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The map label for this gene is vmrA [H]

Identifier: 59714099

GI number: 59714099

Start: 1040298

End: 1041668

Strand: Reverse

Name: vmrA [H]

Synonym: VF_A0916

Alternate gene names: 59714099

Gene position: 1041668-1040298 (Counterclockwise)

Preceding gene: 59714101

Following gene: 59714098

Centisome position: 78.3

GC content: 38.37

Gene sequence:

>1371_bases
ATGACAACATTTCATGCAGATTCATCCATCACACGTACTTTTTGGCGTTATGCTATTCCTTCTATTGCTGCAATGGTGGT
GAGTGGACTGTATCAAATTATTGATGGGATCTTTGTTGGTCACTACATTGGTTTTGAAGGTCTTGCTGGGATTAATATGG
CTTGGCCTGCGATTTGTATATTAGGTGCTATTGGTGTCATGGTTGGCATGGGAACAGGCAGTGTTATGTCTATTTACCGT
GGCGAAAATAAATTAGAAAAAACAAAAGTGGCGTTAACGACAGGTTTTTGGTTACTTGCGATTTTAAGCATCATTGCGAT
CTCCTGTATTGTGTTACTCGCAAAAGACATATTGCTCGCACAAGGTGCGGAAGGTCAAAACTTTGCTTATGCAATGGATT
ACATCAATGTACTTATGTTTGGTGGTTTTTTTACTGCATGTGCAACGGCTCTACCTATGCTTGTGCGTAATGATGAGTCA
CCAAATGTTGCGACATTTCTACTCGTTATTGGAGCATTAATTAATATTGTTTTAGATTACGTATTTATTGGTGTGATGGG
GTTAGGGCTTTCTGGAGCGGCATTAGCAACGTTAATGGCTCAAGCTTGTGTGACCGTTTTGGGTATTGGTTATTTCTTTA
CTCAGCGTTCAAGTATTCAGATCACATTACAAGAAGTGCTATTTTCTTGGAATAAGGCAAAGCAATCTCTCTCTTTAGGT
GCGTCGGCATTAGTTATGTACTTGTATGGCAGCTTTGTTGTTGCTATGCATAATGCGTTAATGATGTATTACGGCTCAGC
AACGACTGTGGGGGCTTATGCCATTGTTGGTTACTTATTTATGCTTTATTACCTTCTTGCGCAAGGTATTGCTGAGGGTG
CACAGCCACCAATAAGTTATTATTTTGGTGCGAGAGAAAATAAAAAAGTTTATCAAATCTTCAAGATTGCATTGAAGTGG
GTAATCATTACTGGCATTGGTTGGGTGACTATTTTAAATATTTCACCAGAGCTAACGACGGCTTTGTTTACTAATGGTGA
TAAAGCTCTGATTGCTGAAACGATTGTTGGTATTCGTTATCACTTATTTGCGATGTTCTTGGATGGCATGATTGTATTGA
TTACTATCTACTTTTTGTCCGTAAATGAAGGCAAAAAAGCCATGGTGATATCAATTAGTAATATCGTTATTCAATTGCCA
TTTTTGCTTATCTTACCTAAATGGTTTGGAATTGATGGGGTTTGGTTAGCGATGCCAGTATCAAACATTGCATTGATTAT
CTGTATTGCACCAATGGTATGGAATCATTTGAAAACCCAGAAGATTATCAAGCCATTACCATTGACTTCTACATCGGTCA
TGAGTCATTAG

Upstream 100 bases:

>100_bases
AATTTATACTCATCCATCCGATAAAGAGATGGATACTAACTTTTTCAATCTTAAATTGTATCATAGAATCACGCCATTCT
TTGTTGTTACCGAGGTTAAA

Downstream 100 bases:

>100_bases
AGTATTTAAAATAGGAAATTTTTTATTCCAATATTTACTCTTTTTATTTTATAGAAATCGAATAGACTTTAACGGTCTAT
TCGATTTTTGCTTTTTAGGG

Product: multidrug efflux pump VmrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTTFHADSSITRTFWRYAIPSIAAMVVSGLYQIIDGIFVGHYIGFEGLAGINMAWPAICILGAIGVMVGMGTGSVMSIYR
GENKLEKTKVALTTGFWLLAILSIIAISCIVLLAKDILLAQGAEGQNFAYAMDYINVLMFGGFFTACATALPMLVRNDES
PNVATFLLVIGALINIVLDYVFIGVMGLGLSGAALATLMAQACVTVLGIGYFFTQRSSIQITLQEVLFSWNKAKQSLSLG
ASALVMYLYGSFVVAMHNALMMYYGSATTVGAYAIVGYLFMLYYLLAQGIAEGAQPPISYYFGARENKKVYQIFKIALKW
VIITGIGWVTILNISPELTTALFTNGDKALIAETIVGIRYHLFAMFLDGMIVLITIYFLSVNEGKKAMVISISNIVIQLP
FLLILPKWFGIDGVWLAMPVSNIALIICIAPMVWNHLKTQKIIKPLPLTSTSVMSH

Sequences:

>Translated_456_residues
MTTFHADSSITRTFWRYAIPSIAAMVVSGLYQIIDGIFVGHYIGFEGLAGINMAWPAICILGAIGVMVGMGTGSVMSIYR
GENKLEKTKVALTTGFWLLAILSIIAISCIVLLAKDILLAQGAEGQNFAYAMDYINVLMFGGFFTACATALPMLVRNDES
PNVATFLLVIGALINIVLDYVFIGVMGLGLSGAALATLMAQACVTVLGIGYFFTQRSSIQITLQEVLFSWNKAKQSLSLG
ASALVMYLYGSFVVAMHNALMMYYGSATTVGAYAIVGYLFMLYYLLAQGIAEGAQPPISYYFGARENKKVYQIFKIALKW
VIITGIGWVTILNISPELTTALFTNGDKALIAETIVGIRYHLFAMFLDGMIVLITIYFLSVNEGKKAMVISISNIVIQLP
FLLILPKWFGIDGVWLAMPVSNIALIICIAPMVWNHLKTQKIIKPLPLTSTSVMSH
>Mature_455_residues
TTFHADSSITRTFWRYAIPSIAAMVVSGLYQIIDGIFVGHYIGFEGLAGINMAWPAICILGAIGVMVGMGTGSVMSIYRG
ENKLEKTKVALTTGFWLLAILSIIAISCIVLLAKDILLAQGAEGQNFAYAMDYINVLMFGGFFTACATALPMLVRNDESP
NVATFLLVIGALINIVLDYVFIGVMGLGLSGAALATLMAQACVTVLGIGYFFTQRSSIQITLQEVLFSWNKAKQSLSLGA
SALVMYLYGSFVVAMHNALMMYYGSATTVGAYAIVGYLFMLYYLLAQGIAEGAQPPISYYFGARENKKVYQIFKIALKWV
IITGIGWVTILNISPELTTALFTNGDKALIAETIVGIRYHLFAMFLDGMIVLITIYFLSVNEGKKAMVISISNIVIQLPF
LLILPKWFGIDGVWLAMPVSNIALIICIAPMVWNHLKTQKIIKPLPLTSTSVMSH

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49642; Mature: 49511

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFHADSSITRTFWRYAIPSIAAMVVSGLYQIIDGIFVGHYIGFEGLAGINMAWPAICI
CCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
LGAIGVMVGMGTGSVMSIYRGENKLEKTKVALTTGFWLLAILSIIAISCIVLLAKDILLA
HHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGAEGQNFAYAMDYINVLMFGGFFTACATALPMLVRNDESPNVATFLLVIGALINIVLDY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VFIGVMGLGLSGAALATLMAQACVTVLGIGYFFTQRSSIQITLQEVLFSWNKAKQSLSLG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHH
ASALVMYLYGSFVVAMHNALMMYYGSATTVGAYAIVGYLFMLYYLLAQGIAEGAQPPISY
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
YFGARENKKVYQIFKIALKWVIITGIGWVTILNISPELTTALFTNGDKALIAETIVGIRY
HCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
HLFAMFLDGMIVLITIYFLSVNEGKKAMVISISNIVIQLPFLLILPKWFGIDGVWLAMPV
HHHHHHHHHHHHHHHHHHHEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECH
SNIALIICIAPMVWNHLKTQKIIKPLPLTSTSVMSH
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
>Mature Secondary Structure 
TTFHADSSITRTFWRYAIPSIAAMVVSGLYQIIDGIFVGHYIGFEGLAGINMAWPAICI
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA