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The map label for this gene is ggt [H]

Identifier: 59713269

GI number: 59713269

Start: 93153

End: 94907

Strand: Reverse

Name: ggt [H]

Synonym: VF_A0086

Alternate gene names: 59713269

Gene position: 94907-93153 (Counterclockwise)

Preceding gene: 59713270

Following gene: 59713268

Centisome position: 7.13

GC content: 41.71

Gene sequence:

>1755_bases
ATGCAATGGAAAGCGTCAACACTCGCCTTATTAATCTCTACCTCTATCGTAAGTCCCGCATCATTCTCAGCTCAAAGCAC
GGACAATATTGCTCCAGAAGCCTCAACAGGGTTAACCAAACAGAACCTAGTTAAAGGCAAAGAATGGATGATTGCTTCTG
CAAATCCTTATGCTAGTGAAGCAGGAGCAGAAATGCTACGCAAAGGCGGTAATGCCATTGATGCGATGGTGGCAACCCAA
TTAGTTCTTGGCTTAGTTGAGCCTCAATCTTCAGGCATCGGTGGCGGCGCATTCCTTGTTTACTGGGATGCAAAAAAACA
AGATCTAACGACTTTTGATGGAAGAGAAACTGCCCCACTAGCAGTTACGCCTCAACTCTTTCAAGATCAAAAAGGAGAGC
CTCTTAAGTTTTATGACGCTGTTGTAGGAGGACGATCGGTTGGTACTCCTGGCACAATAAAACTAATGTGGGATACCCAC
CAAAAGCTTGGGAAATTAGATTGGAAAACCTTATTTAAACCAGCAATAAAGTTGGCAACGGAAGGCTTTATAGTTAGTCC
TCGTTTAGCTAAGTTGGTTGATAATGACCAAGAATTTCTACAGCGTTCTCCAGTAACAAAAGCCTATTTCTTTAATCAAG
ATGGTTCCCCAATTAAAGCAGGACAACAACTTAAAAACCTTCAATATGCCAATACATTAGAAGCGATTTCAGAGCAAGGA
GCAAAGGCGTTCTATCAAGGAGAAATCGCAGAAGATATTGTAAATACAGTAAGAAATGAAACCTCTAACCCTGGGGTGCT
TAATTTAATTGATTTTACAGCTTATCAAGTGAAAGAGCGTGAGCCAGTCTGTGCACCTTATCGTCAATATGCGATCTGTG
GAATGGGACCGCCAAGTTCCGGCGCATTAACCCTTGGGCAAATCATGGGAATACTCAGCCATTACCCAATCTCAAACATG
GGTAAGGATAACGTACAAAGCTGGAGATTGCTCGGTGATGCTTCTCGGTTAGCTTTTGCAGATAGAGGTAAGTACATAGC
TGACAGTGATTATGTACCAATGCCAACTCAAGGCTTATTAGACAAAAACTATTTGGAACAACGAGCCCAATTATTACAAG
GTGAAAATGCGTTAGTTGAGACCACAGCAGGTTCACCTCCGTGGTCACATGCCAATAATTACGCTTTAGACGAAGCGATT
GAATTACCTTCTACGAGTCATTTTTCTATTGTCGATAATGAGCGTAATGTCGTTTCAATCACCACCACAATAGAAAATGG
TTTTGGTTCTCGCTTAATGGTCAGAGGGTTCTTATTAAATAATGAGTTAACCGATTTCTCCTTTAGAAGCCACGTTAATG
GCATACCAATCGCCAACCGTATTGAACCGGGAAAACGTCCGAGATCCTCCATGGCACCGACGATTGTGATGAAAGACAAT
AAACCTTATATAGCAATTGGCTCTCCCGGTGGCAGCCAAATTATAGGGTATGTAGCTAAAACCTTGGTTGCTCATCTTGA
TTGGGGCTTAAATTTACAACAAGCGATTGACTTACCTAATATGAATAATCGATTTGGGGCATTTGAAATAGAGAAAGATA
CGCCAGCCGAAGCGTGGGTTCCTAAATTAGAAAAGCTAGGATTTAAAGTTCAAGTTAAAGAACTAAACTCTGGCGTTCAA
GCGATTAAACTGCAAGAAAACTCACTTATTGGTGCAGCCGATCCCCGTCGTGAAGGTAAGGTTATTACAAAATAA

Upstream 100 bases:

>100_bases
GAGCATCAACCAAGAACCATAATAAGCTATTCGACACTCTTCTTGTCCTCTGTCAGTCTTTTTATCTAACCCAATCTTCT
TTGTTAGACTAGGAGCTTCT

Downstream 100 bases:

>100_bases
AACAGATAAAGTAGGGTTATCATGCCCTACTTATTTTCTTGTGTGACATTAGTTCACACTATTAGGATTCACTTCAATCC
AATAAAACCAAATACGATTG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MQWKASTLALLISTSIVSPASFSAQSTDNIAPEASTGLTKQNLVKGKEWMIASANPYASEAGAEMLRKGGNAIDAMVATQ
LVLGLVEPQSSGIGGGAFLVYWDAKKQDLTTFDGRETAPLAVTPQLFQDQKGEPLKFYDAVVGGRSVGTPGTIKLMWDTH
QKLGKLDWKTLFKPAIKLATEGFIVSPRLAKLVDNDQEFLQRSPVTKAYFFNQDGSPIKAGQQLKNLQYANTLEAISEQG
AKAFYQGEIAEDIVNTVRNETSNPGVLNLIDFTAYQVKEREPVCAPYRQYAICGMGPPSSGALTLGQIMGILSHYPISNM
GKDNVQSWRLLGDASRLAFADRGKYIADSDYVPMPTQGLLDKNYLEQRAQLLQGENALVETTAGSPPWSHANNYALDEAI
ELPSTSHFSIVDNERNVVSITTTIENGFGSRLMVRGFLLNNELTDFSFRSHVNGIPIANRIEPGKRPRSSMAPTIVMKDN
KPYIAIGSPGGSQIIGYVAKTLVAHLDWGLNLQQAIDLPNMNNRFGAFEIEKDTPAEAWVPKLEKLGFKVQVKELNSGVQ
AIKLQENSLIGAADPRREGKVITK

Sequences:

>Translated_584_residues
MQWKASTLALLISTSIVSPASFSAQSTDNIAPEASTGLTKQNLVKGKEWMIASANPYASEAGAEMLRKGGNAIDAMVATQ
LVLGLVEPQSSGIGGGAFLVYWDAKKQDLTTFDGRETAPLAVTPQLFQDQKGEPLKFYDAVVGGRSVGTPGTIKLMWDTH
QKLGKLDWKTLFKPAIKLATEGFIVSPRLAKLVDNDQEFLQRSPVTKAYFFNQDGSPIKAGQQLKNLQYANTLEAISEQG
AKAFYQGEIAEDIVNTVRNETSNPGVLNLIDFTAYQVKEREPVCAPYRQYAICGMGPPSSGALTLGQIMGILSHYPISNM
GKDNVQSWRLLGDASRLAFADRGKYIADSDYVPMPTQGLLDKNYLEQRAQLLQGENALVETTAGSPPWSHANNYALDEAI
ELPSTSHFSIVDNERNVVSITTTIENGFGSRLMVRGFLLNNELTDFSFRSHVNGIPIANRIEPGKRPRSSMAPTIVMKDN
KPYIAIGSPGGSQIIGYVAKTLVAHLDWGLNLQQAIDLPNMNNRFGAFEIEKDTPAEAWVPKLEKLGFKVQVKELNSGVQ
AIKLQENSLIGAADPRREGKVITK
>Mature_584_residues
MQWKASTLALLISTSIVSPASFSAQSTDNIAPEASTGLTKQNLVKGKEWMIASANPYASEAGAEMLRKGGNAIDAMVATQ
LVLGLVEPQSSGIGGGAFLVYWDAKKQDLTTFDGRETAPLAVTPQLFQDQKGEPLKFYDAVVGGRSVGTPGTIKLMWDTH
QKLGKLDWKTLFKPAIKLATEGFIVSPRLAKLVDNDQEFLQRSPVTKAYFFNQDGSPIKAGQQLKNLQYANTLEAISEQG
AKAFYQGEIAEDIVNTVRNETSNPGVLNLIDFTAYQVKEREPVCAPYRQYAICGMGPPSSGALTLGQIMGILSHYPISNM
GKDNVQSWRLLGDASRLAFADRGKYIADSDYVPMPTQGLLDKNYLEQRAQLLQGENALVETTAGSPPWSHANNYALDEAI
ELPSTSHFSIVDNERNVVSITTTIENGFGSRLMVRGFLLNNELTDFSFRSHVNGIPIANRIEPGKRPRSSMAPTIVMKDN
KPYIAIGSPGGSQIIGYVAKTLVAHLDWGLNLQQAIDLPNMNNRFGAFEIEKDTPAEAWVPKLEKLGFKVQVKELNSGVQ
AIKLQENSLIGAADPRREGKVITK

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=555, Percent_Identity=29.7297297297297, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI73915090, Length=555, Percent_Identity=29.7297297297297, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI73915096, Length=555, Percent_Identity=29.7297297297297, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI73915094, Length=555, Percent_Identity=29.7297297297297, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI113429324, Length=542, Percent_Identity=28.5977859778598, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI113429326, Length=546, Percent_Identity=28.2051282051282, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=26.6304347826087, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI153266901, Length=555, Percent_Identity=26.6666666666667, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI109148539, Length=528, Percent_Identity=27.2727272727273, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI153266907, Length=554, Percent_Identity=25.2707581227437, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI30581157, Length=186, Percent_Identity=34.4086021505376, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI30581155, Length=186, Percent_Identity=34.4086021505376, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1789856, Length=544, Percent_Identity=34.5588235294118, Blast_Score=293, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI212646519, Length=530, Percent_Identity=32.2641509433962, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI72000294, Length=530, Percent_Identity=32.2641509433962, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17542894, Length=507, Percent_Identity=30.1775147928994, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI193208245, Length=605, Percent_Identity=30.4132231404959, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI193208247, Length=605, Percent_Identity=30.4132231404959, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17506189, Length=540, Percent_Identity=28.7037037037037, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI72001495, Length=287, Percent_Identity=26.8292682926829, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=287, Percent_Identity=26.8292682926829, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17564448, Length=427, Percent_Identity=27.4004683840749, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323330, Length=535, Percent_Identity=26.3551401869159, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI18859893, Length=552, Percent_Identity=28.804347826087, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI161077496, Length=551, Percent_Identity=27.2232304900181, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24642670, Length=549, Percent_Identity=26.775956284153, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24642666, Length=549, Percent_Identity=26.775956284153, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI45551474, Length=549, Percent_Identity=26.775956284153, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161077878, Length=549, Percent_Identity=26.775956284153, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI161077880, Length=549, Percent_Identity=26.775956284153, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI18859741, Length=500, Percent_Identity=25.8, Blast_Score=138, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 63684; Mature: 63684

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWKASTLALLISTSIVSPASFSAQSTDNIAPEASTGLTKQNLVKGKEWMIASANPYASE
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCCHHH
AGAEMLRKGGNAIDAMVATQLVLGLVEPQSSGIGGGAFLVYWDAKKQDLTTFDGRETAPL
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCE
AVTPQLFQDQKGEPLKFYDAVVGGRSVGTPGTIKLMWDTHQKLGKLDWKTLFKPAIKLAT
EECHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHC
EGFIVSPRLAKLVDNDQEFLQRSPVTKAYFFNQDGSPIKAGQQLKNLQYANTLEAISEQG
CCEEECCHHHHHHCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
AKAFYQGEIAEDIVNTVRNETSNPGVLNLIDFTAYQVKEREPVCAPYRQYAICGMGPPSS
CHHHHCCHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCCCCCCCHHEEEECCCCCCC
GALTLGQIMGILSHYPISNMGKDNVQSWRLLGDASRLAFADRGKYIADSDYVPMPTQGLL
CCEEHHHHHHHHHCCCCCCCCCCCHHHHHEECCHHHHHHHHCCCEEECCCCCCCCCHHCC
DKNYLEQRAQLLQGENALVETTAGSPPWSHANNYALDEAIELPSTSHFSIVDNERNVVSI
CHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCEEEE
TTTIENGFGSRLMVRGFLLNNELTDFSFRSHVNGIPIANRIEPGKRPRSSMAPTIVMKDN
EEEECCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
KPYIAIGSPGGSQIIGYVAKTLVAHLDWGLNLQQAIDLPNMNNRFGAFEIEKDTPAEAWV
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHH
PKLEKLGFKVQVKELNSGVQAIKLQENSLIGAADPRREGKVITK
HHHHHCCCEEEEHHHCCCCEEEEEECCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MQWKASTLALLISTSIVSPASFSAQSTDNIAPEASTGLTKQNLVKGKEWMIASANPYASE
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCCHHH
AGAEMLRKGGNAIDAMVATQLVLGLVEPQSSGIGGGAFLVYWDAKKQDLTTFDGRETAPL
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCE
AVTPQLFQDQKGEPLKFYDAVVGGRSVGTPGTIKLMWDTHQKLGKLDWKTLFKPAIKLAT
EECHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHC
EGFIVSPRLAKLVDNDQEFLQRSPVTKAYFFNQDGSPIKAGQQLKNLQYANTLEAISEQG
CCEEECCHHHHHHCCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
AKAFYQGEIAEDIVNTVRNETSNPGVLNLIDFTAYQVKEREPVCAPYRQYAICGMGPPSS
CHHHHCCHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHCCCCCCCCCCHHEEEECCCCCCC
GALTLGQIMGILSHYPISNMGKDNVQSWRLLGDASRLAFADRGKYIADSDYVPMPTQGLL
CCEEHHHHHHHHHCCCCCCCCCCCHHHHHEECCHHHHHHHHCCCEEECCCCCCCCCHHCC
DKNYLEQRAQLLQGENALVETTAGSPPWSHANNYALDEAIELPSTSHFSIVDNERNVVSI
CHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCEEEEECCCCEEEE
TTTIENGFGSRLMVRGFLLNNELTDFSFRSHVNGIPIANRIEPGKRPRSSMAPTIVMKDN
EEEECCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
KPYIAIGSPGGSQIIGYVAKTLVAHLDWGLNLQQAIDLPNMNNRFGAFEIEKDTPAEAWV
CCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHH
PKLEKLGFKVQVKELNSGVQAIKLQENSLIGAADPRREGKVITK
HHHHHCCCEEEEHHHCCCCEEEEEECCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA