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The map label for this gene is clcB [H]

Identifier: 62388958

GI number: 62388958

Start: 64163

End: 65461

Strand: Direct

Name: clcB [H]

Synonym: cg0082

Alternate gene names: 62388958

Gene position: 64163-65461 (Clockwise)

Preceding gene: 62388955

Following gene: 62388960

Centisome position: 1.95

GC content: 58.58

Gene sequence:

>1299_bases
GTGTTGCGCGTGCCAAATCGAGTTCCTGTGTCAACCATTCCGCTGAATCGTCTAGCCGTTATCGCTGCCATCATTGGTGT
CGGTACCGGGCTGTTTGTTGCTGCACTGAACTGGTCTGCCATTGGCGTGGAGCGTTTAGTTTATGGCGCTGACCATTTGC
ATAATTACAATCCGGTGGCCAATGTGTCGCCACTTCGCCTGTCCATCACGGTGATTGTGCTTAGCGTGGTGGCCTCCTGG
GCGTGGTTTTTTGTGCACCGCACGGGGCCGAAAGAGGTTTCGATTGTGGGTGCGATCCGGGGCGAGAAGATGCCGATTTT
GGAGACCATAGCGTCCGCATTTTTGCAGGTCACCACGGTTGCTGCGGGTGCGCCGGTGGGTGCAGAGAACGCTCCACGTA
TTGCTGGAGCCTTGGTGGGAGAGCGGTTTAGTCGGTGGTTGCAGCTCGATATTGATGCAAAGCGCATCTTGGTGGCCTCT
GCCGCGGGAGCTGGTTTGGGAGCAAGCTTCCACCTTCCCCTAGCAGGCGTGCTGTTTGCCCTTGAGGTCCTACTGGTTGA
GGCCTCCACTCGGACCGTGGTTATCGCAATTATCACCACGACCGCCGCCGTTGCCACCACTGGATTTTTCGTGCAAACCC
CAGATGTGTTCAGCACTGTCCCGCTGACGGAAAGCCCATGGATGCTGCTTGCCGCGATGGTCACCGGAGTAGTCGCCGGC
ATGTGCGGGCACTGGTTTTCAGCGGCGGCGCACAAAATGGCGCAGGCCTCGCCCAAGGGTGTGAAGATTTTGTGGCAGAT
GCCGTTGGGTTTCGTGGTGATCGCTGCGGTGATTTATTTCTTCCCCGAAACCCTGGCGAATCCCCGTTGGCTTGCCGATT
CCATGCTCGGCGATGGCCTGATCCTCAGCACCATTTTATTGGTACTTGTTCTGCGCACCGCCATGTTTTTGCTCGCCTTC
CGCGTGGGCATGGTCGGCGGTAACCTGATCCCCGCATTCGCACTCGGATCCATGGTCGGTGGGGTAGTGGGTGCTGTATT
GGAACCCATCACTAACGTCCCGATCGCCGCTTTTGCGCTGCTTGGCGCCGCCGCATTTTTGTCCACCACCATGGCAGCGC
CACTGTTCGGGCTCATCGCCGCAGTGGAATTCACCGACATGGAAGCCCAAGGCTACCTTCCGATTTTCCTCGCAGTAGCC
TCCGCGGTCCTCGCCGTGCGCGTGTGGTCTGTCATCGCCAAGCACGAGCTCCGCGCCATCCCGATCACGTACGCGAGCTG
GACGGGCGAGCTTAAATAA

Upstream 100 bases:

>100_bases
GGAAAACCTGGAAAATTGAGAAGCTATCCCTCATCATAGTTTTAAATCTGGGGCAGAGGCGGGAATTTAAACACCTCTGA
TACAGCGTTTACTGGCTATA

Downstream 100 bases:

>100_bases
GCTTGTCGACGCCTCCCTCCACCTTCTATTTAGTAAACGCTTTTCAGACTGTCACAGACTCCTGAGCTTCCAGCGCACGA
GCCTTGTCTGCTTTTTGCAC

Product: voltage gated chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLRVPNRVPVSTIPLNRLAVIAAIIGVGTGLFVAALNWSAIGVERLVYGADHLHNYNPVANVSPLRLSITVIVLSVVASW
AWFFVHRTGPKEVSIVGAIRGEKMPILETIASAFLQVTTVAAGAPVGAENAPRIAGALVGERFSRWLQLDIDAKRILVAS
AAGAGLGASFHLPLAGVLFALEVLLVEASTRTVVIAIITTTAAVATTGFFVQTPDVFSTVPLTESPWMLLAAMVTGVVAG
MCGHWFSAAAHKMAQASPKGVKILWQMPLGFVVIAAVIYFFPETLANPRWLADSMLGDGLILSTILLVLVLRTAMFLLAF
RVGMVGGNLIPAFALGSMVGGVVGAVLEPITNVPIAAFALLGAAAFLSTTMAAPLFGLIAAVEFTDMEAQGYLPIFLAVA
SAVLAVRVWSVIAKHELRAIPITYASWTGELK

Sequences:

>Translated_432_residues
MLRVPNRVPVSTIPLNRLAVIAAIIGVGTGLFVAALNWSAIGVERLVYGADHLHNYNPVANVSPLRLSITVIVLSVVASW
AWFFVHRTGPKEVSIVGAIRGEKMPILETIASAFLQVTTVAAGAPVGAENAPRIAGALVGERFSRWLQLDIDAKRILVAS
AAGAGLGASFHLPLAGVLFALEVLLVEASTRTVVIAIITTTAAVATTGFFVQTPDVFSTVPLTESPWMLLAAMVTGVVAG
MCGHWFSAAAHKMAQASPKGVKILWQMPLGFVVIAAVIYFFPETLANPRWLADSMLGDGLILSTILLVLVLRTAMFLLAF
RVGMVGGNLIPAFALGSMVGGVVGAVLEPITNVPIAAFALLGAAAFLSTTMAAPLFGLIAAVEFTDMEAQGYLPIFLAVA
SAVLAVRVWSVIAKHELRAIPITYASWTGELK
>Mature_432_residues
MLRVPNRVPVSTIPLNRLAVIAAIIGVGTGLFVAALNWSAIGVERLVYGADHLHNYNPVANVSPLRLSITVIVLSVVASW
AWFFVHRTGPKEVSIVGAIRGEKMPILETIASAFLQVTTVAAGAPVGAENAPRIAGALVGERFSRWLQLDIDAKRILVAS
AAGAGLGASFHLPLAGVLFALEVLLVEASTRTVVIAIITTTAAVATTGFFVQTPDVFSTVPLTESPWMLLAAMVTGVVAG
MCGHWFSAAAHKMAQASPKGVKILWQMPLGFVVIAAVIYFFPETLANPRWLADSMLGDGLILSTILLVLVLRTAMFLLAF
RVGMVGGNLIPAFALGSMVGGVVGAVLEPITNVPIAAFALLGAAAFLSTTMAAPLFGLIAAVEFTDMEAQGYLPIFLAVA
SAVLAVRVWSVIAKHELRAIPITYASWTGELK

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 45365; Mature: 45365

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00334 MYB_2 ; PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVPNRVPVSTIPLNRLAVIAAIIGVGTGLFVAALNWSAIGVERLVYGADHLHNYNPVA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
NVSPLRLSITVIVLSVVASWAWFFVHRTGPKEVSIVGAIRGEKMPILETIASAFLQVTTV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
AAGAPVGAENAPRIAGALVGERFSRWLQLDIDAKRILVASAAGAGLGASFHLPLAGVLFA
HCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCHHEEEEEECCCCCCCCEECCHHHHHHHH
LEVLLVEASTRTVVIAIITTTAAVATTGFFVQTPDVFSTVPLTESPWMLLAAMVTGVVAG
HHHHHHCCCCCEEEEEEEHHHHHHHHCCCEEECCCHHEECCCCCCHHHHHHHHHHHHHHH
MCGHWFSAAAHKMAQASPKGVKILWQMPLGFVVIAAVIYFFPETLANPRWLADSMLGDGL
HHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHH
ILSTILLVLVLRTAMFLLAFRVGMVGGNLIPAFALGSMVGGVVGAVLEPITNVPIAAFAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGAAAFLSTTMAAPLFGLIAAVEFTDMEAQGYLPIFLAVASAVLAVRVWSVIAKHELRAI
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
PITYASWTGELK
EEEEECCCCCCC
>Mature Secondary Structure
MLRVPNRVPVSTIPLNRLAVIAAIIGVGTGLFVAALNWSAIGVERLVYGADHLHNYNPVA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
NVSPLRLSITVIVLSVVASWAWFFVHRTGPKEVSIVGAIRGEKMPILETIASAFLQVTTV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
AAGAPVGAENAPRIAGALVGERFSRWLQLDIDAKRILVASAAGAGLGASFHLPLAGVLFA
HCCCCCCCCCCCHHHHHHHHHHHHHHEEECCCHHEEEEEECCCCCCCCEECCHHHHHHHH
LEVLLVEASTRTVVIAIITTTAAVATTGFFVQTPDVFSTVPLTESPWMLLAAMVTGVVAG
HHHHHHCCCCCEEEEEEEHHHHHHHHCCCEEECCCHHEECCCCCCHHHHHHHHHHHHHHH
MCGHWFSAAAHKMAQASPKGVKILWQMPLGFVVIAAVIYFFPETLANPRWLADSMLGDGL
HHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHH
ILSTILLVLVLRTAMFLLAFRVGMVGGNLIPAFALGSMVGGVVGAVLEPITNVPIAAFAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGAAAFLSTTMAAPLFGLIAAVEFTDMEAQGYLPIFLAVASAVLAVRVWSVIAKHELRAI
HHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEE
PITYASWTGELK
EEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA