| Definition | Vibrio fischeri ES114 chromosome I, complete genome. |
|---|---|
| Accession | NC_006840 |
| Length | 2,897,536 |
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The map label for this gene is thrA [H]
Identifier: 59712725
GI number: 59712725
Start: 2352651
End: 2355110
Strand: Reverse
Name: thrA [H]
Synonym: VF_2118
Alternate gene names: 59712725
Gene position: 2355110-2352651 (Counterclockwise)
Preceding gene: 172087754
Following gene: 59712724
Centisome position: 81.28
GC content: 39.43
Gene sequence:
>2460_bases ATGCGAGTATTAAAATTTGGTGGTTCGTCATTAGCTGATTCAGATCGTTTTTTACGTGCCGCAGACATTATTGCTAATAA TGCACAGCAACAAGAAGTTTCTGTCGTATTATCAGCGCCTGGAAAAGTAACAAATAAATTAGTTTCAGTGGTTGATAATC TTCTTACCAATGGTGAAGCAGAATTACAAATCTCAGAACTAGAATCTGTTTTTACTCAATTATTTAGTGGTATTTCTAAC ACCCTTCCACAAGTTGATCTTAAATTACTTGAAAATAAGCTGAAAGATTCTATTTCTCAATTACGTCAATATGCTCATGG GATCACCTTGCTTGGTATGTGTCCTGATAATGTATATGCAAAAATCATCAGTAAAGGTGAACGCATTTCTATTGTCATGA TGAAAGCCGTATTAGAAGCAAAAGGTCAACCAGCAAGCTTAATTGATCCTGTTAAGTATTTATATGCGAAAGGCGATTAC CTTGAAGGTGCGGTAGATGTTGATGTATCAACATTAAACTTTAAGAATGAACCATTGCCGCAAGGTCATGTAAATATTAT GCCTGGCTTTACTGCTGGTAATGCGAAAGGAGAGTTGGTAACTCTTGGCCGTAATGGTTCTGATTATTCAGCAGCAGTAC TTGCAGCATGTTTACGAGCTGAATGTTGTGAAATTTGGACTGATGTAGATGGTGTTTATAATTGTGACCCACGTTTAGTT GATGATGCTCGTCTATTAAAATCATTAAGTTATCAAGAAGCTATGGAGCTCTCTTACTTTGGTGCTTCTGTTCTTCACCC GAAAACCATCGCTCCTATTGCTCAATTCCACATTCCTTGTCTAATTAAAAATAGCTTTAACCCTCAAGGTGCAGGGACTC TAATCGGTCAAGATACCGGTGAAGATAATCTGGCTATTAAAGGGATTACGACCCTAAATAACTTAACCATGGTTAATGTT AGTGGGCCGGGTATGAAAGGCATGGTTGGTATGGCAAGTCGTGTATTTGGTGCTATGTCGGCAACAGGGATCTCAATTGT TCTCATTACTCAATCCTCATCAGAATACAGTATAAGTTTTTGTATTGAAGCTGAAGACAAATGCAAGGCAGAGCAAGTAC TAAGAGAAGCGTTTGAATTAGAACTTAAAGATGGCTTATTAGAGCCGGTTGAGTTTACAGATAATGTTGCCATTGTTACT TTGGTTGGCGATGGCATGCGTACATCGAAAGGCGTAGCATCTCAATTCTTTACTTCTCTTACTGAAGTTAATGTGAATAT TATTGCCATCGCGCAAGGATCTTCTGAGCGTGCGATTTCTGCTGTTATTCCTGAAGATAAAGTATCTGAGTCGATAAAAG CATGTCATGAAAACCTATTCAATAGTAAACATTTCTTAGATGTATTTGTTGTTGGTGTTGGTGGTGTTGGTGGTGAATTA GTTGATCAAATCAAACGCCAGCAACCAAAATTGGCAGAGAAAGGCATTGAAATTCGAGTATGTGGTTTGGCAAATAGCCG AGGATTACTACTGGATAGCAAAGGCATTCCGCTAGAAGATTGGCGTGAGCGTATGAGTAATTCCTCTGAGGAGTTCAGCT TAGCTCGTTTAATTGCTTTGGTTCAACGTAACCATATTATTAACCCAGTTATTGTTGATTGTACGTCTGACCATGGTATC GCTGCTCAATACGTTGATTTCCTATCAGCTGGTTTTCACGTTATTACACCAAATAAGAAAGCCAATACGGATTCAATGGC TTATTACCATCAGTTACGTAATGCTGCGCGTGGTACTCGTCGTAAATTTATGTATGAAACAACGGTTGGTGCTGGCTTAC CTGTTATCGAAAACTTACAGAACTTGATTGCAGCAGGTGATGAGCTTGAAAAGTTCAACGGTATCTTGTCTGGCTCTCTT TCTTATATCTTTGGTAAGTTAGATGAAGGTATGTCATTAAGCGAAGCGACAAACGTAGCGAAAGAAAATGGCTTTACAGA ACCAGATCCTCGAGATGATCTTTCAGGTATGGATGTTGCTCGTAAATTATTAATTCTAGCTCGTGAATCAGGATTAGAAA TTGAGCTAGATGATGTAGAAGTTGAGCAAGCATTACCGCCGGGCTTTGACGATTCAGGTACGGTTGAAGAGTTTATGGCT CGACTTCCTGAAGCGGATGCCTATTTTGCTGAGCAATCGGCTATTGCAGCAGAAGATGGCAAGGTATTACGCTATGTTGG TGAGATCTTAGATGGTAAATGTAAAGTAAGAATTGTTGCTGTAGATGGCGATGATCCTATGTTTAAGATTAAAGATGGCG AGAACGCATTGGCTTTCTATAGCCGCTATTATCAACCTATTCCATTAGTATTGCGTGGTTATGGCGCAGGAACCGAAGTA ACCGCTGCTGGTGTGTTCTCTGATTTAATGCGTACGCTTGGTTGGAAATTAGGAGTATAG
Upstream 100 bases:
>100_bases ATTCTTAATTGCATTCTTTTATTATCAAATGAAAAGGTTATGATGATGTTAGTTATGCAGTAAGGATATTGCAGTAACAC TCGTTTTTAGGGAGGAAGAA
Downstream 100 bases:
>100_bases AATGAGTGTTGTTGTTTATGCTCCTGCATCAATAGGAAATGTCAGTGTTGGCTTTGATGTATTAGGCGCAGCAGTCTCAC CTATTGACGGTACATTATTG
Product: bifunctional aspartokinase I/homeserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 819; Mature: 819
Protein sequence:
>819_residues MRVLKFGGSSLADSDRFLRAADIIANNAQQQEVSVVLSAPGKVTNKLVSVVDNLLTNGEAELQISELESVFTQLFSGISN TLPQVDLKLLENKLKDSISQLRQYAHGITLLGMCPDNVYAKIISKGERISIVMMKAVLEAKGQPASLIDPVKYLYAKGDY LEGAVDVDVSTLNFKNEPLPQGHVNIMPGFTAGNAKGELVTLGRNGSDYSAAVLAACLRAECCEIWTDVDGVYNCDPRLV DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLNNLTMVNV SGPGMKGMVGMASRVFGAMSATGISIVLITQSSSEYSISFCIEAEDKCKAEQVLREAFELELKDGLLEPVEFTDNVAIVT LVGDGMRTSKGVASQFFTSLTEVNVNIIAIAQGSSERAISAVIPEDKVSESIKACHENLFNSKHFLDVFVVGVGGVGGEL VDQIKRQQPKLAEKGIEIRVCGLANSRGLLLDSKGIPLEDWRERMSNSSEEFSLARLIALVQRNHIINPVIVDCTSDHGI AAQYVDFLSAGFHVITPNKKANTDSMAYYHQLRNAARGTRRKFMYETTVGAGLPVIENLQNLIAAGDELEKFNGILSGSL SYIFGKLDEGMSLSEATNVAKENGFTEPDPRDDLSGMDVARKLLILARESGLEIELDDVEVEQALPPGFDDSGTVEEFMA RLPEADAYFAEQSAIAAEDGKVLRYVGEILDGKCKVRIVAVDGDDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTEV TAAGVFSDLMRTLGWKLGV
Sequences:
>Translated_819_residues MRVLKFGGSSLADSDRFLRAADIIANNAQQQEVSVVLSAPGKVTNKLVSVVDNLLTNGEAELQISELESVFTQLFSGISN TLPQVDLKLLENKLKDSISQLRQYAHGITLLGMCPDNVYAKIISKGERISIVMMKAVLEAKGQPASLIDPVKYLYAKGDY LEGAVDVDVSTLNFKNEPLPQGHVNIMPGFTAGNAKGELVTLGRNGSDYSAAVLAACLRAECCEIWTDVDGVYNCDPRLV DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLNNLTMVNV SGPGMKGMVGMASRVFGAMSATGISIVLITQSSSEYSISFCIEAEDKCKAEQVLREAFELELKDGLLEPVEFTDNVAIVT LVGDGMRTSKGVASQFFTSLTEVNVNIIAIAQGSSERAISAVIPEDKVSESIKACHENLFNSKHFLDVFVVGVGGVGGEL VDQIKRQQPKLAEKGIEIRVCGLANSRGLLLDSKGIPLEDWRERMSNSSEEFSLARLIALVQRNHIINPVIVDCTSDHGI AAQYVDFLSAGFHVITPNKKANTDSMAYYHQLRNAARGTRRKFMYETTVGAGLPVIENLQNLIAAGDELEKFNGILSGSL SYIFGKLDEGMSLSEATNVAKENGFTEPDPRDDLSGMDVARKLLILARESGLEIELDDVEVEQALPPGFDDSGTVEEFMA RLPEADAYFAEQSAIAAEDGKVLRYVGEILDGKCKVRIVAVDGDDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTEV TAAGVFSDLMRTLGWKLGV >Mature_819_residues MRVLKFGGSSLADSDRFLRAADIIANNAQQQEVSVVLSAPGKVTNKLVSVVDNLLTNGEAELQISELESVFTQLFSGISN TLPQVDLKLLENKLKDSISQLRQYAHGITLLGMCPDNVYAKIISKGERISIVMMKAVLEAKGQPASLIDPVKYLYAKGDY LEGAVDVDVSTLNFKNEPLPQGHVNIMPGFTAGNAKGELVTLGRNGSDYSAAVLAACLRAECCEIWTDVDGVYNCDPRLV DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLNNLTMVNV SGPGMKGMVGMASRVFGAMSATGISIVLITQSSSEYSISFCIEAEDKCKAEQVLREAFELELKDGLLEPVEFTDNVAIVT LVGDGMRTSKGVASQFFTSLTEVNVNIIAIAQGSSERAISAVIPEDKVSESIKACHENLFNSKHFLDVFVVGVGGVGGEL VDQIKRQQPKLAEKGIEIRVCGLANSRGLLLDSKGIPLEDWRERMSNSSEEFSLARLIALVQRNHIINPVIVDCTSDHGI AAQYVDFLSAGFHVITPNKKANTDSMAYYHQLRNAARGTRRKFMYETTVGAGLPVIENLQNLIAAGDELEKFNGILSGSL SYIFGKLDEGMSLSEATNVAKENGFTEPDPRDDLSGMDVARKLLILARESGLEIELDDVEVEQALPPGFDDSGTVEEFMA RLPEADAYFAEQSAIAAEDGKVLRYVGEILDGKCKVRIVAVDGDDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTEV TAAGVFSDLMRTLGWKLGV
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=61.7073170731707, Blast_Score=1045, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=820, Percent_Identity=32.1951219512195, Blast_Score=361, Evalue=1e-100, Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=29.6536796536797, Blast_Score=167, Evalue=3e-42, Organism=Saccharomyces cerevisiae, GI6322599, Length=340, Percent_Identity=35, Blast_Score=171, Evalue=5e-43, Organism=Saccharomyces cerevisiae, GI6320893, Length=507, Percent_Identity=28.4023668639053, Blast_Score=159, Evalue=1e-39,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88638; Mature: 88638
Theoretical pI: Translated: 4.61; Mature: 4.61
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLKFGGSSLADSDRFLRAADIIANNAQQQEVSVVLSAPGKVTNKLVSVVDNLLTNGEA CEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCC ELQISELESVFTQLFSGISNTLPQVDLKLLENKLKDSISQLRQYAHGITLLGMCPDNVYA EEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHH KIISKGERISIVMMKAVLEAKGQPASLIDPVKYLYAKGDYLEGAVDVDVSTLNFKNEPLP HHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCC QGHVNIMPGFTAGNAKGELVTLGRNGSDYSAAVLAACLRAECCEIWTDVDGVYNCDPRLV CCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTG HHHHHHHHCCHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCC EDNLAIKGITTLNNLTMVNVSGPGMKGMVGMASRVFGAMSATGISIVLITQSSSEYSISF CCCEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEE CIEAEDKCKAEQVLREAFELELKDGLLEPVEFTDNVAIVTLVGDGMRTSKGVASQFFTSL EEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH TEVNVNIIAIAQGSSERAISAVIPEDKVSESIKACHENLFNSKHFLDVFVVGVGGVGGEL HHCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHH VDQIKRQQPKLAEKGIEIRVCGLANSRGLLLDSKGIPLEDWRERMSNSSEEFSLARLIAL HHHHHHCCCCHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHH VQRNHIINPVIVDCTSDHGIAAQYVDFLSAGFHVITPNKKANTDSMAYYHQLRNAARGTR HHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHH RKFMYETTVGAGLPVIENLQNLIAAGDELEKFNGILSGSLSYIFGKLDEGMSLSEATNVA HHEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH KENGFTEPDPRDDLSGMDVARKLLILARESGLEIELDDVEVEQALPPGFDDSGTVEEFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCCCCCCCCHHHHHH RLPEADAYFAEQSAIAAEDGKVLRYVGEILDGKCKVRIVAVDGDDPMFKIKDGENALAFY HCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCHHHHH SRYYQPIPLVLRGYGAGTEVTAAGVFSDLMRTLGWKLGV HHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCHHCCC >Mature Secondary Structure MRVLKFGGSSLADSDRFLRAADIIANNAQQQEVSVVLSAPGKVTNKLVSVVDNLLTNGEA CEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCC ELQISELESVFTQLFSGISNTLPQVDLKLLENKLKDSISQLRQYAHGITLLGMCPDNVYA EEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHH KIISKGERISIVMMKAVLEAKGQPASLIDPVKYLYAKGDYLEGAVDVDVSTLNFKNEPLP HHHCCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCC QGHVNIMPGFTAGNAKGELVTLGRNGSDYSAAVLAACLRAECCEIWTDVDGVYNCDPRLV CCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTG HHHHHHHHCCHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCC EDNLAIKGITTLNNLTMVNVSGPGMKGMVGMASRVFGAMSATGISIVLITQSSSEYSISF CCCEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEE CIEAEDKCKAEQVLREAFELELKDGLLEPVEFTDNVAIVTLVGDGMRTSKGVASQFFTSL EEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH TEVNVNIIAIAQGSSERAISAVIPEDKVSESIKACHENLFNSKHFLDVFVVGVGGVGGEL HHCCEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHH VDQIKRQQPKLAEKGIEIRVCGLANSRGLLLDSKGIPLEDWRERMSNSSEEFSLARLIAL HHHHHHCCCCHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHH VQRNHIINPVIVDCTSDHGIAAQYVDFLSAGFHVITPNKKANTDSMAYYHQLRNAARGTR HHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHH RKFMYETTVGAGLPVIENLQNLIAAGDELEKFNGILSGSLSYIFGKLDEGMSLSEATNVA HHEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH KENGFTEPDPRDDLSGMDVARKLLILARESGLEIELDDVEVEQALPPGFDDSGTVEEFMA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHCCCCCCCCCCCHHHHHH RLPEADAYFAEQSAIAAEDGKVLRYVGEILDGKCKVRIVAVDGDDPMFKIKDGENALAFY HCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCEEEEECCCCHHHHH SRYYQPIPLVLRGYGAGTEVTAAGVFSDLMRTLGWKLGV HHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8423151 [H]