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The map label for this gene is echA8 [H]

Identifier: 59713206

GI number: 59713206

Start: 25486

End: 26298

Strand: Reverse

Name: echA8 [H]

Synonym: VF_A0023

Alternate gene names: 59713206

Gene position: 26298-25486 (Counterclockwise)

Preceding gene: 59713208

Following gene: 59713205

Centisome position: 1.98

GC content: 38.75

Gene sequence:

>813_bases
ATGAAAACATTATCAATCACTAACCAAAATGGCATCGCAACAGTAGCTATCAATAACCCACCAGTGAATGTATTAACCAT
TAATCTAATTAACGAAATTAATGAGTATGTACTTTCTTTAAAAGATGACAGAGATACTAAAGTTGTGGTGTTTAAATCAT
TGCATGAAACCTTCTTTTTAGCGCATCTTGATCTAAACGTGATCAACGGTACGCAAGGCGGTCAAGCAGCGTCTATTGAG
TTCAACCACATGATCATGAACATCAAAGCAATGAAACAAGTCTCTGTTGCTTTAGTTGATGGTGTGGCTCGTGGGGGCGG
TAATGAGTTTGTTATGGCGTGTGATCTTGCTTATGGCACCGAGAATGCAGCATTTGCTCAACCAGAAGTTCACGTAAACA
TCCCTACTGGTGGACAAGGTGCGGTTCAGTTCGCAAGAAGAATGGGTAAAAACAAAGCATTACAAGCTCTTCTATTGGGT
AACGATTTCACAGCACAACAAGCTGAAAACTTAAATATCATTACTCAATTTGTTCCTAAAGCGGAAATGGATAACTTTTT
AGCCATGACTTTAGGTGTGATTAGCACATTAGAAGTGCGTGATATTGTGATGTACAAAAAGATCATTGCGGCATCAATTA
AAGATGAAGACGCGGGTGCAGAATTAGAGTTACGTTACTTTTTAGAGCGTGCTAAAGAGCAAAAAACAGCCGCTATTATC
TCTGCATTTTTAAAACATGGCGGACAAACAGAGCGCGAAGCAAAAGATATCCAAGGTATTTTTGTTGATACAGCCGCTGA
ACTATCTAAATAA

Upstream 100 bases:

>100_bases
ATCTAATGGATTGCTTATAGTTACCTCACTGACGCAGAGGACACTCTCTCAACGTAACCATATTTAAACTAGCCGATAGG
CGATTTAGAGGAAGTACATT

Downstream 100 bases:

>100_bases
CATTCAATTACTCCATTATTAGCCGTCGTATTGGCGGCTAATTGTCGTTGAAAACTAACATAATACTGCATGATTGATAG
TACGCATGGCTCAAATTTAT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKTLSITNQNGIATVAINNPPVNVLTINLINEINEYVLSLKDDRDTKVVVFKSLHETFFLAHLDLNVINGTQGGQAASIE
FNHMIMNIKAMKQVSVALVDGVARGGGNEFVMACDLAYGTENAAFAQPEVHVNIPTGGQGAVQFARRMGKNKALQALLLG
NDFTAQQAENLNIITQFVPKAEMDNFLAMTLGVISTLEVRDIVMYKKIIAASIKDEDAGAELELRYFLERAKEQKTAAII
SAFLKHGGQTEREAKDIQGIFVDTAAELSK

Sequences:

>Translated_270_residues
MKTLSITNQNGIATVAINNPPVNVLTINLINEINEYVLSLKDDRDTKVVVFKSLHETFFLAHLDLNVINGTQGGQAASIE
FNHMIMNIKAMKQVSVALVDGVARGGGNEFVMACDLAYGTENAAFAQPEVHVNIPTGGQGAVQFARRMGKNKALQALLLG
NDFTAQQAENLNIITQFVPKAEMDNFLAMTLGVISTLEVRDIVMYKKIIAASIKDEDAGAELELRYFLERAKEQKTAAII
SAFLKHGGQTEREAKDIQGIFVDTAAELSK
>Mature_270_residues
MKTLSITNQNGIATVAINNPPVNVLTINLINEINEYVLSLKDDRDTKVVVFKSLHETFFLAHLDLNVINGTQGGQAASIE
FNHMIMNIKAMKQVSVALVDGVARGGGNEFVMACDLAYGTENAAFAQPEVHVNIPTGGQGAVQFARRMGKNKALQALLLG
NDFTAQQAENLNIITQFVPKAEMDNFLAMTLGVISTLEVRDIVMYKKIIAASIKDEDAGAELELRYFLERAKEQKTAAII
SAFLKHGGQTEREAKDIQGIFVDTAAELSK

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=171, Percent_Identity=28.0701754385965, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI31542718, Length=186, Percent_Identity=26.8817204301075, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1787659, Length=184, Percent_Identity=27.1739130434783, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788597, Length=181, Percent_Identity=28.1767955801105, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI221142681, Length=189, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788682, Length=186, Percent_Identity=26.3440860215054, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=180, Percent_Identity=29.4444444444444, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=189, Percent_Identity=29.1005291005291, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129971, Length=169, Percent_Identity=28.9940828402367, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653477, Length=169, Percent_Identity=28.9940828402367, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653139, Length=180, Percent_Identity=24.4444444444444, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24654903, Length=213, Percent_Identity=23.4741784037559, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19922422, Length=181, Percent_Identity=24.8618784530387, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29411; Mature: 29411

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLSITNQNGIATVAINNPPVNVLTINLINEINEYVLSLKDDRDTKVVVFKSLHETFFL
CCEEEEECCCCEEEEEECCCCCEEEEEHHHHHHHHHHEEECCCCCCEEEEEEHHHHHEEE
AHLDLNVINGTQGGQAASIEFNHMIMNIKAMKQVSVALVDGVARGGGNEFVMACDLAYGT
EEEEEEEEECCCCCEEEEEEEHHEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECC
ENAAFAQPEVHVNIPTGGQGAVQFARRMGKNKALQALLLGNDFTAQQAENLNIITQFVPK
CCCEECCCEEEEECCCCCHHHHHHHHHHCCCHHEEEEEECCCCCCHHCCCCEEEEHHCCC
AEMDNFLAMTLGVISTLEVRDIVMYKKIIAASIKDEDAGAELELRYFLERAKEQKTAAII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SAFLKHGGQTEREAKDIQGIFVDTAAELSK
HHHHHCCCCCCHHHHHHCEEEEECHHHHCC
>Mature Secondary Structure
MKTLSITNQNGIATVAINNPPVNVLTINLINEINEYVLSLKDDRDTKVVVFKSLHETFFL
CCEEEEECCCCEEEEEECCCCCEEEEEHHHHHHHHHHEEECCCCCCEEEEEEHHHHHEEE
AHLDLNVINGTQGGQAASIEFNHMIMNIKAMKQVSVALVDGVARGGGNEFVMACDLAYGT
EEEEEEEEECCCCCEEEEEEEHHEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECC
ENAAFAQPEVHVNIPTGGQGAVQFARRMGKNKALQALLLGNDFTAQQAENLNIITQFVPK
CCCEECCCEEEEECCCCCHHHHHHHHHHCCCHHEEEEEECCCCCCHHCCCCEEEEHHCCC
AEMDNFLAMTLGVISTLEVRDIVMYKKIIAASIKDEDAGAELELRYFLERAKEQKTAAII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SAFLKHGGQTEREAKDIQGIFVDTAAELSK
HHHHHCCCCCCHHHHHHCEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]