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The map label for this gene is ilvY [H]

Identifier: 59713136

GI number: 59713136

Start: 2837770

End: 2838654

Strand: Direct

Name: ilvY [H]

Synonym: VF_2529

Alternate gene names: 59713136

Gene position: 2837770-2838654 (Clockwise)

Preceding gene: 59713132

Following gene: 59713140

Centisome position: 97.94

GC content: 35.82

Gene sequence:

>885_bases
ATGAATATAAAATTACTACAAACGTTTTTGCATTTATGCGAAAGCCATAGTTTCACACATACGTCTAAGGCTATGCATTT
AAGTCCATCAGCTTTAAGCCGACAAATACAAAAATTAGAAGACGACATCGGTCATCCACTGTTTATTAGAGATAACCGAA
GCGTCGAACTAACCAGTGCAGCAAAGCAACTAATACCTATTGCACTGAATATATGCTCCGAATGGAGTGGGTATAAAGCC
AGTTCGAACGTTGTAAATAATGCCTTAAAAGGGCAATTAAAATTATTTTGCTCCGTCACTGCAAGCTACAGCCACCTTCC
TCAATTATTAAATGACTTTAAAGTTAATTACCCACATATAGATATTAAACTATCTACGGGCGATCCTGCTCAAGCGATAG
AAAAGATCGAATCTTCTGAAGTAGATATCGCTATTTCAGCAGTACCAGAAAAACCTTCAAATAAACTAGCTTTTGAAATT
ATTAGTGAGATTCCACTTTCAATTATTGCTCCCTTAGGTAACAACCAATTTATTAGTGAAATAAACAAAGAGAATAGTAA
TTGGGAGTTACTCCCTTTTATACTGCCCGAATCAGGTACCGCTAGAAATCGAGCTAATCAATGGTTTAAAGAACAAGGAA
TAAAACCAACTATCTATGCTCAAGTTTCAGGTCATGAAGCAATTGTGAGCATGGTTGCATTAGGATGTGGGATAGGAATA
GCACCAGATGTTGTGATAAACAACAGCCCAGTGAAAGATAAAGTACAACGGTTAAATACATTACCAATTGCGCCATTTAA
ACTAGGTTTATGCTGTAAAAAATCAAAGTTAAATGATTCTGTTATTCAGGCGCTTTGGCAAGTTGCTGAAAATACTTTTA
TTTAG

Upstream 100 bases:

>100_bases
TCCATTGGGATGATTCTGTGTATGAATTTGATAATAACGAAAGATTAACATTGTAAAAAGTGATATATTGGCAACACATG
ATTGCAATAAACACAACATT

Downstream 100 bases:

>100_bases
TTCTGAAACGAAAAAAGGCTTCCCTATGGGAAGCCTTTTAAATTTGAGCCTAGCGATGTCCTACTCTCACATGGGGAAAC
CCCACACTACCATCGGCGCT

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNIKLLQTFLHLCESHSFTHTSKAMHLSPSALSRQIQKLEDDIGHPLFIRDNRSVELTSAAKQLIPIALNICSEWSGYKA
SSNVVNNALKGQLKLFCSVTASYSHLPQLLNDFKVNYPHIDIKLSTGDPAQAIEKIESSEVDIAISAVPEKPSNKLAFEI
ISEIPLSIIAPLGNNQFISEINKENSNWELLPFILPESGTARNRANQWFKEQGIKPTIYAQVSGHEAIVSMVALGCGIGI
APDVVINNSPVKDKVQRLNTLPIAPFKLGLCCKKSKLNDSVIQALWQVAENTFI

Sequences:

>Translated_294_residues
MNIKLLQTFLHLCESHSFTHTSKAMHLSPSALSRQIQKLEDDIGHPLFIRDNRSVELTSAAKQLIPIALNICSEWSGYKA
SSNVVNNALKGQLKLFCSVTASYSHLPQLLNDFKVNYPHIDIKLSTGDPAQAIEKIESSEVDIAISAVPEKPSNKLAFEI
ISEIPLSIIAPLGNNQFISEINKENSNWELLPFILPESGTARNRANQWFKEQGIKPTIYAQVSGHEAIVSMVALGCGIGI
APDVVINNSPVKDKVQRLNTLPIAPFKLGLCCKKSKLNDSVIQALWQVAENTFI
>Mature_294_residues
MNIKLLQTFLHLCESHSFTHTSKAMHLSPSALSRQIQKLEDDIGHPLFIRDNRSVELTSAAKQLIPIALNICSEWSGYKA
SSNVVNNALKGQLKLFCSVTASYSHLPQLLNDFKVNYPHIDIKLSTGDPAQAIEKIESSEVDIAISAVPEKPSNKLAFEI
ISEIPLSIIAPLGNNQFISEINKENSNWELLPFILPESGTARNRANQWFKEQGIKPTIYAQVSGHEAIVSMVALGCGIGI
APDVVINNSPVKDKVQRLNTLPIAPFKLGLCCKKSKLNDSVIQALWQVAENTFI

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=295, Percent_Identity=42.7118644067797, Blast_Score=264, Evalue=5e-72,
Organism=Escherichia coli, GI1788296, Length=241, Percent_Identity=27.3858921161826, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788887, Length=250, Percent_Identity=24.8, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787806, Length=263, Percent_Identity=23.574144486692, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI157672245, Length=227, Percent_Identity=24.6696035242291, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787879, Length=256, Percent_Identity=26.953125, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693105, Length=141, Percent_Identity=29.7872340425532, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790399, Length=266, Percent_Identity=23.6842105263158, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788748, Length=297, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367136, Length=260, Percent_Identity=22.6923076923077, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787530, Length=238, Percent_Identity=22.6890756302521, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788297, Length=244, Percent_Identity=22.9508196721311, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=175, Percent_Identity=23.4285714285714, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787589, Length=208, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789204, Length=292, Percent_Identity=19.8630136986301, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788626, Length=153, Percent_Identity=30.0653594771242, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32392; Mature: 32392

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKLLQTFLHLCESHSFTHTSKAMHLSPSALSRQIQKLEDDIGHPLFIRDNRSVELTSA
CCHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCEEEEECCCCEEHHHH
AKQLIPIALNICSEWSGYKASSNVVNNALKGQLKLFCSVTASYSHLPQLLNDFKVNYPHI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHCCCCCEE
DIKLSTGDPAQAIEKIESSEVDIAISAVPEKPSNKLAFEIISEIPLSIIAPLGNNQFISE
EEEECCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHH
INKENSNWELLPFILPESGTARNRANQWFKEQGIKPTIYAQVSGHEAIVSMVALGCGIGI
HHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCC
APDVVINNSPVKDKVQRLNTLPIAPFKLGLCCKKSKLNDSVIQALWQVAENTFI
CCCEEECCCCHHHHHHHHHCCCCCHHHHHHECCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIKLLQTFLHLCESHSFTHTSKAMHLSPSALSRQIQKLEDDIGHPLFIRDNRSVELTSA
CCHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCEEEEECCCCEEHHHH
AKQLIPIALNICSEWSGYKASSNVVNNALKGQLKLFCSVTASYSHLPQLLNDFKVNYPHI
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHCCCCCEE
DIKLSTGDPAQAIEKIESSEVDIAISAVPEKPSNKLAFEIISEIPLSIIAPLGNNQFISE
EEEECCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHH
INKENSNWELLPFILPESGTARNRANQWFKEQGIKPTIYAQVSGHEAIVSMVALGCGIGI
HHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCC
APDVVINNSPVKDKVQRLNTLPIAPFKLGLCCKKSKLNDSVIQALWQVAENTFI
CCCEEECCCCHHHHHHHHHCCCCCHHHHHHECCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]