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The map label for this gene is kcsA [H]

Identifier: 59712844

GI number: 59712844

Start: 2512785

End: 2513549

Strand: Direct

Name: kcsA [H]

Synonym: VF_2237

Alternate gene names: 59712844

Gene position: 2512785-2513549 (Clockwise)

Preceding gene: 59712840

Following gene: 59712846

Centisome position: 86.72

GC content: 35.29

Gene sequence:

>765_bases
ATGATGAATCATAACAAAGTTGACCTTAAACCGATGAGCTTAATGTCACTGATACTTTCCTTTTTATCGCTAATTGTGAT
CTCTAGCTTACTGTTTGTACCACTAGAACATAATAGCCGCACAATACTGATCGCACTTGATACTATTATCTGCGTACTCT
TTTTATTTCAACTATCTCTAGACTTATTCCGAACAAAACATAAAACACAATATTTAAAAGATCATTGGATAGATTTTGTT
GCTAGCATTCCGATTATTGAACCTGTTCGTTATGCTCGTATTTTTCACATTCTGCGTGTTTTCCGCTTACTGCGTTCTAG
CCAATCATTACTAAAACAAATCCGTTCAAATCGAAAAGAGGCCACGATTGCTTCTATTTTAGTATTAATGGTTAGCCTTA
TTTCGTTAGGCTCTGTCTTTATGTTGATGTTTGAAGGCCATAACCCTAACGCTAACATACAAACCGCAGGAGATGCTGTA
TGGTGGGCCTTTGTGACTATTTCAACAGTTGGATACGGGGACCATTATCCAATAACAGTGGCAGGAAAAATTTTAGCTGT
AATGATTATTTTATCTGGTGTTGGCATTTTCGGTATGATCTCAGGCTTAATAACATCGATCATCACAGAGCCTGCAAAAC
TAGAACAAAGACGACATGAACAACAAGAAAAGCGAGAAAGAGATGAAAAAATCAATTTACTCTTACAACAGCAAGCTGAA
ATTCTGAAAAAAATTGAATTAATTGAAAATAAAAAAGAGAAGTAA

Upstream 100 bases:

>100_bases
TCCCGCAACCTTTCAGAATTAAATTTTTTAGTGCATGATAAAAATGCTTCATGCAGATACACACATCACTTTTGTTTTTA
ACGGAAATGCATAAATAATT

Downstream 100 bases:

>100_bases
TCAACCCAATGTAGGGAGATGACTTCTCTTCTTTGTTAATCCTAACTCTTATTAACTAAGAGTTGGATAAATAACTACCG
CTATTGCCAATAAGGAGGAT

Product: potassium channel protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MMNHNKVDLKPMSLMSLILSFLSLIVISSLLFVPLEHNSRTILIALDTIICVLFLFQLSLDLFRTKHKTQYLKDHWIDFV
ASIPIIEPVRYARIFHILRVFRLLRSSQSLLKQIRSNRKEATIASILVLMVSLISLGSVFMLMFEGHNPNANIQTAGDAV
WWAFVTISTVGYGDHYPITVAGKILAVMIILSGVGIFGMISGLITSIITEPAKLEQRRHEQQEKRERDEKINLLLQQQAE
ILKKIELIENKKEK

Sequences:

>Translated_254_residues
MMNHNKVDLKPMSLMSLILSFLSLIVISSLLFVPLEHNSRTILIALDTIICVLFLFQLSLDLFRTKHKTQYLKDHWIDFV
ASIPIIEPVRYARIFHILRVFRLLRSSQSLLKQIRSNRKEATIASILVLMVSLISLGSVFMLMFEGHNPNANIQTAGDAV
WWAFVTISTVGYGDHYPITVAGKILAVMIILSGVGIFGMISGLITSIITEPAKLEQRRHEQQEKRERDEKINLLLQQQAE
ILKKIELIENKKEK
>Mature_254_residues
MMNHNKVDLKPMSLMSLILSFLSLIVISSLLFVPLEHNSRTILIALDTIICVLFLFQLSLDLFRTKHKTQYLKDHWIDFV
ASIPIIEPVRYARIFHILRVFRLLRSSQSLLKQIRSNRKEATIASILVLMVSLISLGSVFMLMFEGHNPNANIQTAGDAV
WWAFVTISTVGYGDHYPITVAGKILAVMIILSGVGIFGMISGLITSIITEPAKLEQRRHEQQEKRERDEKINLLLQQQAE
ILKKIELIENKKEK

Specific function: Acts as a potassium ion channel [H]

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the potassium channel family [H]

Homologues:

Organism=Homo sapiens, GI119395748, Length=176, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI88758565, Length=174, Percent_Identity=27.0114942528736, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4504817, Length=113, Percent_Identity=35.3982300884956, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI26051262, Length=139, Percent_Identity=31.6546762589928, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI26051260, Length=139, Percent_Identity=31.6546762589928, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI26051266, Length=139, Percent_Identity=31.6546762589928, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI26051264, Length=139, Percent_Identity=31.6546762589928, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4504821, Length=180, Percent_Identity=27.2222222222222, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI27436974, Length=286, Percent_Identity=23.7762237762238, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4758630, Length=170, Percent_Identity=27.6470588235294, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI26051268, Length=141, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI25952087, Length=113, Percent_Identity=34.5132743362832, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI236462242, Length=170, Percent_Identity=27.6470588235294, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI236462079, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI28373065, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI236461942, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI236461719, Length=170, Percent_Identity=27.6470588235294, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI26638655, Length=162, Percent_Identity=27.1604938271605, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI27436981, Length=201, Percent_Identity=27.363184079602, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI26638653, Length=162, Percent_Identity=27.1604938271605, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25147238, Length=137, Percent_Identity=32.1167883211679, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25147242, Length=137, Percent_Identity=32.1167883211679, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994134, Length=107, Percent_Identity=35.5140186915888, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994313, Length=152, Percent_Identity=28.2894736842105, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193206869, Length=109, Percent_Identity=33.0275229357798, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25148255, Length=109, Percent_Identity=33.0275229357798, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17737641, Length=209, Percent_Identity=25.8373205741627, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221330119, Length=140, Percent_Identity=29.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161084970, Length=209, Percent_Identity=25.8373205741627, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221330117, Length=140, Percent_Identity=29.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363095, Length=140, Percent_Identity=29.2857142857143, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363097, Length=140, Percent_Identity=29.2857142857143, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281365536, Length=137, Percent_Identity=31.3868613138686, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007764, Length=137, Percent_Identity=31.3868613138686, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24656294, Length=137, Percent_Identity=31.3868613138686, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24642916, Length=113, Percent_Identity=30.9734513274336, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24656289, Length=137, Percent_Identity=31.3868613138686, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45555859, Length=113, Percent_Identity=30.0884955752212, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45549143, Length=113, Percent_Identity=30.0884955752212, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013099
- InterPro:   IPR003091 [H]

Pfam domain/function: PF07885 Ion_trans_2 [H]

EC number: NA

Molecular weight: Translated: 29019; Mature: 29019

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNHNKVDLKPMSLMSLILSFLSLIVISSLLFVPLEHNSRTILIALDTIICVLFLFQLSL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHHHHHHHHH
DLFRTKHKTQYLKDHWIDFVASIPIIEPVRYARIFHILRVFRLLRSSQSLLKQIRSNRKE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ATIASILVLMVSLISLGSVFMLMFEGHNPNANIQTAGDAVWWAFVTISTVGYGDHYPITV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCCCCHHH
AGKILAVMIILSGVGIFGMISGLITSIITEPAKLEQRRHEQQEKRERDEKINLLLQQQAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKKIELIENKKEK
HHHHHHHHHCCCCC
>Mature Secondary Structure
MMNHNKVDLKPMSLMSLILSFLSLIVISSLLFVPLEHNSRTILIALDTIICVLFLFQLSL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEHHHHHHHHHHHHHHH
DLFRTKHKTQYLKDHWIDFVASIPIIEPVRYARIFHILRVFRLLRSSQSLLKQIRSNRKE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ATIASILVLMVSLISLGSVFMLMFEGHNPNANIQTAGDAVWWAFVTISTVGYGDHYPITV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCCCCHHH
AGKILAVMIILSGVGIFGMISGLITSIITEPAKLEQRRHEQQEKRERDEKINLLLQQQAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKKIELIENKKEK
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]