAGQNLKGSVPIGKVLFLIDALAWISALFIGVVLRYEFNLSSINWSAFAWFGLAAVILQFVLGLSLHLYRKGLRH
LFGSFEDTLNVSISVIVVGVVLWIASLFVGQRWEISRGVMLLVIPLALVFVLAVRYLARMRVERLRRPAADSTPALILGG
GYIGTNLIQWMMSDPKSPFRPVGVIDDNPELAWQRVRGVPVLGKFDDIAQVASDTGAELLIVAIGDADSALLRRVQDTAN
KNGLSVKVMPAIDRVVSKGVRGNDLRDLSIEDLLGRQPVETNVSEITGYLTGKRVLVTGAGGSIGSQLCTEIAKYGPAEL
MMLDRDETGLQQVLINVAGNGLLDTDAVVLADIREADAMKEIFLKRKPEVVFHAAALKHLPMLEQYPDEGWKTNVLGTLN
VLAAAEAVGVETFVNISTDKAANPTSVLGHSKRVAEKLTAWYGQNSTSKYLSVRFGNVIGSRGSMLPTFTRLIMEDKPLT
VTHPDVTRFFMTIPEACQLVLQAGGIGRSGEVLILDMGEPVSILEIAQRMIAMSGKDIDIVFTGLREGEKMHEELVGDGE
TEDRPFHSKISHAHAESLAPNNLDRDRFMQRAGKLASTDSEII

Specific function: Involved in biofilm formation [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=260, Percent_Identity=23.8461538461538, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 5.1.3.2 [C]

Molecular weight: Translated: 65760; Mature: 65629

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISIGKAGQNLKGSVPIGKVLFLIDALAWISALFIGVVLRYEFNLSSINWSAFAWFGLA
CEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
AVILQFVLGLSLHLYRKGLRHLFGSFEDTLNVSISVIVVGVVLWIASLFVGQRWEISRGV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
MLLVIPLALVFVLAVRYLARMRVERLRRPAADSTPALILGGGYIGTNLIQWMMSDPKSPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCC
RPVGVIDDNPELAWQRVRGVPVLGKFDDIAQVASDTGAELLIVAIGDADSALLRRVQDTA
CCCCEECCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHC
NKNGLSVKVMPAIDRVVSKGVRGNDLRDLSIEDLLGRQPVETNVSEITGYLTGKRVLVTG
CCCCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEE
AGGSIGSQLCTEIAKYGPAELMMLDRDETGLQQVLINVAGNGLLDTDAVVLADIREADAM
CCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KEIFLKRKPEVVFHAAALKHLPMLEQYPDEGWKTNVLGTLNVLAAAEAVGVETFVNISTD
HHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHEEEECCC
KAANPTSVLGHSKRVAEKLTAWYGQNSTSKYLSVRFGNVIGSRGSMLPTFTRLIMEDKPL
CCCCCHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECHHHCCCCCHHHHHHHHHHCCCCC
TVTHPDVTRFFMTIPEACQLVLQAGGIGRSGEVLILDMGEPVSILEIAQRMIAMSGKDID
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEE
IVFTGLREGEKMHEELVGDGETEDRPFHSKISHAHAESLAPNNLDRDRFMQRAGKLASTD
EEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
SEII
CCCC
>Mature Secondary Structure 
AISIGKAGQNLKGSVPIGKVLFLIDALAWISALFIGVVLRYEFNLSSINWSAFAWFGLA
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
AVILQFVLGLSLHLYRKGLRHLFGSFEDTLNVSISVIVVGVVLWIASLFVGQRWEISRGV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
MLLVIPLALVFVLAVRYLARMRVERLRRPAADSTPALILGGGYIGTNLIQWMMSDPKSPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCC
RPVGVIDDNPELAWQRVRGVPVLGKFDDIAQVASDTGAELLIVAIGDADSALLRRVQDTA
CCCCEECCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHC
NKNGLSVKVMPAIDRVVSKGVRGNDLRDLSIEDLLGRQPVETNVSEITGYLTGKRVLVTG
CCCCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEE
AGGSIGSQLCTEIAKYGPAELMMLDRDETGLQQVLINVAGNGLLDTDAVVLADIREADAM
CCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KEIFLKRKPEVVFHAAALKHLPMLEQYPDEGWKTNVLGTLNVLAAAEAVGVETFVNISTD
HHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHEEEECCC
KAANPTSVLGHSKRVAEKLTAWYGQNSTSKYLSVRFGNVIGSRGSMLPTFTRLIMEDKPL
CCCCCHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECHHHCCCCCHHHHHHHHHHCCCCC
TVTHPDVTRFFMTIPEACQLVLQAGGIGRSGEVLILDMGEPVSILEIAQRMIAMSGKDID
EEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEE
IVFTGLREGEKMHEELVGDGETEDRPFHSKISHAHAESLAPNNLDRDRFMQRAGKLASTD
EEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
SEII
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 57600 [C]

Specific activity: 233.3

Km value (mM): 0.256 {UDPgalactose}} 0.225 {UDPgalactose}} 0.2 {UDPgalactose}} 0.18 {UDPgalactose}} 0.16 {UDPgalactose}} 0.14 {UDPgalactose}} 0.048 {UDPgalactose}} 0.026 {UDPgalactose}} [C]

Substrates: UDPglucose [C]

Specific reaction: UDPglucose <==> UDPglucoseal [C]

General reaction: Epimerization (specificity for carbon forming a hexosulose) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969506; 9384377 [H]