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The map label for this gene is hupA [H]

Identifier: 59713004

GI number: 59713004

Start: 2684950

End: 2685222

Strand: Reverse

Name: hupA [H]

Synonym: VF_2397

Alternate gene names: 59713004

Gene position: 2685222-2684950 (Counterclockwise)

Preceding gene: 59713006

Following gene: 59713003

Centisome position: 92.67

GC content: 42.86

Gene sequence:

>273_bases
ATGAATAAAACCCAGTTAATTGATGCTATTGCTGAAAAAGCAGACCTATCAAAAGCACAAGCAAAAGCAGCTCTTGAAGC
GACTCTAGAAGGCGTAACTGGCGCTCTTAAAGATGGCGAGCAAGTTCAACTTATTGGCTTTGGTACTTTTAAAGTTAACA
ACCGCGCTGCGCGCACTGGTCGCAACCCTAAGACTGGTGAAGAGATTCAAATCAAAGCGGCTAAAGTTCCTGCATTTGTT
GCGGGTAAAGCACTGAAAGAATCAGTAAACTAA

Upstream 100 bases:

>100_bases
AACGCGCATTCTACAGCAAGAAAGGGCACAAACCTTTGCCAGATGGGGTCTTTATGCATTAGAGTTACTAGGATTTTAAA
AAAATAGAAGGGAAACCCTA

Downstream 100 bases:

>100_bases
GCTATACTTTGCCGAGTTAATCCTTAACTCGGCATTTTTATGAAGCGCATTCTATCTACCTTACTTCTATCTACTTTTCT
GTTTGGCTGTTCGTCTAATC

Product: HU, DNA-binding transcriptional regulator, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MNKTQLIDAIAEKADLSKAQAKAALEATLEGVTGALKDGEQVQLIGFGTFKVNNRAARTGRNPKTGEEIQIKAAKVPAFV
AGKALKESVN

Sequences:

>Translated_90_residues
MNKTQLIDAIAEKADLSKAQAKAALEATLEGVTGALKDGEQVQLIGFGTFKVNNRAARTGRNPKTGEEIQIKAAKVPAFV
AGKALKESVN
>Mature_90_residues
MNKTQLIDAIAEKADLSKAQAKAALEATLEGVTGALKDGEQVQLIGFGTFKVNNRAARTGRNPKTGEEIQIKAAKVPAFV
AGKALKESVN

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=74.1573033707865, Blast_Score=136, Evalue=3e-34,
Organism=Escherichia coli, GI1786644, Length=90, Percent_Identity=65.5555555555556, Blast_Score=116, Evalue=3e-28,
Organism=Escherichia coli, GI1788005, Length=89, Percent_Identity=42.6966292134831, Blast_Score=75, Evalue=1e-15,
Organism=Escherichia coli, GI1787141, Length=91, Percent_Identity=36.2637362637363, Blast_Score=74, Evalue=1e-15,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9451; Mature: 9451

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTQLIDAIAEKADLSKAQAKAALEATLEGVTGALKDGEQVQLIGFGTFKVNNRAARTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCC
RNPKTGEEIQIKAAKVPAFVAGKALKESVN
CCCCCCCEEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNKTQLIDAIAEKADLSKAQAKAALEATLEGVTGALKDGEQVQLIGFGTFKVNNRAARTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCCCCCC
RNPKTGEEIQIKAAKVPAFVAGKALKESVN
CCCCCCCEEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1508695 [H]