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The map label for this gene is cusR [H]

Identifier: 59713362

GI number: 59713362

Start: 201590

End: 202270

Strand: Reverse

Name: cusR [H]

Synonym: VF_A0179

Alternate gene names: 59713362

Gene position: 202270-201590 (Counterclockwise)

Preceding gene: 59713363

Following gene: 59713361

Centisome position: 15.2

GC content: 36.71

Gene sequence:

>681_bases
ATGAAACTACTTATTATCGAAGATGAAACAAAAACAGGAGAGTACCTAAAAAAGGGATTAACAGAGTCAGGTTATACTGT
TGATCTATCACAAGATGGTGCTGATGGTTTATATAACGCAACCACCAATCAATACGACTTAATCATCTTAGATGTCATGT
TACCTAAGCTAAATGGTTGGCAAATTCTACAAACACTACGGAATTGTGAAAATGATACGCCAATCATTATGCTCACCGCC
AAAGATCAAATTGATGATAGAGTGAAAGGGTTTGAATTAGGTGCAAATGATTACCTAATTAAACCCTTTGCTTTTGCTGA
ACTAAAAGCTCGTGTTGAAAATGCCCTCAGAGCAAAATCAGTGATTTCGCAACCATCATCAAATGAGTTAGTTTTGCATG
ATTTAAAATTGGATCTGTTAAAACGAACCGCCACAAGAAACCAAGATAATATTACCCTTACTGCAAAAGAGTTTTCATTA
CTTGAGTTATTTATGCGTAAACAAGGGGAAGTATTATCAAGAACAACAATCGCCTCCCTGATTTGGGACATGAACTTTGA
TAGTGATACCAATGTCATTGATGTCGCGGTAAAACGACTTCGTTCTAAAATAGATAAACCCTACGACACCCCACTAATTC
ATACTGTTCGCGGTATGGGTTATAAAATGGACGAGTGCTAG

Upstream 100 bases:

>100_bases
TTTATGTTATTTTCTTTAAATCAACGTGTCATCTAAGAACGATACGTCTATATTGTATTGATAACCATTGATTATTCTCC
ATGCAGAAAGAAGTAATGAT

Downstream 100 bases:

>100_bases
TTATATGAAAAAACATTACTTATCAATGAAACTAAAACTGACATTAATGTTTTTCTCTACCTCTGTATTTGTCTTTATTG
GCTTAGGTTTTGCCATTCAA

Product: DNA-binding response regulator in two-component regulatory system with CusS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKLLIIEDETKTGEYLKKGLTESGYTVDLSQDGADGLYNATTNQYDLIILDVMLPKLNGWQILQTLRNCENDTPIIMLTA
KDQIDDRVKGFELGANDYLIKPFAFAELKARVENALRAKSVISQPSSNELVLHDLKLDLLKRTATRNQDNITLTAKEFSL
LELFMRKQGEVLSRTTIASLIWDMNFDSDTNVIDVAVKRLRSKIDKPYDTPLIHTVRGMGYKMDEC

Sequences:

>Translated_226_residues
MKLLIIEDETKTGEYLKKGLTESGYTVDLSQDGADGLYNATTNQYDLIILDVMLPKLNGWQILQTLRNCENDTPIIMLTA
KDQIDDRVKGFELGANDYLIKPFAFAELKARVENALRAKSVISQPSSNELVLHDLKLDLLKRTATRNQDNITLTAKEFSL
LELFMRKQGEVLSRTTIASLIWDMNFDSDTNVIDVAVKRLRSKIDKPYDTPLIHTVRGMGYKMDEC
>Mature_226_residues
MKLLIIEDETKTGEYLKKGLTESGYTVDLSQDGADGLYNATTNQYDLIILDVMLPKLNGWQILQTLRNCENDTPIIMLTA
KDQIDDRVKGFELGANDYLIKPFAFAELKARVENALRAKSVISQPSSNELVLHDLKLDLLKRTATRNQDNITLTAKEFSL
LELFMRKQGEVLSRTTIASLIWDMNFDSDTNVIDVAVKRLRSKIDKPYDTPLIHTVRGMGYKMDEC

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=58.9285714285714, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=51.5695067264574, Blast_Score=241, Evalue=2e-65,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=39.1111111111111, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=32.2869955156951, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=34.6666666666667, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=31.7391304347826, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.2217194570136, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=32.2869955156951, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=32.1266968325792, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=33.1858407079646, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.2105263157895, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=31.4655172413793, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=29.5652173913043, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.0742358078603, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=124, Percent_Identity=32.258064516129, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=29.8245614035088, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=126, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=110, Percent_Identity=30, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25651; Mature: 25651

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLIIEDETKTGEYLKKGLTESGYTVDLSQDGADGLYNATTNQYDLIILDVMLPKLNGW
CEEEEEECCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCH
QILQTLRNCENDTPIIMLTAKDQIDDRVKGFELGANDYLIKPFAFAELKARVENALRAKS
HHHHHHHCCCCCCCEEEEEECCHHHHHHCCEEECCCCEEECCHHHHHHHHHHHHHHHHHH
VISQPSSNELVLHDLKLDLLKRTATRNQDNITLTAKEFSLLELFMRKQGEVLSRTTIASL
HHCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHH
IWDMNFDSDTNVIDVAVKRLRSKIDKPYDTPLIHTVRGMGYKMDEC
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEECCCC
>Mature Secondary Structure
MKLLIIEDETKTGEYLKKGLTESGYTVDLSQDGADGLYNATTNQYDLIILDVMLPKLNGW
CEEEEEECCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCH
QILQTLRNCENDTPIIMLTAKDQIDDRVKGFELGANDYLIKPFAFAELKARVENALRAKS
HHHHHHHCCCCCCCEEEEEECCHHHHHHCCEEECCCCEEECCHHHHHHHHHHHHHHHHHH
VISQPSSNELVLHDLKLDLLKRTATRNQDNITLTAKEFSLLELFMRKQGEVLSRTTIASL
HHCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHH
IWDMNFDSDTNVIDVAVKRLRSKIDKPYDTPLIHTVRGMGYKMDEC
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]