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The map label for this gene is srlR [H]

Identifier: 59712980

GI number: 59712980

Start: 2660313

End: 2661074

Strand: Reverse

Name: srlR [H]

Synonym: VF_2373

Alternate gene names: 59712980

Gene position: 2661074-2660313 (Counterclockwise)

Preceding gene: 59712986

Following gene: 59712979

Centisome position: 91.84

GC content: 38.06

Gene sequence:

>762_bases
ATGTCAAAAAGAAATACAAAACAACGCCGTCATATGATCCTTTCTTTATTAACAGAACAAGGTGAAGTGAGCGTAGAACA
TTTATCAGACTTATTTGATATATCTGAAGTTACCATTAGGAAAGACTTAACTGAGTTAGAGAAAAATGGGCTACTAATGC
GTAAGTATGGTGGTGCTGTTTTAATGCCGTCAAATATCATTCAAGAAGATAATTGTGAAGAAGTTTCGAATCGAAAGTTA
TCTATAGCCGTAGCAGCAGTGGAACTGATTAAAGATCATAATCGGATCATTATTGATAGTGGTAGTACAACCGCTGCATT
AATTAATCAGTTGTCGAAACGAAATGGGTTAGTTGTGATGACAAACTCATTGCCTGTTGCGAATGCATTACAAGAGATTG
AAAACGAACCAACCTTATTAATGACAGGGGGAACATGGGATAGTCACTCTGATTCGTTTCAGGGAAAAGTGGCTGAATCG
GTATTACGATCCTATGATTTTGATCAGTTGTTCATTGGGGCGGATGGGATTGATTTAGAGCGAGGGACGACAACGTTCAA
TGAGCTTGTTGGTTTAAGCCGAGTGATGTCAGAAGTCGCTCGTGAGGTCATTTTGATGGTTGAATCAGAAAAAATAGGTC
GAAAAATCCCGAATGTAGAGTTGCCATGGGAAAGCATTGATGTGCTGATCACCAATAATGATTTAAGCCCAGAGCAACAG
AAAAAAATTGAATCACATAACGTAAAAGTGATTAGAGCTTAA

Upstream 100 bases:

>100_bases
TATAAGGATCTTAATATTTAAAACGAATTAATTTGAAGGGCTAGACAATCAAATAAAACGAAACTAAACTTCTTTCAAAT
CGAAACTTATTGAGTTTTTT

Downstream 100 bases:

>100_bases
CTATTACGTTTCGTTTTAACCGTTGTTTTTATTGCTGTCGAGTTACGGTTAAAAGTAAAAAATTTATATATTTAGAATAA
TGGAGTGTCGCCATGTGTGG

Product: DNA-bindng transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSKRNTKQRRHMILSLLTEQGEVSVEHLSDLFDISEVTIRKDLTELEKNGLLMRKYGGAVLMPSNIIQEDNCEEVSNRKL
SIAVAAVELIKDHNRIIIDSGSTTAALINQLSKRNGLVVMTNSLPVANALQEIENEPTLLMTGGTWDSHSDSFQGKVAES
VLRSYDFDQLFIGADGIDLERGTTTFNELVGLSRVMSEVAREVILMVESEKIGRKIPNVELPWESIDVLITNNDLSPEQQ
KKIESHNVKVIRA

Sequences:

>Translated_253_residues
MSKRNTKQRRHMILSLLTEQGEVSVEHLSDLFDISEVTIRKDLTELEKNGLLMRKYGGAVLMPSNIIQEDNCEEVSNRKL
SIAVAAVELIKDHNRIIIDSGSTTAALINQLSKRNGLVVMTNSLPVANALQEIENEPTLLMTGGTWDSHSDSFQGKVAES
VLRSYDFDQLFIGADGIDLERGTTTFNELVGLSRVMSEVAREVILMVESEKIGRKIPNVELPWESIDVLITNNDLSPEQQ
KKIESHNVKVIRA
>Mature_252_residues
SKRNTKQRRHMILSLLTEQGEVSVEHLSDLFDISEVTIRKDLTELEKNGLLMRKYGGAVLMPSNIIQEDNCEEVSNRKLS
IAVAAVELIKDHNRIIIDSGSTTAALINQLSKRNGLVVMTNSLPVANALQEIENEPTLLMTGGTWDSHSDSFQGKVAESV
LRSYDFDQLFIGADGIDLERGTTTFNELVGLSRVMSEVAREVILMVESEKIGRKIPNVELPWESIDVLITNNDLSPEQQK
KIESHNVKVIRA

Specific function: Unknown

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789059, Length=256, Percent_Identity=44.921875, Blast_Score=210, Evalue=9e-56,
Organism=Escherichia coli, GI1789519, Length=253, Percent_Identity=40.7114624505929, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI226510968, Length=239, Percent_Identity=30.1255230125523, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788069, Length=250, Percent_Identity=29.6, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789829, Length=210, Percent_Identity=31.9047619047619, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790635, Length=254, Percent_Identity=27.9527559055118, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787540, Length=251, Percent_Identity=29.8804780876494, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87082344, Length=209, Percent_Identity=30.1435406698565, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787063, Length=253, Percent_Identity=24.5059288537549, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1789170, Length=214, Percent_Identity=26.6355140186916, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28241; Mature: 28109

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRNTKQRRHMILSLLTEQGEVSVEHLSDLFDISEVTIRKDLTELEKNGLLMRKYGGAV
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEE
LMPSNIIQEDNCEEVSNRKLSIAVAAVELIKDHNRIIIDSGSTTAALINQLSKRNGLVVM
ECCHHHCCCCCHHHHHCCEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEE
TNSLPVANALQEIENEPTLLMTGGTWDSHSDSFQGKVAESVLRSYDFDQLFIGADGIDLE
ECCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
RGTTTFNELVGLSRVMSEVAREVILMVESEKIGRKIPNVELPWESIDVLITNNDLSPEQQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEEECCCCCHHHH
KKIESHNVKVIRA
HHHHHCCEEEEEC
>Mature Secondary Structure 
SKRNTKQRRHMILSLLTEQGEVSVEHLSDLFDISEVTIRKDLTELEKNGLLMRKYGGAV
CCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEE
LMPSNIIQEDNCEEVSNRKLSIAVAAVELIKDHNRIIIDSGSTTAALINQLSKRNGLVVM
ECCHHHCCCCCHHHHHCCEEEHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEE
TNSLPVANALQEIENEPTLLMTGGTWDSHSDSFQGKVAESVLRSYDFDQLFIGADGIDLE
ECCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCC
RGTTTFNELVGLSRVMSEVAREVILMVESEKIGRKIPNVELPWESIDVLITNNDLSPEQQ
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEEECCCCCHHHH
KKIESHNVKVIRA
HHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3062173; 9278503; 9205837 [H]