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The map label for this gene is ung

Identifier: 59712720

GI number: 59712720

Start: 2347960

End: 2348634

Strand: Reverse

Name: ung

Synonym: VF_2113

Alternate gene names: 59712720

Gene position: 2348634-2347960 (Counterclockwise)

Preceding gene: 59712721

Following gene: 59712719

Centisome position: 81.06

GC content: 38.81

Gene sequence:

>675_bases
ATGGCATTAACTTGGAACTCTATTATATCAGCAGAAAAAAAGAAGGCTTACTATCAGTCTATGTCGGAAAAGATTGATGC
CCAACGTTCTCTTGGAAAATCTATTTTCCCAAAAGAAGAGCATATTTTTACTGCGTTTGATTTAACTCCTTTTCATGACG
TTAAAGTGGTGATTCTTGGCCAAGACCCTTATCACGGAGAGGGTCAAGCACATGGTTTGTCCTTTTCTGTGTTACCAGGA
GTAAAAATTCCTCCTTCTTTACGTAATATGTATAAAGAACTGGCTGAGGATATTCCCGGTTTTACTATTCCTGAACATGG
ATATTTAAAAACATGGGCAGAACAAGGGGTGCTGTTGTTGAACACGGTTCTGACCGTTGAGGAAGCAAAAGCTCATTCTC
ATGCCAAGTTTGGTTGGGAAACCTTCACGGATGCCATCATCAAAAAAATCAATGATGATATGGAAGGCGTTATTTTTTTA
TTGTGGGGGGCTCACGCTCAGAAAAAAGGAGCGAATATTGATACAAGTCGTCATTTTATTCTTCAGGCACCTCATCCATC
TCCATTATCTGCACATCGTGGTTTTTTTGGTTGTAAGCATTTTTCACAAACGAATGAATTATTACGCAAGCAAAACTTAT
CTGAAATCAATTGGGGAGCGGTTACATCAAGTTAA

Upstream 100 bases:

>100_bases
ATGACCGATTTAATAATATACCGCTAGTTTTGGAAACGATTGATCCTGATATTTGGAAAGATGAGATAGCTCAATTAAGA
ACGCTGAGTGAGAAAAAATA

Downstream 100 bases:

>100_bases
CTGGATGAAATTTGAACTAAATCCTGTGCTCTCATACTGATGATATACACTTATCTATTGTAATAGTTTACAAAGTAAAG
GAGGACAGGATGCTTATTGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MALTWNSIISAEKKKAYYQSMSEKIDAQRSLGKSIFPKEEHIFTAFDLTPFHDVKVVILGQDPYHGEGQAHGLSFSVLPG
VKIPPSLRNMYKELAEDIPGFTIPEHGYLKTWAEQGVLLLNTVLTVEEAKAHSHAKFGWETFTDAIIKKINDDMEGVIFL
LWGAHAQKKGANIDTSRHFILQAPHPSPLSAHRGFFGCKHFSQTNELLRKQNLSEINWGAVTSS

Sequences:

>Translated_224_residues
MALTWNSIISAEKKKAYYQSMSEKIDAQRSLGKSIFPKEEHIFTAFDLTPFHDVKVVILGQDPYHGEGQAHGLSFSVLPG
VKIPPSLRNMYKELAEDIPGFTIPEHGYLKTWAEQGVLLLNTVLTVEEAKAHSHAKFGWETFTDAIIKKINDDMEGVIFL
LWGAHAQKKGANIDTSRHFILQAPHPSPLSAHRGFFGCKHFSQTNELLRKQNLSEINWGAVTSS
>Mature_223_residues
ALTWNSIISAEKKKAYYQSMSEKIDAQRSLGKSIFPKEEHIFTAFDLTPFHDVKVVILGQDPYHGEGQAHGLSFSVLPGV
KIPPSLRNMYKELAEDIPGFTIPEHGYLKTWAEQGVLLLNTVLTVEEAKAHSHAKFGWETFTDAIIKKINDDMEGVIFLL
WGAHAQKKGANIDTSRHFILQAPHPSPLSAHRGFFGCKHFSQTNELLRKQNLSEINWGAVTSS

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=52.093023255814, Blast_Score=230, Evalue=6e-61,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=52.093023255814, Blast_Score=230, Evalue=7e-61,
Organism=Escherichia coli, GI1788934, Length=219, Percent_Identity=60.2739726027397, Blast_Score=289, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=49.3087557603687, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323620, Length=234, Percent_Identity=41.4529914529915, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_VIBF1 (Q5E2Y8)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205496.1
- HSSP:   P12295
- ProteinModelPortal:   Q5E2Y8
- SMR:   Q5E2Y8
- STRING:   Q5E2Y8
- GeneID:   3279337
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_2113
- NMPDR:   fig|312309.3.peg.2113
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q5E2Y8
- ProtClustDB:   PRK05254
- BioCyc:   VFIS312309:VF2113-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25098; Mature: 24967

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 62-62

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTWNSIISAEKKKAYYQSMSEKIDAQRSLGKSIFPKEEHIFTAFDLTPFHDVKVVILG
CEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEE
QDPYHGEGQAHGLSFSVLPGVKIPPSLRNMYKELAEDIPGFTIPEHGYLKTWAEQGVLLL
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEE
NTVLTVEEAKAHSHAKFGWETFTDAIIKKINDDMEGVIFLLWGAHAQKKGANIDTSRHFI
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEE
LQAPHPSPLSAHRGFFGCKHFSQTNELLRKQNLSEINWGAVTSS
EECCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALTWNSIISAEKKKAYYQSMSEKIDAQRSLGKSIFPKEEHIFTAFDLTPFHDVKVVILG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEEEE
QDPYHGEGQAHGLSFSVLPGVKIPPSLRNMYKELAEDIPGFTIPEHGYLKTWAEQGVLLL
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEE
NTVLTVEEAKAHSHAKFGWETFTDAIIKKINDDMEGVIFLLWGAHAQKKGANIDTSRHFI
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEE
LQAPHPSPLSAHRGFFGCKHFSQTNELLRKQNLSEINWGAVTSS
EECCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA