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The map label for this gene is thrB [H]

Identifier: 59712724

GI number: 59712724

Start: 2351693

End: 2352649

Strand: Reverse

Name: thrB [H]

Synonym: VF_2117

Alternate gene names: 59712724

Gene position: 2352649-2351693 (Counterclockwise)

Preceding gene: 59712725

Following gene: 59712723

Centisome position: 81.19

GC content: 39.29

Gene sequence:

>957_bases
ATGAGTGTTGTTGTTTATGCTCCTGCATCAATAGGAAATGTCAGTGTTGGCTTTGATGTATTAGGCGCAGCAGTCTCACC
TATTGACGGTACATTATTGGGAGATCGTGTTTTAGTTGAGCTTGGAAGTGAGGCATTTACATTAGCTACCGCTGGCAGCT
TTGTGGATAAATTACCTGAAAACCCGAAAGACAATATTGTTTACGACTGTTGGTGTGTATTTTCTCGTGAATTGAATAAA
AAAAATGTGGCATTAAAGAATGTTCACATGATTTTAGAGAAAAATATGCCAATTGGTTCAGGCCTTGGTTCTAGTGCTTG
TTCTATTGTTGCGGCGTTAGATGCATTAAACCAATTTCACGATAACCCTTTAAATGACATGGAACTATTGGCATTAATGG
GAGAAATGGAAGGGCAGATATCAGGTGGTATTCACTATGATAATGTAGCTCCATGTTATCTTGGTGGTTTACAGTTAATG
GTGGAAGAGCTTGGTATTATTAGTCAAGAAGTCCCATGCTTTGATGAATGGTATTGGGTTATGGCTTATCCAGGAATTAA
AGTATCAACCGCTGAAGCTCGTGAGATTTTACCTTCTCAATACCGTCGTCAAGATGTGATTGCACATGGTCGTAACCTTG
CTGGTTTTATTCATGCTTGTTATTCAAAACAACCTGAACTTGCAGCAAAGATGATTAAAGACGTGGTGGCTGAACCTTAT
AGAGAGCGCTTGCTACCAAACTTTGCTAAAGCTCGTGAATACGCAGCATCAGCAGGCGCATTAACGACAGGGATTTCAGG
TTCAGGACCGACTCTTTTTAGTATATGCAAAGATAAAGATGTAGCGGATAGAGTATCTCGTTGGCTACAAGAAAATTACG
TTCAAAATAATGAAGGATTTGTTCATGTTTGTCGTTTAGATAAGCAAGGATCACAAGTGACAGGAAGTAAACTATGA

Upstream 100 bases:

>100_bases
CCATTAGTATTGCGTGGTTATGGCGCAGGAACCGAAGTAACCGCTGCTGGTGTGTTCTCTGATTTAATGCGTACGCTTGG
TTGGAAATTAGGAGTATAGA

Downstream 100 bases:

>100_bases
AGCTGTATAACATAAAAGAAAATGATGAGCAGGTCTCTTTTGGCCAAGCGGTTCGCCAAGGTTTAGGTCGTAATCAAGGA
CTATTTTTTCCATCAGAATT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVLVELGSEAFTLATAGSFVDKLPENPKDNIVYDCWCVFSRELNK
KNVALKNVHMILEKNMPIGSGLGSSACSIVAALDALNQFHDNPLNDMELLALMGEMEGQISGGIHYDNVAPCYLGGLQLM
VEELGIISQEVPCFDEWYWVMAYPGIKVSTAEAREILPSQYRRQDVIAHGRNLAGFIHACYSKQPELAAKMIKDVVAEPY
RERLLPNFAKAREYAASAGALTTGISGSGPTLFSICKDKDVADRVSRWLQENYVQNNEGFVHVCRLDKQGSQVTGSKL

Sequences:

>Translated_318_residues
MSVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVLVELGSEAFTLATAGSFVDKLPENPKDNIVYDCWCVFSRELNK
KNVALKNVHMILEKNMPIGSGLGSSACSIVAALDALNQFHDNPLNDMELLALMGEMEGQISGGIHYDNVAPCYLGGLQLM
VEELGIISQEVPCFDEWYWVMAYPGIKVSTAEAREILPSQYRRQDVIAHGRNLAGFIHACYSKQPELAAKMIKDVVAEPY
RERLLPNFAKAREYAASAGALTTGISGSGPTLFSICKDKDVADRVSRWLQENYVQNNEGFVHVCRLDKQGSQVTGSKL
>Mature_317_residues
SVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVLVELGSEAFTLATAGSFVDKLPENPKDNIVYDCWCVFSRELNKK
NVALKNVHMILEKNMPIGSGLGSSACSIVAALDALNQFHDNPLNDMELLALMGEMEGQISGGIHYDNVAPCYLGGLQLMV
EELGIISQEVPCFDEWYWVMAYPGIKVSTAEAREILPSQYRRQDVIAHGRNLAGFIHACYSKQPELAAKMIKDVVAEPYR
ERLLPNFAKAREYAASAGALTTGISGSGPTLFSICKDKDVADRVSRWLQENYVQNNEGFVHVCRLDKQGSQVTGSKL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=68.4887459807074, Blast_Score=445, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 34580; Mature: 34449

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVLVELGSEAFTLATAGSFVDKLPE
CEEEEECCCCCCCCEECHHHHHHHCCCCCCCHHCCHHHHHHCCCCEEEHHHHHHHHHCCC
NPKDNIVYDCWCVFSRELNKKNVALKNVHMILEKNMPIGSGLGSSACSIVAALDALNQFH
CCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
DNPLNDMELLALMGEMEGQISGGIHYDNVAPCYLGGLQLMVEELGIISQEVPCFDEWYWV
CCCCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCEEE
MAYPGIKVSTAEAREILPSQYRRQDVIAHGRNLAGFIHACYSKQPELAAKMIKDVVAEPY
EECCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RERLLPNFAKAREYAASAGALTTGISGSGPTLFSICKDKDVADRVSRWLQENYVQNNEGF
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHCCCCHHHHHHHHHHHHHCCCCCCE
VHVCRLDKQGSQVTGSKL
EEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SVVVYAPASIGNVSVGFDVLGAAVSPIDGTLLGDRVLVELGSEAFTLATAGSFVDKLPE
EEEEECCCCCCCCEECHHHHHHHCCCCCCCHHCCHHHHHHCCCCEEEHHHHHHHHHCCC
NPKDNIVYDCWCVFSRELNKKNVALKNVHMILEKNMPIGSGLGSSACSIVAALDALNQFH
CCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
DNPLNDMELLALMGEMEGQISGGIHYDNVAPCYLGGLQLMVEELGIISQEVPCFDEWYWV
CCCCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCEEE
MAYPGIKVSTAEAREILPSQYRRQDVIAHGRNLAGFIHACYSKQPELAAKMIKDVVAEPY
EECCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RERLLPNFAKAREYAASAGALTTGISGSGPTLFSICKDKDVADRVSRWLQENYVQNNEGF
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHCCCCHHHHHHHHHHHHHCCCCCCE
VHVCRLDKQGSQVTGSKL
EEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA