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The map label for this gene is tyrR [H]

Identifier: 59713934

GI number: 59713934

Start: 847527

End: 849074

Strand: Reverse

Name: tyrR [H]

Synonym: VF_A0751

Alternate gene names: 59713934

Gene position: 849074-847527 (Counterclockwise)

Preceding gene: 59713938

Following gene: 59713933

Centisome position: 63.82

GC content: 37.86

Gene sequence:

>1548_bases
GTGCGTCTTGAAGTGCAATGCAAGGATCGCTTAGGTCTTACTCGTGAGTTATTAGATATTTTAGCTTCTCAACATATTGA
TTTACGTGACATTGAAATTGATAAGTCAGGCTTAATCTATCTTAACTTCCCAGAAATCGATTTCGATGAGTTTAGTCAAT
TAATGGCGAAAATTCGTCGACTTGATGGTGTGATGGATGTCAGAAAAATTCAATTTTTACCAAGTGAACGTCGAAATACT
GAGTTATTAGCCGTATTAAGTACCTTGCCAGACCCTGTTTTCTCTATCAATTTAAAAGGCAAGATAGACACAATTAATGA
TGCGGTAGTATCACTCTTTAAATTGGATAAAACGTCGCTTATTGGCCAATCAGCAACGGTTTTATTGTCAGACTTTAATG
TGCAATTATGGTTAGAAGAATCTCGTATTCGACAACGTGAACCTATGTTGATTGATGGCATGAACTACATCATGGAGATC
ATGCCAGTTTATATTACAGATGACAGTAACACCTCAATTTTGACCAGTGCGGTTGTCATTATCAAACCCGCTATCGAAGC
GCAAAACGCACGCCCATTTATACCTGAATCATCAAATTTAGGTTTTGAGCACTTTGTAGGTTCATCAACTAAATATAAAC
AACTTATTTCTCAAGCGAAAAAACTGTCTGACATTGATCAATCATTATTGATCCAAGGTGAGACAGGAACGGGTAAAGAG
ATGTTGGCTCGCGCATGTCATAATGCATCTATCCGTTCAGGTAAGGCTTTTATGGTAGTGAACTGTGCAGCGATGCCTGA
TGATGTGGCTGAAACAGAGTTGTTCGGTTATGCACCAGGTGCGTTCCCTAATATGCCAGAAGGTAAGAAAGGCATCATTG
AACAAGCTGATGGTGGTACGGTTTTCTTTGATGAAATCAGTGAGATGAGTCCGCTACTTCAAATTAAACTGTTACGCTTT
ATTCAAGATGGTAATTTCCGTCGAGTAGGTGAAGAAAAAGAGATCCATGTTGATGTAGGTATCATCGGTGCAAGTAAAAA
AGAGCTACTTGAGTTGGTAGAGCAAGGCTTATTCCGTGAAGATTTGTATTACCGTCTAAACGTGCTGTTTTTAGAGATAC
CGCCATTGCGTGATCGTATTTCTGATGTGGCAACCTTGTTTGATTTTTTTGTAGCGCAACTAAGTAAAGAGCTAGGAATT
GTTAAGCCAAGCATAGACGAAGAAGTATACGATTATCTGGCAAGTTATACGTGGCCGGGCAATGTTCGCCAGTTAAGAAG
TACAACATTAAAAGCATTAACGCAAATGGATAGAAATCAACTATCTACCTCTCATTTTATGCTTCCAATTGTTGATAAAA
ATGCGCCAAGAAGTCTTAATATTAATACTGATGGTTCACTGGATGAAATCATGAAATCTTATGAGTCGAGTATTTTATCT
AGTTTATATAATGAATTTCCATCGAGTCGTAAGTTAGCCAAGCGTTTAGGTGTATCACATACTGCAATTGCAAATAAATT
GCGTGATTATGGAATTGGTAAAAAATAG

Upstream 100 bases:

>100_bases
ATTAAAAAGCGTTTTGGATCACTTCTTTCTTGACTCTTTTTTTTCTCTCACGCAAACTGGTGTAAACATATTTTGACACC
CTTATTATTGAGGAATTTTT

Downstream 100 bases:

>100_bases
AGAGAAACGACATGGATGTAAGTTTTGAGTTTGAGCATTACCAAGTTCGTTTAATAAAAAGCAGTGACGCAGTGACGATT
GCCAACTATTTTATGCGTAA

Product: DNA-binding transcriptional regulator, tyrosine-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MRLEVQCKDRLGLTRELLDILASQHIDLRDIEIDKSGLIYLNFPEIDFDEFSQLMAKIRRLDGVMDVRKIQFLPSERRNT
ELLAVLSTLPDPVFSINLKGKIDTINDAVVSLFKLDKTSLIGQSATVLLSDFNVQLWLEESRIRQREPMLIDGMNYIMEI
MPVYITDDSNTSILTSAVVIIKPAIEAQNARPFIPESSNLGFEHFVGSSTKYKQLISQAKKLSDIDQSLLIQGETGTGKE
MLARACHNASIRSGKAFMVVNCAAMPDDVAETELFGYAPGAFPNMPEGKKGIIEQADGGTVFFDEISEMSPLLQIKLLRF
IQDGNFRRVGEEKEIHVDVGIIGASKKELLELVEQGLFREDLYYRLNVLFLEIPPLRDRISDVATLFDFFVAQLSKELGI
VKPSIDEEVYDYLASYTWPGNVRQLRSTTLKALTQMDRNQLSTSHFMLPIVDKNAPRSLNINTDGSLDEIMKSYESSILS
SLYNEFPSSRKLAKRLGVSHTAIANKLRDYGIGKK

Sequences:

>Translated_515_residues
MRLEVQCKDRLGLTRELLDILASQHIDLRDIEIDKSGLIYLNFPEIDFDEFSQLMAKIRRLDGVMDVRKIQFLPSERRNT
ELLAVLSTLPDPVFSINLKGKIDTINDAVVSLFKLDKTSLIGQSATVLLSDFNVQLWLEESRIRQREPMLIDGMNYIMEI
MPVYITDDSNTSILTSAVVIIKPAIEAQNARPFIPESSNLGFEHFVGSSTKYKQLISQAKKLSDIDQSLLIQGETGTGKE
MLARACHNASIRSGKAFMVVNCAAMPDDVAETELFGYAPGAFPNMPEGKKGIIEQADGGTVFFDEISEMSPLLQIKLLRF
IQDGNFRRVGEEKEIHVDVGIIGASKKELLELVEQGLFREDLYYRLNVLFLEIPPLRDRISDVATLFDFFVAQLSKELGI
VKPSIDEEVYDYLASYTWPGNVRQLRSTTLKALTQMDRNQLSTSHFMLPIVDKNAPRSLNINTDGSLDEIMKSYESSILS
SLYNEFPSSRKLAKRLGVSHTAIANKLRDYGIGKK
>Mature_515_residues
MRLEVQCKDRLGLTRELLDILASQHIDLRDIEIDKSGLIYLNFPEIDFDEFSQLMAKIRRLDGVMDVRKIQFLPSERRNT
ELLAVLSTLPDPVFSINLKGKIDTINDAVVSLFKLDKTSLIGQSATVLLSDFNVQLWLEESRIRQREPMLIDGMNYIMEI
MPVYITDDSNTSILTSAVVIIKPAIEAQNARPFIPESSNLGFEHFVGSSTKYKQLISQAKKLSDIDQSLLIQGETGTGKE
MLARACHNASIRSGKAFMVVNCAAMPDDVAETELFGYAPGAFPNMPEGKKGIIEQADGGTVFFDEISEMSPLLQIKLLRF
IQDGNFRRVGEEKEIHVDVGIIGASKKELLELVEQGLFREDLYYRLNVLFLEIPPLRDRISDVATLFDFFVAQLSKELGI
VKPSIDEEVYDYLASYTWPGNVRQLRSTTLKALTQMDRNQLSTSHFMLPIVDKNAPRSLNINTDGSLDEIMKSYESSILS
SLYNEFPSSRKLAKRLGVSHTAIANKLRDYGIGKK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=518, Percent_Identity=50, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1788550, Length=344, Percent_Identity=34.8837209302326, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1790437, Length=303, Percent_Identity=34.6534653465347, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=36.1702127659575, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=32.9153605015674, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1790299, Length=331, Percent_Identity=35.6495468277946, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=35.9621451104101, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789087, Length=317, Percent_Identity=35.9621451104101, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1788905, Length=231, Percent_Identity=40.2597402597403, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=34.9137931034483, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786524, Length=236, Percent_Identity=38.9830508474576, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081858, Length=457, Percent_Identity=26.9146608315098, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789828, Length=232, Percent_Identity=32.3275862068966, Blast_Score=125, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57992; Mature: 57992

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVQCKDRLGLTRELLDILASQHIDLRDIEIDKSGLIYLNFPEIDFDEFSQLMAKIRR
CCEEEECHHHCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHH
LDGVMDVRKIQFLPSERRNTELLAVLSTLPDPVFSINLKGKIDTINDAVVSLFKLDKTSL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
IGQSATVLLSDFNVQLWLEESRIRQREPMLIDGMNYIMEIMPVYITDDSNTSILTSAVVI
CCCCEEEEEECCCEEEEEEHHHHHCCCCCEEHHHHHHHHHEEEEEECCCCCHHHHHEEEE
IKPAIEAQNARPFIPESSNLGFEHFVGSSTKYKQLISQAKKLSDIDQSLLIQGETGTGKE
EECCHHCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCHHHEEECCCCCCHH
MLARACHNASIRSGKAFMVVNCAAMPDDVAETELFGYAPGAFPNMPEGKKGIIEQADGGT
HHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCE
VFFDEISEMSPLLQIKLLRFIQDGNFRRVGEEKEIHVDVGIIGASKKELLELVEQGLFRE
EEHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEEECCCHHHHHHHHHHCCHHH
DLYYRLNVLFLEIPPLRDRISDVATLFDFFVAQLSKELGIVKPSIDEEVYDYLASYTWPG
HHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
NVRQLRSTTLKALTQMDRNQLSTSHFMLPIVDKNAPRSLNINTDGSLDEIMKSYESSILS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHH
SLYNEFPSSRKLAKRLGVSHTAIANKLRDYGIGKK
HHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLEVQCKDRLGLTRELLDILASQHIDLRDIEIDKSGLIYLNFPEIDFDEFSQLMAKIRR
CCEEEECHHHCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHH
LDGVMDVRKIQFLPSERRNTELLAVLSTLPDPVFSINLKGKIDTINDAVVSLFKLDKTSL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHH
IGQSATVLLSDFNVQLWLEESRIRQREPMLIDGMNYIMEIMPVYITDDSNTSILTSAVVI
CCCCEEEEEECCCEEEEEEHHHHHCCCCCEEHHHHHHHHHEEEEEECCCCCHHHHHEEEE
IKPAIEAQNARPFIPESSNLGFEHFVGSSTKYKQLISQAKKLSDIDQSLLIQGETGTGKE
EECCHHCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCHHHEEECCCCCCHH
MLARACHNASIRSGKAFMVVNCAAMPDDVAETELFGYAPGAFPNMPEGKKGIIEQADGGT
HHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCE
VFFDEISEMSPLLQIKLLRFIQDGNFRRVGEEKEIHVDVGIIGASKKELLELVEQGLFRE
EEHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEEEECCCHHHHHHHHHHCCHHH
DLYYRLNVLFLEIPPLRDRISDVATLFDFFVAQLSKELGIVKPSIDEEVYDYLASYTWPG
HHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
NVRQLRSTTLKALTQMDRNQLSTSHFMLPIVDKNAPRSLNINTDGSLDEIMKSYESSILS
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHH
SLYNEFPSSRKLAKRLGVSHTAIANKLRDYGIGKK
HHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]