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The map label for this gene is cobB1 [H]

Identifier: 62388974

GI number: 62388974

Start: 86412

End: 87245

Strand: Direct

Name: cobB1 [H]

Synonym: cg0108

Alternate gene names: 62388974

Gene position: 86412-87245 (Clockwise)

Preceding gene: 62388969

Following gene: 62388977

Centisome position: 2.63

GC content: 59.59

Gene sequence:

>834_bases
GTGGCGAGGGTGGGCGTCGTAAAGCAATTAAAGGCCGGGAACGTGCTGGCGGTGACTGGGGCTGGGGTGTCGACGGACTC
GGGCATCCCTGATTATCGCGGCCCGAAGGGCAGCTTGAGCAGGCATCGGCCGATGACGTACCAGGAGTTTCGGCATGATC
CGGCGGCGTCGCATCGCTATTGGGCGCGGTCGTTTGTGGGGTGGCGGGTGATGGATCAGGCGCGGCCGAATCGAACGCAC
TACGCCATGGTTGAGCTGGAGCAGCATGGTTTTTTAAGTGGTGTGGTCACCCAAAATGTCGATGGTTTACACGCGGAAGC
AGGCACGAAAAACCTGGTCGCGCTGCATGGTGATCTCGCCCATGTGATGTGTTTGAACTGCGGTTTCGGGGAGGATCGAC
ACCTCTTTGATGAACGTCTCGAAGCCGCCAACCCCGGCTACGTCGCTTCCATTCGCCTGGAACCGGGCGCAGTCAACCCC
GACGGCGACGTCTTCCTCGACGAAGAACAAGTACGCCGCTTCACCATGATCGGCTGCTTGCGCTGCGGCTCGCTCATGCT
CAAACCAGACGTGGTTTACTTCGGCGAACCCGTGCCCGCCGCGCGCAAAAAAGATTTAAAAAAGCTTCTCGACGCCTCCT
CCAGCCTCTTAATCGCCGGCTCCTCCCTAGCCGTCATGAGTGGATACCGGATCGTCATCGAAGCGCAACGTCAAGGAAAA
CAAGTGTCTGTCATCAACGGCGGCCCAGGTCGGGCGGATTCCCGCGTGGACATTTTGTGGCGCACCCGCGTTGCACCGGC
CTTTGATGACATTTTGGACGCGCTGGACCTTTAG

Upstream 100 bases:

>100_bases
TAGGGGAGTGTTTGATGAACTCACTGCTCGTGCCCACAATTCAGCGCTGAGGTCTATTGCTCGCGTCGTCGCGGAGACGG
TAGAGCCAATGGGGGAGGAT

Downstream 100 bases:

>100_bases
ACTTTTGGTGGCTTAAGTTCGATTTCACGGTACCGATTTCGCAAGTTCGGTACCTTGCGCTCAATTTCTCAACGGCGATT
TCGGTTTTTGGTGGTTTTCC

Product: SIR2-like regulatory protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MARVGVVKQLKAGNVLAVTGAGVSTDSGIPDYRGPKGSLSRHRPMTYQEFRHDPAASHRYWARSFVGWRVMDQARPNRTH
YAMVELEQHGFLSGVVTQNVDGLHAEAGTKNLVALHGDLAHVMCLNCGFGEDRHLFDERLEAANPGYVASIRLEPGAVNP
DGDVFLDEEQVRRFTMIGCLRCGSLMLKPDVVYFGEPVPAARKKDLKKLLDASSSLLIAGSSLAVMSGYRIVIEAQRQGK
QVSVINGGPGRADSRVDILWRTRVAPAFDDILDALDL

Sequences:

>Translated_277_residues
MARVGVVKQLKAGNVLAVTGAGVSTDSGIPDYRGPKGSLSRHRPMTYQEFRHDPAASHRYWARSFVGWRVMDQARPNRTH
YAMVELEQHGFLSGVVTQNVDGLHAEAGTKNLVALHGDLAHVMCLNCGFGEDRHLFDERLEAANPGYVASIRLEPGAVNP
DGDVFLDEEQVRRFTMIGCLRCGSLMLKPDVVYFGEPVPAARKKDLKKLLDASSSLLIAGSSLAVMSGYRIVIEAQRQGK
QVSVINGGPGRADSRVDILWRTRVAPAFDDILDALDL
>Mature_276_residues
ARVGVVKQLKAGNVLAVTGAGVSTDSGIPDYRGPKGSLSRHRPMTYQEFRHDPAASHRYWARSFVGWRVMDQARPNRTHY
AMVELEQHGFLSGVVTQNVDGLHAEAGTKNLVALHGDLAHVMCLNCGFGEDRHLFDERLEAANPGYVASIRLEPGAVNPD
GDVFLDEEQVRRFTMIGCLRCGSLMLKPDVVYFGEPVPAARKKDLKKLLDASSSLLIAGSSLAVMSGYRIVIEAQRQGKQ
VSVINGGPGRADSRVDILWRTRVAPAFDDILDALDL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=255, Percent_Identity=42.3529411764706, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI13787215, Length=252, Percent_Identity=30.1587301587302, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI6912664, Length=252, Percent_Identity=30.1587301587302, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI300795542, Length=254, Percent_Identity=29.1338582677165, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI7657575, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI300797577, Length=119, Percent_Identity=39.4957983193277, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI300797597, Length=119, Percent_Identity=39.4957983193277, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI308199517, Length=123, Percent_Identity=36.5853658536585, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71990482, Length=256, Percent_Identity=37.890625, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17567771, Length=271, Percent_Identity=37.2693726937269, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71990487, Length=258, Percent_Identity=37.5968992248062, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17541892, Length=223, Percent_Identity=27.3542600896861, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325242, Length=255, Percent_Identity=25.8823529411765, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571445, Length=267, Percent_Identity=40.0749063670412, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28571443, Length=225, Percent_Identity=38.2222222222222, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28571441, Length=225, Percent_Identity=38.2222222222222, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24645650, Length=119, Percent_Identity=39.4957983193277, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17137536, Length=241, Percent_Identity=26.1410788381743, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30293; Mature: 30162

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVGVVKQLKAGNVLAVTGAGVSTDSGIPDYRGPKGSLSRHRPMTYQEFRHDPAASHRY
CCCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHH
WARSFVGWRVMDQARPNRTHYAMVELEQHGFLSGVVTQNVDGLHAEAGTKNLVALHGDLA
HHHHHHCEEEHHHCCCCCCEEEEEEEECCCCEEEHHHCCCCCCCCCCCCCCEEEEECCEE
HVMCLNCGFGEDRHLFDERLEAANPGYVASIRLEPGAVNPDGDVFLDEEQVRRFTMIGCL
EEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHH
RCGSLMLKPDVVYFGEPVPAARKKDLKKLLDASSSLLIAGSSLAVMSGYRIVIEAQRQGK
HHCCEEECCCEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCCEEEEEECCCCC
QVSVINGGPGRADSRVDILWRTRVAPAFDDILDALDL
EEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ARVGVVKQLKAGNVLAVTGAGVSTDSGIPDYRGPKGSLSRHRPMTYQEFRHDPAASHRY
CCCCCHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHH
WARSFVGWRVMDQARPNRTHYAMVELEQHGFLSGVVTQNVDGLHAEAGTKNLVALHGDLA
HHHHHHCEEEHHHCCCCCCEEEEEEEECCCCEEEHHHCCCCCCCCCCCCCCEEEEECCEE
HVMCLNCGFGEDRHLFDERLEAANPGYVASIRLEPGAVNPDGDVFLDEEQVRRFTMIGCL
EEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHH
RCGSLMLKPDVVYFGEPVPAARKKDLKKLLDASSSLLIAGSSLAVMSGYRIVIEAQRQGK
HHCCEEECCCEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCCEEEEEECCCCC
QVSVINGGPGRADSRVDILWRTRVAPAFDDILDALDL
EEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]