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The map label for this gene is uhpT [H]

Identifier: 59713225

GI number: 59713225

Start: 45710

End: 47104

Strand: Reverse

Name: uhpT [H]

Synonym: VF_A0042

Alternate gene names: 59713225

Gene position: 47104-45710 (Counterclockwise)

Preceding gene: 59713226

Following gene: 59713224

Centisome position: 3.54

GC content: 39.64

Gene sequence:

>1395_bases
ATGTTAAAGTTCTTAGATCAGGTTAGAAAACCAACATTAGATCTTCCGGTAGAAGTACGAAGAAAAATGTGGTTTAAGCC
TTTCCTACAATCTTACCTAGTTGTATTTATTGGTTATTTAACCATGTATCTGATCCGTAAAAACTTCAATGTCGCACAAA
ACGACATGATTTCAACTTACGGATTATCAATGACTGACTTAGGTCTGATTGGTCTTGGCTTTTCAATTACTTATGGTATT
GGTAAAACCGTTGTGTCTTACTATGCTGATGGTAAAAACACCAAACAATTCTTACCTTTCATGCTGATTCTTTCTGGTTT
AGCTATGCTAGGTTTTAGCTTCAGTATGGGTGGCGGCAGCGCGAGTCTATTCATGATGGTCGCTTTCTATGCGTTAAGTG
GTTTTTTCCAAAGTACAGGTGGTCCTTCAAGTTACTCAACCATCACTAAATGGACGCCTCGTAATAAACGTGGTTCATAT
TTAGGTCTTTGGAATATGTCACACAACGTTGGTGGTGCTGGTGCGGCTGGTGTTGCTCTATTTGGTGCAAACTACCTATT
TGATGGCAACGTTATCGGTATGTTCGTATTCCCATCTATCATTGCAATCATTGTTGGCTTTATTGGTATGCGTTTTGGTA
GTGACTCACCAGAAGCTTATGGCCTAGGTAAAGTTGAAGAACTTTTTGATGAAGAGATCAGTGAAGAAGATACTGCTGCT
GAAGAAAATCAAATGACGAAAAAAGAGATCTTTGTTGAGTATGTACTTAAAAACAAAGTGATCTGGTTACTCTGCTTTGC
GAATATTTTCTTATACATTGTTCGTATTGGTATCGATCAATGGTCTACGGTTTACGCTTATCAAGAATTAGGTCTATCAA
AAGAAACTGCTATTTCAGGCTTTACTCTATTTGAAGTCGGCGCTCTTGTTGGCACATTAATGTGGGGTTATTTATCTGAC
CTTGCTAACGGTCGTCGTGCTTTGGTTGCTTGTGTTTCTCTTGGCTTAATCATTGTGTCACTAGAGTTTTACCAACACGC
GACCAGTGAGTTCATGTATCTTGCTTCTCTGTTTGTACTTGGTTTCTTAGTGTTTGGTCCTCAGTTATTAATTGGTGTTG
CTGCGGTTGGTTTTGTTCCCAAAAAAGCCATCAGTGTTGCCGATGGTGTGAAAGGTACTTTCGCTTACTTAATTGGTGAC
AGCTTTGCAAAACTAGGCCTTGGTATGATTGCAGATGGTACTCCTATCTTTGGCTTAACCGGTTGGAAAGGCACATTTGC
GGCGTTAGATACTTCTGCTGCAATCTGTATTTTCTTACTTGTGTTTGTCGCTATCGCCGAAGAGAAGAAAATCCGTCACG
CTAAAAAAATGCACCTAGCTGCAAAACAAGCGTAA

Upstream 100 bases:

>100_bases
GTCGCTTTTTAGACTCCTTACTATTCTCCTGTCAAATAACAAAGAGAGTATGGAGCACATGACTCCGTACATATCCTTAT
AGATTATAAGAGAGTTCACA

Downstream 100 bases:

>100_bases
TACTTTCGCGCGCTTTACCTAGCTAAAGCGCGCGAGATCATACCAATAACGTTCTCAATTCAGTATCATTACCCCACCTT
ATATTTATATTCTTGTCGCT

Product: sugar phosphate antiporter

Products: Proton [Cytoplasm]; glucose-6-phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MLKFLDQVRKPTLDLPVEVRRKMWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGI
GKTVVSYYADGKNTKQFLPFMLILSGLAMLGFSFSMGGGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSY
LGLWNMSHNVGGAGAAGVALFGANYLFDGNVIGMFVFPSIIAIIVGFIGMRFGSDSPEAYGLGKVEELFDEEISEEDTAA
EENQMTKKEIFVEYVLKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD
LANGRRALVACVSLGLIIVSLEFYQHATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGD
SFAKLGLGMIADGTPIFGLTGWKGTFAALDTSAAICIFLLVFVAIAEEKKIRHAKKMHLAAKQA

Sequences:

>Translated_464_residues
MLKFLDQVRKPTLDLPVEVRRKMWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGI
GKTVVSYYADGKNTKQFLPFMLILSGLAMLGFSFSMGGGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSY
LGLWNMSHNVGGAGAAGVALFGANYLFDGNVIGMFVFPSIIAIIVGFIGMRFGSDSPEAYGLGKVEELFDEEISEEDTAA
EENQMTKKEIFVEYVLKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD
LANGRRALVACVSLGLIIVSLEFYQHATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGD
SFAKLGLGMIADGTPIFGLTGWKGTFAALDTSAAICIFLLVFVAIAEEKKIRHAKKMHLAAKQA
>Mature_464_residues
MLKFLDQVRKPTLDLPVEVRRKMWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGI
GKTVVSYYADGKNTKQFLPFMLILSGLAMLGFSFSMGGGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSY
LGLWNMSHNVGGAGAAGVALFGANYLFDGNVIGMFVFPSIIAIIVGFIGMRFGSDSPEAYGLGKVEELFDEEISEEDTAA
EENQMTKKEIFVEYVLKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD
LANGRRALVACVSLGLIIVSLEFYQHATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGD
SFAKLGLGMIADGTPIFGLTGWKGTFAALDTSAAICIFLLVFVAIAEEKKIRHAKKMHLAAKQA

Specific function: Transport protein for sugar phosphate uptake [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=392, Percent_Identity=24.234693877551, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI4503847, Length=392, Percent_Identity=24.234693877551, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI256219483, Length=392, Percent_Identity=24.234693877551, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI256219543, Length=414, Percent_Identity=23.4299516908213, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI256219564, Length=322, Percent_Identity=23.6024844720497, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI2367259, Length=458, Percent_Identity=81.8777292576419, Blast_Score=752, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=456, Percent_Identity=30.7017543859649, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI87082310, Length=455, Percent_Identity=35.3846153846154, Blast_Score=211, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17542316, Length=379, Percent_Identity=23.4828496042216, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133901854, Length=368, Percent_Identity=24.1847826086957, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI133901856, Length=368, Percent_Identity=24.1847826086957, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI133930953, Length=481, Percent_Identity=20.7900207900208, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24656861, Length=513, Percent_Identity=23.1968810916179, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24656866, Length=514, Percent_Identity=23.1517509727626, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45550478, Length=514, Percent_Identity=23.1517509727626, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50740; Mature: 50740

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKFLDQVRKPTLDLPVEVRRKMWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTY
CCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHC
GLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLILSGLAMLGFSFSMGGGS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCH
ASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVAL
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHH
FGANYLFDGNVIGMFVFPSIIAIIVGFIGMRFGSDSPEAYGLGKVEELFDEEISEEDTAA
HCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHCCH
EENQMTKKEIFVEYVLKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCC
FTLFEVGALVGTLMWGYLSDLANGRRALVACVSLGLIIVSLEFYQHATSEFMYLASLFVL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFAKLGLGMIADGTPIFGLT
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCCEEEEC
GWKGTFAALDTSAAICIFLLVFVAIAEEKKIRHAKKMHLAAKQA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKFLDQVRKPTLDLPVEVRRKMWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTY
CCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHC
GLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLILSGLAMLGFSFSMGGGS
CCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCH
ASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVAL
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCHHHHHH
FGANYLFDGNVIGMFVFPSIIAIIVGFIGMRFGSDSPEAYGLGKVEELFDEEISEEDTAA
HCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHCCH
EENQMTKKEIFVEYVLKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCC
FTLFEVGALVGTLMWGYLSDLANGRRALVACVSLGLIIVSLEFYQHATSEFMYLASLFVL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFAKLGLGMIADGTPIFGLT
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCCEEEEC
GWKGTFAALDTSAAICIFLLVFVAIAEEKKIRHAKKMHLAAKQA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; glucose-6-phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + glucose-6-phosphate [Periplasm] = Proton [Cytoplasm] + glucose-6-phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]