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The map label for this gene is sapD [H]

Identifier: 59713489

GI number: 59713489

Start: 340400

End: 341413

Strand: Reverse

Name: sapD [H]

Synonym: VF_A0306

Alternate gene names: 59713489

Gene position: 341413-340400 (Counterclockwise)

Preceding gene: 59713490

Following gene: 59713488

Centisome position: 25.66

GC content: 42.01

Gene sequence:

>1014_bases
ATGCCATTATTAGATATTCGCCATTTAACCATTGAGTTAGAAACGCCACAAGGCATGGTGAAAGCCGTTGACCGCATGAG
CTTAACCTTAAATGAAGGTGAAATTCGTGGTTTAGTGGGAGAATCTGGCTCAGGAAAATCTCTCGTTGCTAAAGCCATTT
TAGGTATCACTAAAGATAACTGGAAAATCAGTGCAGACCGTATGCGTCTAGGTAACATTGATTTATTAGCCCTATCTCCT
AAAGAGCGACGCCGAGTTATCGGACGTGAAATGGCAATGATCTTCCAAGAGCCATCAACCTGCCTTGACCCATCAGAACA
AGTGGGTAACCAACTAAAAGAAGCGATTCCTTCCAAGTACTTTACTGGTAGCTGGTGGCAAAGATGGAATTGGCGAACGA
AAGGTGCAATAGCCCTACTCCACAAGGTTGGTATTAAAGATCATAAACACATAATGAAATGCTATCCATATGAATTAACG
GATGGTGAATGTCAAAAAGTGATGATCGCAATGGCGATTGCCAACAAACCACGTATCTTAATTGCAGATGAACCAACCGA
TGAATTAGATGCAGTGACACAGTCACAAATATTCCGTCTACTAAGTCGAATGAACCAGGTTAATAACACGACAATTTTAT
TAATCAGCCACGACTTAATCACCCTTACTCAGTGGGTAGACCGAATCACGGTGATGTATTGTGGTCAATCGGTAGAATCA
GCTTGTCGTAAAGATATCCTTGAAGCACCAAAGCATCCCTATACCAATGCACTGCTTCGTGCTATGCCTGATTTTAGTAA
AGATGGGATCCCACATAAAGCTAAGTTGGAATCACTACCTGGCACAATTCCACCTCTACAACATTTACCCATTGGCTGCC
GTCTTGGGCCTCGTTGTCCATATGCGCAACGTAAATGTGTTCAAGTTCCAGAGAGACAAAAAGTGAAAGATCACAAATTT
AGCTGCCATTTCCCATTAAATTTTGAGGAGAAGAAGAATGACTGCGCTTCTTGA

Upstream 100 bases:

>100_bases
GGACAGTGACGTTACCTGGAATTGTAATTACCTTTACAGTCATCATCATCAACTTAGTTGGTGACGGTATTCAACGTGCG
TTAAATGCGGGGACAGAATA

Downstream 100 bases:

>100_bases
AGTTACTGATCTTAAAAAAGACTATGTATTTCGTACTGGATTATTTCGTAAACAAGTACGTGAGGCAGTTAAGCCCGTTA
GCTTTTCTTTAGAAGCGGGA

Product: peptide transport system ATP-binding protein SapD

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MPLLDIRHLTIELETPQGMVKAVDRMSLTLNEGEIRGLVGESGSGKSLVAKAILGITKDNWKISADRMRLGNIDLLALSP
KERRRVIGREMAMIFQEPSTCLDPSEQVGNQLKEAIPSKYFTGSWWQRWNWRTKGAIALLHKVGIKDHKHIMKCYPYELT
DGECQKVMIAMAIANKPRILIADEPTDELDAVTQSQIFRLLSRMNQVNNTTILLISHDLITLTQWVDRITVMYCGQSVES
ACRKDILEAPKHPYTNALLRAMPDFSKDGIPHKAKLESLPGTIPPLQHLPIGCRLGPRCPYAQRKCVQVPERQKVKDHKF
SCHFPLNFEEKKNDCAS

Sequences:

>Translated_337_residues
MPLLDIRHLTIELETPQGMVKAVDRMSLTLNEGEIRGLVGESGSGKSLVAKAILGITKDNWKISADRMRLGNIDLLALSP
KERRRVIGREMAMIFQEPSTCLDPSEQVGNQLKEAIPSKYFTGSWWQRWNWRTKGAIALLHKVGIKDHKHIMKCYPYELT
DGECQKVMIAMAIANKPRILIADEPTDELDAVTQSQIFRLLSRMNQVNNTTILLISHDLITLTQWVDRITVMYCGQSVES
ACRKDILEAPKHPYTNALLRAMPDFSKDGIPHKAKLESLPGTIPPLQHLPIGCRLGPRCPYAQRKCVQVPERQKVKDHKF
SCHFPLNFEEKKNDCAS
>Mature_336_residues
PLLDIRHLTIELETPQGMVKAVDRMSLTLNEGEIRGLVGESGSGKSLVAKAILGITKDNWKISADRMRLGNIDLLALSPK
ERRRVIGREMAMIFQEPSTCLDPSEQVGNQLKEAIPSKYFTGSWWQRWNWRTKGAIALLHKVGIKDHKHIMKCYPYELTD
GECQKVMIAMAIANKPRILIADEPTDELDAVTQSQIFRLLSRMNQVNNTTILLISHDLITLTQWVDRITVMYCGQSVESA
CRKDILEAPKHPYTNALLRAMPDFSKDGIPHKAKLESLPGTIPPLQHLPIGCRLGPRCPYAQRKCVQVPERQKVKDHKFS
CHFPLNFEEKKNDCAS

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4170

COG function: function code V; ABC-type antimicrobial peptide transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787548, Length=331, Percent_Identity=63.7462235649547, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1789963, Length=329, Percent_Identity=43.4650455927052, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1787759, Length=327, Percent_Identity=38.5321100917431, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI48994883, Length=322, Percent_Identity=35.4037267080745, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI145693107, Length=270, Percent_Identity=36.2962962962963, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1787500, Length=330, Percent_Identity=33.6363636363636, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1788506, Length=271, Percent_Identity=36.5313653136531, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789962, Length=304, Percent_Identity=29.9342105263158, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1787758, Length=291, Percent_Identity=30.9278350515464, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789890, Length=251, Percent_Identity=32.6693227091633, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI48994997, Length=267, Percent_Identity=29.5880149812734, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787547, Length=266, Percent_Identity=27.8195488721804, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789891, Length=248, Percent_Identity=30.241935483871, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789032, Length=247, Percent_Identity=30.3643724696356, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789873, Length=223, Percent_Identity=32.2869955156951, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786398, Length=242, Percent_Identity=28.5123966942149, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081791, Length=296, Percent_Identity=26.6891891891892, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786703, Length=241, Percent_Identity=29.4605809128631, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87081834, Length=195, Percent_Identity=31.7948717948718, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788450, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788761, Length=254, Percent_Identity=25.1968503937008, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789672, Length=246, Percent_Identity=28.0487804878049, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788225, Length=238, Percent_Identity=24.3697478991597, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082267, Length=242, Percent_Identity=23.9669421487603, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790467, Length=242, Percent_Identity=23.5537190082645, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786345, Length=231, Percent_Identity=27.7056277056277, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI48995001, Length=236, Percent_Identity=30.0847457627119, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787105, Length=217, Percent_Identity=27.6497695852535, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081709, Length=242, Percent_Identity=22.7272727272727, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790162, Length=244, Percent_Identity=22.9508196721311, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789864, Length=253, Percent_Identity=25.296442687747, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790190, Length=224, Percent_Identity=25, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787089, Length=242, Percent_Identity=26.8595041322314, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=228, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593
- InterPro:   IPR010066
- InterPro:   IPR013563 [H]

Pfam domain/function: PF00005 ABC_tran; PF08352 oligo_HPY [H]

EC number: NA

Molecular weight: Translated: 38158; Mature: 38027

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLDIRHLTIELETPQGMVKAVDRMSLTLNEGEIRGLVGESGSGKSLVAKAILGITKDN
CCCEEEEEEEEEEECCCHHHHHHHHHEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCC
WKISADRMRLGNIDLLALSPKERRRVIGREMAMIFQEPSTCLDPSEQVGNQLKEAIPSKY
CEEEHHHEEECCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
FTGSWWQRWNWRTKGAIALLHKVGIKDHKHIMKCYPYELTDGECQKVMIAMAIANKPRIL
CCCCHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
IADEPTDELDAVTQSQIFRLLSRMNQVNNTTILLISHDLITLTQWVDRITVMYCGQSVES
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHHH
ACRKDILEAPKHPYTNALLRAMPDFSKDGIPHKAKLESLPGTIPPLQHLPIGCRLGPRCP
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHCCCCCCCCCCCC
YAQRKCVQVPERQKVKDHKFSCHFPLNFEEKKNDCAS
HHHHHHHCCCCHHHHCCCCEEEECCCCCHHCCCCCCC
>Mature Secondary Structure 
PLLDIRHLTIELETPQGMVKAVDRMSLTLNEGEIRGLVGESGSGKSLVAKAILGITKDN
CCEEEEEEEEEEECCCHHHHHHHHHEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCC
WKISADRMRLGNIDLLALSPKERRRVIGREMAMIFQEPSTCLDPSEQVGNQLKEAIPSKY
CEEEHHHEEECCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
FTGSWWQRWNWRTKGAIALLHKVGIKDHKHIMKCYPYELTDGECQKVMIAMAIANKPRIL
CCCCHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEE
IADEPTDELDAVTQSQIFRLLSRMNQVNNTTILLISHDLITLTQWVDRITVMYCGQSVES
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHCCHHHHH
ACRKDILEAPKHPYTNALLRAMPDFSKDGIPHKAKLESLPGTIPPLQHLPIGCRLGPRCP
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHCCCCCCCCCCCC
YAQRKCVQVPERQKVKDHKFSCHFPLNFEEKKNDCAS
HHHHHHHCCCCHHHHCCCCEEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]