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The map label for this gene is cysQ [H]

Identifier: 59713069

GI number: 59713069

Start: 2760455

End: 2761273

Strand: Reverse

Name: cysQ [H]

Synonym: VF_2462

Alternate gene names: 59713069

Gene position: 2761273-2760455 (Counterclockwise)

Preceding gene: 172087780

Following gene: 59713068

Centisome position: 95.3

GC content: 42.12

Gene sequence:

>819_bases
ATGGATTCTACACTTTCTCACCTTATCCCTGAGGTGATCAATATTGCACGTGCATCGGGTCAACTCATTCTCGATATATA
CGAGAAAGGAGATTTCGAAGAGTTCATTAAGTCAGATGAAACTCCGGTGACCAGTGCTGATCTCGCCGCTCATAAATTAA
TTATCGAAAAACTTTCTCAACTAACACCAGATATTCCTATTCTTTCTGAAGAAGATGCAGGGATATCTTTAGAGCAACGT
GCTCAATGGGAGCGTTATGGGTTGGTTGACCCTCTTGATGGTACGCAAGAGTTCATCGCTCGCAGTGGTGATTTTGCTAC
GATTATTGCTTTAGTTGAAAATAACCGTCCAGTAATGGGGGTTGTATATGGCCCAGTTTCTGGTGTGACGTACTACGCCT
ATGAAGGGAAAGGTGCGTGGAAAATTCCTGATATGGATGAAAGTGTTCGTATTAGCACGTTAAAGCATGAAGATGAAAAA
CAGCCAATTGCGATAGCGATCAGTCGACGCCAAGATATCAATAACATAACACGTTGTATGAGTTCTGATTGGAATTACGA
TTTGGTTCCATTAGGGTCAGCTGCACTTAAAGCCTGTTTGGTCGCAGAAGGTGCTGTGGATTGTTATTTACGATTAGGAC
CAACTGGCGAATGGGATACGGCTGCAACCCAGTGTATTGTTCAAGAAGCGGGAGGTCGCATCTTATCGACAGAGCTTGAA
CCGCTTTCTTATAATGAACGAGAGTCATTAGAAAACCCGAATTTTATTGTTCTCGGTGACGAAAATTTACCGTGGAATAA
CATTCTTACATGTAAATAA

Upstream 100 bases:

>100_bases
CTCAGGCATCAGAGTTATTACATCATCTCGATTTTTCAGAGGCAAGATGCATTACCGCACTATTACTTGCTCAACAATTT
TTAGCTAAGGAGTAATATTG

Downstream 100 bases:

>100_bases
TTAGACCAAATCTTGATAAATTGATTATTAAGATTGCTATAATTTGACTACGCTACTCGAAAATTATTTTTTTTCAGAGT
ACAATCCTTAATCATACTAA

Product: PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDSTLSHLIPEVINIARASGQLILDIYEKGDFEEFIKSDETPVTSADLAAHKLIIEKLSQLTPDIPILSEEDAGISLEQR
AQWERYGLVDPLDGTQEFIARSGDFATIIALVENNRPVMGVVYGPVSGVTYYAYEGKGAWKIPDMDESVRISTLKHEDEK
QPIAIAISRRQDINNITRCMSSDWNYDLVPLGSAALKACLVAEGAVDCYLRLGPTGEWDTAATQCIVQEAGGRILSTELE
PLSYNERESLENPNFIVLGDENLPWNNILTCK

Sequences:

>Translated_272_residues
MDSTLSHLIPEVINIARASGQLILDIYEKGDFEEFIKSDETPVTSADLAAHKLIIEKLSQLTPDIPILSEEDAGISLEQR
AQWERYGLVDPLDGTQEFIARSGDFATIIALVENNRPVMGVVYGPVSGVTYYAYEGKGAWKIPDMDESVRISTLKHEDEK
QPIAIAISRRQDINNITRCMSSDWNYDLVPLGSAALKACLVAEGAVDCYLRLGPTGEWDTAATQCIVQEAGGRILSTELE
PLSYNERESLENPNFIVLGDENLPWNNILTCK
>Mature_272_residues
MDSTLSHLIPEVINIARASGQLILDIYEKGDFEEFIKSDETPVTSADLAAHKLIIEKLSQLTPDIPILSEEDAGISLEQR
AQWERYGLVDPLDGTQEFIARSGDFATIIALVENNRPVMGVVYGPVSGVTYYAYEGKGAWKIPDMDESVRISTLKHEDEK
QPIAIAISRRQDINNITRCMSSDWNYDLVPLGSAALKACLVAEGAVDCYLRLGPTGEWDTAATQCIVQEAGGRILSTELE
PLSYNERESLENPNFIVLGDENLPWNNILTCK

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=259, Percent_Identity=25.8687258687259, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI221625487, Length=259, Percent_Identity=25.8687258687259, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1790659, Length=251, Percent_Identity=41.4342629482072, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1788882, Length=225, Percent_Identity=32.4444444444444, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71995905, Length=285, Percent_Identity=23.1578947368421, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71995897, Length=285, Percent_Identity=23.1578947368421, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=252, Percent_Identity=28.1746031746032, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=202, Percent_Identity=29.7029702970297, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321836, Length=204, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664922, Length=245, Percent_Identity=27.7551020408163, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24641722, Length=277, Percent_Identity=24.9097472924188, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664926, Length=236, Percent_Identity=25.8474576271186, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664918, Length=273, Percent_Identity=24.9084249084249, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 30090; Mature: 30090

Theoretical pI: Translated: 4.14; Mature: 4.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSTLSHLIPEVINIARASGQLILDIYEKGDFEEFIKSDETPVTSADLAAHKLIIEKLSQ
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LTPDIPILSEEDAGISLEQRAQWERYGLVDPLDGTQEFIARSGDFATIIALVENNRPVMG
HCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCEEE
VVYGPVSGVTYYAYEGKGAWKIPDMDESVRISTLKHEDEKQPIAIAISRRQDINNITRCM
EEECCCCCEEEEEECCCCCEECCCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHH
SSDWNYDLVPLGSAALKACLVAEGAVDCYLRLGPTGEWDTAATQCIVQEAGGRILSTELE
CCCCCEEEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCC
PLSYNERESLENPNFIVLGDENLPWNNILTCK
CCCCCHHHCCCCCCEEEECCCCCCCCCEEECC
>Mature Secondary Structure
MDSTLSHLIPEVINIARASGQLILDIYEKGDFEEFIKSDETPVTSADLAAHKLIIEKLSQ
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LTPDIPILSEEDAGISLEQRAQWERYGLVDPLDGTQEFIARSGDFATIIALVENNRPVMG
HCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCEEE
VVYGPVSGVTYYAYEGKGAWKIPDMDESVRISTLKHEDEKQPIAIAISRRQDINNITRCM
EEECCCCCEEEEEECCCCCEECCCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHHHH
SSDWNYDLVPLGSAALKACLVAEGAVDCYLRLGPTGEWDTAATQCIVQEAGGRILSTELE
CCCCCEEEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCC
PLSYNERESLENPNFIVLGDENLPWNNILTCK
CCCCCHHHCCCCCCEEEECCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]