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The map label for this gene is cirA [H]

Identifier: 59713242

GI number: 59713242

Start: 62931

End: 65114

Strand: Reverse

Name: cirA [H]

Synonym: VF_A0059

Alternate gene names: 59713242

Gene position: 65114-62931 (Counterclockwise)

Preceding gene: 59713249

Following gene: 59713241

Centisome position: 4.89

GC content: 38.97

Gene sequence:

>2184_bases
ATGTCGATGCTATCTCGTGCTCCATTTTTGTATGCTTTATGTATCTTTGTGTCTTCACCCGTTATCGCAAACATAGATAA
TGAATTTGATGATCTTGATGCATTACTCAATATGCCACTTGAATCGCTAGCCGATACGAAAGTCGTCACTGCAACCAAAA
CATCACTTAGTCTGTCAGATGTTCCAGCTTCTGTTCATGTAATCACTTCCAAAGAAATAGAACGTTCTAGTGCCCGTTCT
ATTGCCGATGTATTAATTCTTGCTCCAGGGCTTCATGTTGCCAAATTTTCCGATTACGACTGGACCGTTTCAGCTCGCAG
TAAAAACCAAGGTGAAAATAATACGCTTTTAGTCATGATAGATGGCCGAAGTGCCGTTAACCCAATGTACTCTGGTGTTA
ACTGGGATACTTTACCTGTCAGCCTAGATAGTATTGACCGTATTGAAGTGGTCTTAGGCCCTGTAGGTACAATGTGGGGA
GGAAACGCGGTTAATGGTGTCATAAATATCATTACAAAAGATGCAGAAAGCGCACCTAAAGCACAATTAAGTGCTTCAAC
AGGTAATTTTGACTACAAAGAGTTTAAAGCTCACCACAGCGGTCAAATTAGCGAAAACACGCATTTATCTGGCTATATTG
AATCATTACAACACTCACCGTTTACTGATACTGATGAACATTTTAAAGAGCTTAGACACCTAAAAGTATTAACCGAACGT
TTTGGGATGCGCGCTGATTACCAAAACTTACAAAATACGGTTTCTGTTCAGTTTGGCGGGATCCAGTCTCGTGAAGATTA
TCAGTGGCTAACTTATACTCCTGCTTTTCTTGATCCTACGACACATAAAAATGACTATGATGTGTTTTTAACTGAAATGA
ACTCACAAGAGTTATTTGCAGGTTTCCAATACCTTCACGAAAAACTAAACGGTAACCAATGGGAAAACCAACTATGGGTT
ACTCATAGTGAATCTGATAGCACCAATGAACCAGCAAGTTTTACTCGCATTGATCTTGATACTCGTTACACCTTTAATAC
TCAAGATTGGGGAATATTAACACTTGGTGCAAATGCTCGTATTATTGATGAAGAATACGCTCAATTCTCTGAAAAAGAGC
AGTACTTCTCACCTTATATTCGCACCATTGATGATCATAAGTTCTTAAACCAAAGCTATGGTTTTTATGCAAACTGGGCT
GTTGATGTAACTGATTCAACAGAAATCACACTAGGCAATCGTATTCAATATGCCAATATCACTGAAGAGTGGTACTCACA
ACCTCAAGTTCGCGCATTACAAAAATTAACGGACAACCAACGTTTATGGATGGGTTGGGGTCGAGCAGTCATTACACCTT
CTCGTTTAGAGCTAGATACACAGTTTCAAAAAAACAGTTATTGCAGTAGTTGTGCTTATACCGTCAATCCTGATGGTAGT
GTAAATTATTATGACTACATGATGTCCTATCATTACTTAGGTAATCGTGATTTAGACATGGAATCTGTCGATACGTATGA
AATTGGTTACCGTTATTGGCAAGATAATCAATTCCAAGTAAGCCTAAGCCTATTCTATAGTCAGCATGATAATGTTAGAG
CTTATAGAGGTCTCGGAGGAAGTCGATACTTTACACCTGATAGCTCTCAGCATTCTAGCGGCACAATTATTGATGATATG
TTTGCTCAATTAGTTGACCCTCTCTCCCAAGAAACTATGGGAGGAGAGGTGAGTATCCAATGGCAACCAATCGATGTCTT
GCAAATCAATGCCAATTACAGCTATAAGACAATCGAGGGAGATTGTAACGGCTCTATCTGCGGTTCAAATGAATTGCCTA
TTTTAGATCTAGAAAATACGCCTCATCACTATGCCACACTGCACGTGATGTGGGATATTCATCCAACAGTTTGGGTTTCA
TCAGTAGTGAATTATGTTTCAGCATCAGAACCTGACGAAGCATTAATTCAAGCATATCAATCTTATGGTGACGATTATAC
GATCTGGCCAGAAGTCGTTACGATTGATATGTCGATTAATTGGCAACATAAACCAACATGGCCAAGCATAAAATTAAGTG
CTGAGAACCTAGGTAGTGACCAATTAAAAGAATACCCAGAGCAATTTGGGCCATTTGCAAATGGTACTCAATACTATGCT
GAATTAAGTTGGAATTTTATATAG

Upstream 100 bases:

>100_bases
ACATTATCTTAAACTTAAGAATTACATCAAAATATACAAAATGGGTATTCAGTTAATACCTTATATTTATTTCAGTTATA
TTTGGTGTTAATTCAATATC

Downstream 100 bases:

>100_bases
CCATGTTCAAAACAAAAGCACAGGCAAACTCACCCACACCATTATTTTATGGGCTATGCTCTAAAGTAATAGGCTGCCTG
CTGCTTTTACTTATAAGTTT

Product: TonB-dependent outer membrane receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 727; Mature: 726

Protein sequence:

>727_residues
MSMLSRAPFLYALCIFVSSPVIANIDNEFDDLDALLNMPLESLADTKVVTATKTSLSLSDVPASVHVITSKEIERSSARS
IADVLILAPGLHVAKFSDYDWTVSARSKNQGENNTLLVMIDGRSAVNPMYSGVNWDTLPVSLDSIDRIEVVLGPVGTMWG
GNAVNGVINIITKDAESAPKAQLSASTGNFDYKEFKAHHSGQISENTHLSGYIESLQHSPFTDTDEHFKELRHLKVLTER
FGMRADYQNLQNTVSVQFGGIQSREDYQWLTYTPAFLDPTTHKNDYDVFLTEMNSQELFAGFQYLHEKLNGNQWENQLWV
THSESDSTNEPASFTRIDLDTRYTFNTQDWGILTLGANARIIDEEYAQFSEKEQYFSPYIRTIDDHKFLNQSYGFYANWA
VDVTDSTEITLGNRIQYANITEEWYSQPQVRALQKLTDNQRLWMGWGRAVITPSRLELDTQFQKNSYCSSCAYTVNPDGS
VNYYDYMMSYHYLGNRDLDMESVDTYEIGYRYWQDNQFQVSLSLFYSQHDNVRAYRGLGGSRYFTPDSSQHSSGTIIDDM
FAQLVDPLSQETMGGEVSIQWQPIDVLQINANYSYKTIEGDCNGSICGSNELPILDLENTPHHYATLHVMWDIHPTVWVS
SVVNYVSASEPDEALIQAYQSYGDDYTIWPEVVTIDMSINWQHKPTWPSIKLSAENLGSDQLKEYPEQFGPFANGTQYYA
ELSWNFI

Sequences:

>Translated_727_residues
MSMLSRAPFLYALCIFVSSPVIANIDNEFDDLDALLNMPLESLADTKVVTATKTSLSLSDVPASVHVITSKEIERSSARS
IADVLILAPGLHVAKFSDYDWTVSARSKNQGENNTLLVMIDGRSAVNPMYSGVNWDTLPVSLDSIDRIEVVLGPVGTMWG
GNAVNGVINIITKDAESAPKAQLSASTGNFDYKEFKAHHSGQISENTHLSGYIESLQHSPFTDTDEHFKELRHLKVLTER
FGMRADYQNLQNTVSVQFGGIQSREDYQWLTYTPAFLDPTTHKNDYDVFLTEMNSQELFAGFQYLHEKLNGNQWENQLWV
THSESDSTNEPASFTRIDLDTRYTFNTQDWGILTLGANARIIDEEYAQFSEKEQYFSPYIRTIDDHKFLNQSYGFYANWA
VDVTDSTEITLGNRIQYANITEEWYSQPQVRALQKLTDNQRLWMGWGRAVITPSRLELDTQFQKNSYCSSCAYTVNPDGS
VNYYDYMMSYHYLGNRDLDMESVDTYEIGYRYWQDNQFQVSLSLFYSQHDNVRAYRGLGGSRYFTPDSSQHSSGTIIDDM
FAQLVDPLSQETMGGEVSIQWQPIDVLQINANYSYKTIEGDCNGSICGSNELPILDLENTPHHYATLHVMWDIHPTVWVS
SVVNYVSASEPDEALIQAYQSYGDDYTIWPEVVTIDMSINWQHKPTWPSIKLSAENLGSDQLKEYPEQFGPFANGTQYYA
ELSWNFI
>Mature_726_residues
SMLSRAPFLYALCIFVSSPVIANIDNEFDDLDALLNMPLESLADTKVVTATKTSLSLSDVPASVHVITSKEIERSSARSI
ADVLILAPGLHVAKFSDYDWTVSARSKNQGENNTLLVMIDGRSAVNPMYSGVNWDTLPVSLDSIDRIEVVLGPVGTMWGG
NAVNGVINIITKDAESAPKAQLSASTGNFDYKEFKAHHSGQISENTHLSGYIESLQHSPFTDTDEHFKELRHLKVLTERF
GMRADYQNLQNTVSVQFGGIQSREDYQWLTYTPAFLDPTTHKNDYDVFLTEMNSQELFAGFQYLHEKLNGNQWENQLWVT
HSESDSTNEPASFTRIDLDTRYTFNTQDWGILTLGANARIIDEEYAQFSEKEQYFSPYIRTIDDHKFLNQSYGFYANWAV
DVTDSTEITLGNRIQYANITEEWYSQPQVRALQKLTDNQRLWMGWGRAVITPSRLELDTQFQKNSYCSSCAYTVNPDGSV
NYYDYMMSYHYLGNRDLDMESVDTYEIGYRYWQDNQFQVSLSLFYSQHDNVRAYRGLGGSRYFTPDSSQHSSGTIIDDMF
AQLVDPLSQETMGGEVSIQWQPIDVLQINANYSYKTIEGDCNGSICGSNELPILDLENTPHHYATLHVMWDIHPTVWVSS
VVNYVSASEPDEALIQAYQSYGDDYTIWPEVVTIDMSINWQHKPTWPSIKLSAENLGSDQLKEYPEQFGPFANGTQYYAE
LSWNFI

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=207, Percent_Identity=28.9855072463768, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1790405, Length=297, Percent_Identity=25.2525252525253, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787723, Length=224, Percent_Identity=25, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 82701; Mature: 82570

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLSRAPFLYALCIFVSSPVIANIDNEFDDLDALLNMPLESLADTKVVTATKTSLSLSD
CCCHHHCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHHCCCEEEEEEECEEEECC
VPASVHVITSKEIERSSARSIADVLILAPGLHVAKFSDYDWTVSARSKNQGENNTLLVMI
CCCEEEEEECHHHHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEE
DGRSAVNPMYSGVNWDTLPVSLDSIDRIEVVLGPVGTMWGGNAVNGVINIITKDAESAPK
CCCCCCCHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHCCEEEEEECCCCCCCC
AQLSASTGNFDYKEFKAHHSGQISENTHLSGYIESLQHSPFTDTDEHFKELRHLKVLTER
CEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
FGMRADYQNLQNTVSVQFGGIQSREDYQWLTYTPAFLDPTTHKNDYDVFLTEMNSQELFA
HCCCCCHHHHCCEEEEEECCCCCCCCCEEEEECCHHCCCCCCCCCCEEEEEECCCHHHHH
GFQYLHEKLNGNQWENQLWVTHSESDSTNEPASFTRIDLDTRYTFNTQDWGILTLGANAR
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEECCEEEEECCCCCEEEEECCCCE
IIDEEYAQFSEKEQYFSPYIRTIDDHKFLNQSYGFYANWAVDVTDSTEITLGNRIQYANI
EECHHHHHHHHHHHHHCHHHHCCCCHHHHHCCCCEEEEEEEEECCCCEEEECCEEEECCC
TEEWYSQPQVRALQKLTDNQRLWMGWGRAVITPSRLELDTQFQKNSYCSSCAYTVNPDGS
CHHHCCCHHHHHHHHHCCCCEEEEECCCEEECCCCEEECCHHHCCCCCCCCEEEECCCCC
VNYYDYMMSYHYLGNRDLDMESVDTYEIGYRYWQDNQFQVSLSLFYSQHDNVRAYRGLGG
CCHHHHHHHHHCCCCCCCCCCCCCEEEECEEEECCCEEEEEEEEEECCCCCCEEECCCCC
SRYFTPDSSQHSSGTIIDDMFAQLVDPLSQETMGGEVSIQWQPIDVLQINANYSYKTIEG
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECEEEEEEECCCEEEEEEC
DCNGSICGSNELPILDLENTPHHYATLHVMWDIHPTVWVSSVVNYVSASEPDEALIQAYQ
CCCCCEECCCCCEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
SYGDDYTIWPEVVTIDMSINWQHKPTWPSIKLSAENLGSDQLKEYPEQFGPFANGTQYYA
HHCCCEEECCEEEEEEEEEECCCCCCCCCEEEEHHHCCHHHHHHHHHHHCCCCCCCEEEE
ELSWNFI
EEEEECC
>Mature Secondary Structure 
SMLSRAPFLYALCIFVSSPVIANIDNEFDDLDALLNMPLESLADTKVVTATKTSLSLSD
CCHHHCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCHHHHCCCEEEEEEECEEEECC
VPASVHVITSKEIERSSARSIADVLILAPGLHVAKFSDYDWTVSARSKNQGENNTLLVMI
CCCEEEEEECHHHHHHHHHHHHHHHEECCCCEEEEECCCCEEEEECCCCCCCCCEEEEEE
DGRSAVNPMYSGVNWDTLPVSLDSIDRIEVVLGPVGTMWGGNAVNGVINIITKDAESAPK
CCCCCCCHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHCCEEEEEECCCCCCCC
AQLSASTGNFDYKEFKAHHSGQISENTHLSGYIESLQHSPFTDTDEHFKELRHLKVLTER
CEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
FGMRADYQNLQNTVSVQFGGIQSREDYQWLTYTPAFLDPTTHKNDYDVFLTEMNSQELFA
HCCCCCHHHHCCEEEEEECCCCCCCCCEEEEECCHHCCCCCCCCCCEEEEEECCCHHHHH
GFQYLHEKLNGNQWENQLWVTHSESDSTNEPASFTRIDLDTRYTFNTQDWGILTLGANAR
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEECCEEEEECCCCCEEEEECCCCE
IIDEEYAQFSEKEQYFSPYIRTIDDHKFLNQSYGFYANWAVDVTDSTEITLGNRIQYANI
EECHHHHHHHHHHHHHCHHHHCCCCHHHHHCCCCEEEEEEEEECCCCEEEECCEEEECCC
TEEWYSQPQVRALQKLTDNQRLWMGWGRAVITPSRLELDTQFQKNSYCSSCAYTVNPDGS
CHHHCCCHHHHHHHHHCCCCEEEEECCCEEECCCCEEECCHHHCCCCCCCCEEEECCCCC
VNYYDYMMSYHYLGNRDLDMESVDTYEIGYRYWQDNQFQVSLSLFYSQHDNVRAYRGLGG
CCHHHHHHHHHCCCCCCCCCCCCCEEEECEEEECCCEEEEEEEEEECCCCCCEEECCCCC
SRYFTPDSSQHSSGTIIDDMFAQLVDPLSQETMGGEVSIQWQPIDVLQINANYSYKTIEG
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECEEEEEEECCCEEEEEEC
DCNGSICGSNELPILDLENTPHHYATLHVMWDIHPTVWVSSVVNYVSASEPDEALIQAYQ
CCCCCEECCCCCEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
SYGDDYTIWPEVVTIDMSINWQHKPTWPSIKLSAENLGSDQLKEYPEQFGPFANGTQYYA
HHCCCEEECCEEEEEEEEEECCCCCCCCCEEEEHHHCCHHHHHHHHHHHCCCCCCCEEEE
ELSWNFI
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]