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The map label for this gene is prmA

Identifier: 59712995

GI number: 59712995

Start: 2677327

End: 2678211

Strand: Direct

Name: prmA

Synonym: VF_2388

Alternate gene names: 59712995

Gene position: 2677327-2678211 (Clockwise)

Preceding gene: 59712994

Following gene: 172087771

Centisome position: 92.4

GC content: 43.5

Gene sequence:

>885_bases
ATGCCTTGGATTCAAGTAAAACTAAATGCAACCTCTGAAAACGCTGAACAGATCGGTGATATGTTAATGGAAGAGACTGG
CGCTCTATCTATTACTTTTTTAGACGCTAAAGATACGCCTGTATTTGAACCTCTTCCGGGTGAAACTCGCCTGTGGGGTG
AAACGGATATTCTTGCTCTTTATGATGCAGAAGCGGACATGGATTTTGTTATTACTCAATTAAAAGCAAGCCGTCTTCTT
GAGGAAGGTTTTGCACATAAAATTGAACAACTTGAAGATAAAGATTGGGAACGTGAGTGGATGGATAACTTCCACCCGAT
GCAGTTTGGTAAACGTCTATGGATTTGCCCAAGCTGGCGTGAAATTCCAGAGCCCGATGCTGTAAATGTAATGCTAGACC
CAGGCCTTGCTTTTGGTACTGGTACACACCCAACAACGTCTCTTTGTCTTGAATGGCTAGAAGGATTAGATCTTGAAGGC
AAAACCGTTGTCGATTTTGGTTGTGGTTCTGGCATTTTAGCGATCGCAGCGATCAAATTAGGTGCAGCTAAAGTTATCGG
GATCGACATTGATCCTCAAGCAATCTTAGCATCAAAAGACAACGCAACTCGTAACGGCGTTGCAGATCAAATTGAACTAT
ACCTTCCTCAAGACCAACCAGAAGGTCTCATCGCTGACGTAGTTGTTGCAAACATTCTTGCAGGCCCACTACGCGAGCTT
TCAGGCATCATTACCTCTCTAGTTAAGCCGCAAGGTCAACTAGCTATGTCAGGCGTATTAGACACGCAGGCAGAAGATGT
AGCGTCATACTATGCTGAACAATTCGACTTAGATGCGATTGTTGAGCAACAAGAATGGTGCCGAATCTCAGGTAAAAAGA
AATAA

Upstream 100 bases:

>100_bases
CAATAAATAAGAACGAATTAAAGACGGTGAGTATGATTACTCACCGTCTTTTTTTGTGTTAAAATCGCCCACATTTTCGA
CTAAAACAAAAGTGATCCCC

Downstream 100 bases:

>100_bases
GCACTGCGCTTTTTTGATAAAACTTCAATGCCACAATACTAAATTTGAGGCATGAAACCGCCTAATTGACTGAATTATAG
ACAATTTACAAAAAGAAAAT

Product: ribosomal protein L11 methyltransferase

Products: NA

Alternate protein names: L11 Mtase

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MPWIQVKLNATSENAEQIGDMLMEETGALSITFLDAKDTPVFEPLPGETRLWGETDILALYDAEADMDFVITQLKASRLL
EEGFAHKIEQLEDKDWEREWMDNFHPMQFGKRLWICPSWREIPEPDAVNVMLDPGLAFGTGTHPTTSLCLEWLEGLDLEG
KTVVDFGCGSGILAIAAIKLGAAKVIGIDIDPQAILASKDNATRNGVADQIELYLPQDQPEGLIADVVVANILAGPLREL
SGIITSLVKPQGQLAMSGVLDTQAEDVASYYAEQFDLDAIVEQQEWCRISGKKK

Sequences:

>Translated_294_residues
MPWIQVKLNATSENAEQIGDMLMEETGALSITFLDAKDTPVFEPLPGETRLWGETDILALYDAEADMDFVITQLKASRLL
EEGFAHKIEQLEDKDWEREWMDNFHPMQFGKRLWICPSWREIPEPDAVNVMLDPGLAFGTGTHPTTSLCLEWLEGLDLEG
KTVVDFGCGSGILAIAAIKLGAAKVIGIDIDPQAILASKDNATRNGVADQIELYLPQDQPEGLIADVVVANILAGPLREL
SGIITSLVKPQGQLAMSGVLDTQAEDVASYYAEQFDLDAIVEQQEWCRISGKKK
>Mature_293_residues
PWIQVKLNATSENAEQIGDMLMEETGALSITFLDAKDTPVFEPLPGETRLWGETDILALYDAEADMDFVITQLKASRLLE
EGFAHKIEQLEDKDWEREWMDNFHPMQFGKRLWICPSWREIPEPDAVNVMLDPGLAFGTGTHPTTSLCLEWLEGLDLEGK
TVVDFGCGSGILAIAAIKLGAAKVIGIDIDPQAILASKDNATRNGVADQIELYLPQDQPEGLIADVVVANILAGPLRELS
GIITSLVKPQGQLAMSGVLDTQAEDVASYYAEQFDLDAIVEQQEWCRISGKKK

Specific function: Methylates ribosomal protein L11

COG id: COG2264

COG function: function code J; Ribosomal protein L11 methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. PrmA family

Homologues:

Organism=Escherichia coli, GI2367208, Length=294, Percent_Identity=71.4285714285714, Blast_Score=411, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRMA_VIBF1 (Q5E263)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205771.1
- HSSP:   Q84BQ9
- ProteinModelPortal:   Q5E263
- STRING:   Q5E263
- GeneID:   3279533
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2388
- NMPDR:   fig|312309.3.peg.2388
- eggNOG:   COG2264
- HOGENOM:   HBG584653
- OMA:   EREEWCR
- PhylomeDB:   Q5E263
- ProtClustDB:   PRK00517
- BioCyc:   VFIS312309:VF2388-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00735
- InterPro:   IPR010456
- InterPro:   IPR004498
- TIGRFAMs:   TIGR00406

Pfam domain/function: PF06325 PrmA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 32373; Mature: 32242

Theoretical pI: Translated: 4.01; Mature: 4.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWIQVKLNATSENAEQIGDMLMEETGALSITFLDAKDTPVFEPLPGETRLWGETDILAL
CCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCEEEE
YDAEADMDFVITQLKASRLLEEGFAHKIEQLEDKDWEREWMDNFHPMQFGKRLWICPSWR
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHCCEEEECCCCC
EIPEPDAVNVMLDPGLAFGTGTHPTTSLCLEWLEGLDLEGKTVVDFGCGSGILAIAAIKL
CCCCCCCEEEEECCCEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHH
GAAKVIGIDIDPQAILASKDNATRNGVADQIELYLPQDQPEGLIADVVVANILAGPLREL
CCEEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
SGIITSLVKPQGQLAMSGVLDTQAEDVASYYAEQFDLDAIVEQQEWCRISGKKK
HHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCC
>Mature Secondary Structure 
PWIQVKLNATSENAEQIGDMLMEETGALSITFLDAKDTPVFEPLPGETRLWGETDILAL
CEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCEEEE
YDAEADMDFVITQLKASRLLEEGFAHKIEQLEDKDWEREWMDNFHPMQFGKRLWICPSWR
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHCCEEEECCCCC
EIPEPDAVNVMLDPGLAFGTGTHPTTSLCLEWLEGLDLEGKTVVDFGCGSGILAIAAIKL
CCCCCCCEEEEECCCEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHH
GAAKVIGIDIDPQAILASKDNATRNGVADQIELYLPQDQPEGLIADVVVANILAGPLREL
CCEEEEEECCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
SGIITSLVKPQGQLAMSGVLDTQAEDVASYYAEQFDLDAIVEQQEWCRISGKKK
HHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHCCHHHHHCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Catalyzes the methylation of ribosomal protein L11 by S-adenosyl methionine [C]

General reaction: Transferases; Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA